Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Maja Sedic, Adam Skibinski, Nelson Brown, Mercedes Gallardo, Peter Mulligan, Paula Martinez, Patricia J. Keller, Eugene Glover, Andrea L. Richardson, Janet Cowan, Amanda E. Toland, Krithika Ravichandran, Harold Riethman, Stephen P. Naber, Anders M. Näär, Maria A. Blasco, Philip W. Hinds, Charlotte Kuperwasser

ABSTRACT

Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select few tissues. Here we show that human mammary epithelial cells (HMECs) from BRCA1-mutation carriers (BRCA1(mut/+)) exhibit increased genomic instability and rapid telomere erosion in the absence of tumour-suppressor loss. Furthermore, we uncover a novel form of haploinsufficiency-induced senescence (HIS) specific to epithelial cells, which is triggered by pRb pathway activation rather than p53 induction. HIS and telomere erosion in HMECs correlate with misregulation of SIRT1 leading to increased levels of acetylated pRb as well as acetylated H4K16 both globally and at telomeric regions. These results identify a novel form of cellular senescence and provide a potential molecular basis for the rapid cell- and tissue- specific predisposition of breast cancer development associated with BRCA1 haploinsufficiency. More... »

PAGES

7505

References to SciGraph publications

  • 2008-03. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400 in NATURE CELL BIOLOGY
  • 2010-02. BRCA1 and its toolbox for the maintenance of genome integrity in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-02. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes in NATURE
  • 2002-02. A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining in ONCOGENE
  • 2006-08. Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers in BRITISH JOURNAL OF CANCER
  • 2014-12. BRCA1 haploinsufficiency for replication stress suppression in primary cells in NATURE COMMUNICATIONS
  • 2007-06. Extraction, purification and analysis of histones in NATURE PROTOCOLS
  • 2012-01. BRCA1 and BRCA2: different roles in a common pathway of genome protection in NATURE REVIEWS CANCER
  • 2008-08. Hereditary breast cancer: new genetic developments, new therapeutic avenues in HUMAN GENETICS
  • 2009-11. Preclinical mouse models for BRCA1-associated breast cancer in BRITISH JOURNAL OF CANCER
  • 2004-01. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases in NATURE GENETICS
  • 2009-08. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers in NATURE MEDICINE
  • 1995-06. A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL
  • 2011-08. A continuum model for tumour suppression in NATURE
  • 2001-07. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis in NATURE GENETICS
  • 2010-12. BRCA1 and BRCA2 families and the risk of skin cancer in FAMILIAL CANCER
  • 2009-08. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion in NATURE CELL BIOLOGY
  • 2009-12. Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo in NATURE PROTOCOLS
  • 1998-07. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation in ONCOGENE
  • 2009-06. Histone H4 lysine 16 acetylation regulates cellular lifespan in NATURE
  • 2006-08. Chromatin immunoprecipitation and microarray-based analysis of protein location in NATURE PROTOCOLS
  • 1999-05. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation in NATURE GENETICS
  • 2004-09. BRCA1 and BRCA2: 1994 and beyond in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms8505

    DOI

    http://dx.doi.org/10.1038/ncomms8505

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050373754

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26106036


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