MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Julia R. Pon, Jackson Wong, Saeed Saberi, Olivia Alder, Michelle Moksa, S. -W. Grace Cheng, Gregg B. Morin, Pamela A. Hoodless, Martin Hirst, Marco A. Marra

ABSTRACT

Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL). To provide insight into the regulatory network of MEF2B, in this study, we analyse global gene expression and DNA-binding patterns. We find that candidate MEF2B direct target genes include RHOB, RHOD, CDH13, ITGA5 and CAV1, and that indirect target genes of MEF2B include MYC, TGFB1, CARD11, MEF2C, NDRG1 and FN1. MEF2B overexpression increases HEK293A cell migration and epithelial-mesenchymal transition, and decreases DLBCL cell chemotaxis. K4E, Y69H and D83V MEF2B mutations decrease the capacity of MEF2B to activate transcription and decrease its' effects on cell migration. The K4E and D83V mutations decrease MEF2B DNA binding. In conclusion, our map of the MEF2B regulome connects MEF2B to drivers of oncogenesis. More... »

PAGES

7953

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms8953

DOI

http://dx.doi.org/10.1038/ncomms8953

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049320519

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26245647


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