Stem and progenitor cell division kinetics during postnatal mouse mammary gland development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Rajshekhar R. Giraddi, Mona Shehata, Mercedes Gallardo, Maria A. Blasco, Benjamin D. Simons, John Stingl

ABSTRACT

The cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, we administered synthetic nucleosides for varying periods of time to mice at different stages of postnatal development and monitored the rate of uptake of these nucleosides in the different mammary cell compartments. Here we show that most cell division in the adult virgin gland is restricted to the oestrogen receptor-expressing luminal cell lineage. Our data also demonstrate that the oestrogen receptor-expressing, milk and basal cell subpopulations have telomere lengths and cell division kinetics that are not compatible with these cells being hierarchically organized; instead, our data indicate that in the adult homeostatic gland, each cell type is largely maintained by its own restricted progenitors. We also observe that transplantable stem cells are largely quiescent during oestrus, but are cycling during dioestrus when progesterone levels are high. More... »

PAGES

8487

References to SciGraph publications

  • 2009-08. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers in NATURE MEDICINE
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  • 2010-06. Progesterone induces adult mammary stem cell expansion in NATURE
  • 2013-08. Unravelling stem cell dynamics by lineage tracing in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-02. New insights into lineage restriction of mammary gland epithelium using parity-identified mammary epithelial cells in BREAST CANCER RESEARCH
  • 2001-05. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue in BREAST CANCER RESEARCH AND TREATMENT
  • 2012-10. Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland in BREAST CANCER RESEARCH
  • 2015-01. Identification of multipotent mammary stem cells by protein C receptor expression in NATURE
  • 2006-01. Generation of a functional mammary gland from a single stem cell in NATURE
  • 2006-02. Purification and unique properties of mammary epithelial stem cells in NATURE
  • 2010-06. Control of mammary stem cell function by steroid hormone signalling in NATURE
  • 2014-10. Mammary stem cells have myoepithelial cell properties in NATURE CELL BIOLOGY
  • 2012-02. c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer in ONCOGENE
  • 2014-02. In situ identification of bipotent stem cells in the mammary gland in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms9487

    DOI

    http://dx.doi.org/10.1038/ncomms9487

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047726240

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26511661


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