Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSDuygu Sag, Caglar Cekic, Runpei Wu, Joel Linden, Catherine C. Hedrick
ABSTRACTATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutaneous MB49-bladder carcinoma and B16-melanoma growth and prolonged survival. We show that reduced tumour growth in Abcg1(-/-) mice is myeloid cell intrinsic and is associated with a phenotypic shift of the macrophages from a tumour-promoting M2 to a tumour-fighting M1 within the tumour. Abcg1(-/-) macrophages exhibit an intrinsic bias towards M1 polarization with increased NF-κB activation and direct cytotoxicity for tumour cells in vitro. Overall, our study demonstrates that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour, and illustrates a link between cholesterol homeostasis and cancer. More... »
PAGES6354
http://scigraph.springernature.com/pub.10.1038/ncomms7354
DOIhttp://dx.doi.org/10.1038/ncomms7354
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25724068
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]Download the RDF metadata as: json-ld nt turtle xml License info
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373 TRIPLES
21 PREDICATES
110 URIs
38 LITERALS
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