Noninvasive detection of therapeutic cytolytic T cells with 18F–FHBG PET in a patient with glioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-11-18

AUTHORS

Shahriar S Yaghoubi, Michael C Jensen, Nagichettiar Satyamurthy, Shradha Budhiraja, David Paik, Johannes Czernin, Sanjiv S Gambhir

ABSTRACT

BACKGROUND: A 57-year-old man had been diagnosed with grade IV glioblastoma multiforme and was enrolled in a trial of adoptive cellular immunotherapy. The trial involved infusion of ex vivo expanded autologous cytolytic CD8+ T cells (CTLs), genetically engineered to express the interleukin 13 zetakine gene (which encodes a receptor protein that targets these T cells to tumor cells) and the herpes simplex virus 1 thymidine kinase (HSV1 tk) suicide gene, and PET imaging reporter gene. INVESTIGATIONS: MRI, whole-body and brain PET scan with (18)F-radiolabelled 9-[4-fluoro-3-(hydroxymethyl)butyl]guanine ((18)F-FHBG) to detect CTLs that express HSV1 tk, and safety monitoring after injection of (18)F-FHBG. DIAGNOSIS: MRI detected grade III-IV glioblastoma multiforme plus two tumors recurrences that developed after resection of the initial tumor. MANAGEMENT: Surgical resection of primary glioblastoma tumor, enrollment in CTL therapy trial, reresection of glioma recurrences, infusion of approximately 1 x 10(9) CTLs into the site of tumor reresection, and (18)F-FHBG PET scan to detect infused CTLs. More... »

PAGES

53-58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncponc1278

DOI

http://dx.doi.org/10.1038/ncponc1278

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022871634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19015650


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