RHOA inactivation enhances Wnt signalling and promotes colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Paulo Rodrigues, Irati Macaya, Sarah Bazzocco, Rocco Mazzolini, Elena Andretta, Higinio Dopeso, Silvia Mateo-Lozano, Josipa Bilić, Fernando Cartón-García, Rocio Nieto, Lucia Suárez-López, Elsa Afonso, Stefania Landolfi, Javier Hernandez-Losa, Kazuto Kobayashi, Santiago Ramón y Cajal, Josep Tabernero, Niall C Tebbutt, John M Mariadason, Simo Schwartz, Diego Arango

ABSTRACT

Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types, although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation contributes to colorectal cancer progression/metastasis, largely through the activation of Wnt/β-catenin signalling. RhoA inactivation in the murine intestine accelerates the tumorigenic process and in human colon cancer cells leads to the redistribution of β-catenin from the membrane to the nucleus and enhanced Wnt/β-catenin signalling, resulting in increased proliferation, invasion and de-differentiation. In mice, RHOA inactivation contributes to colon cancer metastasis and reduced RHOA levels were observed at metastatic sites compared with primary human colon tumours. Therefore, we have identified a new mechanism of activation of Wnt/β-catenin signalling and characterized the role of RHOA as a novel tumour suppressor in colorectal cancer. These results constitute a shift from the current paradigm and demonstrate that RHO GTPases can suppress tumour progression and metastasis. More... »

PAGES

5458

References to SciGraph publications

  • 1999-02. An essential part for Rho–associated kinase in the transcellular invasion of tumor cells in NATURE MEDICINE
  • 2002-12. Rho GTPases in cell biology in NATURE
  • 2010-12. Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2005-04. Wnt signalling in stem cells and cancer in NATURE
  • 2014-12. Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis in MOLECULAR CANCER
  • 2007-07. Energy-dependent regulation of cell structure by AMP-activated protein kinase in NATURE
  • 2002-02. RHO–GTPases and cancer in NATURE REVIEWS CANCER
  • 2003-06. Up-Regulation of Small GTPases, RhoA and RhoC, Is Associated with Tumor Progression in Ovarian Carcinoma in LABORATORY INVESTIGATION
  • 2009-10. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling in NATURE
  • 1998-07. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1 in NATURE
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2002-06. ROCK and Dia have opposing effects on adherens junctions downstream of Rho in NATURE CELL BIOLOGY
  • 2002-08. Metastasis: Dissemination and growth of cancer cells in metastatic sites in NATURE REVIEWS CANCER
  • 2006-11. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma in ONCOGENE
  • 2010-05. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms6458

    DOI

    http://dx.doi.org/10.1038/ncomms6458

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005542162

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25413277


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colonic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wnt Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "beta Catenin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "rhoA GTP-Binding Protein", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodrigues", 
            "givenName": "Paulo", 
            "id": "sg:person.0625053261.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625053261.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Macaya", 
            "givenName": "Irati", 
            "id": "sg:person.01301654762.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301654762.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bazzocco", 
            "givenName": "Sarah", 
            "id": "sg:person.0673166461.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673166461.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mazzolini", 
            "givenName": "Rocco", 
            "id": "sg:person.01151260421.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151260421.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andretta", 
            "givenName": "Elena", 
            "id": "sg:person.01123643461.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123643461.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dopeso", 
            "givenName": "Higinio", 
            "id": "sg:person.01273233570.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273233570.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mateo-Lozano", 
            "givenName": "Silvia", 
            "id": "sg:person.01302344161.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302344161.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bili\u0107", 
            "givenName": "Josipa", 
            "id": "sg:person.0726576321.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726576321.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cart\u00f3n-Garc\u00eda", 
            "givenName": "Fernando", 
            "id": "sg:person.0612163107.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612163107.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nieto", 
            "givenName": "Rocio", 
            "id": "sg:person.01110412671.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110412671.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain [2] Group of Drug Delivery and Targeting, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su\u00e1rez-L\u00f3pez", 
            "givenName": "Lucia", 
            "id": "sg:person.01023551344.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023551344.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Afonso", 
            "givenName": "Elsa", 
            "id": "sg:person.0613204326.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613204326.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Department of Pathology, Vall d'Hebron Hospital, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Landolfi", 
            "givenName": "Stefania", 
            "id": "sg:person.0576610417.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576610417.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Department of Pathology, Vall d'Hebron Hospital, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hernandez-Losa", 
            "givenName": "Javier", 
            "id": "sg:person.01055530261.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055530261.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fukushima Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411582.b", 
              "name": [
                "Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Kazuto", 
            "id": "sg:person.012700474604.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012700474604.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Department of Pathology, Vall d'Hebron Hospital, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ram\u00f3n y Cajal", 
            "givenName": "Santiago", 
            "id": "sg:person.0667354677.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667354677.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Autonomous University of Barcelona", 
              "id": "https://www.grid.ac/institutes/grid.7080.f", 
              "name": [
                "Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Aut\u00f2noma de Barcelona, 119-129, Barcelona 08035, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tabernero", 
            "givenName": "Josep", 
            "id": "sg:person.01053427102.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053427102.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.482095.2", 
              "name": [
                "Ludwig Institute for Cancer Research, Melbourne-Branch, Austin Health, Heidelberg, Victoria 3084, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tebbutt", 
            "givenName": "Niall C", 
            "id": "sg:person.01000056651.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000056651.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Institute for Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.482095.2", 
              "name": [
                "Ludwig Institute for Cancer Research, Melbourne-Branch, Austin Health, Heidelberg, Victoria 3084, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mariadason", 
            "givenName": "John M", 
            "id": "sg:person.0756737242.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756737242.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain [2] Group of Drug Delivery and Targeting, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schwartz", 
            "givenName": "Simo", 
            "id": "sg:person.01000566750.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000566750.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arango", 
            "givenName": "Diego", 
            "id": "sg:person.0633243647.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633243647.52"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejmc0809996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000706170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-13-167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002138950", 
              "https://doi.org/10.1186/1476-4598-13-167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002417644", 
              "https://doi.org/10.1038/nature01148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002417644", 
              "https://doi.org/10.1038/nature01148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003303566", 
              "https://doi.org/10.1038/nature05828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.287404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004027822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0023524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005264724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.05.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005670808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0037823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005674461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgt215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007668286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2004.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008357853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.03.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008596750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1760809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009412853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1090772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009536401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.23.10629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010246968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2013.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010439369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1108411109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010545049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19990531)81:5<682::aid-ijc2>3.0.co;2-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011749725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mds024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012331439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012347371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1094291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013806160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016950591", 
              "https://doi.org/10.1038/ncb2047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2005.06.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017559400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2005.06.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017559400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018211800", 
              "https://doi.org/10.1038/nature08356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019149476", 
              "https://doi.org/10.1038/nrc865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019149476", 
              "https://doi.org/10.1038/nrc865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.1.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020888252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.embor865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021465672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.24153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021691395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022902509", 
              "https://doi.org/10.1038/nrc725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022902509", 
              "https://doi.org/10.1038/nrc725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.06.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024099191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.78.6.3328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024126432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2004.06.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024398596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0501535102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025075134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200803020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025147583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3318-09.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027032324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1534-5807(02)00259-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027056804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2012.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028393824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)01014-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029474411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00114-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029501223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766632", 
              "https://doi.org/10.1038/nature03319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766632", 
              "https://doi.org/10.1038/nature03319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029921641", 
              "https://doi.org/10.1038/sj.onc.1209682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029921641", 
              "https://doi.org/10.1038/sj.onc.1209682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(03)00098-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030976005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(03)00098-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030976005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1105718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033030663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.52.32966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033994507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/01.lab.0000073128.16098.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035146509", 
              "https://doi.org/10.1097/01.lab.0000073128.16098.31"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.genet.42.110807.091432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036135366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/28425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036161326", 
              "https://doi.org/10.1038/28425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/28425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036161326", 
              "https://doi.org/10.1038/28425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-29-123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036251740", 
              "https://doi.org/10.1186/1756-9966-29-123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037076392", 
              "https://doi.org/10.1038/ncb796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037076392", 
              "https://doi.org/10.1038/ncb796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037102569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-3812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040541139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041675627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.10.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041684641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m204935200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042470571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fon.11.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043083411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.16.4848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043757048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-0706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046106355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0295-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046350810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.279.5350.509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047090124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagen.2007.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047804840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1464-410x.2003.03063.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048453546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048889140", 
              "https://doi.org/10.1038/5587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048889140", 
              "https://doi.org/10.1038/5587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.18.2295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051224316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.137.6.1421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051678525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.25.11781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052510457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3480241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056714765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7652575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.2011.1288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071531401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.58.6.1188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074732333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074801146", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077886941", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-12", 
        "datePublishedReg": "2014-12-01", 
        "description": "Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types, although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation contributes to colorectal cancer progression/metastasis, largely through the activation of Wnt/\u03b2-catenin signalling. RhoA inactivation in the murine intestine accelerates the tumorigenic process and in human colon cancer cells leads to the redistribution of \u03b2-catenin from the membrane to the nucleus and enhanced Wnt/\u03b2-catenin signalling, resulting in increased proliferation, invasion and de-differentiation. In mice, RHOA inactivation contributes to colon cancer metastasis and reduced RHOA levels were observed at metastatic sites compared with primary human colon tumours. Therefore, we have identified a new mechanism of activation of Wnt/\u03b2-catenin signalling and characterized the role of RHOA as a novel tumour suppressor in colorectal cancer. These results constitute a shift from the current paradigm and demonstrate that RHO GTPases can suppress tumour progression and metastasis. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ncomms6458", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5150727", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6117096", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "name": "RHOA inactivation enhances Wnt signalling and promotes colorectal cancer", 
        "pagination": "5458", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1a68094edc5e3359df450b7f0c643b650282af46bc5b3933b4f40d33ce5aed31"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25413277"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncomms6458"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1005542162"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncomms6458", 
          "https://app.dimensions.ai/details/publication/pub.1005542162"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/ncomms6458"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6458'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6458'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6458'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6458'


     

    This table displays all metadata directly associated to this object as RDF triples.

    523 TRIPLES      21 PREDICATES      112 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncomms6458 schema:about N0c2766aa44af42cbaa46269dec131977
    2 N16d74616b7374299ab1cf2a6759d5030
    3 N31726b2104f041afa278a8b292d76507
    4 N564711e1093c47af8ce8f55037fe4020
    5 N62621caebdea496ebc0bc4215eb96adb
    6 N8069b156c40948739e5226e77c32baf6
    7 N8631cf66ef474c90964087f5c8ff5618
    8 Nb757e74f368b4e6684803dd7bf414c8c
    9 Nd0fe7e27f25c4f438b3be5901a5931d8
    10 Ndf53ce28be5f48fc8b8b386c1711ebac
    11 Ne2daf136e5eb4b68b64b1eaa7b7d5fa6
    12 Nfd2cde539a1b4075bee2c4d9224d460e
    13 anzsrc-for:11
    14 anzsrc-for:1112
    15 schema:author N5d7253fa626344c78d340058e05e4342
    16 schema:citation sg:pub.10.1038/28425
    17 sg:pub.10.1038/5587
    18 sg:pub.10.1038/nature01148
    19 sg:pub.10.1038/nature03319
    20 sg:pub.10.1038/nature05828
    21 sg:pub.10.1038/nature08356
    22 sg:pub.10.1038/nature11252
    23 sg:pub.10.1038/ncb2047
    24 sg:pub.10.1038/ncb796
    25 sg:pub.10.1038/nrc725
    26 sg:pub.10.1038/nrc865
    27 sg:pub.10.1038/sj.onc.1209682
    28 sg:pub.10.1097/01.lab.0000073128.16098.31
    29 sg:pub.10.1186/1476-4598-13-167
    30 sg:pub.10.1186/1756-9966-29-123
    31 https://app.dimensions.ai/details/publication/pub.1074801146
    32 https://app.dimensions.ai/details/publication/pub.1077886941
    33 https://doi.org/10.1002/(sici)1097-0215(19990531)81:5<682::aid-ijc2>3.0.co;2-b
    34 https://doi.org/10.1002/jcb.24153
    35 https://doi.org/10.1016/j.bbagen.2007.04.008
    36 https://doi.org/10.1016/j.canlet.2004.06.028
    37 https://doi.org/10.1016/j.cell.2006.10.018
    38 https://doi.org/10.1016/j.cell.2009.03.047
    39 https://doi.org/10.1016/j.cell.2011.06.010
    40 https://doi.org/10.1016/j.cell.2012.05.012
    41 https://doi.org/10.1016/j.cell.2012.12.012
    42 https://doi.org/10.1016/j.ejso.2004.12.014
    43 https://doi.org/10.1016/s0092-8674(02)01014-0
    44 https://doi.org/10.1016/s0092-8674(04)00114-x
    45 https://doi.org/10.1016/s0955-0674(03)00098-x
    46 https://doi.org/10.1016/s1534-5807(02)00259-9
    47 https://doi.org/10.1038/embor.2012.127
    48 https://doi.org/10.1038/sj.embor.embor865
    49 https://doi.org/10.1042/0264-6021:3480241
    50 https://doi.org/10.1046/j.1464-410x.2003.03063.x
    51 https://doi.org/10.1053/j.gastro.2005.06.066
    52 https://doi.org/10.1053/j.gastro.2013.06.021
    53 https://doi.org/10.1056/nejmc0809996
    54 https://doi.org/10.1073/pnas.0501535102
    55 https://doi.org/10.1073/pnas.1108411109
    56 https://doi.org/10.1073/pnas.78.6.3328
    57 https://doi.org/10.1073/pnas.79.16.4848
    58 https://doi.org/10.1073/pnas.92.23.10629
    59 https://doi.org/10.1073/pnas.92.25.11781
    60 https://doi.org/10.1074/jbc.272.1.13
    61 https://doi.org/10.1074/jbc.272.52.32966
    62 https://doi.org/10.1074/jbc.m204935200
    63 https://doi.org/10.1083/jcb.137.6.1421
    64 https://doi.org/10.1083/jcb.200803020
    65 https://doi.org/10.1093/annonc/mds024
    66 https://doi.org/10.1093/carcin/bgt215
    67 https://doi.org/10.1101/gad.11.18.2295
    68 https://doi.org/10.1101/gad.1760809
    69 https://doi.org/10.1101/gad.287404
    70 https://doi.org/10.1124/mol.58.6.1188
    71 https://doi.org/10.1126/science.1090772
    72 https://doi.org/10.1126/science.1094291
    73 https://doi.org/10.1126/science.1105718
    74 https://doi.org/10.1126/science.279.5350.509
    75 https://doi.org/10.1126/science.7652575
    76 https://doi.org/10.1146/annurev.genet.42.110807.091432
    77 https://doi.org/10.1158/0008-5472.can-05-1947
    78 https://doi.org/10.1158/0008-5472.can-09-0706
    79 https://doi.org/10.1158/0008-5472.can-11-3812
    80 https://doi.org/10.1371/journal.pone.0000898
    81 https://doi.org/10.1371/journal.pone.0023524
    82 https://doi.org/10.1371/journal.pone.0037823
    83 https://doi.org/10.1523/jneurosci.0295-04.2004
    84 https://doi.org/10.1523/jneurosci.3318-09.2010
    85 https://doi.org/10.2217/fon.11.143
    86 https://doi.org/10.3892/or.2011.1288
    87 schema:datePublished 2014-12
    88 schema:datePublishedReg 2014-12-01
    89 schema:description Activation of the small GTPase RHOA has strong oncogenic effects in many tumour types, although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation contributes to colorectal cancer progression/metastasis, largely through the activation of Wnt/β-catenin signalling. RhoA inactivation in the murine intestine accelerates the tumorigenic process and in human colon cancer cells leads to the redistribution of β-catenin from the membrane to the nucleus and enhanced Wnt/β-catenin signalling, resulting in increased proliferation, invasion and de-differentiation. In mice, RHOA inactivation contributes to colon cancer metastasis and reduced RHOA levels were observed at metastatic sites compared with primary human colon tumours. Therefore, we have identified a new mechanism of activation of Wnt/β-catenin signalling and characterized the role of RHOA as a novel tumour suppressor in colorectal cancer. These results constitute a shift from the current paradigm and demonstrate that RHO GTPases can suppress tumour progression and metastasis.
    90 schema:genre research_article
    91 schema:inLanguage en
    92 schema:isAccessibleForFree true
    93 schema:isPartOf N599fc20bc7104e758bc86a82ff6148c8
    94 Nbf2088ee5d23465cb32cd8d31a1c2bb7
    95 sg:journal.1043282
    96 schema:name RHOA inactivation enhances Wnt signalling and promotes colorectal cancer
    97 schema:pagination 5458
    98 schema:productId N1363cb9abc354e98a86605efd6779623
    99 Na17b9e56774147609cc8c64e94e24485
    100 Nef095a6aec474891a29eacd7f1181d15
    101 Nf25f62ff48774b479905e28f461b435c
    102 Nfa0e2baea31b412cb7c80a5915de8ff9
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005542162
    104 https://doi.org/10.1038/ncomms6458
    105 schema:sdDatePublished 2019-04-10T13:57
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher N527d1134dba3403db64e9efcb69d0aca
    108 schema:url https://www.nature.com/articles/ncomms6458
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N0c25fe6fcdbb42bd82662ad7625b9808 rdf:first sg:person.01055530261.92
    113 rdf:rest N89a91569a77d47489e8723eb3929d2fd
    114 N0c2766aa44af42cbaa46269dec131977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Signal Transduction
    116 rdf:type schema:DefinedTerm
    117 N11fe3b15b8cb445c89e6272f39be3f9f schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    118 rdf:type schema:Organization
    119 N1363cb9abc354e98a86605efd6779623 schema:name nlm_unique_id
    120 schema:value 101528555
    121 rdf:type schema:PropertyValue
    122 N16d74616b7374299ab1cf2a6759d5030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name beta Catenin
    124 rdf:type schema:DefinedTerm
    125 N1b577701ab2942c984c543e922cfd8b5 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    126 rdf:type schema:Organization
    127 N1b878d67147241b18dd2fe801f63344d schema:name 1] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain [2] Group of Drug Delivery and Targeting, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain.
    128 rdf:type schema:Organization
    129 N2041613c32ab4398a628a5e37acd7b02 rdf:first sg:person.0576610417.35
    130 rdf:rest N0c25fe6fcdbb42bd82662ad7625b9808
    131 N23eb0977e0e745e0b3fb1c7d65f628e1 rdf:first sg:person.01302344161.29
    132 rdf:rest Nbed988f7c0c549eba669d7869fc00417
    133 N31726b2104f041afa278a8b292d76507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Gene Expression Regulation, Neoplastic
    135 rdf:type schema:DefinedTerm
    136 N3910562bad1344918569d306dddd5288 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    137 rdf:type schema:Organization
    138 N3be152c18c834cfe9722366860b3f39d rdf:first sg:person.0667354677.33
    139 rdf:rest N4ffbbfc3dff14c08a698a8b77eb85c7c
    140 N499d5089154144e1ab1871144fc6e030 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    141 rdf:type schema:Organization
    142 N4ffbbfc3dff14c08a698a8b77eb85c7c rdf:first sg:person.01053427102.11
    143 rdf:rest N530290e0ab4949618c73f1a6f84d1494
    144 N50e7f2f7f62f4f2fa1ef2682d1115cb2 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    145 rdf:type schema:Organization
    146 N527d1134dba3403db64e9efcb69d0aca schema:name Springer Nature - SN SciGraph project
    147 rdf:type schema:Organization
    148 N530290e0ab4949618c73f1a6f84d1494 rdf:first sg:person.01000056651.46
    149 rdf:rest N86f9a64142cf40cf996052f93bb8d0d9
    150 N54833a4515d94f7a9479f35d2d527deb schema:name 1] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain [2] Group of Drug Delivery and Targeting, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain.
    151 rdf:type schema:Organization
    152 N564711e1093c47af8ce8f55037fe4020 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Wnt Proteins
    154 rdf:type schema:DefinedTerm
    155 N599fc20bc7104e758bc86a82ff6148c8 schema:issueNumber 1
    156 rdf:type schema:PublicationIssue
    157 N5d7253fa626344c78d340058e05e4342 rdf:first sg:person.0625053261.33
    158 rdf:rest N65399d223fda4d0ca984580ecaec9b9c
    159 N62621caebdea496ebc0bc4215eb96adb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Colonic Neoplasms
    161 rdf:type schema:DefinedTerm
    162 N65399d223fda4d0ca984580ecaec9b9c rdf:first sg:person.01301654762.76
    163 rdf:rest Nae8248bc94584913b799a118aae23c9e
    164 N6a2f5742bff146f29ef662a07f28abdb schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    165 rdf:type schema:Organization
    166 N6ae0e27b25994e20877e927899a24790 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    167 rdf:type schema:Organization
    168 N6dd217aea21e497db0d94aebc48e6d4b rdf:first sg:person.01273233570.11
    169 rdf:rest N23eb0977e0e745e0b3fb1c7d65f628e1
    170 N7939430312ae49bdb8baf5f8d6f33206 rdf:first sg:person.01000566750.30
    171 rdf:rest N90cb10904b8c41d4a11a0c297565bbc1
    172 N7940e63a50bb40209952060a9d8fd4d7 rdf:first sg:person.0613204326.71
    173 rdf:rest N2041613c32ab4398a628a5e37acd7b02
    174 N8069b156c40948739e5226e77c32baf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Disease Progression
    176 rdf:type schema:DefinedTerm
    177 N80f98fb9e78d45eeb3d5bcd8bffc75c1 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    178 rdf:type schema:Organization
    179 N8631cf66ef474c90964087f5c8ff5618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Humans
    181 rdf:type schema:DefinedTerm
    182 N86f9a64142cf40cf996052f93bb8d0d9 rdf:first sg:person.0756737242.43
    183 rdf:rest N7939430312ae49bdb8baf5f8d6f33206
    184 N89a91569a77d47489e8723eb3929d2fd rdf:first sg:person.012700474604.36
    185 rdf:rest N3be152c18c834cfe9722366860b3f39d
    186 N90cb10904b8c41d4a11a0c297565bbc1 rdf:first sg:person.0633243647.52
    187 rdf:rest rdf:nil
    188 N995570be76af477989117176be0ff5b6 rdf:first sg:person.01110412671.58
    189 rdf:rest Nf049ff5e71db4eddbec80d81f35bb717
    190 N9c77573460f74cce858ce18b5cc88fcd schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    191 rdf:type schema:Organization
    192 Na17b9e56774147609cc8c64e94e24485 schema:name readcube_id
    193 schema:value 1a68094edc5e3359df450b7f0c643b650282af46bc5b3933b4f40d33ce5aed31
    194 rdf:type schema:PropertyValue
    195 Na6a015af98d64e939df2cb5af507aa69 rdf:first sg:person.01151260421.67
    196 rdf:rest Ne43367a63ec7410f97f1235c9836fc0d
    197 Nae8248bc94584913b799a118aae23c9e rdf:first sg:person.0673166461.74
    198 rdf:rest Na6a015af98d64e939df2cb5af507aa69
    199 Nb757e74f368b4e6684803dd7bf414c8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Cell Line, Tumor
    201 rdf:type schema:DefinedTerm
    202 Nbed988f7c0c549eba669d7869fc00417 rdf:first sg:person.0726576321.24
    203 rdf:rest Nf7cb80d583db472e9a90896b5fb25709
    204 Nbf2088ee5d23465cb32cd8d31a1c2bb7 schema:volumeNumber 5
    205 rdf:type schema:PublicationVolume
    206 Nc25a26d1cf074115b2bdad60772e86cd schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    207 rdf:type schema:Organization
    208 Nd0fe7e27f25c4f438b3be5901a5931d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name rhoA GTP-Binding Protein
    210 rdf:type schema:DefinedTerm
    211 Nd469b6338a6345219ef7f72028dd79d0 schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    212 rdf:type schema:Organization
    213 Ndf53ce28be5f48fc8b8b386c1711ebac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Animals
    215 rdf:type schema:DefinedTerm
    216 Ne2daf136e5eb4b68b64b1eaa7b7d5fa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Mice
    218 rdf:type schema:DefinedTerm
    219 Ne43367a63ec7410f97f1235c9836fc0d rdf:first sg:person.01123643461.32
    220 rdf:rest N6dd217aea21e497db0d94aebc48e6d4b
    221 Nef095a6aec474891a29eacd7f1181d15 schema:name doi
    222 schema:value 10.1038/ncomms6458
    223 rdf:type schema:PropertyValue
    224 Nf049ff5e71db4eddbec80d81f35bb717 rdf:first sg:person.01023551344.24
    225 rdf:rest N7940e63a50bb40209952060a9d8fd4d7
    226 Nf25f62ff48774b479905e28f461b435c schema:name dimensions_id
    227 schema:value pub.1005542162
    228 rdf:type schema:PropertyValue
    229 Nf7cb80d583db472e9a90896b5fb25709 rdf:first sg:person.0612163107.98
    230 rdf:rest N995570be76af477989117176be0ff5b6
    231 Nf85d6ec32ae247cdb318a2c426321deb schema:name 1] Group of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.
    232 rdf:type schema:Organization
    233 Nfa0e2baea31b412cb7c80a5915de8ff9 schema:name pubmed_id
    234 schema:value 25413277
    235 rdf:type schema:PropertyValue
    236 Nfd2cde539a1b4075bee2c4d9224d460e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Gene Silencing
    238 rdf:type schema:DefinedTerm
    239 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    240 schema:name Medical and Health Sciences
    241 rdf:type schema:DefinedTerm
    242 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Oncology and Carcinogenesis
    244 rdf:type schema:DefinedTerm
    245 sg:grant.5150727 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6458
    246 rdf:type schema:MonetaryGrant
    247 sg:grant.6117096 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6458
    248 rdf:type schema:MonetaryGrant
    249 sg:journal.1043282 schema:issn 2041-1723
    250 schema:name Nature Communications
    251 rdf:type schema:Periodical
    252 sg:person.01000056651.46 schema:affiliation https://www.grid.ac/institutes/grid.482095.2
    253 schema:familyName Tebbutt
    254 schema:givenName Niall C
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000056651.46
    256 rdf:type schema:Person
    257 sg:person.01000566750.30 schema:affiliation N54833a4515d94f7a9479f35d2d527deb
    258 schema:familyName Schwartz
    259 schema:givenName Simo
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000566750.30
    261 rdf:type schema:Person
    262 sg:person.01023551344.24 schema:affiliation N1b878d67147241b18dd2fe801f63344d
    263 schema:familyName Suárez-López
    264 schema:givenName Lucia
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023551344.24
    266 rdf:type schema:Person
    267 sg:person.01053427102.11 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
    268 schema:familyName Tabernero
    269 schema:givenName Josep
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053427102.11
    271 rdf:type schema:Person
    272 sg:person.01055530261.92 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    273 schema:familyName Hernandez-Losa
    274 schema:givenName Javier
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055530261.92
    276 rdf:type schema:Person
    277 sg:person.01110412671.58 schema:affiliation Nc25a26d1cf074115b2bdad60772e86cd
    278 schema:familyName Nieto
    279 schema:givenName Rocio
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110412671.58
    281 rdf:type schema:Person
    282 sg:person.01123643461.32 schema:affiliation N9c77573460f74cce858ce18b5cc88fcd
    283 schema:familyName Andretta
    284 schema:givenName Elena
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123643461.32
    286 rdf:type schema:Person
    287 sg:person.01151260421.67 schema:affiliation N499d5089154144e1ab1871144fc6e030
    288 schema:familyName Mazzolini
    289 schema:givenName Rocco
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151260421.67
    291 rdf:type schema:Person
    292 sg:person.012700474604.36 schema:affiliation https://www.grid.ac/institutes/grid.411582.b
    293 schema:familyName Kobayashi
    294 schema:givenName Kazuto
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012700474604.36
    296 rdf:type schema:Person
    297 sg:person.01273233570.11 schema:affiliation N11fe3b15b8cb445c89e6272f39be3f9f
    298 schema:familyName Dopeso
    299 schema:givenName Higinio
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273233570.11
    301 rdf:type schema:Person
    302 sg:person.01301654762.76 schema:affiliation Nf85d6ec32ae247cdb318a2c426321deb
    303 schema:familyName Macaya
    304 schema:givenName Irati
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301654762.76
    306 rdf:type schema:Person
    307 sg:person.01302344161.29 schema:affiliation N1b577701ab2942c984c543e922cfd8b5
    308 schema:familyName Mateo-Lozano
    309 schema:givenName Silvia
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302344161.29
    311 rdf:type schema:Person
    312 sg:person.0576610417.35 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    313 schema:familyName Landolfi
    314 schema:givenName Stefania
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576610417.35
    316 rdf:type schema:Person
    317 sg:person.0612163107.98 schema:affiliation N6a2f5742bff146f29ef662a07f28abdb
    318 schema:familyName Cartón-García
    319 schema:givenName Fernando
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612163107.98
    321 rdf:type schema:Person
    322 sg:person.0613204326.71 schema:affiliation N3910562bad1344918569d306dddd5288
    323 schema:familyName Afonso
    324 schema:givenName Elsa
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613204326.71
    326 rdf:type schema:Person
    327 sg:person.0625053261.33 schema:affiliation N50e7f2f7f62f4f2fa1ef2682d1115cb2
    328 schema:familyName Rodrigues
    329 schema:givenName Paulo
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625053261.33
    331 rdf:type schema:Person
    332 sg:person.0633243647.52 schema:affiliation Nd469b6338a6345219ef7f72028dd79d0
    333 schema:familyName Arango
    334 schema:givenName Diego
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633243647.52
    336 rdf:type schema:Person
    337 sg:person.0667354677.33 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    338 schema:familyName Ramón y Cajal
    339 schema:givenName Santiago
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667354677.33
    341 rdf:type schema:Person
    342 sg:person.0673166461.74 schema:affiliation N6ae0e27b25994e20877e927899a24790
    343 schema:familyName Bazzocco
    344 schema:givenName Sarah
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673166461.74
    346 rdf:type schema:Person
    347 sg:person.0726576321.24 schema:affiliation N80f98fb9e78d45eeb3d5bcd8bffc75c1
    348 schema:familyName Bilić
    349 schema:givenName Josipa
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726576321.24
    351 rdf:type schema:Person
    352 sg:person.0756737242.43 schema:affiliation https://www.grid.ac/institutes/grid.482095.2
    353 schema:familyName Mariadason
    354 schema:givenName John M
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756737242.43
    356 rdf:type schema:Person
    357 sg:pub.10.1038/28425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036161326
    358 https://doi.org/10.1038/28425
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/5587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048889140
    361 https://doi.org/10.1038/5587
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nature01148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002417644
    364 https://doi.org/10.1038/nature01148
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nature03319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766632
    367 https://doi.org/10.1038/nature03319
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nature05828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003303566
    370 https://doi.org/10.1038/nature05828
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nature08356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018211800
    373 https://doi.org/10.1038/nature08356
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    376 https://doi.org/10.1038/nature11252
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/ncb2047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016950591
    379 https://doi.org/10.1038/ncb2047
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/ncb796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037076392
    382 https://doi.org/10.1038/ncb796
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/nrc725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022902509
    385 https://doi.org/10.1038/nrc725
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/nrc865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019149476
    388 https://doi.org/10.1038/nrc865
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/sj.onc.1209682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029921641
    391 https://doi.org/10.1038/sj.onc.1209682
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1097/01.lab.0000073128.16098.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035146509
    394 https://doi.org/10.1097/01.lab.0000073128.16098.31
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1186/1476-4598-13-167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002138950
    397 https://doi.org/10.1186/1476-4598-13-167
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1186/1756-9966-29-123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036251740
    400 https://doi.org/10.1186/1756-9966-29-123
    401 rdf:type schema:CreativeWork
    402 https://app.dimensions.ai/details/publication/pub.1074801146 schema:CreativeWork
    403 https://app.dimensions.ai/details/publication/pub.1077886941 schema:CreativeWork
    404 https://doi.org/10.1002/(sici)1097-0215(19990531)81:5<682::aid-ijc2>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1011749725
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1002/jcb.24153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021691395
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/j.bbagen.2007.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047804840
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/j.canlet.2004.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024398596
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/j.cell.2006.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684641
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/j.cell.2009.03.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008596750
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/j.cell.2011.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024099191
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/j.cell.2012.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005670808
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/j.cell.2012.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012347371
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.ejso.2004.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008357853
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/s0092-8674(02)01014-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029474411
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/s0092-8674(04)00114-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029501223
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1016/s0955-0674(03)00098-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030976005
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1016/s1534-5807(02)00259-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027056804
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1038/embor.2012.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028393824
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1038/sj.embor.embor865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021465672
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1042/0264-6021:3480241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714765
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1046/j.1464-410x.2003.03063.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048453546
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1053/j.gastro.2005.06.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017559400
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1053/j.gastro.2013.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010439369
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1056/nejmc0809996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000706170
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1073/pnas.0501535102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025075134
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1073/pnas.1108411109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010545049
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1073/pnas.78.6.3328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024126432
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1073/pnas.79.16.4848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043757048
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1073/pnas.92.23.10629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010246968
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1073/pnas.92.25.11781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052510457
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1074/jbc.272.1.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020888252
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1074/jbc.272.52.32966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033994507
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1074/jbc.m204935200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042470571
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1083/jcb.137.6.1421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051678525
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1083/jcb.200803020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025147583
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1093/annonc/mds024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012331439
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1093/carcin/bgt215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007668286
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1101/gad.11.18.2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051224316
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1101/gad.1760809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009412853
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1101/gad.287404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004027822
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1124/mol.58.6.1188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074732333
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1126/science.1090772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009536401
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1126/science.1094291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013806160
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1126/science.1105718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033030663
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1126/science.279.5350.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047090124
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1126/science.7652575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648307
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1146/annurev.genet.42.110807.091432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036135366
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1158/0008-5472.can-05-1947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041675627
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1158/0008-5472.can-09-0706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046106355
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1158/0008-5472.can-11-3812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040541139
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1371/journal.pone.0000898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037102569
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1371/journal.pone.0023524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005264724
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1371/journal.pone.0037823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005674461
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1523/jneurosci.0295-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046350810
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1523/jneurosci.3318-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027032324
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.2217/fon.11.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043083411
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.3892/or.2011.1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071531401
    511 rdf:type schema:CreativeWork
    512 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
    513 schema:name Department of Pathology, Vall d'Hebron Hospital, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain.
    514 rdf:type schema:Organization
    515 https://www.grid.ac/institutes/grid.411582.b schema:alternateName Fukushima Medical University
    516 schema:name Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
    517 rdf:type schema:Organization
    518 https://www.grid.ac/institutes/grid.482095.2 schema:alternateName Ludwig Institute for Cancer Research
    519 schema:name Ludwig Institute for Cancer Research, Melbourne-Branch, Austin Health, Heidelberg, Victoria 3084, Australia.
    520 rdf:type schema:Organization
    521 https://www.grid.ac/institutes/grid.7080.f schema:alternateName Autonomous University of Barcelona
    522 schema:name Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, 119-129, Barcelona 08035, Spain.
    523 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...