Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12-12

AUTHORS

Shinji Noda, Yoshihide Asano, Satoshi Nishimura, Takashi Taniguchi, Katsuhito Fujiu, Ichiro Manabe, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Kaname Akamata, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Daisuke Tsuruta, Maria Trojanowska, Ryozo Nagai, Shinichi Sato

ABSTRACT

Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation. So far, a unifying hypothesis underpinning these pathological events remains unknown. Given that SSc is a multifactorial disease caused by both genetic and environmental factors, we focus on the two transcription factors, which modulate the fibrotic reaction and are epigenetically suppressed in SSc dermal fibroblasts, Friend leukaemia integration 1 (Fli1) and Krüppel-like factor 5 (KLF5). In addition to the Fli1 silencing-dependent collagen induction, the simultaneous knockdown of Fli1 and KLF5 synergistically enhances expression of connective tissue growth factor. Notably, mice with double heterozygous deficiency of Klf5 and Fli1 mimicking the epigenetic phenotype of SSc skin spontaneously recapitulate all the three features of SSc, including fibrosis and vasculopathy of the skin and lung, B-cell activation and autoantibody production. These studies implicate the epigenetic downregulation of Fli1 and KLF5 as a central event triggering the pathogenic triad of SSc. More... »

PAGES

5797

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms6797

DOI

http://dx.doi.org/10.1038/ncomms6797

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005151747

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25504335


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