Gut microbiome development along the colorectal adenoma–carcinoma sequence View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03-11

AUTHORS

Qiang Feng, Suisha Liang, Huijue Jia, Andreas Stadlmayr, Longqing Tang, Zhou Lan, Dongya Zhang, Huihua Xia, Xiaoying Xu, Zhuye Jie, Lili Su, Xiaoping Li, Xin Li, Junhua Li, Liang Xiao, Ursula Huber-Schönauer, David Niederseer, Xun Xu, Jumana Yousuf Al-Aama, Huanming Yang, Jian Wang, Karsten Kristiansen, Manimozhiyan Arumugam, Herbert Tilg, Christian Datz, Jun Wang

ABSTRACT

Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma. More... »

PAGES

6528

References to SciGraph publications

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  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms7528

    DOI

    http://dx.doi.org/10.1038/ncomms7528

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047959844

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25758642


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