Rituximab treatment for a patient with type I cryoglobulinemic glomerulonephritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

Sushma Pandrangi, Atul Singh, Donald E Wheeler, Noreen F Rossi

ABSTRACT

BACKGROUND: A 74-year-old woman with a history of type I cryoglobulinemia with glomerulonephritis that had been successfully treated with plasmapheresis and cyclophosphamide approximately 9 years earlier presented with hemoptysis and mediastinal lymphadenopathy. Evaluation revealed the reappearance of cryoglobulins and nephrotic-range proteinuria. In addition, the patient's serum creatinine level, which had been stable for approximately 9 years after her first treatment, had increased from 79.2 micromol/l (0.9 mg/dl) to 281.6 micromol/l (3.2 mg/dl) over 6 months. INVESTIGATIONS: Physical examination, serum and urine laboratory analyses, CT scan, mediastinoscopy with lymph node biopsy, bone marrow biopsy, flow cytometry analysis of bone marrow, peripheral blood and lymph node tissue, and percutaneous ultrasound-guided renal biopsy. DIAGNOSIS: Type I cryoglobulinemic glomerulonephritis associated with a CD20(+) lymphoid disorder. MANAGEMENT: One plasmapheresis treatment, one dose of cyclophosphamide, and four weekly cycles of rituximab. More... »

PAGES

393-397

References to SciGraph publications

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URI

http://scigraph.springernature.com/pub.10.1038/ncpneph0823

DOI

http://dx.doi.org/10.1038/ncpneph0823

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035133114

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18493239


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