Mitotic catenation is monitored and resolved by a PKCε-regulated pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Nicola Brownlow, Tanya Pike, Daniel Zicha, Lucy Collinson, Peter J. Parker

ABSTRACT

Exit from mitosis is controlled by silencing of the spindle assembly checkpoint (SAC). It is important that preceding exit, all sister chromatid pairs are correctly bioriented, and that residual catenation is resolved, permitting complete sister chromatid separation in the ensuing anaphase. Here we determine that the metaphase response to catenation in mammalian cells operates through PKCε. The PKCε-controlled pathway regulates exit from the SAC only when mitotic cells are challenged by retained catenation and this delayed exit is characterized by BubR1-high and Mad2-low kinetochores. In addition, we show that this pathway is necessary to facilitate resolution of retained catenanes in mitosis. When delayed by catenation in mitosis, inhibition of PKCε results in premature entry into anaphase with PICH-positive strands and chromosome bridging. These findings demonstrate the importance of PKCε-mediated regulation in protection from loss of chromosome integrity in cells failing to resolve catenation in G2. More... »

PAGES

5685

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms6685

DOI

http://dx.doi.org/10.1038/ncomms6685

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014019532

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25483024


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Separation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Segregation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dyneins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "G2 Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetochores", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metaphase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C-epsilon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sister Chromatid Exchange", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spindle Apparatus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3LY, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brownlow", 
        "givenName": "Nicola", 
        "id": "sg:person.01066562416.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066562416.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3LY, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pike", 
        "givenName": "Tanya", 
        "id": "sg:person.01041043262.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041043262.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Light Microscopy, Cancer Research UK London Research Institute, London, WC2A 3LY, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zicha", 
        "givenName": "Daniel", 
        "id": "sg:person.01065777610.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065777610.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Electron Microscopy, Cancer Research UK London Research Institute, London WC2A 3LY, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collinson", 
        "givenName": "Lucy", 
        "id": "sg:person.0677742110.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677742110.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3LY, UK", 
            "Division of Cancer Studies, King\u2019s College London, New Hunt\u2019s House, Guy\u2019s Campus, London SE1 1UL, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Peter J.", 
        "id": "sg:person.01111564441.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1091/mbc.e11-03-0213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000402327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m407588200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000479055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.9.1.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000665123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200910085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001004051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35046598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002885997", 
          "https://doi.org/10.1038/35046598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35046598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002885997", 
          "https://doi.org/10.1038/35046598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2005.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003399765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2005.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003399765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2013.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003987970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2004.1607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004005302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.132.4.617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006970475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1367206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007909197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000134517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008006481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e08-05-0547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008325687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0070696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009415377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201001006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009724511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1003832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012005753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201305157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013116390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2011.10.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014013116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200710106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017228048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m104383200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017353085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017685794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2013.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018611500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2009.05.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020338630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200105093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020494262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0033905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021310530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022310437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199910)26:2<176::aid-gcc11>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023520595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.059501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024669499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/000114137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026056389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.090013497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026747570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201304197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027455042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.150.5.975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027728941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00110-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027840701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028946343", 
          "https://doi.org/10.1038/nature05734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028946343", 
          "https://doi.org/10.1038/nature05734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2443.2003.00643.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030329131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359536a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030516958", 
          "https://doi.org/10.1038/359536a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031193848", 
          "https://doi.org/10.1038/sj.bjc.6603537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031193848", 
          "https://doi.org/10.1038/sj.bjc.6603537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031860331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034186396", 
          "https://doi.org/10.1038/nrm2163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034186396", 
          "https://doi.org/10.1038/nrm2163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2009.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036613186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200804114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036757067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037488877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-199904000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038201076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-199904000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038201076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-012-0378-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039021287", 
          "https://doi.org/10.1007/s00412-012-0378-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-012-0378-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039021287", 
          "https://doi.org/10.1007/s00412-012-0378-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2004.05.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039908878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040029942", 
          "https://doi.org/10.1038/nature07098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040046496", 
          "https://doi.org/10.1038/nrm3494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(97)00282-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040400856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200805163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040500933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(85)80028-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041778124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00202-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042200004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043751695", 
          "https://doi.org/10.1038/ncb1749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/21831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043821401", 
          "https://doi.org/10.1038/21831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/21831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043821401", 
          "https://doi.org/10.1038/21831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-007-0131-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043999051", 
          "https://doi.org/10.1007/s00412-007-0131-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-007-0131-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043999051", 
          "https://doi.org/10.1007/s00412-007-0131-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045218643", 
          "https://doi.org/10.1038/onc.2010.232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045218643", 
          "https://doi.org/10.1038/onc.2010.232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200112023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046185895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046356293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048715041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e04-08-0732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049235470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0016494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049631537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e05-11-1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049657899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.11.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050256596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djg120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050343942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)01226-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051953595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)01226-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051953595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.221430898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052786695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2006.02.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053246804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.8.4.7653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072300560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074949008", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075087959", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082752354", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "Exit from mitosis is controlled by silencing of the spindle assembly checkpoint (SAC). It is important that preceding exit, all sister chromatid pairs are correctly bioriented, and that residual catenation is resolved, permitting complete sister chromatid separation in the ensuing anaphase. Here we determine that the metaphase response to catenation in mammalian cells operates through PKC\u03b5. The PKC\u03b5-controlled pathway regulates exit from the SAC only when mitotic cells are challenged by retained catenation and this delayed exit is characterized by BubR1-high and Mad2-low kinetochores. In addition, we show that this pathway is necessary to facilitate resolution of retained catenanes in mitosis. When delayed by catenation in mitosis, inhibition of PKC\u03b5 results in premature entry into anaphase with PICH-positive strands and chromosome bridging. These findings demonstrate the importance of PKC\u03b5-mediated regulation in protection from loss of chromosome integrity in cells failing to resolve catenation in G2. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms6685", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5147994", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5140849", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Mitotic catenation is monitored and resolved by a PKC\u03b5-regulated pathway", 
    "pagination": "5685", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "42c8ee11234e1bfec1b6be6ef5a68f3e43e114fe5a52b9c74b1050635f6d0089"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25483024"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms6685"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014019532"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms6685", 
      "https://app.dimensions.ai/details/publication/pub.1014019532"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms6685"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6685'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6685'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6685'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6685'


 

This table displays all metadata directly associated to this object as RDF triples.

406 TRIPLES      21 PREDICATES      119 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms6685 schema:about N19a9dc5e63924a8e93129674630af42d
2 N36a5eb04dda6449b8e85c10138772536
3 N3815678d336841448d7c1fab9bcf9fc3
4 N391cc4f7b21b4c9aa31848b9245b29cf
5 N4f58aaa9d1644558937330be3afcbce5
6 N540daea975b74a1c90d1fc3504c36aa3
7 N5921fb975f5740c78343814ce8ee3239
8 N61b1dedeb3be4469a6a322770a74b20a
9 N6ca61c5dc2cf4d68b5b50e270b357c43
10 N79e479b8590446e481404ef25838b2a3
11 N9034e80c29634ebbab53d7a1f5cce271
12 N9497c40fadb34c28a98e1efef8918de7
13 N95d2005226984221b5217d581a06d88c
14 Nb0358c74b0ed4462bf95a16239acf3fd
15 Nb3335ad9388d4579b5d52bd1dc5ead59
16 Nb38ad55891b14b0e9bd76e870a9c3265
17 Nd804974dbba64e1db61cec1180599036
18 Nde49ab8fc0ad4bb4b82ed2aa8c0b220f
19 Neff71ad44d144f5791c83dbb53a3ff9d
20 Nf6850d6e369144d2b02767d38f8382cc
21 Nfba3aaab9bb74e6ea1ad7cad0a1435cd
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author N3e5005af38674097b2034d0b9397c20c
25 schema:citation sg:pub.10.1007/s00412-007-0131-7
26 sg:pub.10.1007/s00412-012-0378-5
27 sg:pub.10.1038/21831
28 sg:pub.10.1038/35046598
29 sg:pub.10.1038/359536a0
30 sg:pub.10.1038/nature05734
31 sg:pub.10.1038/nature07098
32 sg:pub.10.1038/ncb1749
33 sg:pub.10.1038/nrm2163
34 sg:pub.10.1038/nrm3494
35 sg:pub.10.1038/onc.2010.232
36 sg:pub.10.1038/sj.bjc.6603537
37 https://app.dimensions.ai/details/publication/pub.1074949008
38 https://app.dimensions.ai/details/publication/pub.1075087959
39 https://app.dimensions.ai/details/publication/pub.1082752354
40 https://doi.org/10.1002/(sici)1098-2264(199910)26:2<176::aid-gcc11>3.0.co;2-3
41 https://doi.org/10.1016/j.bmcl.2011.10.025
42 https://doi.org/10.1016/j.cell.2006.11.041
43 https://doi.org/10.1016/j.cell.2007.01.021
44 https://doi.org/10.1016/j.cub.2004.05.053
45 https://doi.org/10.1016/j.cub.2009.05.060
46 https://doi.org/10.1016/j.cub.2009.06.043
47 https://doi.org/10.1016/j.cub.2013.09.003
48 https://doi.org/10.1016/j.molcel.2004.08.018
49 https://doi.org/10.1016/j.molcel.2013.05.019
50 https://doi.org/10.1016/j.tcb.2005.05.003
51 https://doi.org/10.1016/j.yexcr.2006.02.029
52 https://doi.org/10.1016/s0014-5793(97)00282-2
53 https://doi.org/10.1016/s0092-8674(00)00202-6
54 https://doi.org/10.1016/s0092-8674(85)80028-3
55 https://doi.org/10.1016/s0960-9822(02)01226-5
56 https://doi.org/10.1016/s1535-6108(03)00110-7
57 https://doi.org/10.1038/emboj.2008.182
58 https://doi.org/10.1046/j.1365-2443.2003.00643.x
59 https://doi.org/10.1073/pnas.090013497
60 https://doi.org/10.1073/pnas.221430898
61 https://doi.org/10.1074/jbc.m104383200
62 https://doi.org/10.1074/jbc.m407588200
63 https://doi.org/10.1083/jcb.132.4.617
64 https://doi.org/10.1083/jcb.150.5.975
65 https://doi.org/10.1083/jcb.200105093
66 https://doi.org/10.1083/jcb.200112023
67 https://doi.org/10.1083/jcb.200710106
68 https://doi.org/10.1083/jcb.200804114
69 https://doi.org/10.1083/jcb.200805163
70 https://doi.org/10.1083/jcb.200910085
71 https://doi.org/10.1083/jcb.201001006
72 https://doi.org/10.1083/jcb.201304197
73 https://doi.org/10.1083/jcb.201305157
74 https://doi.org/10.1091/mbc.e04-08-0732
75 https://doi.org/10.1091/mbc.e05-11-1089
76 https://doi.org/10.1091/mbc.e08-05-0547
77 https://doi.org/10.1091/mbc.e11-03-0213
78 https://doi.org/10.1093/jnci/djg120
79 https://doi.org/10.1093/nar/gkn302
80 https://doi.org/10.1093/nar/gks931
81 https://doi.org/10.1097/00001813-199904000-00008
82 https://doi.org/10.1098/rstb.2004.1607
83 https://doi.org/10.1101/gad.1367206
84 https://doi.org/10.1128/mcb.9.1.159
85 https://doi.org/10.1158/0008-5472.can-04-0871
86 https://doi.org/10.1159/000134517
87 https://doi.org/10.1242/jcs.059501
88 https://doi.org/10.1371/journal.pgen.1003832
89 https://doi.org/10.1371/journal.pone.0016494
90 https://doi.org/10.1371/journal.pone.0033905
91 https://doi.org/10.1371/journal.pone.0070696
92 https://doi.org/10.2144/000114137
93 https://doi.org/10.4161/cc.8.4.7653
94 schema:datePublished 2014-12
95 schema:datePublishedReg 2014-12-01
96 schema:description Exit from mitosis is controlled by silencing of the spindle assembly checkpoint (SAC). It is important that preceding exit, all sister chromatid pairs are correctly bioriented, and that residual catenation is resolved, permitting complete sister chromatid separation in the ensuing anaphase. Here we determine that the metaphase response to catenation in mammalian cells operates through PKCε. The PKCε-controlled pathway regulates exit from the SAC only when mitotic cells are challenged by retained catenation and this delayed exit is characterized by BubR1-high and Mad2-low kinetochores. In addition, we show that this pathway is necessary to facilitate resolution of retained catenanes in mitosis. When delayed by catenation in mitosis, inhibition of PKCε results in premature entry into anaphase with PICH-positive strands and chromosome bridging. These findings demonstrate the importance of PKCε-mediated regulation in protection from loss of chromosome integrity in cells failing to resolve catenation in G2.
97 schema:genre research_article
98 schema:inLanguage en
99 schema:isAccessibleForFree true
100 schema:isPartOf N7397383f82684fec89c65319990f384c
101 Neee6a1d3845d48ab87ab68ea5444403a
102 sg:journal.1043282
103 schema:name Mitotic catenation is monitored and resolved by a PKCε-regulated pathway
104 schema:pagination 5685
105 schema:productId N09058fad79cd44488463f2ec815ff281
106 N26d63afa30e84fee80ccacc679591ab8
107 N32b626e2fe834ab1bf79efb49dfd2682
108 N34cff09120ec4d17a60ac75c1ed7eb2a
109 Nfa4415cff3254f3d856be91b28723ebd
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019532
111 https://doi.org/10.1038/ncomms6685
112 schema:sdDatePublished 2019-04-10T19:46
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher Nb5d6dab242f54b1487c8ba6d06517ba5
115 schema:url https://www.nature.com/articles/ncomms6685
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N09058fad79cd44488463f2ec815ff281 schema:name pubmed_id
120 schema:value 25483024
121 rdf:type schema:PropertyValue
122 N196ab4f3de5148999e54090de7626e78 rdf:first sg:person.01111564441.81
123 rdf:rest rdf:nil
124 N19a9dc5e63924a8e93129674630af42d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Gene Silencing
126 rdf:type schema:DefinedTerm
127 N26d63afa30e84fee80ccacc679591ab8 schema:name dimensions_id
128 schema:value pub.1014019532
129 rdf:type schema:PropertyValue
130 N32b626e2fe834ab1bf79efb49dfd2682 schema:name readcube_id
131 schema:value 42c8ee11234e1bfec1b6be6ef5a68f3e43e114fe5a52b9c74b1050635f6d0089
132 rdf:type schema:PropertyValue
133 N34cff09120ec4d17a60ac75c1ed7eb2a schema:name nlm_unique_id
134 schema:value 101528555
135 rdf:type schema:PropertyValue
136 N36a5eb04dda6449b8e85c10138772536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Green Fluorescent Proteins
138 rdf:type schema:DefinedTerm
139 N3815678d336841448d7c1fab9bcf9fc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name HEK293 Cells
141 rdf:type schema:DefinedTerm
142 N391cc4f7b21b4c9aa31848b9245b29cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Flow Cytometry
144 rdf:type schema:DefinedTerm
145 N3e5005af38674097b2034d0b9397c20c rdf:first sg:person.01066562416.42
146 rdf:rest N6e3a25d49c724e8096a9c99c6285cfb8
147 N4f58aaa9d1644558937330be3afcbce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Protein Kinase C-epsilon
149 rdf:type schema:DefinedTerm
150 N540daea975b74a1c90d1fc3504c36aa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name HeLa Cells
152 rdf:type schema:DefinedTerm
153 N5921fb975f5740c78343814ce8ee3239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Sister Chromatid Exchange
155 rdf:type schema:DefinedTerm
156 N61b1dedeb3be4469a6a322770a74b20a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Microscopy, Fluorescence
158 rdf:type schema:DefinedTerm
159 N6ca61c5dc2cf4d68b5b50e270b357c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Chromosomes
161 rdf:type schema:DefinedTerm
162 N6e3a25d49c724e8096a9c99c6285cfb8 rdf:first sg:person.01041043262.46
163 rdf:rest N735349908e2c41c4be6abbe3a57dd5cb
164 N706e9f05ed5b408ab7f810d173c03aac rdf:first sg:person.0677742110.53
165 rdf:rest N196ab4f3de5148999e54090de7626e78
166 N735349908e2c41c4be6abbe3a57dd5cb rdf:first sg:person.01065777610.88
167 rdf:rest N706e9f05ed5b408ab7f810d173c03aac
168 N7397383f82684fec89c65319990f384c schema:issueNumber 1
169 rdf:type schema:PublicationIssue
170 N79e479b8590446e481404ef25838b2a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Kinetochores
172 rdf:type schema:DefinedTerm
173 N9034e80c29634ebbab53d7a1f5cce271 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Chromosome Segregation
175 rdf:type schema:DefinedTerm
176 N9497c40fadb34c28a98e1efef8918de7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Cell Separation
178 rdf:type schema:DefinedTerm
179 N95d2005226984221b5217d581a06d88c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Dyneins
181 rdf:type schema:DefinedTerm
182 Nb0358c74b0ed4462bf95a16239acf3fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Neoplasms
184 rdf:type schema:DefinedTerm
185 Nb3335ad9388d4579b5d52bd1dc5ead59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name RNA, Small Interfering
187 rdf:type schema:DefinedTerm
188 Nb38ad55891b14b0e9bd76e870a9c3265 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name G2 Phase
190 rdf:type schema:DefinedTerm
191 Nb5d6dab242f54b1487c8ba6d06517ba5 schema:name Springer Nature - SN SciGraph project
192 rdf:type schema:Organization
193 Nd804974dbba64e1db61cec1180599036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Humans
195 rdf:type schema:DefinedTerm
196 Nde49ab8fc0ad4bb4b82ed2aa8c0b220f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Spindle Apparatus
198 rdf:type schema:DefinedTerm
199 Neee6a1d3845d48ab87ab68ea5444403a schema:volumeNumber 5
200 rdf:type schema:PublicationVolume
201 Neff71ad44d144f5791c83dbb53a3ff9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Metaphase
203 rdf:type schema:DefinedTerm
204 Nf6850d6e369144d2b02767d38f8382cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Cell Cycle Proteins
206 rdf:type schema:DefinedTerm
207 Nfa4415cff3254f3d856be91b28723ebd schema:name doi
208 schema:value 10.1038/ncomms6685
209 rdf:type schema:PropertyValue
210 Nfba3aaab9bb74e6ea1ad7cad0a1435cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Mitosis
212 rdf:type schema:DefinedTerm
213 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
214 schema:name Biological Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
217 schema:name Biochemistry and Cell Biology
218 rdf:type schema:DefinedTerm
219 sg:grant.5140849 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6685
220 rdf:type schema:MonetaryGrant
221 sg:grant.5147994 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6685
222 rdf:type schema:MonetaryGrant
223 sg:journal.1043282 schema:issn 2041-1723
224 schema:name Nature Communications
225 rdf:type schema:Periodical
226 sg:person.01041043262.46 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
227 schema:familyName Pike
228 schema:givenName Tanya
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041043262.46
230 rdf:type schema:Person
231 sg:person.01065777610.88 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
232 schema:familyName Zicha
233 schema:givenName Daniel
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065777610.88
235 rdf:type schema:Person
236 sg:person.01066562416.42 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
237 schema:familyName Brownlow
238 schema:givenName Nicola
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066562416.42
240 rdf:type schema:Person
241 sg:person.01111564441.81 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
242 schema:familyName Parker
243 schema:givenName Peter J.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81
245 rdf:type schema:Person
246 sg:person.0677742110.53 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
247 schema:familyName Collinson
248 schema:givenName Lucy
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677742110.53
250 rdf:type schema:Person
251 sg:pub.10.1007/s00412-007-0131-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043999051
252 https://doi.org/10.1007/s00412-007-0131-7
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s00412-012-0378-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039021287
255 https://doi.org/10.1007/s00412-012-0378-5
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/21831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043821401
258 https://doi.org/10.1038/21831
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/35046598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002885997
261 https://doi.org/10.1038/35046598
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/359536a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030516958
264 https://doi.org/10.1038/359536a0
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nature05734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028946343
267 https://doi.org/10.1038/nature05734
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nature07098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040029942
270 https://doi.org/10.1038/nature07098
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/ncb1749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043751695
273 https://doi.org/10.1038/ncb1749
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nrm2163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034186396
276 https://doi.org/10.1038/nrm2163
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nrm3494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040046496
279 https://doi.org/10.1038/nrm3494
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/onc.2010.232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045218643
282 https://doi.org/10.1038/onc.2010.232
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.bjc.6603537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031193848
285 https://doi.org/10.1038/sj.bjc.6603537
286 rdf:type schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1074949008 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1075087959 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1082752354 schema:CreativeWork
290 https://doi.org/10.1002/(sici)1098-2264(199910)26:2<176::aid-gcc11>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023520595
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.bmcl.2011.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014013116
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.cell.2006.11.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050256596
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.cell.2007.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017685794
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.cub.2004.05.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039908878
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.cub.2009.05.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020338630
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.cub.2009.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036613186
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.cub.2013.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003987970
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.molcel.2004.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037488877
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.molcel.2013.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018611500
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.tcb.2005.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003399765
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.yexcr.2006.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053246804
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0014-5793(97)00282-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040400856
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0092-8674(00)00202-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042200004
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s0092-8674(85)80028-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041778124
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s0960-9822(02)01226-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051953595
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s1535-6108(03)00110-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027840701
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1038/emboj.2008.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046356293
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1046/j.1365-2443.2003.00643.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030329131
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.090013497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026747570
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.221430898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052786695
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.m104383200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017353085
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1074/jbc.m407588200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000479055
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1083/jcb.132.4.617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006970475
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1083/jcb.150.5.975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027728941
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1083/jcb.200105093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020494262
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1083/jcb.200112023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046185895
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1083/jcb.200710106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017228048
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1083/jcb.200804114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036757067
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1083/jcb.200805163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040500933
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1083/jcb.200910085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001004051
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1083/jcb.201001006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009724511
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1083/jcb.201304197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027455042
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1083/jcb.201305157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013116390
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1091/mbc.e04-08-0732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049235470
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1091/mbc.e05-11-1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049657899
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1091/mbc.e08-05-0547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008325687
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1091/mbc.e11-03-0213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000402327
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1093/jnci/djg120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050343942
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1093/nar/gkn302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022310437
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1093/nar/gks931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031860331
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1097/00001813-199904000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038201076
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1098/rstb.2004.1607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004005302
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1101/gad.1367206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007909197
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1128/mcb.9.1.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000665123
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1158/0008-5472.can-04-0871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048715041
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1159/000134517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008006481
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1242/jcs.059501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024669499
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1371/journal.pgen.1003832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012005753
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1371/journal.pone.0016494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049631537
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1371/journal.pone.0033905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021310530
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1371/journal.pone.0070696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009415377
393 rdf:type schema:CreativeWork
394 https://doi.org/10.2144/000114137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026056389
395 rdf:type schema:CreativeWork
396 https://doi.org/10.4161/cc.8.4.7653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300560
397 rdf:type schema:CreativeWork
398 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
399 schema:name Division of Cancer Studies, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
400 Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3LY, UK
401 rdf:type schema:Organization
402 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
403 schema:name Electron Microscopy, Cancer Research UK London Research Institute, London WC2A 3LY, UK
404 Light Microscopy, Cancer Research UK London Research Institute, London, WC2A 3LY, UK
405 Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3LY, UK
406 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...