Mechanisms of Disease: angiogenesis and the management of breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-09

AUTHORS

Susana Banerjee, Mitch Dowsett, Alan Ashworth, Lesley-Ann Martin

ABSTRACT

Demonstration of the clinically significant activity of bevacizumab in breast cancer has attracted a great deal of interest. Numerous other antiangiogenic treatments are in clinical development and some established therapies including tamoxifen and trastuzumab might function, in part, by suppressing angiogenesis. In this Review, we discuss the potential of various components of the angiogenic pathway as prognostic and predictive factors in breast cancer. In addition, we describe existing clinical trials of antiangiogenic agents and the challenges facing the clinical development and optimum use of these agents for the treatment of breast cancer. More... »

PAGES

536-550

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncponc0905

DOI

http://dx.doi.org/10.1038/ncponc0905

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036209952

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17728712


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