PD-L1hi B cells are critical regulators of humoral immunity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Adnan R. Khan, Emily Hams, Achilleas Floudas, Tim Sparwasser, Casey T. Weaver, Padraic G. Fallon

ABSTRACT

Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4(+)CXCR5(+)PD-1(+) follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to αCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases. More... »

PAGES

5997

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms6997

DOI

http://dx.doi.org/10.1038/ncomms6997

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020737207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25609381


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