Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Gemma L. Kay, Martin J. Sergeant, Zhemin Zhou, Jacqueline Z.-M. Chan, Andrew Millard, Joshua Quick, Ildikó Szikossy, Ildikó Pap, Mark Spigelman, Nicholas J. Loman, Mark Achtman, Helen D. Donoghue, Mark J. Pallen

ABSTRACT

Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. More... »

PAGES

6717

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms7717

DOI

http://dx.doi.org/10.1038/ncomms7717

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038071297

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25848958


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