Antiemetics: an update and the MASCC guidelines applied in clinical practice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Jørn Herrstedt

ABSTRACT

Nausea and vomiting are two of the most severe problems for patients treated with chemotherapy. Until the late 1970s, nausea and vomiting induced by chemotherapy was an almost neglected research area. With the introduction of cisplatin, the cytotoxin with the highest emetic potential, research was stimulated and has now resulted in the development of two new classes of antiemetics, the serotonin and neurokinin antagonists. A large number of trials have fine-tuned antiemetic therapy and made evidence-based recommendations possible for the majority of patients receiving chemotherapy. This Review discusses the pathophysiology of nausea and vomiting, the development of antiemetics, highlights some of the newest antiemetics, and finally summarizes recommendations from the evidence-based guidelines developed by the Multinational Association of Supportive Care in Cancer. More... »

PAGES

32-43

References to SciGraph publications

  • 2005-02. Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy in SUPPORTIVE CARE IN CANCER
  • 2007-11. A phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier oncology group study in SUPPORTIVE CARE IN CANCER
  • 2001-11. Implementing evidence based antiemetic guidelines in the oncology setting: results of a 4-month prospective intervention study in SUPPORTIVE CARE IN CANCER
  • 1998-04. Corticosteroids, dopamine antagonists and other drugs in SUPPORTIVE CARE IN CANCER
  • 1981-12. A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation in NATURE
  • 1891-01. Ueber das Brechcentrum und über die Wirkung einiger pharmakologischer Mittel auf dasselbe in VIRCHOWS ARCHIV
  • 2005-02. Delayed emesis: moderately emetogenic chemotherapy in SUPPORTIVE CARE IN CANCER
  • 1984-05. MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1987-12. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding in NATURE
  • 2005-06. Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study in SUPPORTIVE CARE IN CANCER
  • 2005-06. Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1997-07. Clinical and methodological issues in antiemetic therapy: a worldwide survey of experts' opinions in SUPPORTIVE CARE IN CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncponc1021

    DOI

    http://dx.doi.org/10.1038/ncponc1021

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016793645

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18097455


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