Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Chenggang Xu, Ranran Huang, Lin Teng, Xiaoyan Jing, Jianqiang Hu, Guzhen Cui, Yilin Wang, Qiu Cui, Jian Xu

ABSTRACT

The mechanism, physiological relevance and evolutionary implication of selective RNA processing and stabilization (SRPS) remain elusive. Here we report the genome-wide maps of transcriptional start sites (TSs) and post-transcriptional processed sites (PSs) for Clostridium cellulolyticum. The PS-associated genes are preferably associated with subunits of heteromultimeric protein complexes, and the intergenic PSs (iPSs) are enriched in operons exhibiting highly skewed transcript-abundance landscape. Stem-loop structures associated with those iPSs located at 3' termini of highly transcribed genes exhibit folding free energy negatively correlated with transcript-abundance ratio of flanking genes. In the cellulosome-encoding cip-cel operon, iPSs and stem-loops precisely regulate structure and abundance of the subunit-encoding transcripts processed from a primary polycistronic RNA, quantitatively specifying cellulosome stoichiometry. Moreover, cellulosome evolution is shaped by the number, position and biophysical nature of TSs, iPSs and stem-loops. Our findings unveil a genome-wide RNA-encoded strategy controlling in vivo stoichiometry of protein complexes. More... »

PAGES

6900

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms7900

    DOI

    http://dx.doi.org/10.1038/ncomms7900

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052736794

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25908225


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