Genomic landscape of paediatric adrenocortical tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Emilia M. Pinto, Xiang Chen, John Easton, David Finkelstein, Zhifa Liu, Stanley Pounds, Carlos Rodriguez-Galindo, Troy C. Lund, Elaine R. Mardis, Richard K. Wilson, Kristy Boggs, Donald Yergeau, Jinjun Cheng, Heather L. Mulder, Jayanthi Manne, Jesse Jenkins, Maria J. Mastellaro, Bonald C. Figueiredo, Michael A. Dyer, Alberto Pappo, Jinghui Zhang, James R. Downing, Raul C. Ribeiro, Gerard P. Zambetti

ABSTRACT

Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal chromosome. IGF2 on chromosome 11p is overexpressed in 100% of the tumours. TP53 mutations and chromosome 17 LOH with selection against wild-type TP53 are observed in 28 ACTs (76%). Chromosomes 11p and 17 undergo copy-neutral LOH early during tumorigenesis, suggesting tumour-driver events. Additional genetic alterations include recurrent somatic mutations in ATRX and CTNNB1 and integration of human herpesvirus-6 in chromosome 11p. A dismal outcome is predicted by concomitant TP53 and ATRX mutations and associated genomic abnormalities, including massive structural variations and frequent background mutations. Collectively, these findings demonstrate the nature, timing and potential prognostic significance of key genetic alterations in paediatric ACT and outline a hypothetical model of paediatric adrenocortical tumorigenesis. More... »

PAGES

6302

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms7302

DOI

http://dx.doi.org/10.1038/ncomms7302

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006983905

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25743702


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenal Cortex Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenocortical Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 17", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-linked Nuclear Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biochemistry, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinto", 
        "givenName": "Emilia M.", 
        "id": "sg:person.01234624673.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234624673.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiang", 
        "id": "sg:person.015526027337.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526027337.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Easton", 
        "givenName": "John", 
        "id": "sg:person.0721607077.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721607077.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finkelstein", 
        "givenName": "David", 
        "id": "sg:person.015743405662.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015743405662.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biostatistics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Zhifa", 
        "id": "sg:person.01174371031.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174371031.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biostatistics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pounds", 
        "givenName": "Stanley", 
        "id": "sg:person.013021764377.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013021764377.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Pediatric Oncology, Dana-Farber/Boston Children\u2019s Cancer and Blood Disorders Center, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez-Galindo", 
        "givenName": "Carlos", 
        "id": "sg:person.01110535142.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110535142.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lund", 
        "givenName": "Troy C.", 
        "id": "sg:person.0627302535.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627302535.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mardis", 
        "givenName": "Elaine R.", 
        "id": "sg:person.01023627236.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA", 
            "Department of Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Richard K.", 
        "id": "sg:person.013076541047.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boggs", 
        "givenName": "Kristy", 
        "id": "sg:person.01333523432.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333523432.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yergeau", 
        "givenName": "Donald", 
        "id": "sg:person.01045415307.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045415307.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Jinjun", 
        "id": "sg:person.01302773626.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302773626.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mulder", 
        "givenName": "Heather L.", 
        "id": "sg:person.01045613146.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045613146.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manne", 
        "givenName": "Jayanthi", 
        "id": "sg:person.01232247124.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232247124.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jenkins", 
        "givenName": "Jesse", 
        "id": "sg:person.011376733577.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011376733577.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Boldrini Children\u2019s Research Hospital, Campinas 13083-210, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mastellaro", 
        "givenName": "Maria J.", 
        "id": "sg:person.01172612266.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172612266.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba 80-250-200, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Figueiredo", 
        "givenName": "Bonald C.", 
        "id": "sg:person.01231014011.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231014011.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dyer", 
        "givenName": "Michael A.", 
        "id": "sg:person.0723007550.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723007550.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pappo", 
        "givenName": "Alberto", 
        "id": "sg:person.01323070226.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323070226.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jinghui", 
        "id": "sg:person.011367065707.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367065707.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Downing", 
        "givenName": "James R.", 
        "id": "sg:person.0776022700.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776022700.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribeiro", 
        "givenName": "Raul C.", 
        "id": "sg:person.0575513332.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575513332.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biochemistry, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zambetti", 
        "givenName": "Gerard P.", 
        "id": "sg:person.0711416333.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711416333.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/onc.2016.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000875315", 
          "https://doi.org/10.1038/onc.2016.78"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2009.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001268857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.05.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004037668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004171938", 
          "https://doi.org/10.1038/nmeth.1628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005765336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006487337", 
          "https://doi.org/10.1038/nature10725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006780793", 
          "https://doi.org/10.1038/nature10733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-911x(199703)28:3<175::aid-mpo3>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006943124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.52.6863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008735978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116910", 
          "https://doi.org/10.1038/nrc1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116910", 
          "https://doi.org/10.1038/nrc1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362747a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010381628", 
          "https://doi.org/10.1038/362747a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.08.085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011001954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2009.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013049070", 
          "https://doi.org/10.1038/ejhg.2009.106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2009.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013049070", 
          "https://doi.org/10.1038/ejhg.2009.106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0913586107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013343344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2012-13-12-r113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016157732", 
          "https://doi.org/10.1186/gb-2012-13-12-r113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-011-1455-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020116412", 
          "https://doi.org/10.1007/s00431-011-1455-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2011.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020498406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2013.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021124710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2011.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022690047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025042764", 
          "https://doi.org/10.1038/modpathol.3880339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025042764", 
          "https://doi.org/10.1038/modpathol.3880339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026374177", 
          "https://doi.org/10.1038/nrc3352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2013.263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026754993", 
          "https://doi.org/10.1038/nrendo.2013.263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2010.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028003636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2004.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028661001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029474313", 
          "https://doi.org/10.1038/39797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029474313", 
          "https://doi.org/10.1038/39797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.161479898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030767494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031035095", 
          "https://doi.org/10.1038/nbt.1621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2011.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032202841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033941123", 
          "https://doi.org/10.1038/sj.cdd.4401183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033941123", 
          "https://doi.org/10.1038/sj.cdd.4401183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033974084", 
          "https://doi.org/10.1038/sj.onc.1205651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033974084", 
          "https://doi.org/10.1038/sj.onc.1205651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0004-27302004000500009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035320845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10024001-0110-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035734773", 
          "https://doi.org/10.1007/s10024001-0110-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btt372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036619961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.2009.073429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037125388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(200005)28:1<1::aid-gcc1>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039831611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.46.3711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040965071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1208215109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045267086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045709558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.41.1165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046405779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01169-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046700789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2350/08-06-0489.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047013260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2350/08-06-0489.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047013260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047195002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.21299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048084056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052056080", 
          "https://doi.org/10.1038/ng.2953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-1184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.82.8.2559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064299745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.10.7957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064323921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074773784", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078552827", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082893716", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal chromosome. IGF2 on chromosome 11p is overexpressed in 100% of the tumours. TP53 mutations and chromosome 17 LOH with selection against wild-type TP53 are observed in 28 ACTs (76%). Chromosomes 11p and 17 undergo copy-neutral LOH early during tumorigenesis, suggesting tumour-driver events. Additional genetic alterations include recurrent somatic mutations in ATRX and CTNNB1 and integration of human herpesvirus-6 in chromosome 11p. A dismal outcome is predicted by concomitant TP53 and ATRX mutations and associated genomic abnormalities, including massive structural variations and frequent background mutations. Collectively, these findings demonstrate the nature, timing and potential prognostic significance of key genetic alterations in paediatric ACT and outline a hypothetical model of paediatric adrenocortical tumorigenesis. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms7302", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2414430", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2482007", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2507148", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2507638", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Genomic landscape of paediatric adrenocortical tumours", 
    "pagination": "6302", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2144b8c141fd3d39fbbb6c9b83441c817d4973e89eef8322e728b158b53f919e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25743702"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms7302"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006983905"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms7302", 
      "https://app.dimensions.ai/details/publication/pub.1006983905"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms7302"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms7302'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms7302'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms7302'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms7302'


 

This table displays all metadata directly associated to this object as RDF triples.

504 TRIPLES      21 PREDICATES      99 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms7302 schema:about N027e23df27f84e50b9190e9c65979dd8
2 N0828a78fb89141efb51a43897a121a99
3 N156dd34c54ad4598a8e13f6cc855d20e
4 N1774e63db7c84f9693d6b30a24dbedef
5 N19b4ac2cf2534b5f93ee803874d423f9
6 N37c2d23a7cee48c1a1df9f84a84e8fe1
7 N4e381f19752a4d18885ed2324244c1b8
8 N5fa9ad85a69a4c7b883c28004becff30
9 N6aeabbb446294c38b0e0c90be019d962
10 N6caab846f5c84d6395bf5b4a29f08fe2
11 N6db3a9e132ab48a1bbc464a4425041bd
12 N7b2371b67de24de89bb5f1fecab9fffb
13 N96272e51b361469a945e09e94156b8d0
14 N9b660415301d4bac9febb14dc4c315a8
15 Nb9a30cb0584a42559ccf48eb14001ea8
16 Nc4d166860a2a438d8490ef6ddc9bf2a9
17 Nd8c398fdf2da43eeac1a4ff6dabda3e5
18 Ne4ba5ad0177f401ca5857cc71a322b66
19 Nfa1f0738ea1e467890827f3b64d5707c
20 anzsrc-for:06
21 anzsrc-for:0604
22 schema:author N780df82e74cb499da709c56b1bfdc82a
23 schema:citation sg:pub.10.1007/s00431-011-1455-0
24 sg:pub.10.1007/s10024001-0110-6
25 sg:pub.10.1038/362747a0
26 sg:pub.10.1038/39797
27 sg:pub.10.1038/ejhg.2009.106
28 sg:pub.10.1038/modpathol.3880339
29 sg:pub.10.1038/nature10725
30 sg:pub.10.1038/nature10733
31 sg:pub.10.1038/nbt.1621
32 sg:pub.10.1038/ng.2953
33 sg:pub.10.1038/nmeth.1628
34 sg:pub.10.1038/nrc1279
35 sg:pub.10.1038/nrc3352
36 sg:pub.10.1038/nrendo.2013.263
37 sg:pub.10.1038/onc.2016.78
38 sg:pub.10.1038/sj.cdd.4401183
39 sg:pub.10.1038/sj.onc.1205651
40 sg:pub.10.1186/gb-2012-13-12-r113
41 https://app.dimensions.ai/details/publication/pub.1074773784
42 https://app.dimensions.ai/details/publication/pub.1078552827
43 https://app.dimensions.ai/details/publication/pub.1082893716
44 https://doi.org/10.1002/(sici)1096-911x(199703)28:3<175::aid-mpo3>3.0.co;2-g
45 https://doi.org/10.1002/(sici)1098-2264(200005)28:1<1::aid-gcc1>3.0.co;2-#
46 https://doi.org/10.1002/jmv.21299
47 https://doi.org/10.1016/j.ajpath.2012.05.026
48 https://doi.org/10.1016/j.canlet.2004.11.010
49 https://doi.org/10.1016/j.ccr.2013.11.002
50 https://doi.org/10.1016/j.cell.2012.04.024
51 https://doi.org/10.1016/j.humpath.2009.03.010
52 https://doi.org/10.1016/j.humpath.2011.04.016
53 https://doi.org/10.1016/j.mce.2010.11.008
54 https://doi.org/10.1016/j.mce.2011.09.010
55 https://doi.org/10.1016/j.mce.2011.10.015
56 https://doi.org/10.1016/j.tibs.2013.06.011
57 https://doi.org/10.1073/pnas.0913586107
58 https://doi.org/10.1073/pnas.1208215109
59 https://doi.org/10.1073/pnas.161479898
60 https://doi.org/10.1093/bioinformatics/btp324
61 https://doi.org/10.1093/bioinformatics/btt372
62 https://doi.org/10.1093/nar/gkt840
63 https://doi.org/10.1128/jvi.01169-10
64 https://doi.org/10.1136/jmg.2009.073429
65 https://doi.org/10.1200/jco.2004.08.085
66 https://doi.org/10.1200/jco.2011.41.1165
67 https://doi.org/10.1200/jco.2012.46.3711
68 https://doi.org/10.1200/jco.2013.52.6863
69 https://doi.org/10.1210/jc.2012-1184
70 https://doi.org/10.1210/jc.82.8.2559
71 https://doi.org/10.1210/jcem.86.10.7957
72 https://doi.org/10.1590/s0004-27302004000500009
73 https://doi.org/10.2350/08-06-0489.1
74 schema:datePublished 2015-12
75 schema:datePublishedReg 2015-12-01
76 schema:description Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal chromosome. IGF2 on chromosome 11p is overexpressed in 100% of the tumours. TP53 mutations and chromosome 17 LOH with selection against wild-type TP53 are observed in 28 ACTs (76%). Chromosomes 11p and 17 undergo copy-neutral LOH early during tumorigenesis, suggesting tumour-driver events. Additional genetic alterations include recurrent somatic mutations in ATRX and CTNNB1 and integration of human herpesvirus-6 in chromosome 11p. A dismal outcome is predicted by concomitant TP53 and ATRX mutations and associated genomic abnormalities, including massive structural variations and frequent background mutations. Collectively, these findings demonstrate the nature, timing and potential prognostic significance of key genetic alterations in paediatric ACT and outline a hypothetical model of paediatric adrenocortical tumorigenesis.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N5a172a3a333940c2a38f8e20db4e1719
81 Nb0243fa119834b20ae7861348d477146
82 sg:journal.1043282
83 schema:name Genomic landscape of paediatric adrenocortical tumours
84 schema:pagination 6302
85 schema:productId N0f79777bff804ffe98741cefbf9be21f
86 N2a2a0c8ee4694d619943996608efb915
87 N5c30e3e99c6e427db7f3c16848552601
88 N9af8a6f491a7473b958d07a0c9818f8e
89 Ne83ff11ba1234cb7979b3b24bfed152c
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006983905
91 https://doi.org/10.1038/ncomms7302
92 schema:sdDatePublished 2019-04-10T17:20
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Ndbdddb7f50bc47d28e3e0166099e1d45
95 schema:url https://www.nature.com/articles/ncomms7302
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N0062630173bb4ad6a6d51dd81a1c2777 rdf:first sg:person.0711416333.21
100 rdf:rest rdf:nil
101 N027e23df27f84e50b9190e9c65979dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Insulin-Like Growth Factor II
103 rdf:type schema:DefinedTerm
104 N07b78dbe69584349bb54c35016eb3e6b rdf:first sg:person.01110535142.70
105 rdf:rest N7e96ecfd139c4ae2aded7edce11dfa6b
106 N0828a78fb89141efb51a43897a121a99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Molecular Sequence Data
108 rdf:type schema:DefinedTerm
109 N0daf61ff8ea64919af969581efcbc9ad rdf:first sg:person.01302773626.07
110 rdf:rest N1fc4efefd4434e78bb2545104414a159
111 N0f79777bff804ffe98741cefbf9be21f schema:name readcube_id
112 schema:value 2144b8c141fd3d39fbbb6c9b83441c817d4973e89eef8322e728b158b53f919e
113 rdf:type schema:PropertyValue
114 N156dd34c54ad4598a8e13f6cc855d20e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Gene Expression Profiling
116 rdf:type schema:DefinedTerm
117 N1774e63db7c84f9693d6b30a24dbedef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name DNA Helicases
119 rdf:type schema:DefinedTerm
120 N17857b20db6c4849b4ebd84ebeef41c8 rdf:first sg:person.0575513332.66
121 rdf:rest N0062630173bb4ad6a6d51dd81a1c2777
122 N19b4ac2cf2534b5f93ee803874d423f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Tumor Suppressor Protein p53
124 rdf:type schema:DefinedTerm
125 N1fc4efefd4434e78bb2545104414a159 rdf:first sg:person.01045613146.32
126 rdf:rest N9fed28a7e7eb4d1d8c7e794992196356
127 N233a6a4987844cfeba44566262864ed1 rdf:first sg:person.013021764377.67
128 rdf:rest N07b78dbe69584349bb54c35016eb3e6b
129 N2606114e3b2a4511a7066242a177e379 rdf:first sg:person.015526027337.83
130 rdf:rest Nc39e63617c3f4a528ff86e401b3ce442
131 N2a047c424bda48379542f38e30f04a8d rdf:first sg:person.01231014011.29
132 rdf:rest N4bb8c29caf914b2aa679fe673efaf510
133 N2a2a0c8ee4694d619943996608efb915 schema:name dimensions_id
134 schema:value pub.1006983905
135 rdf:type schema:PropertyValue
136 N37c2d23a7cee48c1a1df9f84a84e8fe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Chromosomes, Human, Pair 17
138 rdf:type schema:DefinedTerm
139 N4a0ce0487f79411f96ae61642f0bed1a rdf:first sg:person.011367065707.90
140 rdf:rest N8db936ff01e84276aac0a9d8399e62d2
141 N4bb8c29caf914b2aa679fe673efaf510 rdf:first sg:person.0723007550.69
142 rdf:rest N5fe149df542443e7af53e50a6ba60738
143 N4e381f19752a4d18885ed2324244c1b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Child
145 rdf:type schema:DefinedTerm
146 N5a172a3a333940c2a38f8e20db4e1719 schema:volumeNumber 6
147 rdf:type schema:PublicationVolume
148 N5c30e3e99c6e427db7f3c16848552601 schema:name doi
149 schema:value 10.1038/ncomms7302
150 rdf:type schema:PropertyValue
151 N5fa9ad85a69a4c7b883c28004becff30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Sequence Analysis, DNA
153 rdf:type schema:DefinedTerm
154 N5fe149df542443e7af53e50a6ba60738 rdf:first sg:person.01323070226.76
155 rdf:rest N4a0ce0487f79411f96ae61642f0bed1a
156 N6362108dfcd9475ebb35e6d115b3557c rdf:first sg:person.01174371031.78
157 rdf:rest N233a6a4987844cfeba44566262864ed1
158 N6aeabbb446294c38b0e0c90be019d962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name X-linked Nuclear Protein
160 rdf:type schema:DefinedTerm
161 N6caab846f5c84d6395bf5b4a29f08fe2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Humans
163 rdf:type schema:DefinedTerm
164 N6db3a9e132ab48a1bbc464a4425041bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Adrenocortical Carcinoma
166 rdf:type schema:DefinedTerm
167 N780df82e74cb499da709c56b1bfdc82a rdf:first sg:person.01234624673.27
168 rdf:rest N2606114e3b2a4511a7066242a177e379
169 N7b2371b67de24de89bb5f1fecab9fffb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Genome, Human
171 rdf:type schema:DefinedTerm
172 N7e96ecfd139c4ae2aded7edce11dfa6b rdf:first sg:person.0627302535.49
173 rdf:rest Nfda4727c89604491abc8cdecbfebe0c6
174 N89332917426f41ff93ca53b04cd1517e rdf:first sg:person.01333523432.48
175 rdf:rest N89b923a2bde04624a3b1d5513c7489d2
176 N89b923a2bde04624a3b1d5513c7489d2 rdf:first sg:person.01045415307.80
177 rdf:rest N0daf61ff8ea64919af969581efcbc9ad
178 N8db936ff01e84276aac0a9d8399e62d2 rdf:first sg:person.0776022700.87
179 rdf:rest N17857b20db6c4849b4ebd84ebeef41c8
180 N96272e51b361469a945e09e94156b8d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gene Expression Regulation, Neoplastic
182 rdf:type schema:DefinedTerm
183 N9af8a6f491a7473b958d07a0c9818f8e schema:name pubmed_id
184 schema:value 25743702
185 rdf:type schema:PropertyValue
186 N9b660415301d4bac9febb14dc4c315a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Chromosomes, Human, Pair 11
188 rdf:type schema:DefinedTerm
189 N9c11b5e4ba6b4c3f92fde81109b190e6 rdf:first sg:person.01172612266.41
190 rdf:rest N2a047c424bda48379542f38e30f04a8d
191 N9fed28a7e7eb4d1d8c7e794992196356 rdf:first sg:person.01232247124.54
192 rdf:rest Nbbd57d257ef449aabdfaa9576ba75c46
193 Na620c7e2185a435eb8cfcba602d571e8 schema:name Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80-250-200, Brazil
194 rdf:type schema:Organization
195 Nad4fa3e73f2945f6ac1025a6ea04f992 schema:name Boldrini Children’s Research Hospital, Campinas 13083-210, Brazil
196 rdf:type schema:Organization
197 Nb0243fa119834b20ae7861348d477146 schema:issueNumber 1
198 rdf:type schema:PublicationIssue
199 Nb22a3105083b4c4eb5fe90b0aa74c9ad rdf:first sg:person.015743405662.61
200 rdf:rest N6362108dfcd9475ebb35e6d115b3557c
201 Nb9a30cb0584a42559ccf48eb14001ea8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Nuclear Proteins
203 rdf:type schema:DefinedTerm
204 Nbbd57d257ef449aabdfaa9576ba75c46 rdf:first sg:person.011376733577.76
205 rdf:rest N9c11b5e4ba6b4c3f92fde81109b190e6
206 Nbd9ec8bedd4b49a0bd3acb7144f66d70 rdf:first sg:person.013076541047.38
207 rdf:rest N89332917426f41ff93ca53b04cd1517e
208 Nc39e63617c3f4a528ff86e401b3ce442 rdf:first sg:person.0721607077.65
209 rdf:rest Nb22a3105083b4c4eb5fe90b0aa74c9ad
210 Nc4d166860a2a438d8490ef6ddc9bf2a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Adrenal Cortex Neoplasms
212 rdf:type schema:DefinedTerm
213 Nd8c398fdf2da43eeac1a4ff6dabda3e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Loss of Heterozygosity
215 rdf:type schema:DefinedTerm
216 Ndbdddb7f50bc47d28e3e0166099e1d45 schema:name Springer Nature - SN SciGraph project
217 rdf:type schema:Organization
218 Ne4ba5ad0177f401ca5857cc71a322b66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name beta Catenin
220 rdf:type schema:DefinedTerm
221 Ne83ff11ba1234cb7979b3b24bfed152c schema:name nlm_unique_id
222 schema:value 101528555
223 rdf:type schema:PropertyValue
224 Nfa1f0738ea1e467890827f3b64d5707c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Base Sequence
226 rdf:type schema:DefinedTerm
227 Nfda4727c89604491abc8cdecbfebe0c6 rdf:first sg:person.01023627236.33
228 rdf:rest Nbd9ec8bedd4b49a0bd3acb7144f66d70
229 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
230 schema:name Biological Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
233 schema:name Genetics
234 rdf:type schema:DefinedTerm
235 sg:grant.2414430 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7302
236 rdf:type schema:MonetaryGrant
237 sg:grant.2438833 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7302
238 rdf:type schema:MonetaryGrant
239 sg:grant.2482007 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7302
240 rdf:type schema:MonetaryGrant
241 sg:grant.2507148 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7302
242 rdf:type schema:MonetaryGrant
243 sg:grant.2507638 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms7302
244 rdf:type schema:MonetaryGrant
245 sg:journal.1043282 schema:issn 2041-1723
246 schema:name Nature Communications
247 rdf:type schema:Periodical
248 sg:person.01023627236.33 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
249 schema:familyName Mardis
250 schema:givenName Elaine R.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33
252 rdf:type schema:Person
253 sg:person.01045415307.80 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
254 schema:familyName Yergeau
255 schema:givenName Donald
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045415307.80
257 rdf:type schema:Person
258 sg:person.01045613146.32 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
259 schema:familyName Mulder
260 schema:givenName Heather L.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045613146.32
262 rdf:type schema:Person
263 sg:person.01110535142.70 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
264 schema:familyName Rodriguez-Galindo
265 schema:givenName Carlos
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110535142.70
267 rdf:type schema:Person
268 sg:person.011367065707.90 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
269 schema:familyName Zhang
270 schema:givenName Jinghui
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367065707.90
272 rdf:type schema:Person
273 sg:person.011376733577.76 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
274 schema:familyName Jenkins
275 schema:givenName Jesse
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011376733577.76
277 rdf:type schema:Person
278 sg:person.01172612266.41 schema:affiliation Nad4fa3e73f2945f6ac1025a6ea04f992
279 schema:familyName Mastellaro
280 schema:givenName Maria J.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172612266.41
282 rdf:type schema:Person
283 sg:person.01174371031.78 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
284 schema:familyName Liu
285 schema:givenName Zhifa
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174371031.78
287 rdf:type schema:Person
288 sg:person.01231014011.29 schema:affiliation Na620c7e2185a435eb8cfcba602d571e8
289 schema:familyName Figueiredo
290 schema:givenName Bonald C.
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231014011.29
292 rdf:type schema:Person
293 sg:person.01232247124.54 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
294 schema:familyName Manne
295 schema:givenName Jayanthi
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232247124.54
297 rdf:type schema:Person
298 sg:person.01234624673.27 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
299 schema:familyName Pinto
300 schema:givenName Emilia M.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234624673.27
302 rdf:type schema:Person
303 sg:person.013021764377.67 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
304 schema:familyName Pounds
305 schema:givenName Stanley
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013021764377.67
307 rdf:type schema:Person
308 sg:person.01302773626.07 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
309 schema:familyName Cheng
310 schema:givenName Jinjun
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302773626.07
312 rdf:type schema:Person
313 sg:person.013076541047.38 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
314 schema:familyName Wilson
315 schema:givenName Richard K.
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38
317 rdf:type schema:Person
318 sg:person.01323070226.76 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
319 schema:familyName Pappo
320 schema:givenName Alberto
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323070226.76
322 rdf:type schema:Person
323 sg:person.01333523432.48 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
324 schema:familyName Boggs
325 schema:givenName Kristy
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333523432.48
327 rdf:type schema:Person
328 sg:person.015526027337.83 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
329 schema:familyName Chen
330 schema:givenName Xiang
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526027337.83
332 rdf:type schema:Person
333 sg:person.015743405662.61 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
334 schema:familyName Finkelstein
335 schema:givenName David
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015743405662.61
337 rdf:type schema:Person
338 sg:person.0575513332.66 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
339 schema:familyName Ribeiro
340 schema:givenName Raul C.
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575513332.66
342 rdf:type schema:Person
343 sg:person.0627302535.49 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
344 schema:familyName Lund
345 schema:givenName Troy C.
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627302535.49
347 rdf:type schema:Person
348 sg:person.0711416333.21 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
349 schema:familyName Zambetti
350 schema:givenName Gerard P.
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711416333.21
352 rdf:type schema:Person
353 sg:person.0721607077.65 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
354 schema:familyName Easton
355 schema:givenName John
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721607077.65
357 rdf:type schema:Person
358 sg:person.0723007550.69 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
359 schema:familyName Dyer
360 schema:givenName Michael A.
361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723007550.69
362 rdf:type schema:Person
363 sg:person.0776022700.87 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
364 schema:familyName Downing
365 schema:givenName James R.
366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776022700.87
367 rdf:type schema:Person
368 sg:pub.10.1007/s00431-011-1455-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020116412
369 https://doi.org/10.1007/s00431-011-1455-0
370 rdf:type schema:CreativeWork
371 sg:pub.10.1007/s10024001-0110-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035734773
372 https://doi.org/10.1007/s10024001-0110-6
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/362747a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010381628
375 https://doi.org/10.1038/362747a0
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/39797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029474313
378 https://doi.org/10.1038/39797
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/ejhg.2009.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013049070
381 https://doi.org/10.1038/ejhg.2009.106
382 rdf:type schema:CreativeWork
383 sg:pub.10.1038/modpathol.3880339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025042764
384 https://doi.org/10.1038/modpathol.3880339
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/nature10725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006487337
387 https://doi.org/10.1038/nature10725
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/nature10733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006780793
390 https://doi.org/10.1038/nature10733
391 rdf:type schema:CreativeWork
392 sg:pub.10.1038/nbt.1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031035095
393 https://doi.org/10.1038/nbt.1621
394 rdf:type schema:CreativeWork
395 sg:pub.10.1038/ng.2953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052056080
396 https://doi.org/10.1038/ng.2953
397 rdf:type schema:CreativeWork
398 sg:pub.10.1038/nmeth.1628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004171938
399 https://doi.org/10.1038/nmeth.1628
400 rdf:type schema:CreativeWork
401 sg:pub.10.1038/nrc1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009116910
402 https://doi.org/10.1038/nrc1279
403 rdf:type schema:CreativeWork
404 sg:pub.10.1038/nrc3352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026374177
405 https://doi.org/10.1038/nrc3352
406 rdf:type schema:CreativeWork
407 sg:pub.10.1038/nrendo.2013.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026754993
408 https://doi.org/10.1038/nrendo.2013.263
409 rdf:type schema:CreativeWork
410 sg:pub.10.1038/onc.2016.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000875315
411 https://doi.org/10.1038/onc.2016.78
412 rdf:type schema:CreativeWork
413 sg:pub.10.1038/sj.cdd.4401183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033941123
414 https://doi.org/10.1038/sj.cdd.4401183
415 rdf:type schema:CreativeWork
416 sg:pub.10.1038/sj.onc.1205651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033974084
417 https://doi.org/10.1038/sj.onc.1205651
418 rdf:type schema:CreativeWork
419 sg:pub.10.1186/gb-2012-13-12-r113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016157732
420 https://doi.org/10.1186/gb-2012-13-12-r113
421 rdf:type schema:CreativeWork
422 https://app.dimensions.ai/details/publication/pub.1074773784 schema:CreativeWork
423 https://app.dimensions.ai/details/publication/pub.1078552827 schema:CreativeWork
424 https://app.dimensions.ai/details/publication/pub.1082893716 schema:CreativeWork
425 https://doi.org/10.1002/(sici)1096-911x(199703)28:3<175::aid-mpo3>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1006943124
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1002/(sici)1098-2264(200005)28:1<1::aid-gcc1>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1039831611
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1002/jmv.21299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048084056
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1016/j.ajpath.2012.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004037668
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1016/j.canlet.2004.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028661001
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1016/j.ccr.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047195002
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1016/j.cell.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045709558
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1016/j.humpath.2009.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001268857
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1016/j.humpath.2011.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032202841
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1016/j.mce.2010.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028003636
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1016/j.mce.2011.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020498406
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1016/j.mce.2011.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022690047
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1016/j.tibs.2013.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021124710
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1073/pnas.0913586107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013343344
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1073/pnas.1208215109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045267086
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1073/pnas.161479898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767494
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1093/bioinformatics/btt372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036619961
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1093/nar/gkt840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005765336
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1128/jvi.01169-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046700789
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1136/jmg.2009.073429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037125388
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1200/jco.2004.08.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011001954
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1200/jco.2011.41.1165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046405779
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1200/jco.2012.46.3711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040965071
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1200/jco.2013.52.6863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008735978
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1210/jc.2012-1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293428
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1210/jc.82.8.2559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064299745
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1210/jcem.86.10.7957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064323921
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1590/s0004-27302004000500009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035320845
482 rdf:type schema:CreativeWork
483 https://doi.org/10.2350/08-06-0489.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047013260
484 rdf:type schema:CreativeWork
485 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
486 schema:name University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
487 rdf:type schema:Organization
488 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
489 schema:name Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
490 Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
491 Department of Computational Biology and Bioinformatics, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
492 Department of Developmental Neurobiology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
493 Department of Oncology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
494 Department of Pathology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
495 rdf:type schema:Organization
496 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
497 schema:name Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02215, USA
498 rdf:type schema:Organization
499 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
500 schema:name Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
501 Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63108, USA
502 Department of Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
503 The Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA
504 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...