A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6+CD27− subset View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Elham Kashani, Lisa Föhse, Solaiman Raha, Inga Sandrock, Linda Oberdörfer, Christian Koenecke, Sebastian Suerbaum, Siegfried Weiss, Immo Prinz

ABSTRACT

Here we investigate the TCR repertoire of mouse Vγ4(+) γδ T cells in correlation with their developmental origin and homeostasis. By deep sequencing we identify a high frequency of straight Vδ5Dδ2Jδ1 germline rearrangements without P- and N-nucleotides within the otherwise highly diverse Trd repertoire of Vγ4(+) cells. This sequence is infrequent in CCR6(-)CD27(+) cells, but abundant among CCR6(+)CD27(-) γδ T cells. Using an inducible Rag1 knock-in mouse model, we show that γδ T cells generated in the adult thymus rarely contain this germline-rearranged Vδ5Dδ2Jδ1 sequence, confirming its fetal origin. Single-cell analysis and deep sequencing of the Trg locus reveal a dominant CDR3 junctional motif that completes the TCR repertoire of invariant Vγ4(+)Vδ5(+) cells. In conclusion, this study identifies an innate subset of fetal thymus-derived γδ T cells with an invariant Vγ4(+)Vδ5(+) TCR that is restricted to the CCR6(+)CD27(-) subset of γδ T cells. More... »

PAGES

6477

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms7477

    DOI

    http://dx.doi.org/10.1038/ncomms7477

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038752857

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25765849


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