Metastasis: a therapeutic target for cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-04

AUTHORS

Patricia S Steeg, Dan Theodorescu

ABSTRACT

Metastasis remains the major driver of mortality in patients with cancer. Our growing body of knowledge regarding this process provides the basis for the development of molecularly targeted therapeutics aimed at the tumor cell or its interaction with the host microenvironment. Here we discuss the similarity and differences between primary tumors and metastases, pathways controlling the colonization of a distant organ, and incorporation of antimetastatic therapies into clinical testing. More... »

PAGES

206-219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncponc1066

DOI

http://dx.doi.org/10.1038/ncponc1066

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016512262

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18253104


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