Allele-specific analysis of DNA replication origins in mammalian cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Boris Bartholdy, Rituparna Mukhopadhyay, Julien Lajugie, Mirit I. Aladjem, Eric E. Bouhassira

ABSTRACT

The mechanisms that control the location and timing of firing of replication origins are poorly understood. Using a novel functional genomic approach based on the analysis of SNPs and indels in phased human genomes, we observe that replication asynchrony is associated with small cumulative variations in the initiation efficiency of multiple origins between the chromosome homologues, rather than with the activation of dormant origins. Allele-specific measurements demonstrate that the presence of G-quadruplex-forming sequences does not correlate with the efficiency of initiation. Sequence analysis reveals that the origins are highly enriched in sequences with profoundly asymmetric G/C and A/T nucleotide distributions and are almost completely depleted of antiparallel triplex-forming sequences. We therefore propose that although G4-forming sequences are abundant in replication origins, an asymmetry in nucleotide distribution, which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ability to form G4, is directly associated with origin activity. More... »

PAGES

7051

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms8051

DOI

http://dx.doi.org/10.1038/ncomms8051

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040436854

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25987481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CpG Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Replication Origin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bartholdy", 
        "givenName": "Boris", 
        "id": "sg:person.01102431252.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102431252.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukhopadhyay", 
        "givenName": "Rituparna", 
        "id": "sg:person.01237226540.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237226540.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lajugie", 
        "givenName": "Julien", 
        "id": "sg:person.01273307254.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273307254.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.417768.b", 
          "name": [
            "Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, Maryland 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aladjem", 
        "givenName": "Mirit I.", 
        "id": "sg:person.0577534542.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577534542.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouhassira", 
        "givenName": "Eric E.", 
        "id": "sg:person.0713750405.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713750405.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/bioinformatics/btu588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002385523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003676239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004520725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004981843", 
          "https://doi.org/10.1038/nrg2830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004981843", 
          "https://doi.org/10.1038/nrg2830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.14.9517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006592182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007915246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007915246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/344410a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008619790", 
          "https://doi.org/10.1038/344410a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009335235", 
          "https://doi.org/10.1038/nrg2143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.052308.103205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009427734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2010.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011886468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2012-13-4-r27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012852964", 
          "https://doi.org/10.1186/gb-2012-13-4-r27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a012971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013709969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.10.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014310642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0500577102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014371504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0064571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014841467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msb.134859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018801428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msb.134859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018801428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.201400077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019631377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.121830.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020515934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023245520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.7.2958-2967.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027608848", 
          "https://doi.org/10.1186/gb-2008-9-9-r137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(05)80094-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027754146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4061/2010/564946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030306901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.107524.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032096953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.161828.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032557401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1004319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033283831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.23.14588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035310008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035484107", 
          "https://doi.org/10.1038/nsmb.2339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1200804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035489696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2012-0059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036067042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036892131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/embj.201387506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037394162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0060245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038654851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.096701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038756958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.094060.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038779049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.21.8081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038917854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.8.5.2149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039257317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.10.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039946917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.6.2286-2295.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040157092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041238764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btt299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041285269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.124644.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042008136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042186534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045307844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a010116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046322928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mmbr.00030-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046647440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.8.3373-3386.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047149718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2012.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047779835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.8.2426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047930839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.079566.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050291995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bc.2001.073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050894516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0912402107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053165778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053221983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00204a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055165124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi902099u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055210555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi902099u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055210555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.1983.047.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060405328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.270.5237.815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062551553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.11.4.19097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072296587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082798119", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "The mechanisms that control the location and timing of firing of replication origins are poorly understood. Using a novel functional genomic approach based on the analysis of SNPs and indels in phased human genomes, we observe that replication asynchrony is associated with small cumulative variations in the initiation efficiency of multiple origins between the chromosome homologues, rather than with the activation of dormant origins. Allele-specific measurements demonstrate that the presence of G-quadruplex-forming sequences does not correlate with the efficiency of initiation. Sequence analysis reveals that the origins are highly enriched in sequences with profoundly asymmetric G/C and A/T nucleotide distributions and are almost completely depleted of antiparallel triplex-forming sequences. We therefore propose that although G4-forming sequences are abundant in replication origins, an asymmetry in nucleotide distribution, which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ability to form G4, is directly associated with origin activity. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms8051", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438800", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723674", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Allele-specific analysis of DNA replication origins in mammalian cells", 
    "pagination": "7051", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c09f9bf064c9a49c8cde354e2791a145a72abe50171be06bf8ef889bfe6f8f8d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25987481"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms8051"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040436854"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms8051", 
      "https://app.dimensions.ai/details/publication/pub.1040436854"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms8051"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms8051'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms8051'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms8051'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms8051'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      21 PREDICATES      102 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms8051 schema:about N041c714f0a324ca2849cc48f2ac94601
2 N1d9d77d3a8d54b659791b1317f4889a7
3 N30b4c63a16da401ea067b1872333fc9a
4 N395d8043b3844a4084662660d6832596
5 N7a385d9219e04116884c5e792ef62eba
6 Na412aef463374907a4aebeb64cc1bb75
7 Nb88afa0263064f0dbcdb51310fe8c37a
8 Nbe90060a8cac448994b979e50eef3255
9 Ncc991a7951bd4344aef0a456692a67fc
10 Ncfe0d833bc3e4df1ab026b929ba81d70
11 Nd5719d7e770c43b687c7cd51e3cdc382
12 Nde398bfac9b9490eb09f746cc1c4adbd
13 Nebb1532eadc44f76ae799488261cea79
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N675028fe60fa4f71b71d643896d11e4c
17 schema:citation sg:pub.10.1038/344410a0
18 sg:pub.10.1038/nrg2143
19 sg:pub.10.1038/nrg2830
20 sg:pub.10.1038/nsmb.2339
21 sg:pub.10.1186/gb-2008-9-9-r137
22 sg:pub.10.1186/gb-2012-13-4-r27
23 https://app.dimensions.ai/details/publication/pub.1082798119
24 https://doi.org/10.1002/bies.201400077
25 https://doi.org/10.1002/embj.201387506
26 https://doi.org/10.1002/msb.134859
27 https://doi.org/10.1016/j.cell.2011.04.015
28 https://doi.org/10.1016/j.cell.2014.10.025
29 https://doi.org/10.1016/j.febslet.2010.07.007
30 https://doi.org/10.1016/j.molcel.2005.10.029
31 https://doi.org/10.1016/j.molcel.2012.01.017
32 https://doi.org/10.1016/s0959-437x(05)80094-2
33 https://doi.org/10.1021/bi00204a001
34 https://doi.org/10.1021/bi902099u
35 https://doi.org/10.1038/emboj.2008.205
36 https://doi.org/10.1073/pnas.0500577102
37 https://doi.org/10.1073/pnas.0912402107
38 https://doi.org/10.1073/pnas.85.21.8081
39 https://doi.org/10.1074/jbc.272.14.9517
40 https://doi.org/10.1074/jbc.273.23.14588
41 https://doi.org/10.1093/bioinformatics/btp324
42 https://doi.org/10.1093/bioinformatics/btp340
43 https://doi.org/10.1093/bioinformatics/btq033
44 https://doi.org/10.1093/bioinformatics/btr309
45 https://doi.org/10.1093/bioinformatics/btr439
46 https://doi.org/10.1093/bioinformatics/btt299
47 https://doi.org/10.1093/bioinformatics/btu588
48 https://doi.org/10.1093/emboj/17.8.2426
49 https://doi.org/10.1093/hmg/ddh016
50 https://doi.org/10.1093/nar/gkp335
51 https://doi.org/10.1101/cshperspect.a010116
52 https://doi.org/10.1101/cshperspect.a012971
53 https://doi.org/10.1101/gad.1200804
54 https://doi.org/10.1101/gr.079566.108
55 https://doi.org/10.1101/gr.094060.109
56 https://doi.org/10.1101/gr.107524.110
57 https://doi.org/10.1101/gr.121830.111
58 https://doi.org/10.1101/gr.124644.111
59 https://doi.org/10.1101/gr.161828.113
60 https://doi.org/10.1101/sqb.1983.047.01.008
61 https://doi.org/10.1126/science.270.5237.815
62 https://doi.org/10.1128/mcb.24.6.2286-2295.2004
63 https://doi.org/10.1128/mcb.24.7.2958-2967.2004
64 https://doi.org/10.1128/mcb.24.8.3373-3386.2004
65 https://doi.org/10.1128/mcb.8.5.2149
66 https://doi.org/10.1128/mmbr.00030-06
67 https://doi.org/10.1146/annurev.biochem.052308.103205
68 https://doi.org/10.1242/jcs.096701
69 https://doi.org/10.1371/journal.pbio.0060245
70 https://doi.org/10.1371/journal.pgen.1004319
71 https://doi.org/10.1371/journal.pone.0000579
72 https://doi.org/10.1371/journal.pone.0064571
73 https://doi.org/10.1515/bc.2001.073
74 https://doi.org/10.4061/2010/564946
75 https://doi.org/10.4161/cc.11.4.19097
76 https://doi.org/10.5966/sctm.2012-0059
77 schema:datePublished 2015-12
78 schema:datePublishedReg 2015-12-01
79 schema:description The mechanisms that control the location and timing of firing of replication origins are poorly understood. Using a novel functional genomic approach based on the analysis of SNPs and indels in phased human genomes, we observe that replication asynchrony is associated with small cumulative variations in the initiation efficiency of multiple origins between the chromosome homologues, rather than with the activation of dormant origins. Allele-specific measurements demonstrate that the presence of G-quadruplex-forming sequences does not correlate with the efficiency of initiation. Sequence analysis reveals that the origins are highly enriched in sequences with profoundly asymmetric G/C and A/T nucleotide distributions and are almost completely depleted of antiparallel triplex-forming sequences. We therefore propose that although G4-forming sequences are abundant in replication origins, an asymmetry in nucleotide distribution, which increases the propensity of origins to unwind and adopt non-B DNA structure, rather than the ability to form G4, is directly associated with origin activity.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree true
83 schema:isPartOf N728dfa82ec61436694ec1d39b3b0b3fe
84 Nc84fa56ef3d145cb9d07fe66d428cebe
85 sg:journal.1043282
86 schema:name Allele-specific analysis of DNA replication origins in mammalian cells
87 schema:pagination 7051
88 schema:productId N026e89cdd3de4305a7c67bf0d69cfa85
89 N2f54be1003ca46c5bc819bcdb5c5b3c3
90 N599c41b1e5944cfdaccad5e1e06513be
91 N5f60b4f2284142daaf6e64ade64f8d3c
92 N67e674aaab054e1eb8ac0d141dfec4a8
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040436854
94 https://doi.org/10.1038/ncomms8051
95 schema:sdDatePublished 2019-04-11T00:23
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher Nefa4f7535be0428daac898ddab337dc9
98 schema:url https://www.nature.com/articles/ncomms8051
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N026e89cdd3de4305a7c67bf0d69cfa85 schema:name nlm_unique_id
103 schema:value 101528555
104 rdf:type schema:PropertyValue
105 N041c714f0a324ca2849cc48f2ac94601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name DNA Replication
107 rdf:type schema:DefinedTerm
108 N08ab811ee51d40c590723dafc261a0d1 rdf:first sg:person.0713750405.12
109 rdf:rest rdf:nil
110 N0de253954bf94243a0084d6ccee15367 rdf:first sg:person.01237226540.57
111 rdf:rest N7f66bfff2f1c44eaa9061ae1c2844fdc
112 N1d9d77d3a8d54b659791b1317f4889a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Replication Origin
114 rdf:type schema:DefinedTerm
115 N2da7131c343443d09edc1a99f2cd9740 rdf:first sg:person.0577534542.31
116 rdf:rest N08ab811ee51d40c590723dafc261a0d1
117 N2f54be1003ca46c5bc819bcdb5c5b3c3 schema:name readcube_id
118 schema:value c09f9bf064c9a49c8cde354e2791a145a72abe50171be06bf8ef889bfe6f8f8d
119 rdf:type schema:PropertyValue
120 N30b4c63a16da401ea067b1872333fc9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Leukocytes
122 rdf:type schema:DefinedTerm
123 N395d8043b3844a4084662660d6832596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Polymorphism, Single Nucleotide
125 rdf:type schema:DefinedTerm
126 N599c41b1e5944cfdaccad5e1e06513be schema:name doi
127 schema:value 10.1038/ncomms8051
128 rdf:type schema:PropertyValue
129 N5f60b4f2284142daaf6e64ade64f8d3c schema:name pubmed_id
130 schema:value 25987481
131 rdf:type schema:PropertyValue
132 N675028fe60fa4f71b71d643896d11e4c rdf:first sg:person.01102431252.47
133 rdf:rest N0de253954bf94243a0084d6ccee15367
134 N67e674aaab054e1eb8ac0d141dfec4a8 schema:name dimensions_id
135 schema:value pub.1040436854
136 rdf:type schema:PropertyValue
137 N728dfa82ec61436694ec1d39b3b0b3fe schema:issueNumber 1
138 rdf:type schema:PublicationIssue
139 N7a385d9219e04116884c5e792ef62eba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Chromosomes
141 rdf:type schema:DefinedTerm
142 N7f66bfff2f1c44eaa9061ae1c2844fdc rdf:first sg:person.01273307254.56
143 rdf:rest N2da7131c343443d09edc1a99f2cd9740
144 Na412aef463374907a4aebeb64cc1bb75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Genome, Human
146 rdf:type schema:DefinedTerm
147 Nb88afa0263064f0dbcdb51310fe8c37a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name DNA
149 rdf:type schema:DefinedTerm
150 Nbe90060a8cac448994b979e50eef3255 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 Nc84fa56ef3d145cb9d07fe66d428cebe schema:volumeNumber 6
154 rdf:type schema:PublicationVolume
155 Ncc991a7951bd4344aef0a456692a67fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Time Factors
157 rdf:type schema:DefinedTerm
158 Ncfe0d833bc3e4df1ab026b929ba81d70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Models, Genetic
160 rdf:type schema:DefinedTerm
161 Nd5719d7e770c43b687c7cd51e3cdc382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Alleles
163 rdf:type schema:DefinedTerm
164 Nde398bfac9b9490eb09f746cc1c4adbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name CpG Islands
166 rdf:type schema:DefinedTerm
167 Nebb1532eadc44f76ae799488261cea79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Computational Biology
169 rdf:type schema:DefinedTerm
170 Nefa4f7535be0428daac898ddab337dc9 schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biological Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
176 schema:name Genetics
177 rdf:type schema:DefinedTerm
178 sg:grant.2438800 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms8051
179 rdf:type schema:MonetaryGrant
180 sg:grant.2723674 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms8051
181 rdf:type schema:MonetaryGrant
182 sg:journal.1043282 schema:issn 2041-1723
183 schema:name Nature Communications
184 rdf:type schema:Periodical
185 sg:person.01102431252.47 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
186 schema:familyName Bartholdy
187 schema:givenName Boris
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102431252.47
189 rdf:type schema:Person
190 sg:person.01237226540.57 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
191 schema:familyName Mukhopadhyay
192 schema:givenName Rituparna
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237226540.57
194 rdf:type schema:Person
195 sg:person.01273307254.56 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
196 schema:familyName Lajugie
197 schema:givenName Julien
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273307254.56
199 rdf:type schema:Person
200 sg:person.0577534542.31 schema:affiliation https://www.grid.ac/institutes/grid.417768.b
201 schema:familyName Aladjem
202 schema:givenName Mirit I.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577534542.31
204 rdf:type schema:Person
205 sg:person.0713750405.12 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
206 schema:familyName Bouhassira
207 schema:givenName Eric E.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713750405.12
209 rdf:type schema:Person
210 sg:pub.10.1038/344410a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008619790
211 https://doi.org/10.1038/344410a0
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/nrg2143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009335235
214 https://doi.org/10.1038/nrg2143
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nrg2830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004981843
217 https://doi.org/10.1038/nrg2830
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nsmb.2339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035484107
220 https://doi.org/10.1038/nsmb.2339
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
223 https://doi.org/10.1186/gb-2008-9-9-r137
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/gb-2012-13-4-r27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012852964
226 https://doi.org/10.1186/gb-2012-13-4-r27
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1082798119 schema:CreativeWork
229 https://doi.org/10.1002/bies.201400077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019631377
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/embj.201387506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037394162
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/msb.134859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018801428
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.cell.2011.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045307844
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.cell.2014.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039946917
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.febslet.2010.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011886468
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.molcel.2005.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014310642
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.molcel.2012.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047779835
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0959-437x(05)80094-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027754146
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1021/bi00204a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055165124
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1021/bi902099u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055210555
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1038/emboj.2008.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042186534
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1073/pnas.0500577102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014371504
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1073/pnas.0912402107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053165778
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1073/pnas.85.21.8081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038917854
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1074/jbc.272.14.9517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006592182
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1074/jbc.273.23.14588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035310008
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/bioinformatics/btp340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041238764
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/bioinformatics/btq033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036892131
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/bioinformatics/btr309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004520725
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/bioinformatics/btr439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053221983
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1093/bioinformatics/btt299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041285269
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1093/bioinformatics/btu588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002385523
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1093/emboj/17.8.2426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047930839
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1093/hmg/ddh016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003676239
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/nar/gkp335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007915246
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1101/cshperspect.a010116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046322928
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1101/cshperspect.a012971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013709969
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1101/gad.1200804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035489696
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1101/gr.079566.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050291995
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1101/gr.094060.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038779049
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1101/gr.121830.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020515934
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1101/gr.124644.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042008136
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1101/gr.161828.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032557401
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1101/sqb.1983.047.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060405328
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1126/science.270.5237.815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551553
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1128/mcb.24.6.2286-2295.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040157092
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1128/mcb.24.7.2958-2967.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706743
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1128/mcb.24.8.3373-3386.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047149718
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1128/mcb.8.5.2149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039257317
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1128/mmbr.00030-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046647440
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1146/annurev.biochem.052308.103205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009427734
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1242/jcs.096701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038756958
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1371/journal.pbio.0060245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038654851
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1371/journal.pgen.1004319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033283831
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1371/journal.pone.0000579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023245520
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1371/journal.pone.0064571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014841467
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1515/bc.2001.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050894516
328 rdf:type schema:CreativeWork
329 https://doi.org/10.4061/2010/564946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030306901
330 rdf:type schema:CreativeWork
331 https://doi.org/10.4161/cc.11.4.19097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296587
332 rdf:type schema:CreativeWork
333 https://doi.org/10.5966/sctm.2012-0059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036067042
334 rdf:type schema:CreativeWork
335 https://www.grid.ac/institutes/grid.251993.5 schema:alternateName Albert Einstein College of Medicine
336 schema:name Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.417768.b schema:alternateName Center for Cancer Research
339 schema:name Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, Maryland 20892, USA
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...