The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Ho-Soo Lee, Yong-Yea Park, Mi-Young Cho, Sunyoung Chae, Young-Suk Yoo, Myung-Hee Kwon, Chang-Woo Lee, Hyeseong Cho

ABSTRACT

Accumulation of PLK1 at kinetochores is essential for chromosome alignment and segregation; however, the mechanism underlying PLK1 recruitment to kinetochores remains unresolved. The chromatin remodeller RSF1 tightly associates with centromere proteins, but its mitotic function is unknown. Here we show that RSF1 localizes at mitotic kinetochores and directly binds PLK1. RSF1 depletion disrupts localization of PLK1 at kinetochores; the C-terminal fragment of RSF1, which can bind PLK1, is sufficient to restore PLK1 localization. Moreover, CDK1 phosphorylates RSF1 at Ser1375, and this phosphorylation is necessary for PLK1 recruitment. Subsequently, PLK1 phosphorylates RSF1 at Ser1359, stabilizing PLK1 deposition. Importantly, RSF1 depletion mimicks the chromosome misalignment phenotype resulting from PLK1 knockdown; these defects are rescued by RSF1 S1375D or RSF1 S1359D but not RSF1 S1375A, showing a functional link between phosphorylation of RSF1 and chromosome alignment. Together, these data show that RSF1 is an essential centromeric component that recruits PLK1 to kinetochores and plays a crucial role in faithful cell division. More... »

PAGES

7904

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms8904

DOI

http://dx.doi.org/10.1038/ncomms8904

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028301452

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26259146


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