CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Emma C. Mackley, Stephanie Houston, Clare L. Marriott, Emily E. Halford, Beth Lucas, Vuk Cerovic, Kara J. Filbey, Rick M. Maizels, Matthew R. Hepworth, Gregory F. Sonnenberg, Simon Milling, David R. Withers

ABSTRACT

Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms. More... »

PAGES

5862

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms6862

    DOI

    http://dx.doi.org/10.1038/ncomms6862

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031334338

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25575242


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