Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-02

AUTHORS

Charlotte Lussey-Lepoutre, Kate E. R. Hollinshead, Christian Ludwig, Mélanie Menara, Aurélie Morin, Luis-Jaime Castro-Vega, Seth J. Parker, Maxime Janin, Cosimo Martinelli, Chris Ottolenghi, Christian Metallo, Anne-Paule Gimenez-Roqueplo, Judith Favier, Daniel A. Tennant

ABSTRACT

The tricarboxylic acid (TCA) cycle is a central metabolic pathway responsible for supplying reducing potential for oxidative phosphorylation and anabolic substrates for cell growth, repair and proliferation. As such it thought to be essential for cell proliferation and tissue homeostasis. However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Here, we show that loss of SDH activity leads to changes in the metabolism of non-essential amino acids. In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool of aspartate in SDH-deficient cells. Our results demonstrate that the loss of SDH reduces the metabolic plasticity of cells, suggesting vulnerabilities that can be targeted therapeutically. More... »

PAGES

8784

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms9784

DOI

http://dx.doi.org/10.1038/ncomms9784

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044755286

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26522426


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspartic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electron Transport Complex II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroendocrine Tumors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paraganglioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyruvic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Succinate Dehydrogenase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Genetics, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414093.b", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
            "Department of Genetics, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lussey-Lepoutre", 
        "givenName": "Charlotte", 
        "id": "sg:person.01331647615.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331647615.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hollinshead", 
        "givenName": "Kate E. R.", 
        "id": "sg:person.0606243515.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606243515.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ludwig", 
        "givenName": "Christian", 
        "id": "sg:person.01112544071.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112544071.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menara", 
        "givenName": "M\u00e9lanie", 
        "id": "sg:person.01213751254.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213751254.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morin", 
        "givenName": "Aur\u00e9lie", 
        "id": "sg:person.0670025330.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670025330.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castro-Vega", 
        "givenName": "Luis-Jaime", 
        "id": "sg:person.0775751012.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775751012.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Seth J.", 
        "id": "sg:person.01154176444.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154176444.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM, Unit 1124, F-75015 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
            "Metabolic Biochemistry Laboratory, H\u00f4pital Necker-Enfants Malades, F-75015 Paris, France", 
            "INSERM, Unit 1124, F-75015 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janin", 
        "givenName": "Maxime", 
        "id": "sg:person.01145636054.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145636054.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinelli", 
        "givenName": "Cosimo", 
        "id": "sg:person.0676257175.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676257175.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM, Unit 1124, F-75015 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
            "Metabolic Biochemistry Laboratory, H\u00f4pital Necker-Enfants Malades, F-75015 Paris, France", 
            "INSERM, Unit 1124, F-75015 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ottolenghi", 
        "givenName": "Chris", 
        "id": "sg:person.01255465342.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255465342.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Metallo", 
        "givenName": "Christian", 
        "id": "sg:person.01324763237.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324763237.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.414093.b", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
            "Department of Genetics, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gimenez-Roqueplo", 
        "givenName": "Anne-Paule", 
        "id": "sg:person.0717711677.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717711677.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.508487.6", 
          "name": [
            "INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, F-75006 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Favier", 
        "givenName": "Judith", 
        "id": "sg:person.01276322234.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276322234.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tennant", 
        "givenName": "Daniel A.", 
        "id": "sg:person.0736565277.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736565277.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2105-12-366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016369639", 
          "https://doi.org/10.1186/1471-2105-12-366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2049-3002-1-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033496592", 
          "https://doi.org/10.1186/2049-3002-1-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00197809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001469691", 
          "https://doi.org/10.1007/bf00197809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/81551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013213756", 
          "https://doi.org/10.1038/81551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2049-3002-2-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019627735", 
          "https://doi.org/10.1186/2049-3002-2-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms7044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032420339", 
          "https://doi.org/10.1038/ncomms7044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2014.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037812379", 
          "https://doi.org/10.1038/onc.2014.47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050053957", 
          "https://doi.org/10.1038/nature10642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053544093", 
          "https://doi.org/10.1038/nature10602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044931865", 
          "https://doi.org/10.1038/nature10363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045502595", 
          "https://doi.org/10.1038/nature10350"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-11-02", 
    "datePublishedReg": "2015-11-02", 
    "description": "The tricarboxylic acid (TCA) cycle is a central metabolic pathway responsible for supplying reducing potential for oxidative phosphorylation and anabolic substrates for cell growth, repair and proliferation. As such it thought to be essential for cell proliferation and tissue homeostasis. However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Here, we show that loss of SDH activity leads to changes in the metabolism of non-essential amino acids. In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool of aspartate in SDH-deficient cells. Our results demonstrate that the loss of SDH reduces the metabolic plasticity of cells, suggesting vulnerabilities that can be targeted therapeutically. ", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms9784", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3624707", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3790173", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "succinate dehydrogenase", 
      "loss of SDH", 
      "SDH-deficient cells", 
      "central metabolic pathways", 
      "TCA cycle enzymes", 
      "tricarboxylic acid cycle", 
      "cellular anabolism", 
      "metabolic plasticity", 
      "tissue homeostasis", 
      "anabolic substrates", 
      "TCA cycle", 
      "oxidative phosphorylation", 
      "cycle enzymes", 
      "non-essential amino acids", 
      "acid cycle", 
      "pyruvate carboxylase", 
      "metabolic pathways", 
      "proliferative phenotype", 
      "amino acids", 
      "cell growth", 
      "cell proliferation", 
      "pyruvate carboxylation", 
      "depleted pool", 
      "cells", 
      "SDH activity", 
      "proliferation", 
      "activity results", 
      "carboxylase", 
      "phosphorylation", 
      "homeostasis", 
      "mutations", 
      "phenotype", 
      "enzyme", 
      "pathway", 
      "carboxylation", 
      "dehydrogenase", 
      "plasticity", 
      "anabolism", 
      "metabolism", 
      "cycle", 
      "pool", 
      "aspartate", 
      "loss", 
      "growth", 
      "tissue", 
      "acid", 
      "repair", 
      "substrate", 
      "activity", 
      "potential", 
      "changes", 
      "results", 
      "initial report", 
      "paraganglioma", 
      "tumors", 
      "vulnerability", 
      "report", 
      "dependency", 
      "succinate dehydrogenase activity results", 
      "dehydrogenase activity results"
    ], 
    "name": "Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism", 
    "pagination": "8784", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044755286"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms9784"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26522426"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms9784", 
      "https://app.dimensions.ai/details/publication/pub.1044755286"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_682.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms9784"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms9784'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms9784'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms9784'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms9784'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      22 PREDICATES      109 URIs      90 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms9784 schema:about N14776aae61e142219ed64b204f85dc60
2 N2e58d57eebea4e3d911dbc162bd7d752
3 N2f36d6c0dbb741d699e03f53ccc4a2ce
4 N69c7f5533c1640f492fe7435397ce2ea
5 N77861656d58d443c82d5196fc3d7073f
6 N913a41a32be244b4968fb35c2b4afed8
7 N942cd38ac53b441eb462a44585fc5420
8 N964423e4229c43339abb287162c2d5d1
9 Ndcb572a9c98f4f98ad06754a036dea86
10 Ne61719ffea8c44a493bd08d51891c96d
11 Neeb140b3cef94badb15562062532aa22
12 Nff76c8c77d0d4a15a5aa087e45c9cdcf
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N66d4fe44990640309d14de5be334106c
16 schema:citation sg:pub.10.1007/bf00197809
17 sg:pub.10.1038/81551
18 sg:pub.10.1038/nature10350
19 sg:pub.10.1038/nature10363
20 sg:pub.10.1038/nature10602
21 sg:pub.10.1038/nature10642
22 sg:pub.10.1038/ncomms7044
23 sg:pub.10.1038/onc.2014.47
24 sg:pub.10.1186/1471-2105-12-366
25 sg:pub.10.1186/2049-3002-1-12
26 sg:pub.10.1186/2049-3002-2-10
27 schema:datePublished 2015-11-02
28 schema:datePublishedReg 2015-11-02
29 schema:description The tricarboxylic acid (TCA) cycle is a central metabolic pathway responsible for supplying reducing potential for oxidative phosphorylation and anabolic substrates for cell growth, repair and proliferation. As such it thought to be essential for cell proliferation and tissue homeostasis. However, since the initial report of an inactivating mutation in the TCA cycle enzyme complex, succinate dehydrogenase (SDH) in paraganglioma (PGL), it has become clear that some cells and tissues are not only able to survive with a truncated TCA cycle, but that they are also able of supporting proliferative phenotype observed in tumours. Here, we show that loss of SDH activity leads to changes in the metabolism of non-essential amino acids. In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool of aspartate in SDH-deficient cells. Our results demonstrate that the loss of SDH reduces the metabolic plasticity of cells, suggesting vulnerabilities that can be targeted therapeutically.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree true
33 schema:isPartOf N20b3e9cab3d7485697aebaa61ddc8f03
34 N9f898d32209a4f4f80d781db27cc477d
35 sg:journal.1043282
36 schema:keywords SDH activity
37 SDH-deficient cells
38 TCA cycle
39 TCA cycle enzymes
40 acid
41 acid cycle
42 activity
43 activity results
44 amino acids
45 anabolic substrates
46 anabolism
47 aspartate
48 carboxylase
49 carboxylation
50 cell growth
51 cell proliferation
52 cells
53 cellular anabolism
54 central metabolic pathways
55 changes
56 cycle
57 cycle enzymes
58 dehydrogenase
59 dehydrogenase activity results
60 dependency
61 depleted pool
62 enzyme
63 growth
64 homeostasis
65 initial report
66 loss
67 loss of SDH
68 metabolic pathways
69 metabolic plasticity
70 metabolism
71 mutations
72 non-essential amino acids
73 oxidative phosphorylation
74 paraganglioma
75 pathway
76 phenotype
77 phosphorylation
78 plasticity
79 pool
80 potential
81 proliferation
82 proliferative phenotype
83 pyruvate carboxylase
84 pyruvate carboxylation
85 repair
86 report
87 results
88 substrate
89 succinate dehydrogenase
90 succinate dehydrogenase activity results
91 tissue
92 tissue homeostasis
93 tricarboxylic acid cycle
94 tumors
95 vulnerability
96 schema:name Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
97 schema:pagination 8784
98 schema:productId N0e5cb9b143fb445fb87813ac185db9b0
99 N7e17c76075f74b6ca085b5bdfa21f8f7
100 N9d592e1d937b448692150352bb60fa40
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044755286
102 https://doi.org/10.1038/ncomms9784
103 schema:sdDatePublished 2021-11-01T18:26
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N530e24bfb446490f9b0cc2d85bc2874d
106 schema:url https://doi.org/10.1038/ncomms9784
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N0e5cb9b143fb445fb87813ac185db9b0 schema:name pubmed_id
111 schema:value 26522426
112 rdf:type schema:PropertyValue
113 N14776aae61e142219ed64b204f85dc60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Paraganglioma
115 rdf:type schema:DefinedTerm
116 N17ea9c71f113407e96e3f56efa1b94eb rdf:first sg:person.0717711677.25
117 rdf:rest Na4096aa0fb644241916d949129147efc
118 N1cd382f5b04742bfae78c4d7300cb405 rdf:first sg:person.01255465342.08
119 rdf:rest N9e4498625e37481b916521af46037e16
120 N20b3e9cab3d7485697aebaa61ddc8f03 schema:issueNumber 1
121 rdf:type schema:PublicationIssue
122 N211d6fbe433045b3a82a2a0b5165c46e rdf:first sg:person.01213751254.33
123 rdf:rest N4dfb092bca284d36a7ccf67b2767ab51
124 N2e58d57eebea4e3d911dbc162bd7d752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mice
126 rdf:type schema:DefinedTerm
127 N2f36d6c0dbb741d699e03f53ccc4a2ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N49ebcd064c1a4e529a3a67015342bda8 rdf:first sg:person.01154176444.58
131 rdf:rest Nb09edc7699ae468e9d7380865296687e
132 N4dfb092bca284d36a7ccf67b2767ab51 rdf:first sg:person.0670025330.46
133 rdf:rest N51f4e96d64f14ff485fc6c3be98d241e
134 N51f4e96d64f14ff485fc6c3be98d241e rdf:first sg:person.0775751012.91
135 rdf:rest N49ebcd064c1a4e529a3a67015342bda8
136 N530e24bfb446490f9b0cc2d85bc2874d schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N61b113a9bf4e4e2e9def244e63215154 rdf:first sg:person.0736565277.32
139 rdf:rest rdf:nil
140 N66d4fe44990640309d14de5be334106c rdf:first sg:person.01331647615.72
141 rdf:rest Ncae61fe40e834e6da156ebde9c63d0e4
142 N69c7f5533c1640f492fe7435397ce2ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Pyruvic Acid
144 rdf:type schema:DefinedTerm
145 N6e689d43f6b1430ba3c0fced7b81455e rdf:first sg:person.01112544071.19
146 rdf:rest N211d6fbe433045b3a82a2a0b5165c46e
147 N77861656d58d443c82d5196fc3d7073f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Electron Transport Complex II
149 rdf:type schema:DefinedTerm
150 N7e17c76075f74b6ca085b5bdfa21f8f7 schema:name doi
151 schema:value 10.1038/ncomms9784
152 rdf:type schema:PropertyValue
153 N913a41a32be244b4968fb35c2b4afed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Mice, Knockout
155 rdf:type schema:DefinedTerm
156 N942cd38ac53b441eb462a44585fc5420 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Animals
158 rdf:type schema:DefinedTerm
159 N964423e4229c43339abb287162c2d5d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Neuroendocrine Tumors
161 rdf:type schema:DefinedTerm
162 N9d592e1d937b448692150352bb60fa40 schema:name dimensions_id
163 schema:value pub.1044755286
164 rdf:type schema:PropertyValue
165 N9e4498625e37481b916521af46037e16 rdf:first sg:person.01324763237.16
166 rdf:rest N17ea9c71f113407e96e3f56efa1b94eb
167 N9f898d32209a4f4f80d781db27cc477d schema:volumeNumber 6
168 rdf:type schema:PublicationVolume
169 Na4096aa0fb644241916d949129147efc rdf:first sg:person.01276322234.58
170 rdf:rest N61b113a9bf4e4e2e9def244e63215154
171 Nb09edc7699ae468e9d7380865296687e rdf:first sg:person.01145636054.38
172 rdf:rest Nbd82827f9f3542e3b5b531d5c1adc17b
173 Nbd82827f9f3542e3b5b531d5c1adc17b rdf:first sg:person.0676257175.04
174 rdf:rest N1cd382f5b04742bfae78c4d7300cb405
175 Ncae61fe40e834e6da156ebde9c63d0e4 rdf:first sg:person.0606243515.95
176 rdf:rest N6e689d43f6b1430ba3c0fced7b81455e
177 Ndcb572a9c98f4f98ad06754a036dea86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Aspartic Acid
179 rdf:type schema:DefinedTerm
180 Ne61719ffea8c44a493bd08d51891c96d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Membrane Proteins
182 rdf:type schema:DefinedTerm
183 Neeb140b3cef94badb15562062532aa22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Succinate Dehydrogenase
185 rdf:type schema:DefinedTerm
186 Nff76c8c77d0d4a15a5aa087e45c9cdcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Oxidative Phosphorylation
188 rdf:type schema:DefinedTerm
189 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
190 schema:name Biological Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biochemistry and Cell Biology
194 rdf:type schema:DefinedTerm
195 sg:grant.3624707 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9784
196 rdf:type schema:MonetaryGrant
197 sg:grant.3790173 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9784
198 rdf:type schema:MonetaryGrant
199 sg:journal.1043282 schema:issn 2041-1723
200 schema:name Nature Communications
201 schema:publisher Springer Nature
202 rdf:type schema:Periodical
203 sg:person.01112544071.19 schema:affiliation grid-institutes:grid.6572.6
204 schema:familyName Ludwig
205 schema:givenName Christian
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112544071.19
207 rdf:type schema:Person
208 sg:person.01145636054.38 schema:affiliation grid-institutes:grid.7429.8
209 schema:familyName Janin
210 schema:givenName Maxime
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145636054.38
212 rdf:type schema:Person
213 sg:person.01154176444.58 schema:affiliation grid-institutes:grid.266100.3
214 schema:familyName Parker
215 schema:givenName Seth J.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154176444.58
217 rdf:type schema:Person
218 sg:person.01213751254.33 schema:affiliation grid-institutes:grid.508487.6
219 schema:familyName Menara
220 schema:givenName Mélanie
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213751254.33
222 rdf:type schema:Person
223 sg:person.01255465342.08 schema:affiliation grid-institutes:grid.7429.8
224 schema:familyName Ottolenghi
225 schema:givenName Chris
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255465342.08
227 rdf:type schema:Person
228 sg:person.01276322234.58 schema:affiliation grid-institutes:grid.508487.6
229 schema:familyName Favier
230 schema:givenName Judith
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276322234.58
232 rdf:type schema:Person
233 sg:person.01324763237.16 schema:affiliation grid-institutes:grid.266100.3
234 schema:familyName Metallo
235 schema:givenName Christian
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324763237.16
237 rdf:type schema:Person
238 sg:person.01331647615.72 schema:affiliation grid-institutes:grid.414093.b
239 schema:familyName Lussey-Lepoutre
240 schema:givenName Charlotte
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331647615.72
242 rdf:type schema:Person
243 sg:person.0606243515.95 schema:affiliation grid-institutes:grid.6572.6
244 schema:familyName Hollinshead
245 schema:givenName Kate E. R.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606243515.95
247 rdf:type schema:Person
248 sg:person.0670025330.46 schema:affiliation grid-institutes:grid.508487.6
249 schema:familyName Morin
250 schema:givenName Aurélie
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670025330.46
252 rdf:type schema:Person
253 sg:person.0676257175.04 schema:affiliation grid-institutes:grid.508487.6
254 schema:familyName Martinelli
255 schema:givenName Cosimo
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676257175.04
257 rdf:type schema:Person
258 sg:person.0717711677.25 schema:affiliation grid-institutes:grid.414093.b
259 schema:familyName Gimenez-Roqueplo
260 schema:givenName Anne-Paule
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717711677.25
262 rdf:type schema:Person
263 sg:person.0736565277.32 schema:affiliation grid-institutes:grid.6572.6
264 schema:familyName Tennant
265 schema:givenName Daniel A.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736565277.32
267 rdf:type schema:Person
268 sg:person.0775751012.91 schema:affiliation grid-institutes:grid.508487.6
269 schema:familyName Castro-Vega
270 schema:givenName Luis-Jaime
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775751012.91
272 rdf:type schema:Person
273 sg:pub.10.1007/bf00197809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001469691
274 https://doi.org/10.1007/bf00197809
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/81551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013213756
277 https://doi.org/10.1038/81551
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nature10350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045502595
280 https://doi.org/10.1038/nature10350
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nature10363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044931865
283 https://doi.org/10.1038/nature10363
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature10602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053544093
286 https://doi.org/10.1038/nature10602
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nature10642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050053957
289 https://doi.org/10.1038/nature10642
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/ncomms7044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032420339
292 https://doi.org/10.1038/ncomms7044
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/onc.2014.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037812379
295 https://doi.org/10.1038/onc.2014.47
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/1471-2105-12-366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016369639
298 https://doi.org/10.1186/1471-2105-12-366
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/2049-3002-1-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033496592
301 https://doi.org/10.1186/2049-3002-1-12
302 rdf:type schema:CreativeWork
303 sg:pub.10.1186/2049-3002-2-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019627735
304 https://doi.org/10.1186/2049-3002-2-10
305 rdf:type schema:CreativeWork
306 grid-institutes:grid.266100.3 schema:alternateName Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
307 schema:name Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
308 rdf:type schema:Organization
309 grid-institutes:grid.414093.b schema:alternateName Department of Genetics, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
310 schema:name Department of Genetics, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France
311 INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France
312 Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France
313 rdf:type schema:Organization
314 grid-institutes:grid.508487.6 schema:alternateName Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France
315 schema:name INSERM, UMR970, Paris-Cardiovascular Research Center at HEGP, F-75015 Paris, France
316 Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France
317 rdf:type schema:Organization
318 grid-institutes:grid.6572.6 schema:alternateName Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
319 schema:name Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
320 rdf:type schema:Organization
321 grid-institutes:grid.7429.8 schema:alternateName INSERM, Unit 1124, F-75015 Paris, France
322 schema:name INSERM, Unit 1124, F-75015 Paris, France
323 Metabolic Biochemistry Laboratory, Hôpital Necker-Enfants Malades, F-75015 Paris, France
324 Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...