Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSJiří Schimer, Marcela Pávová, Maria Anders, Petr Pachl, Pavel Šácha, Petr Cígler, Jan Weber, Pavel Majer, Pavlína Řezáčová, Hans-Georg Kräusslich, Barbara Müller, Jan Konvalinka
ABSTRACTHIV protease (PR) is required for proteolytic maturation in the late phase of HIV replication and represents a prime therapeutic target. The regulation and kinetics of viral polyprotein processing and maturation are currently not understood in detail. Here we design, synthesize, validate and apply a potent, photodegradable HIV PR inhibitor to achieve synchronized induction of proteolysis. The compound exhibits subnanomolar inhibition in vitro. Its photolabile moiety is released on light irradiation, reducing the inhibitory potential by 4 orders of magnitude. We determine the structure of the PR-inhibitor complex, analyze its photolytic products, and show that the enzymatic activity of inhibited PR can be fully restored on inhibitor photolysis. We also demonstrate that proteolysis of immature HIV particles produced in the presence of the inhibitor can be rapidly triggered by light enabling thus to analyze the timing, regulation and spatial requirements of viral processing in real time. More... »
PAGES6461
http://scigraph.springernature.com/pub.10.1038/ncomms7461
DOIhttp://dx.doi.org/10.1038/ncomms7461
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25751579
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"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000436.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ncomms7461"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms7461'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms7461'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms7461'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms7461'
This table displays all metadata directly associated to this object as RDF triples.
334 TRIPLES
21 PREDICATES
84 URIs
39 LITERALS
27 BLANK NODES