Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09-29

AUTHORS

Zhihong Sun, Hugh M. B. Harris, Angela McCann, Chenyi Guo, Silvia Argimón, Wenyi Zhang, Xianwei Yang, Ian B Jeffery, Jakki C. Cooney, Todd F. Kagawa, Wenjun Liu, Yuqin Song, Elisa Salvetti, Agnieszka Wrobel, Pia Rasinkangas, Julian Parkhill, Mary C. Rea, Orla O’Sullivan, Jarmo Ritari, François P. Douillard, R. Paul Ross, Ruifu Yang, Alexandra E. Briner, Giovanna E. Felis, Willem M. de Vos, Rodolphe Barrangou, Todd R. Klaenhammer, Page W. Caufield, Yujun Cui, Heping Zhang, Paul W. O’Toole

ABSTRACT

Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species. More... »

PAGES

8322

References to SciGraph publications

  • 2011-08-02. Glycogen with short average chain length enhances bacterial durability in THE SCIENCE OF NATURE
  • 2014-03-02. CRISPR-Cas systems for editing, regulating and targeting genomes in NATURE BIOTECHNOLOGY
  • 2006-02. Helicobacter pylori phase variation, immune modulation and gastric autoimmunity in NATURE REVIEWS MICROBIOLOGY
  • 1983-05. Carbohydrate metabolism in lactic acid bacteria in ANTONIE VAN LEEUWENHOEK
  • 2014-06-10. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2010-05-27. Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2009-06. Dextranase in sugar industry: A review in SUGAR TECH
  • 2012-12-23. Defining bacterial species in the genomic era: insights from the genus Acinetobacter in BMC MICROBIOLOGY
  • 2003-09-11. The COG database: an updated version includes eukaryotes in BMC BIOINFORMATICS
  • 2007-08. Dichotomy in post-genomic microbiology in NATURE BIOTECHNOLOGY
  • 2007-05-23. The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats in BMC BIOINFORMATICS
  • 2001-08. Microbial xylanases and their industrial applications: a review in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2012-11-07. The Genus Lactobacillus: A Taxonomic Update in PROBIOTICS AND ANTIMICROBIAL PROTEINS
  • 2011-01-01. Phylogenomic reconstruction of lactic acid bacteria: an update in BMC ECOLOGY AND EVOLUTION
  • 2012-09-25. The impact of probiotics and prebiotics on the immune system in NATURE REVIEWS IMMUNOLOGY
  • 2014-09-08. Unusual genome complexity in Lactobacillus salivarius JCM1046 in BMC GENOMICS
  • 1999-11. Multi-domain, cell-envelope proteinases of lactic acid bacteria in ANTONIE VAN LEEUWENHOEK
  • 2013-01-29. RNA-guided editing of bacterial genomes using CRISPR-Cas systems in NATURE BIOTECHNOLOGY
  • 1995. The genus Lactobacillus in THE GENERA OF LACTIC ACID BACTERIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms9322

    DOI

    http://dx.doi.org/10.1038/ncomms9322

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036078654

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26415554


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biotechnology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Bacterial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lactobacillus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leuconostoc", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pediococcus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phylogeny", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China", 
              "id": "http://www.grid.ac/institutes/grid.411638.9", 
              "name": [
                "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Zhihong", 
            "id": "sg:person.01266267457.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266267457.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harris", 
            "givenName": "Hugh M. B.", 
            "id": "sg:person.012731144752.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731144752.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCann", 
            "givenName": "Angela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China", 
              "id": "http://www.grid.ac/institutes/grid.410740.6", 
              "name": [
                "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "Chenyi", 
            "id": "sg:person.01264130270.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264130270.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Dentistry, New York University, 10010, New York City, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "College of Dentistry, New York University, 10010, New York City, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Argim\u00f3n", 
            "givenName": "Silvia", 
            "id": "sg:person.01257154656.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257154656.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China", 
              "id": "http://www.grid.ac/institutes/grid.411638.9", 
              "name": [
                "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Wenyi", 
            "id": "sg:person.01221767155.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221767155.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China", 
              "id": "http://www.grid.ac/institutes/grid.410740.6", 
              "name": [
                "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Xianwei", 
            "id": "sg:person.0641227034.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641227034.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jeffery", 
            "givenName": "Ian B", 
            "id": "sg:person.0750017374.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750017374.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department Life Sciences & MSSI, University of Limerick, V94 T9PX, Limerick, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.10049.3c", 
              "name": [
                "Department Life Sciences & MSSI, University of Limerick, V94 T9PX, Limerick, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cooney", 
            "givenName": "Jakki C.", 
            "id": "sg:person.01301362237.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301362237.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department Life Sciences & MSSI, University of Limerick, V94 T9PX, Limerick, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.10049.3c", 
              "name": [
                "Department Life Sciences & MSSI, University of Limerick, V94 T9PX, Limerick, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kagawa", 
            "givenName": "Todd F.", 
            "id": "sg:person.01254363134.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254363134.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China", 
              "id": "http://www.grid.ac/institutes/grid.411638.9", 
              "name": [
                "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Wenjun", 
            "id": "sg:person.01103144213.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103144213.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China", 
              "id": "http://www.grid.ac/institutes/grid.411638.9", 
              "name": [
                "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Yuqin", 
            "id": "sg:person.01355661675.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355661675.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biotechnology, University of Verona, 37134, Verona, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5611.3", 
              "name": [
                "Department of Biotechnology, University of Verona, 37134, Verona, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salvetti", 
            "givenName": "Elisa", 
            "id": "sg:person.0716567706.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716567706.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wrobel", 
            "givenName": "Agnieszka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rasinkangas", 
            "givenName": "Pia", 
            "id": "sg:person.0723054564.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723054564.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Trust Sanger Centre, CB10 1SA, Hinxton, UK", 
              "id": "http://www.grid.ac/institutes/grid.52788.30", 
              "name": [
                "Wellcome Trust Sanger Centre, CB10 1SA, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parkhill", 
            "givenName": "Julian", 
            "id": "sg:person.01273656103.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273656103.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rea", 
            "givenName": "Mary C.", 
            "id": "sg:person.0737720307.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737720307.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Sullivan", 
            "givenName": "Orla", 
            "id": "sg:person.01204776264.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204776264.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ritari", 
            "givenName": "Jarmo", 
            "id": "sg:person.01324670045.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324670045.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland", 
              "id": "http://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Douillard", 
            "givenName": "Fran\u00e7ois P.", 
            "id": "sg:person.01225300522.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225300522.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paul Ross", 
            "givenName": "R.", 
            "id": "sg:person.0702431361.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702431361.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China", 
              "id": "http://www.grid.ac/institutes/grid.410740.6", 
              "name": [
                "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Ruifu", 
            "id": "sg:person.0612632261.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612632261.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA", 
              "id": "http://www.grid.ac/institutes/grid.40803.3f", 
              "name": [
                "Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Briner", 
            "givenName": "Alexandra E.", 
            "id": "sg:person.01320140272.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320140272.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biotechnology, University of Verona, 37134, Verona, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5611.3", 
              "name": [
                "Department of Biotechnology, University of Verona, 37134, Verona, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Felis", 
            "givenName": "Giovanna E.", 
            "id": "sg:person.01127637404.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127637404.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Microbiology, Wageningen University, 6703HB, Wageningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4818.5", 
              "name": [
                "Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland", 
                "Laboratory of Microbiology, Wageningen University, 6703HB, Wageningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Vos", 
            "givenName": "Willem M.", 
            "id": "sg:person.01114225554.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114225554.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA", 
              "id": "http://www.grid.ac/institutes/grid.40803.3f", 
              "name": [
                "Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barrangou", 
            "givenName": "Rodolphe", 
            "id": "sg:person.01125557540.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125557540.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA", 
              "id": "http://www.grid.ac/institutes/grid.40803.3f", 
              "name": [
                "Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klaenhammer", 
            "givenName": "Todd R.", 
            "id": "sg:person.053670260.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053670260.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Dentistry, New York University, 10010, New York City, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "College of Dentistry, New York University, 10010, New York City, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caufield", 
            "givenName": "Page W.", 
            "id": "sg:person.014703742367.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014703742367.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China", 
              "id": "http://www.grid.ac/institutes/grid.410740.6", 
              "name": [
                "State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cui", 
            "givenName": "Yujun", 
            "id": "sg:person.01246443321.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246443321.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China", 
              "id": "http://www.grid.ac/institutes/grid.411638.9", 
              "name": [
                "Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Heping", 
            "id": "sg:person.0666573320.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666573320.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Toole", 
            "givenName": "Paul W.", 
            "id": "sg:person.01305242542.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242542.02"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1471-2105-8-172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040124966", 
              "https://doi.org/10.1186/1471-2105-8-172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0807-848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044891234", 
              "https://doi.org/10.1038/nbt0807-848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1002036906922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013699408", 
              "https://doi.org/10.1023/a:1002036906922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12602-012-9117-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052576414", 
              "https://doi.org/10.1007/s12602-012-9117-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2148-11-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035841015", 
              "https://doi.org/10.1186/1471-2148-11-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2010.61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037681660", 
              "https://doi.org/10.1038/ismej.2010.61"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044893278", 
              "https://doi.org/10.1038/nrmicro1344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-4-41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013163036", 
              "https://doi.org/10.1186/1471-2105-4-41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00399499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017726664", 
              "https://doi.org/10.1007/bf00399499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002530100704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021301331", 
              "https://doi.org/10.1007/s002530100704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2180-12-302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024137643", 
              "https://doi.org/10.1186/1471-2180-12-302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2014.66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012609471", 
              "https://doi.org/10.1038/nrgastro.2014.66"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00114-011-0832-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025072298", 
              "https://doi.org/10.1007/s00114-011-0832-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038520013", 
              "https://doi.org/10.1038/nbt.2842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002258704", 
              "https://doi.org/10.1038/nri3312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-5817-0_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044121657", 
              "https://doi.org/10.1007/978-1-4615-5817-0_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019888616", 
              "https://doi.org/10.1038/nbt.2508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011364384", 
              "https://doi.org/10.1186/1471-2164-15-771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12355-009-0019-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016648182", 
              "https://doi.org/10.1007/s12355-009-0019-3"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-09-29", 
        "datePublishedReg": "2015-09-29", 
        "description": "Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ncomms9322", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3983169", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4251338", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4250665", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3790209", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8182966", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2491299", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3984108", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "keywords": [
          "nutrient-rich niche", 
          "CRISPR-Cas immune systems", 
          "robust phylogenomic framework", 
          "important lactic acid bacteria", 
          "host interaction factors", 
          "phylogenomic distribution", 
          "comparative genomics", 
          "phylogenomic framework", 
          "metabolic diversity", 
          "genetic catalog", 
          "species identity", 
          "genome sequence", 
          "genome editing", 
          "biotechnology potential", 
          "new species", 
          "biotechnology resource", 
          "lactic acid bacteria", 
          "species", 
          "genus", 
          "diverse group", 
          "acid bacteria", 
          "diverse presence", 
          "Lactobacillus", 
          "immune system", 
          "genomics", 
          "uncertain relationship", 
          "niche", 
          "plants", 
          "protein", 
          "strains", 
          "diversity", 
          "Lactobacillus strains", 
          "editing", 
          "bacteria", 
          "biotechnology", 
          "food preservation", 
          "sequence", 
          "bacteriocin", 
          "therapeutics", 
          "carbohydrates", 
          "animals", 
          "biotransformation", 
          "humans", 
          "mechanism", 
          "stress", 
          "identity", 
          "food", 
          "presence", 
          "environment", 
          "addition", 
          "factors", 
          "potential", 
          "catalogue", 
          "distribution", 
          "process", 
          "resources", 
          "capacity", 
          "preservation", 
          "relationship", 
          "interaction factors", 
          "system", 
          "group", 
          "framework", 
          "industrial environment", 
          "technological processes"
        ], 
        "name": "Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera", 
        "pagination": "8322", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036078654"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncomms9322"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26415554"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncomms9322", 
          "https://app.dimensions.ai/details/publication/pub.1036078654"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_672.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ncomms9322"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms9322'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms9322'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms9322'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms9322'


     

    This table displays all metadata directly associated to this object as RDF triples.

    487 TRIPLES      22 PREDICATES      118 URIs      90 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncomms9322 schema:about N286f0704b84c48afb4cf9a7d6e64e812
    2 N2d29e8f2372e4b8ea6c0fff4d5c31bd9
    3 N2dc7d0f2222745998a980422e4e9aad3
    4 N430e276d38d644f1880fc6abc6d0ef03
    5 N4a189a82175c40b8a7bb8992032a985d
    6 N5b63de85127f404599b92ae8e66a917a
    7 N9496ff28ff444732bc4eb8022b49af53
    8 anzsrc-for:06
    9 anzsrc-for:0604
    10 anzsrc-for:0605
    11 schema:author Nce3e6f59d28049f69cabefd3de5f76f0
    12 schema:citation sg:pub.10.1007/978-1-4615-5817-0_3
    13 sg:pub.10.1007/bf00399499
    14 sg:pub.10.1007/s00114-011-0832-x
    15 sg:pub.10.1007/s002530100704
    16 sg:pub.10.1007/s12355-009-0019-3
    17 sg:pub.10.1007/s12602-012-9117-8
    18 sg:pub.10.1023/a:1002036906922
    19 sg:pub.10.1038/ismej.2010.61
    20 sg:pub.10.1038/nbt.2508
    21 sg:pub.10.1038/nbt.2842
    22 sg:pub.10.1038/nbt0807-848
    23 sg:pub.10.1038/nrgastro.2014.66
    24 sg:pub.10.1038/nri3312
    25 sg:pub.10.1038/nrmicro1344
    26 sg:pub.10.1186/1471-2105-4-41
    27 sg:pub.10.1186/1471-2105-8-172
    28 sg:pub.10.1186/1471-2148-11-1
    29 sg:pub.10.1186/1471-2164-15-771
    30 sg:pub.10.1186/1471-2180-12-302
    31 schema:datePublished 2015-09-29
    32 schema:datePublishedReg 2015-09-29
    33 schema:description Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.
    34 schema:genre article
    35 schema:inLanguage en
    36 schema:isAccessibleForFree true
    37 schema:isPartOf N5f5b968f71dd4ec7972ce76bad6fce1e
    38 Nca3089448e324190aef9d0a1af1871aa
    39 sg:journal.1043282
    40 schema:keywords CRISPR-Cas immune systems
    41 Lactobacillus
    42 Lactobacillus strains
    43 acid bacteria
    44 addition
    45 animals
    46 bacteria
    47 bacteriocin
    48 biotechnology
    49 biotechnology potential
    50 biotechnology resource
    51 biotransformation
    52 capacity
    53 carbohydrates
    54 catalogue
    55 comparative genomics
    56 distribution
    57 diverse group
    58 diverse presence
    59 diversity
    60 editing
    61 environment
    62 factors
    63 food
    64 food preservation
    65 framework
    66 genetic catalog
    67 genome editing
    68 genome sequence
    69 genomics
    70 genus
    71 group
    72 host interaction factors
    73 humans
    74 identity
    75 immune system
    76 important lactic acid bacteria
    77 industrial environment
    78 interaction factors
    79 lactic acid bacteria
    80 mechanism
    81 metabolic diversity
    82 new species
    83 niche
    84 nutrient-rich niche
    85 phylogenomic distribution
    86 phylogenomic framework
    87 plants
    88 potential
    89 presence
    90 preservation
    91 process
    92 protein
    93 relationship
    94 resources
    95 robust phylogenomic framework
    96 sequence
    97 species
    98 species identity
    99 strains
    100 stress
    101 system
    102 technological processes
    103 therapeutics
    104 uncertain relationship
    105 schema:name Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera
    106 schema:pagination 8322
    107 schema:productId N719d3c5c4e9c45b7bb04f04831f2967e
    108 N87ef3cfa0af54bd5b68bd2c42f5460ac
    109 Nd0638aad356445068fb92534898f29c7
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036078654
    111 https://doi.org/10.1038/ncomms9322
    112 schema:sdDatePublished 2022-05-10T10:14
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N09e37aab923b4235aad7bfbdc0d7eee8
    115 schema:url https://doi.org/10.1038/ncomms9322
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N0351ebbc27034300849c5a8ded287a48 rdf:first sg:person.01273656103.87
    120 rdf:rest N6b8781eb15814b08b1361e306f8c1c32
    121 N04187d264c72462cbf54c0c96e24bbe0 rdf:first sg:person.0716567706.33
    122 rdf:rest N506b5ba2d13b4c5dbab77f704cd43575
    123 N09e37aab923b4235aad7bfbdc0d7eee8 schema:name Springer Nature - SN SciGraph project
    124 rdf:type schema:Organization
    125 N0ca5e0bc7b7c49b99a49330c012d5da3 rdf:first sg:person.0641227034.46
    126 rdf:rest N7b5f5977a1c94078b36da92fca1f8403
    127 N0f6ce9c72792495faf374dd82bbc9d6c rdf:first sg:person.01114225554.30
    128 rdf:rest N31af175cb3d941a680734851b92b230d
    129 N20327fc47bcd450992f540b69b10c0a4 rdf:first sg:person.053670260.25
    130 rdf:rest N81033f2ec95f489c887dabc963e271b8
    131 N286f0704b84c48afb4cf9a7d6e64e812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Phylogeny
    133 rdf:type schema:DefinedTerm
    134 N2bc2bff2891f483d96d180de4c907dba rdf:first sg:person.01320140272.61
    135 rdf:rest Nfecda21f7b014f879cff734a22a7773f
    136 N2d29e8f2372e4b8ea6c0fff4d5c31bd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Lactobacillus
    138 rdf:type schema:DefinedTerm
    139 N2dc7d0f2222745998a980422e4e9aad3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Genome, Bacterial
    141 rdf:type schema:DefinedTerm
    142 N31af175cb3d941a680734851b92b230d rdf:first sg:person.01125557540.35
    143 rdf:rest N20327fc47bcd450992f540b69b10c0a4
    144 N430e276d38d644f1880fc6abc6d0ef03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Sequence Analysis, DNA
    146 rdf:type schema:DefinedTerm
    147 N4a189a82175c40b8a7bb8992032a985d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Leuconostoc
    149 rdf:type schema:DefinedTerm
    150 N506b5ba2d13b4c5dbab77f704cd43575 rdf:first N6049a8a232064b0e9b84ff055f1f45b9
    151 rdf:rest Nfdfd27e4b2e94a84a3e7fe45bd2b1223
    152 N5b63de85127f404599b92ae8e66a917a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Pediococcus
    154 rdf:type schema:DefinedTerm
    155 N5e205f2ef89849b7898a21eb084400be rdf:first sg:person.012731144752.28
    156 rdf:rest Na2b3514b5bfe431782f20d6d33da579d
    157 N5f5b968f71dd4ec7972ce76bad6fce1e schema:volumeNumber 6
    158 rdf:type schema:PublicationVolume
    159 N6049a8a232064b0e9b84ff055f1f45b9 schema:affiliation grid-institutes:grid.7872.a
    160 schema:familyName Wrobel
    161 schema:givenName Agnieszka
    162 rdf:type schema:Person
    163 N6330e28561634fad95d466415060dd8e rdf:first sg:person.0666573320.65
    164 rdf:rest N686fca464be441e49b1554fa1d4693f9
    165 N686fca464be441e49b1554fa1d4693f9 rdf:first sg:person.01305242542.02
    166 rdf:rest rdf:nil
    167 N6b8781eb15814b08b1361e306f8c1c32 rdf:first sg:person.0737720307.11
    168 rdf:rest N7a14b72b7f06470ea9f3d6ecef6e5550
    169 N6dc4372300a848b28eca67eabc41f748 rdf:first sg:person.0612632261.50
    170 rdf:rest N2bc2bff2891f483d96d180de4c907dba
    171 N719d3c5c4e9c45b7bb04f04831f2967e schema:name pubmed_id
    172 schema:value 26415554
    173 rdf:type schema:PropertyValue
    174 N7a14b72b7f06470ea9f3d6ecef6e5550 rdf:first sg:person.01204776264.89
    175 rdf:rest Nea0fd6d82abe4dc8bd961f25516eae06
    176 N7b5f5977a1c94078b36da92fca1f8403 rdf:first sg:person.0750017374.55
    177 rdf:rest Nf12c088c591c4c788d6066d0855c7d73
    178 N81033f2ec95f489c887dabc963e271b8 rdf:first sg:person.014703742367.10
    179 rdf:rest Ncc87476649ba4e2cae2bd19315d896c4
    180 N87ef3cfa0af54bd5b68bd2c42f5460ac schema:name dimensions_id
    181 schema:value pub.1036078654
    182 rdf:type schema:PropertyValue
    183 N8c70d23f437842faa36bc917c84784cf rdf:first sg:person.01225300522.52
    184 rdf:rest Nf240377e02394a0a9d23aae2d116e3a8
    185 N9496ff28ff444732bc4eb8022b49af53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Biotechnology
    187 rdf:type schema:DefinedTerm
    188 Na2b3514b5bfe431782f20d6d33da579d rdf:first Ndd55fc859b2a43ab9b01903ce28a5578
    189 rdf:rest Nd086cd1ae5fa4a30ad81072e280c4484
    190 Nbd64400d1aed4bb7973db719c99476a0 rdf:first sg:person.01257154656.14
    191 rdf:rest Neaaf2f3298b74bd9abd450e4e6e87035
    192 Nc0caed24c76a474189765c124fd246b5 rdf:first sg:person.01355661675.25
    193 rdf:rest N04187d264c72462cbf54c0c96e24bbe0
    194 Nca3089448e324190aef9d0a1af1871aa schema:issueNumber 1
    195 rdf:type schema:PublicationIssue
    196 Ncc87476649ba4e2cae2bd19315d896c4 rdf:first sg:person.01246443321.10
    197 rdf:rest N6330e28561634fad95d466415060dd8e
    198 Nce3e6f59d28049f69cabefd3de5f76f0 rdf:first sg:person.01266267457.31
    199 rdf:rest N5e205f2ef89849b7898a21eb084400be
    200 Ncea828deefb842f9bde72788ce333114 rdf:first sg:person.01103144213.48
    201 rdf:rest Nc0caed24c76a474189765c124fd246b5
    202 Nd0638aad356445068fb92534898f29c7 schema:name doi
    203 schema:value 10.1038/ncomms9322
    204 rdf:type schema:PropertyValue
    205 Nd086cd1ae5fa4a30ad81072e280c4484 rdf:first sg:person.01264130270.48
    206 rdf:rest Nbd64400d1aed4bb7973db719c99476a0
    207 Ndd55fc859b2a43ab9b01903ce28a5578 schema:affiliation grid-institutes:grid.7872.a
    208 schema:familyName McCann
    209 schema:givenName Angela
    210 rdf:type schema:Person
    211 Nea0fd6d82abe4dc8bd961f25516eae06 rdf:first sg:person.01324670045.61
    212 rdf:rest N8c70d23f437842faa36bc917c84784cf
    213 Neaaf2f3298b74bd9abd450e4e6e87035 rdf:first sg:person.01221767155.00
    214 rdf:rest N0ca5e0bc7b7c49b99a49330c012d5da3
    215 Nee5966b0431b4dc795959e8ff8a234ca rdf:first sg:person.01254363134.31
    216 rdf:rest Ncea828deefb842f9bde72788ce333114
    217 Nf12c088c591c4c788d6066d0855c7d73 rdf:first sg:person.01301362237.34
    218 rdf:rest Nee5966b0431b4dc795959e8ff8a234ca
    219 Nf240377e02394a0a9d23aae2d116e3a8 rdf:first sg:person.0702431361.50
    220 rdf:rest N6dc4372300a848b28eca67eabc41f748
    221 Nfdfd27e4b2e94a84a3e7fe45bd2b1223 rdf:first sg:person.0723054564.75
    222 rdf:rest N0351ebbc27034300849c5a8ded287a48
    223 Nfecda21f7b014f879cff734a22a7773f rdf:first sg:person.01127637404.45
    224 rdf:rest N0f6ce9c72792495faf374dd82bbc9d6c
    225 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Biological Sciences
    227 rdf:type schema:DefinedTerm
    228 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    229 schema:name Genetics
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Microbiology
    233 rdf:type schema:DefinedTerm
    234 sg:grant.2491299 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.3790209 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.3983169 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.3984108 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.4250665 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.4251338 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    245 rdf:type schema:MonetaryGrant
    246 sg:grant.8182966 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms9322
    247 rdf:type schema:MonetaryGrant
    248 sg:journal.1043282 schema:issn 2041-1723
    249 schema:name Nature Communications
    250 schema:publisher Springer Nature
    251 rdf:type schema:Periodical
    252 sg:person.01103144213.48 schema:affiliation grid-institutes:grid.411638.9
    253 schema:familyName Liu
    254 schema:givenName Wenjun
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103144213.48
    256 rdf:type schema:Person
    257 sg:person.01114225554.30 schema:affiliation grid-institutes:grid.4818.5
    258 schema:familyName de Vos
    259 schema:givenName Willem M.
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114225554.30
    261 rdf:type schema:Person
    262 sg:person.01125557540.35 schema:affiliation grid-institutes:grid.40803.3f
    263 schema:familyName Barrangou
    264 schema:givenName Rodolphe
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125557540.35
    266 rdf:type schema:Person
    267 sg:person.01127637404.45 schema:affiliation grid-institutes:grid.5611.3
    268 schema:familyName Felis
    269 schema:givenName Giovanna E.
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127637404.45
    271 rdf:type schema:Person
    272 sg:person.01204776264.89 schema:affiliation grid-institutes:None
    273 schema:familyName O’Sullivan
    274 schema:givenName Orla
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204776264.89
    276 rdf:type schema:Person
    277 sg:person.01221767155.00 schema:affiliation grid-institutes:grid.411638.9
    278 schema:familyName Zhang
    279 schema:givenName Wenyi
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221767155.00
    281 rdf:type schema:Person
    282 sg:person.01225300522.52 schema:affiliation grid-institutes:grid.7737.4
    283 schema:familyName Douillard
    284 schema:givenName François P.
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225300522.52
    286 rdf:type schema:Person
    287 sg:person.01246443321.10 schema:affiliation grid-institutes:grid.410740.6
    288 schema:familyName Cui
    289 schema:givenName Yujun
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246443321.10
    291 rdf:type schema:Person
    292 sg:person.01254363134.31 schema:affiliation grid-institutes:grid.10049.3c
    293 schema:familyName Kagawa
    294 schema:givenName Todd F.
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254363134.31
    296 rdf:type schema:Person
    297 sg:person.01257154656.14 schema:affiliation grid-institutes:grid.137628.9
    298 schema:familyName Argimón
    299 schema:givenName Silvia
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257154656.14
    301 rdf:type schema:Person
    302 sg:person.01264130270.48 schema:affiliation grid-institutes:grid.410740.6
    303 schema:familyName Guo
    304 schema:givenName Chenyi
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264130270.48
    306 rdf:type schema:Person
    307 sg:person.01266267457.31 schema:affiliation grid-institutes:grid.411638.9
    308 schema:familyName Sun
    309 schema:givenName Zhihong
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266267457.31
    311 rdf:type schema:Person
    312 sg:person.012731144752.28 schema:affiliation grid-institutes:grid.7872.a
    313 schema:familyName Harris
    314 schema:givenName Hugh M. B.
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731144752.28
    316 rdf:type schema:Person
    317 sg:person.01273656103.87 schema:affiliation grid-institutes:grid.52788.30
    318 schema:familyName Parkhill
    319 schema:givenName Julian
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273656103.87
    321 rdf:type schema:Person
    322 sg:person.01301362237.34 schema:affiliation grid-institutes:grid.10049.3c
    323 schema:familyName Cooney
    324 schema:givenName Jakki C.
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301362237.34
    326 rdf:type schema:Person
    327 sg:person.01305242542.02 schema:affiliation grid-institutes:grid.7872.a
    328 schema:familyName O’Toole
    329 schema:givenName Paul W.
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242542.02
    331 rdf:type schema:Person
    332 sg:person.01320140272.61 schema:affiliation grid-institutes:grid.40803.3f
    333 schema:familyName Briner
    334 schema:givenName Alexandra E.
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320140272.61
    336 rdf:type schema:Person
    337 sg:person.01324670045.61 schema:affiliation grid-institutes:grid.7737.4
    338 schema:familyName Ritari
    339 schema:givenName Jarmo
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324670045.61
    341 rdf:type schema:Person
    342 sg:person.01355661675.25 schema:affiliation grid-institutes:grid.411638.9
    343 schema:familyName Song
    344 schema:givenName Yuqin
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355661675.25
    346 rdf:type schema:Person
    347 sg:person.014703742367.10 schema:affiliation grid-institutes:grid.137628.9
    348 schema:familyName Caufield
    349 schema:givenName Page W.
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014703742367.10
    351 rdf:type schema:Person
    352 sg:person.053670260.25 schema:affiliation grid-institutes:grid.40803.3f
    353 schema:familyName Klaenhammer
    354 schema:givenName Todd R.
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053670260.25
    356 rdf:type schema:Person
    357 sg:person.0612632261.50 schema:affiliation grid-institutes:grid.410740.6
    358 schema:familyName Yang
    359 schema:givenName Ruifu
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612632261.50
    361 rdf:type schema:Person
    362 sg:person.0641227034.46 schema:affiliation grid-institutes:grid.410740.6
    363 schema:familyName Yang
    364 schema:givenName Xianwei
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641227034.46
    366 rdf:type schema:Person
    367 sg:person.0666573320.65 schema:affiliation grid-institutes:grid.411638.9
    368 schema:familyName Zhang
    369 schema:givenName Heping
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666573320.65
    371 rdf:type schema:Person
    372 sg:person.0702431361.50 schema:affiliation grid-institutes:None
    373 schema:familyName Paul Ross
    374 schema:givenName R.
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702431361.50
    376 rdf:type schema:Person
    377 sg:person.0716567706.33 schema:affiliation grid-institutes:grid.5611.3
    378 schema:familyName Salvetti
    379 schema:givenName Elisa
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716567706.33
    381 rdf:type schema:Person
    382 sg:person.0723054564.75 schema:affiliation grid-institutes:grid.7737.4
    383 schema:familyName Rasinkangas
    384 schema:givenName Pia
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723054564.75
    386 rdf:type schema:Person
    387 sg:person.0737720307.11 schema:affiliation grid-institutes:None
    388 schema:familyName Rea
    389 schema:givenName Mary C.
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737720307.11
    391 rdf:type schema:Person
    392 sg:person.0750017374.55 schema:affiliation grid-institutes:grid.7872.a
    393 schema:familyName Jeffery
    394 schema:givenName Ian B
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750017374.55
    396 rdf:type schema:Person
    397 sg:pub.10.1007/978-1-4615-5817-0_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044121657
    398 https://doi.org/10.1007/978-1-4615-5817-0_3
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1007/bf00399499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017726664
    401 https://doi.org/10.1007/bf00399499
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1007/s00114-011-0832-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025072298
    404 https://doi.org/10.1007/s00114-011-0832-x
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1007/s002530100704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021301331
    407 https://doi.org/10.1007/s002530100704
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1007/s12355-009-0019-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016648182
    410 https://doi.org/10.1007/s12355-009-0019-3
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1007/s12602-012-9117-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052576414
    413 https://doi.org/10.1007/s12602-012-9117-8
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1023/a:1002036906922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013699408
    416 https://doi.org/10.1023/a:1002036906922
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/ismej.2010.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037681660
    419 https://doi.org/10.1038/ismej.2010.61
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/nbt.2508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888616
    422 https://doi.org/10.1038/nbt.2508
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nbt.2842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038520013
    425 https://doi.org/10.1038/nbt.2842
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/nbt0807-848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044891234
    428 https://doi.org/10.1038/nbt0807-848
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/nrgastro.2014.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012609471
    431 https://doi.org/10.1038/nrgastro.2014.66
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/nri3312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002258704
    434 https://doi.org/10.1038/nri3312
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/nrmicro1344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044893278
    437 https://doi.org/10.1038/nrmicro1344
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1186/1471-2105-4-41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013163036
    440 https://doi.org/10.1186/1471-2105-4-41
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1186/1471-2105-8-172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040124966
    443 https://doi.org/10.1186/1471-2105-8-172
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1186/1471-2148-11-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035841015
    446 https://doi.org/10.1186/1471-2148-11-1
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1186/1471-2164-15-771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011364384
    449 https://doi.org/10.1186/1471-2164-15-771
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1186/1471-2180-12-302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024137643
    452 https://doi.org/10.1186/1471-2180-12-302
    453 rdf:type schema:CreativeWork
    454 grid-institutes:None schema:alternateName Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland
    455 schema:name Department of Biotechnology, Teagasc, Moorepark, P61 C996, Fermoy Co, Cork, Ireland
    456 rdf:type schema:Organization
    457 grid-institutes:grid.10049.3c schema:alternateName Department Life Sciences & MSSI, University of Limerick, V94 T9PX, Limerick, Ireland
    458 schema:name Department Life Sciences & MSSI, University of Limerick, V94 T9PX, Limerick, Ireland
    459 rdf:type schema:Organization
    460 grid-institutes:grid.137628.9 schema:alternateName College of Dentistry, New York University, 10010, New York City, New York, USA
    461 schema:name College of Dentistry, New York University, 10010, New York City, New York, USA
    462 rdf:type schema:Organization
    463 grid-institutes:grid.40803.3f schema:alternateName Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA
    464 schema:name Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 27695, Raleigh, North Carolina, USA
    465 rdf:type schema:Organization
    466 grid-institutes:grid.410740.6 schema:alternateName State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China
    467 schema:name State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 100071, Beijing, China
    468 rdf:type schema:Organization
    469 grid-institutes:grid.411638.9 schema:alternateName Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China
    470 schema:name Key Laboratory of Dairy Biotechnology and Engineering, Education Ministry of China, Inner Mongolia Agricultural University, 010018, Hohhot, Inner Mongolia, China
    471 rdf:type schema:Organization
    472 grid-institutes:grid.4818.5 schema:alternateName Laboratory of Microbiology, Wageningen University, 6703HB, Wageningen, The Netherlands
    473 schema:name Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland
    474 Laboratory of Microbiology, Wageningen University, 6703HB, Wageningen, The Netherlands
    475 rdf:type schema:Organization
    476 grid-institutes:grid.52788.30 schema:alternateName Wellcome Trust Sanger Centre, CB10 1SA, Hinxton, UK
    477 schema:name Wellcome Trust Sanger Centre, CB10 1SA, Hinxton, UK
    478 rdf:type schema:Organization
    479 grid-institutes:grid.5611.3 schema:alternateName Department of Biotechnology, University of Verona, 37134, Verona, Italy
    480 schema:name Department of Biotechnology, University of Verona, 37134, Verona, Italy
    481 rdf:type schema:Organization
    482 grid-institutes:grid.7737.4 schema:alternateName Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland
    483 schema:name Department of Veterinary Biosciences, University of Helsinki, 00014, Helsinki, Finland
    484 rdf:type schema:Organization
    485 grid-institutes:grid.7872.a schema:alternateName School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland
    486 schema:name School of Microbiology, Alimentary Pharmabiotic Centre, University College Cork, T12 Y337, Cork, Ireland
    487 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...