Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-05-13

AUTHORS

Changgui Li, Zhiqiang Li, Shiguo Liu, Can Wang, Lin Han, Lingling Cui, Jingguo Zhou, Hejian Zou, Zhen Liu, Jianhua Chen, Xiaoyu Cheng, Zhaowei Zhou, Chengcheng Ding, Meng Wang, Tong Chen, Ying Cui, Hongmei He, Keke Zhang, Congcong Yin, Yunlong Wang, Shichao Xing, Baojie Li, Jue Ji, Zhaotong Jia, Lidan Ma, Jiapeng Niu, Ying Xin, Tian Liu, Nan Chu, Qing Yu, Wei Ren, Xuefeng Wang, Aiqing Zhang, Yuping Sun, Haili Wang, Jie Lu, Yuanyuan Li, Yufeng Qing, Gang Chen, Yangang Wang, Li Zhou, Haitao Niu, Jun Liang, Qian Dong, Xinde Li, Qing-Sheng Mi, Yongyong Shi

ABSTRACT

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10−13, BCAS3), 9p24.2 (rs12236871, P=1.48 × 10−10, RFX3) and 11p15.5 (rs179785, P=1.28 × 10−8, KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis. More... »

PAGES

7041

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms8041

DOI

http://dx.doi.org/10.1038/ncomms8041

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031524864

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25967671


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30 schema:description Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10−13, BCAS3), 9p24.2 (rs12236871, P=1.48 × 10−10, RFX3) and 11p15.5 (rs179785, P=1.28 × 10−8, KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.
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37 Han Chinese
38 analysis
39 arthritis
40 association analysis
41 association studies
42 candidate genes
43 common type
44 concentration
45 control
46 crystals
47 deposition
48 development
49 genes
50 genetic loci
51 genome-wide association analysis
52 genome-wide association studies
53 gout
54 gout arthritis
55 gout patients
56 hyperuricemia
57 hyperuricemic control
58 inflammatory arthritis
59 inflammatory candidate genes
60 insights
61 joints
62 loci
63 male controls
64 male gout patients
65 monosodium urate crystals
66 multistage genome-wide association study
67 new insights
68 new risk loci
69 normal male controls
70 pathogenesis
71 patients
72 previous genome-wide association study
73 progression
74 results
75 risk loci
76 serum urate concentration
77 study
78 types
79 urate concentration
80 urate crystals
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