Ontology type: schema:ScholarlyArticle Open Access: True
2014-12-12
AUTHORSShinji Noda, Yoshihide Asano, Satoshi Nishimura, Takashi Taniguchi, Katsuhito Fujiu, Ichiro Manabe, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Kaname Akamata, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Daisuke Tsuruta, Maria Trojanowska, Ryozo Nagai, Shinichi Sato
ABSTRACTSystemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation. So far, a unifying hypothesis underpinning these pathological events remains unknown. Given that SSc is a multifactorial disease caused by both genetic and environmental factors, we focus on the two transcription factors, which modulate the fibrotic reaction and are epigenetically suppressed in SSc dermal fibroblasts, Friend leukaemia integration 1 (Fli1) and Krüppel-like factor 5 (KLF5). In addition to the Fli1 silencing-dependent collagen induction, the simultaneous knockdown of Fli1 and KLF5 synergistically enhances expression of connective tissue growth factor. Notably, mice with double heterozygous deficiency of Klf5 and Fli1 mimicking the epigenetic phenotype of SSc skin spontaneously recapitulate all the three features of SSc, including fibrosis and vasculopathy of the skin and lung, B-cell activation and autoantibody production. These studies implicate the epigenetic downregulation of Fli1 and KLF5 as a central event triggering the pathogenic triad of SSc. More... »
PAGES5797
http://scigraph.springernature.com/pub.10.1038/ncomms6797
DOIhttp://dx.doi.org/10.1038/ncomms6797
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25504335
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"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_623.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/ncomms6797"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6797'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6797'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6797'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6797'
This table displays all metadata directly associated to this object as RDF triples.
375 TRIPLES
22 PREDICATES
112 URIs
96 LITERALS
30 BLANK NODES