A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells View Full Text


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Article Info

DATE

2015-06-22

AUTHORS

Yuping Mei, Yuyan Wang, Priti Kumari, Amol Carl Shetty, David Clark, Tyler Gable, Alexander D. MacKerell, Mark Z. Ma, David J. Weber, Austin J. Yang, Martin J. Edelman, Li Mao

ABSTRACT

PIWI-interacting RNAs (piRNAs) are thought to silence transposon and gene expression during development. However, the roles of piRNAs in somatic tissues are largely unknown. Here we report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell lung cancer (NSCLC) cell lines, including 295 that do not exist in databases termed as piRNA-like sncRNAs or piRNA-Ls. Distinctive piRNA/piRNA-L expression patterns are observed between HBE and NSCLC cells. piRNA-like-163 (piR-L-163), the top downregulated piRNA-L in NSCLC cells, binds directly to phosphorylated ERM proteins (p-ERM), which is dependent on the central part of UUNNUUUNNUU motif in piR-L-163 and the RRRKPDT element in ERM. The piR-L-163/p-ERM interaction is critical for p-ERM’s binding capability to filamentous actin (F-actin) and ERM-binding phosphoprotein 50 (EBP50). Thus, piRNA/piRNA-L may play a regulatory role through direct interaction with proteins in physiological and pathophysiological conditions. More... »

PAGES

7316

References to SciGraph publications

  • 2006-06-04. A novel class of small RNAs bind to MILI protein in mouse testes in NATURE
  • 2012-10-09. A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm in CELL RESEARCH
  • 2011-03-23. PIWI-interacting small RNAs: the vanguard of genome defence in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-03-04. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome in GENOME BIOLOGY
  • 2011-07-04. Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration in ONCOGENE
  • 2014-01-15. PIWI proteins and PIWI-interacting RNAs in the soma in NATURE
  • 2013-07-10. A compendium of RNA-binding motifs for decoding gene regulation in NATURE
  • 2006-06-04. A germline-specific class of small RNAs binds mammalian Piwi proteins in NATURE
  • 2000-04-07. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho in NATURE CELL BIOLOGY
  • 2007-03-25. Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-10-27. Differential expression analysis for sequence count data in GENOME BIOLOGY
  • 2002-09-23. Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis in NATURE CELL BIOLOGY
  • 1998-02. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans in NATURE
  • 2002-08. ERM proteins and merlin: integrators at the cell cortex in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-04. Organizing the cell cortex: the role of ERM proteins in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-08-26. Paramutation in Drosophila linked to emergence of a piRNA-producing locus in NATURE
  • 2013-06-25. PIWI-interacting RNAs: from generation to transgenerational epigenetics in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms8316

    DOI

    http://dx.doi.org/10.1038/ncomms8316

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009027263

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26095918


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