Piezo1 ion channel pore properties are dictated by C-terminal region View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05-26

AUTHORS

Bertrand Coste, Swetha E. Murthy, Jayanti Mathur, Manuela Schmidt, Yasmine Mechioukhi, Patrick Delmas, Ardem Patapoutian

ABSTRACT

Piezo1 and Piezo2 encode mechanically activated cation channels that function as mechanotransducers involved in vascular system development and touch sensing, respectively. Structural features of Piezos remain unknown. Mouse Piezo1 is bioinformatically predicted to have 30-40 transmembrane (TM) domains. Here, we find that nine of the putative inter-transmembrane regions are accessible from the extracellular side. We use chimeras between mPiezo1 and dPiezo to show that ion-permeation properties are conferred by C-terminal region. We further identify a glutamate residue within a conserved region adjacent to the last two putative TM domains of the protein, that when mutated, affects unitary conductance and ion selectivity, and modulates pore block. We propose that this amino acid is either in the pore or closely associates with the pore. Our results describe important structural motifs of this channel family and lay the groundwork for a mechanistic understanding of how Piezos are mechanically gated and conduct ions. More... »

PAGES

7223

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms8223

DOI

http://dx.doi.org/10.1038/ncomms8223

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018560485

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26008989


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