Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Satoshi Fukuyama, Hiroaki Katsura, Dongming Zhao, Makoto Ozawa, Tomomi Ando, Jason E. Shoemaker, Izumi Ishikawa, Shinya Yamada, Gabriele Neumann, Shinji Watanabe, Hiroaki Kitano, Yoshihiro Kawaoka

ABSTRACT

Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours ('Color-flu' viruses) to facilitate the study of viral infection in in vivo models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allows their detection by different types of microscopy and by flow cytometry. We use this system to analyse the progression of viral spread in mouse lungs, for live imaging of virus-infected cells, and for differential gene expression studies in virus antigen-positive and virus antigen-negative live cells in the lungs of Color-flu-infected mice. Collectively, Color-flu viruses are powerful tools to analyse virus infections at the cellular level in vivo to better understand influenza pathogenesis. More... »

PAGES

6600

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms7600

DOI

http://dx.doi.org/10.1038/ncomms7600

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048545873

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25807527


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Artificial Gene Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Reporter", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza A Virus, H1N1 Subtype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Orthomyxoviridae Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Nonstructural Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuyama", 
        "givenName": "Satoshi", 
        "id": "sg:person.01220457314.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220457314.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katsura", 
        "givenName": "Hiroaki", 
        "id": "sg:person.0713543627.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713543627.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Dongming", 
        "id": "sg:person.0617754125.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617754125.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan", 
            "Transboundary Animal Distance Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ozawa", 
        "givenName": "Makoto", 
        "id": "sg:person.0647024313.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647024313.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ando", 
        "givenName": "Tomomi", 
        "id": "sg:person.01261126423.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261126423.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoemaker", 
        "givenName": "Jason E.", 
        "id": "sg:person.01225663214.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225663214.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishikawa", 
        "givenName": "Izumi", 
        "id": "sg:person.01312371631.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312371631.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Shinya", 
        "id": "sg:person.01143144573.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143144573.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neumann", 
        "givenName": "Gabriele", 
        "id": "sg:person.0745305576.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745305576.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Miyazaki", 
          "id": "https://www.grid.ac/institutes/grid.410849.0", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki, Miyazaki 889-2192, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Shinji", 
        "id": "sg:person.01035367535.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035367535.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Okinawa Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.250464.1", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "The Systems Biology Institute, Minato-ku, Tokyo 108-0071, Japan", 
            "Sony Computer Science Laboratories, Shinagawa-ku, Tokyo 141-0022, Japan", 
            "Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0495, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitano", 
        "givenName": "Hiroaki", 
        "id": "sg:person.01355755204.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355755204.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan", 
            "Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan", 
            "Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA", 
            "Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawaoka", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.01261074774.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261074774.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.virusres.2011.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001784748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.6.3083-3088.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003471022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0914994107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004607116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0102-87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007758048", 
          "https://doi.org/10.1038/nbt0102-87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0102-87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007758048", 
          "https://doi.org/10.1038/nbt0102-87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci60659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008436449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008766382", 
          "https://doi.org/10.1038/86684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/86684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008766382", 
          "https://doi.org/10.1038/86684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pathol-011811-120902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011661271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20051938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016165071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.0030133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016689655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02200-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018424490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00969-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020636991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2010.100115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021353598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(78)90153-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022224561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1132998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023018481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025103202", 
          "https://doi.org/10.1038/nbt1037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025103202", 
          "https://doi.org/10.1038/nbt1037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1093616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027055845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030155839", 
          "https://doi.org/10.1038/nature08182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030155839", 
          "https://doi.org/10.1038/nature08182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030205261", 
          "https://doi.org/10.1038/ncomms3369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02381-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030499785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20080201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031991544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.201100619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032796942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035074550", 
          "https://doi.org/10.1038/nature12392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2004.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035436515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.031575198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036679201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60627-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039786739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-13-627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039887021", 
          "https://doi.org/10.1186/1471-2164-13-627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040995552", 
          "https://doi.org/10.1038/nri1900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040995552", 
          "https://doi.org/10.1038/nri1900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041002773", 
          "https://doi.org/10.1038/nature08260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041002773", 
          "https://doi.org/10.1038/nature08260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041947444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.16.9345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043005932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2011.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045219101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049804558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1240532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062468813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.929199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062660887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2202/1544-6115.1027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069289261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074754590", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079375669", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours ('Color-flu' viruses) to facilitate the study of viral infection in in vivo models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allows their detection by different types of microscopy and by flow cytometry. We use this system to analyse the progression of viral spread in mouse lungs, for live imaging of virus-infected cells, and for differential gene expression studies in virus antigen-positive and virus antigen-negative live cells in the lungs of Color-flu-infected mice. Collectively, Color-flu viruses are powerful tools to analyse virus infections at the cellular level in vivo to better understand influenza pathogenesis. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms7600", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6147612", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5811537", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies", 
    "pagination": "6600", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e7439f092bad9540a2282718db5ee39fa874e498d5e06486eedcf97c23972590"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25807527"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms7600"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048545873"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms7600", 
      "https://app.dimensions.ai/details/publication/pub.1048545873"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms7600"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms7600'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms7600'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms7600'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms7600'


 

This table displays all metadata directly associated to this object as RDF triples.

339 TRIPLES      21 PREDICATES      79 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms7600 schema:about N1b160956691246eeae8cfa722afa3c27
2 N31e174f3a28a4e3196170c02351bca2d
3 N3a50541687704d04ae82875c79cdd4ec
4 N5c7c208f60d9414c91ee99fe534f60bd
5 N81a3b3666afd4889b361d00b225070cb
6 N84a1240afa084cde82d8f5e60d1e474c
7 Nacff84d575a64d0998f6b2ca59c33bc9
8 Nc20d43c6289e4a71ad2a6ec7aeae588e
9 Nd375ddecbc494fccaf3c9e64f778bfe8
10 Ne8f80866121b46dfb4b01678088ee4b1
11 Nef353b80c5964471b42f889a979b7e46
12 Nf70e663c605c467b8629f2d8175e5a2a
13 Nfb627702d09449b1ac84e2c3c503b49c
14 anzsrc-for:11
15 anzsrc-for:1108
16 schema:author Nf60330337eaa42efacd1ba908eb5db1a
17 schema:citation sg:pub.10.1038/86684
18 sg:pub.10.1038/nature08182
19 sg:pub.10.1038/nature08260
20 sg:pub.10.1038/nature12392
21 sg:pub.10.1038/nbt0102-87
22 sg:pub.10.1038/nbt1037
23 sg:pub.10.1038/ncomms3369
24 sg:pub.10.1038/nri1900
25 sg:pub.10.1186/1471-2164-13-627
26 https://app.dimensions.ai/details/publication/pub.1074754590
27 https://app.dimensions.ai/details/publication/pub.1079375669
28 https://doi.org/10.1002/pmic.201100619
29 https://doi.org/10.1016/0042-6822(78)90153-8
30 https://doi.org/10.1016/j.coi.2011.07.016
31 https://doi.org/10.1016/j.virol.2004.03.035
32 https://doi.org/10.1016/j.virusres.2011.10.017
33 https://doi.org/10.1016/s0140-6736(08)60627-3
34 https://doi.org/10.1073/pnas.031575198
35 https://doi.org/10.1073/pnas.0914994107
36 https://doi.org/10.1073/pnas.96.16.9345
37 https://doi.org/10.1084/jem.20051938
38 https://doi.org/10.1084/jem.20080201
39 https://doi.org/10.1093/nar/gkq418
40 https://doi.org/10.1126/science.1093616
41 https://doi.org/10.1126/science.1132998
42 https://doi.org/10.1126/science.1240532
43 https://doi.org/10.1126/science.929199
44 https://doi.org/10.1128/jvi.00969-13
45 https://doi.org/10.1128/jvi.02200-10
46 https://doi.org/10.1128/jvi.02381-13
47 https://doi.org/10.1128/jvi.78.6.3083-3088.2004
48 https://doi.org/10.1146/annurev-pathol-011811-120902
49 https://doi.org/10.1172/jci60659
50 https://doi.org/10.1371/journal.ppat.0030133
51 https://doi.org/10.1371/journal.ppat.1000115
52 https://doi.org/10.2202/1544-6115.1027
53 https://doi.org/10.2353/ajpath.2010.100115
54 schema:datePublished 2015-12
55 schema:datePublishedReg 2015-12-01
56 schema:description Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours ('Color-flu' viruses) to facilitate the study of viral infection in in vivo models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allows their detection by different types of microscopy and by flow cytometry. We use this system to analyse the progression of viral spread in mouse lungs, for live imaging of virus-infected cells, and for differential gene expression studies in virus antigen-positive and virus antigen-negative live cells in the lungs of Color-flu-infected mice. Collectively, Color-flu viruses are powerful tools to analyse virus infections at the cellular level in vivo to better understand influenza pathogenesis.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N82e03cfa30224538aa8c1b723a1d59ce
61 Na6770c5da32b4f94ba34003ff5fb3815
62 sg:journal.1043282
63 schema:name Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies
64 schema:pagination 6600
65 schema:productId N0e574f4ad26a4b049b7887d09b9d17a2
66 N25f873bf666941279da7601b115365cb
67 N9097eda8c4024149918a24b28affd10b
68 N9d1056d47cb34f2999355e241dfe339d
69 Ned423c0e0a20412694aa8276e899005d
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048545873
71 https://doi.org/10.1038/ncomms7600
72 schema:sdDatePublished 2019-04-10T21:26
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nde226327c0e342799bfdcdc5e1c89887
75 schema:url https://www.nature.com/articles/ncomms7600
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0e574f4ad26a4b049b7887d09b9d17a2 schema:name readcube_id
80 schema:value e7439f092bad9540a2282718db5ee39fa874e498d5e06486eedcf97c23972590
81 rdf:type schema:PropertyValue
82 N1a88532f9d814e77be17df4accc240d1 rdf:first sg:person.0617754125.49
83 rdf:rest Naa6c71e0b0874c4ebed1d25f0bd244a4
84 N1b160956691246eeae8cfa722afa3c27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Bacterial Proteins
86 rdf:type schema:DefinedTerm
87 N25f873bf666941279da7601b115365cb schema:name nlm_unique_id
88 schema:value 101528555
89 rdf:type schema:PropertyValue
90 N2dcd5a447781458ea1be9f9144e7ebae rdf:first sg:person.01225663214.64
91 rdf:rest N5e2bfe98383a43d2a464734b666343c7
92 N31e174f3a28a4e3196170c02351bca2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Influenza A Virus, H1N1 Subtype
94 rdf:type schema:DefinedTerm
95 N3a50541687704d04ae82875c79cdd4ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Luminescent Proteins
97 rdf:type schema:DefinedTerm
98 N59931acdc26149429eeeba3b25e1fbc3 rdf:first sg:person.0745305576.71
99 rdf:rest Nd25d51fe5618497593c16570329d7ebc
100 N5c7c208f60d9414c91ee99fe534f60bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Artificial Gene Fusion
102 rdf:type schema:DefinedTerm
103 N5e2bfe98383a43d2a464734b666343c7 rdf:first sg:person.01312371631.08
104 rdf:rest Nc13c986e885e416c9b0e2a955ab6e608
105 N787767864d2d4782bb03ea41a1cc1961 rdf:first sg:person.01261126423.32
106 rdf:rest N2dcd5a447781458ea1be9f9144e7ebae
107 N81a3b3666afd4889b361d00b225070cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Mice, Inbred C57BL
109 rdf:type schema:DefinedTerm
110 N82e03cfa30224538aa8c1b723a1d59ce schema:volumeNumber 6
111 rdf:type schema:PublicationVolume
112 N84a1240afa084cde82d8f5e60d1e474c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mice
114 rdf:type schema:DefinedTerm
115 N9097eda8c4024149918a24b28affd10b schema:name doi
116 schema:value 10.1038/ncomms7600
117 rdf:type schema:PropertyValue
118 N9d1056d47cb34f2999355e241dfe339d schema:name pubmed_id
119 schema:value 25807527
120 rdf:type schema:PropertyValue
121 Na6770c5da32b4f94ba34003ff5fb3815 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 Naa6c71e0b0874c4ebed1d25f0bd244a4 rdf:first sg:person.0647024313.77
124 rdf:rest N787767864d2d4782bb03ea41a1cc1961
125 Nac250d559b37478aa87e2b489347d604 rdf:first sg:person.01355755204.11
126 rdf:rest Nc065d184203941e29bc2fae9788a9423
127 Nacff84d575a64d0998f6b2ca59c33bc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Genes, Reporter
129 rdf:type schema:DefinedTerm
130 Nc065d184203941e29bc2fae9788a9423 rdf:first sg:person.01261074774.41
131 rdf:rest rdf:nil
132 Nc13c986e885e416c9b0e2a955ab6e608 rdf:first sg:person.01143144573.82
133 rdf:rest N59931acdc26149429eeeba3b25e1fbc3
134 Nc20d43c6289e4a71ad2a6ec7aeae588e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Virus Replication
136 rdf:type schema:DefinedTerm
137 Nd25d51fe5618497593c16570329d7ebc rdf:first sg:person.01035367535.97
138 rdf:rest Nac250d559b37478aa87e2b489347d604
139 Nd375ddecbc494fccaf3c9e64f778bfe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Green Fluorescent Proteins
141 rdf:type schema:DefinedTerm
142 Nde226327c0e342799bfdcdc5e1c89887 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Ne8f80866121b46dfb4b01678088ee4b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Viral Nonstructural Proteins
146 rdf:type schema:DefinedTerm
147 Ned423c0e0a20412694aa8276e899005d schema:name dimensions_id
148 schema:value pub.1048545873
149 rdf:type schema:PropertyValue
150 Nef353b80c5964471b42f889a979b7e46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Animals
152 rdf:type schema:DefinedTerm
153 Nf473af28696f44d582916900ed5a2923 rdf:first sg:person.0713543627.79
154 rdf:rest N1a88532f9d814e77be17df4accc240d1
155 Nf60330337eaa42efacd1ba908eb5db1a rdf:first sg:person.01220457314.00
156 rdf:rest Nf473af28696f44d582916900ed5a2923
157 Nf70e663c605c467b8629f2d8175e5a2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Lung
159 rdf:type schema:DefinedTerm
160 Nfb627702d09449b1ac84e2c3c503b49c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Orthomyxoviridae Infections
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical Microbiology
168 rdf:type schema:DefinedTerm
169 sg:grant.5811537 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7600
170 rdf:type schema:MonetaryGrant
171 sg:grant.6147612 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7600
172 rdf:type schema:MonetaryGrant
173 sg:journal.1043282 schema:issn 2041-1723
174 schema:name Nature Communications
175 rdf:type schema:Periodical
176 sg:person.01035367535.97 schema:affiliation https://www.grid.ac/institutes/grid.410849.0
177 schema:familyName Watanabe
178 schema:givenName Shinji
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035367535.97
180 rdf:type schema:Person
181 sg:person.01143144573.82 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
182 schema:familyName Yamada
183 schema:givenName Shinya
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143144573.82
185 rdf:type schema:Person
186 sg:person.01220457314.00 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
187 schema:familyName Fukuyama
188 schema:givenName Satoshi
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220457314.00
190 rdf:type schema:Person
191 sg:person.01225663214.64 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
192 schema:familyName Shoemaker
193 schema:givenName Jason E.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225663214.64
195 rdf:type schema:Person
196 sg:person.01261074774.41 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
197 schema:familyName Kawaoka
198 schema:givenName Yoshihiro
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261074774.41
200 rdf:type schema:Person
201 sg:person.01261126423.32 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
202 schema:familyName Ando
203 schema:givenName Tomomi
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261126423.32
205 rdf:type schema:Person
206 sg:person.01312371631.08 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
207 schema:familyName Ishikawa
208 schema:givenName Izumi
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312371631.08
210 rdf:type schema:Person
211 sg:person.01355755204.11 schema:affiliation https://www.grid.ac/institutes/grid.250464.1
212 schema:familyName Kitano
213 schema:givenName Hiroaki
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355755204.11
215 rdf:type schema:Person
216 sg:person.0617754125.49 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
217 schema:familyName Zhao
218 schema:givenName Dongming
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617754125.49
220 rdf:type schema:Person
221 sg:person.0647024313.77 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
222 schema:familyName Ozawa
223 schema:givenName Makoto
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647024313.77
225 rdf:type schema:Person
226 sg:person.0713543627.79 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
227 schema:familyName Katsura
228 schema:givenName Hiroaki
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713543627.79
230 rdf:type schema:Person
231 sg:person.0745305576.71 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
232 schema:familyName Neumann
233 schema:givenName Gabriele
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745305576.71
235 rdf:type schema:Person
236 sg:pub.10.1038/86684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008766382
237 https://doi.org/10.1038/86684
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature08182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030155839
240 https://doi.org/10.1038/nature08182
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature08260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041002773
243 https://doi.org/10.1038/nature08260
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nature12392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035074550
246 https://doi.org/10.1038/nature12392
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nbt0102-87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007758048
249 https://doi.org/10.1038/nbt0102-87
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nbt1037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025103202
252 https://doi.org/10.1038/nbt1037
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/ncomms3369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030205261
255 https://doi.org/10.1038/ncomms3369
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nri1900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040995552
258 https://doi.org/10.1038/nri1900
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/1471-2164-13-627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039887021
261 https://doi.org/10.1186/1471-2164-13-627
262 rdf:type schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1074754590 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1079375669 schema:CreativeWork
265 https://doi.org/10.1002/pmic.201100619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032796942
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0042-6822(78)90153-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022224561
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.coi.2011.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045219101
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.virol.2004.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035436515
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.virusres.2011.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001784748
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0140-6736(08)60627-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039786739
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1073/pnas.031575198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036679201
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1073/pnas.0914994107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004607116
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.96.16.9345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043005932
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1084/jem.20051938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016165071
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1084/jem.20080201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031991544
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1093/nar/gkq418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041947444
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1126/science.1093616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027055845
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1126/science.1132998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023018481
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1126/science.1240532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062468813
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1126/science.929199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062660887
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1128/jvi.00969-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020636991
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1128/jvi.02200-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424490
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1128/jvi.02381-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030499785
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1128/jvi.78.6.3083-3088.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003471022
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1146/annurev-pathol-011811-120902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011661271
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1172/jci60659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008436449
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1371/journal.ppat.0030133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016689655
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1371/journal.ppat.1000115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049804558
312 rdf:type schema:CreativeWork
313 https://doi.org/10.2202/1544-6115.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069289261
314 rdf:type schema:CreativeWork
315 https://doi.org/10.2353/ajpath.2010.100115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021353598
316 rdf:type schema:CreativeWork
317 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
318 schema:name Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.250464.1 schema:alternateName Okinawa Institute of Science and Technology
321 schema:name Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan
322 Okinawa Institute of Science and Technology Graduate University, Onna-son, Okinawa 904-0495, Japan
323 Sony Computer Science Laboratories, Shinagawa-ku, Tokyo 141-0022, Japan
324 The Systems Biology Institute, Minato-ku, Tokyo 108-0071, Japan
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.258333.c schema:alternateName Kagoshima University
327 schema:name Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
328 Transboundary Animal Distance Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
331 schema:name Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
332 Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
333 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
334 Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.410849.0 schema:alternateName University of Miyazaki
337 schema:name Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan
338 Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki, Miyazaki 889-2192, Japan
339 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...