Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-05

AUTHORS

Lynn M Boyden, Julia M Lewis, Susannah D Barbee, Anna Bas, Michael Girardi, Adrian C Hayday, Robert E Tigelaar, Richard P Lifton

ABSTRACT

B cells, alphabeta T cells and gammadelta T cells are conserved lymphocyte subtypes encoding their antigen receptors from somatically rearranged genes. alphabeta T cells undergo positive selection in the thymus by engagement of their T cell receptors (TCRs) with self-peptides presented by major histocompatibility complex molecules. The molecules that select gammadelta T cells are unknown. Vgamma5+Vdelta1+ cells comprise 90% of mouse epidermal gammadelta T cells. By mapping and genetic complementation using a strain showing loss of Vgamma5+Vdelta1+ cells due to a failure of thymic selection, we show that this defect is caused by mutation in Skint1, a newly identified gene expressed in thymus and skin that encodes a protein with immunoglobulin-like and transmembrane domains. Skint1 is the prototypic member of a rapidly evolving family of at least 11 genes in mouse, with greatest similarity to the butyrophilin genes. These findings define a new family of proteins mediating key epithelial-immune interactions. More... »

PAGES

656-662

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.108

DOI

http://dx.doi.org/10.1038/ng.108

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048242401

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18408721


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