IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Chi-Keung Wan, Peng Li, Rosanne Spolski, Jangsuk Oh, Allison B. Andraski, Ning Du, Zu-Xi Yu, Christopher P. Dillon, Douglas R. Green, Warren J. Leonard

ABSTRACT

The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. Here we show that IL-21 unexpectedly induces IL-1β production in conventional dendritic cells (cDCs) via a STAT3-dependent but NF-κB-independent pathway. IL-21 does not induce Il1b expression in CD4(+) T cells, with differential histone marks present in these cells versus cDCs. IL-21-induced IL-1β processing in cDCs does not require caspase-1 or caspase-8 but depends on IL-21-mediated death and activation of serine protease(s). Moreover, STAT3-dependent IL-1β expression in cDCs at least partially explains the IL-21-mediated pathologic response occurring during infection with pneumonia virus of mice. These results demonstrate lineage-restricted IL-21-induced IL-1β via a non-canonical pathway and provide evidence for its importance in vivo. More... »

PAGES

7988

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms8988

DOI

http://dx.doi.org/10.1038/ncomms8988

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033941467

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26269257


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