Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-31

AUTHORS

Priyank Maindola, Rahul Raina, Parveen Goyal, Krishnamohan Atmakuri, Abhishek Ojha, Sourabh Gupta, Peter J. Christie, Lakshminarayan M. Iyer, L. Aravind, Arulandu Arockiasamy

ABSTRACT

Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts. More... »

PAGES

5322-5322

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms6322

DOI

http://dx.doi.org/10.1038/ncomms6322

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021643359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25358815


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conjugation, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fertility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Multimerization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Type IV Secretion Systems", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maindola", 
        "givenName": "Priyank", 
        "id": "sg:person.0660715212.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660715212.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raina", 
        "givenName": "Rahul", 
        "id": "sg:person.0727030412.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727030412.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goyal", 
        "givenName": "Parveen", 
        "id": "sg:person.01202610400.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202610400.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atmakuri", 
        "givenName": "Krishnamohan", 
        "id": "sg:person.01032050352.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032050352.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ojha", 
        "givenName": "Abhishek", 
        "id": "sg:person.01241513464.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241513464.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Sourabh", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christie", 
        "givenName": "Peter J.", 
        "id": "sg:person.01145607040.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145607040.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iyer", 
        "givenName": "Lakshminarayan M.", 
        "id": "sg:person.012162224357.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aravind", 
        "givenName": "L.", 
        "id": "sg:person.01106662166.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arockiasamy", 
        "givenName": "Arulandu", 
        "id": "sg:person.01046024123.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046024123.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nprot.2006.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017826253", 
          "https://doi.org/10.1038/nprot.2006.286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00290681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035818697", 
          "https://doi.org/10.1007/bf00290681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6150-7-18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040385591", 
          "https://doi.org/10.1186/1745-6150-7-18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-12-r81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016542336", 
          "https://doi.org/10.1186/gb-2003-4-12-r81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053603492", 
          "https://doi.org/10.1038/nature06415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025213356", 
          "https://doi.org/10.1038/ncb2083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.2007.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041150506", 
          "https://doi.org/10.1038/nchembio.2007.39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025433172", 
          "https://doi.org/10.1038/nature04149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6150-8-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034075663", 
          "https://doi.org/10.1186/1745-6150-8-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-11-r237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033209125", 
          "https://doi.org/10.1186/gb-2007-8-11-r237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-003-3387-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041122654", 
          "https://doi.org/10.1007/s00018-003-3387-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10-31", 
    "datePublishedReg": "2014-10-31", 
    "description": "Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts. ", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms6322", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2726065", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2514016", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "sexual conflict", 
      "Agrobacterium tumefaciens VirB/D4 type IV secretion system", 
      "VirB/D4 type IV secretion system", 
      "type IV secretion system", 
      "diverse biological contexts", 
      "DNase activity", 
      "first crystal structure", 
      "multiple enzymatic activities", 
      "P1 ParB", 
      "secretion system", 
      "conjugative plasmids", 
      "proteobacterial plasmids", 
      "DNA transfer", 
      "conjugative T4SS", 
      "biological context", 
      "active version", 
      "functional implications", 
      "enzymatic activity", 
      "sulfiredoxin", 
      "T4SS", 
      "plasmid", 
      "translocation", 
      "ATPase", 
      "ParB", 
      "KorB", 
      "crystal structure", 
      "plants", 
      "DNA", 
      "conservation", 
      "activity", 
      "family", 
      "complexes", 
      "members", 
      "Srx", 
      "relatives", 
      "interplay", 
      "switch", 
      "evidence", 
      "structure", 
      "factors", 
      "inhibition factor", 
      "transfer", 
      "implications", 
      "rivals", 
      "system", 
      "context", 
      "conflict", 
      "OSA", 
      "version", 
      "co-resident rivals", 
      "fertility inhibition factors", 
      "enigmatic FIN Osa", 
      "FIN Osa", 
      "ParB/Sulfiredoxin", 
      "ATP-dependent switch", 
      "tumefaciens VirB/D4 type IV secretion system", 
      "D4 type IV secretion system", 
      "IV secretion system", 
      "active Osa", 
      "DNA-VirD2 complex", 
      "RK2 KorB", 
      "general functional implications", 
      "ParB/Srx"
    ], 
    "name": "Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids", 
    "pagination": "5322-5322", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021643359"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms6322"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25358815"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms6322", 
      "https://app.dimensions.ai/details/publication/pub.1021643359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_618.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms6322"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      22 PREDICATES      109 URIs      90 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms6322 schema:about N05f59f66e185454fbd85de0d3afa90e3
2 N0eb7096125464e4a93d47e4d63665882
3 N25959e0a8cd54ed28375425965b19022
4 N4f2c76f2c9b74ed3bc81caad2f07045c
5 N911cc1879955495a920874913407ac46
6 N9daafe6fc8c44ef1b0c4916daab40782
7 Nd76a2996a7c4407fbe5d291cb6d67c1f
8 Nf81c8e9c1d7c42a3acf932434ae26623
9 Nfe3e6c416fd5461399082ed1194104a4
10 anzsrc-for:06
11 anzsrc-for:0604
12 schema:author Na1f2d938036843f5bfa9573479d31804
13 schema:citation sg:pub.10.1007/bf00290681
14 sg:pub.10.1007/s00018-003-3387-y
15 sg:pub.10.1038/nature04149
16 sg:pub.10.1038/nature06415
17 sg:pub.10.1038/ncb2083
18 sg:pub.10.1038/nchembio.2007.39
19 sg:pub.10.1038/nprot.2006.286
20 sg:pub.10.1186/1745-6150-7-18
21 sg:pub.10.1186/1745-6150-8-15
22 sg:pub.10.1186/gb-2003-4-12-r81
23 sg:pub.10.1186/gb-2007-8-11-r237
24 schema:datePublished 2014-10-31
25 schema:datePublishedReg 2014-10-31
26 schema:description Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N070d21d9440446c8bdb718f68ee81927
31 Na166b48a216842f1a3b9a489caa2623b
32 sg:journal.1043282
33 schema:keywords ATP-dependent switch
34 ATPase
35 Agrobacterium tumefaciens VirB/D4 type IV secretion system
36 D4 type IV secretion system
37 DNA
38 DNA transfer
39 DNA-VirD2 complex
40 DNase activity
41 FIN Osa
42 IV secretion system
43 KorB
44 OSA
45 P1 ParB
46 ParB
47 ParB/Srx
48 ParB/Sulfiredoxin
49 RK2 KorB
50 Srx
51 T4SS
52 VirB/D4 type IV secretion system
53 active Osa
54 active version
55 activity
56 biological context
57 co-resident rivals
58 complexes
59 conflict
60 conjugative T4SS
61 conjugative plasmids
62 conservation
63 context
64 crystal structure
65 diverse biological contexts
66 enigmatic FIN Osa
67 enzymatic activity
68 evidence
69 factors
70 family
71 fertility inhibition factors
72 first crystal structure
73 functional implications
74 general functional implications
75 implications
76 inhibition factor
77 interplay
78 members
79 multiple enzymatic activities
80 plants
81 plasmid
82 proteobacterial plasmids
83 relatives
84 rivals
85 secretion system
86 sexual conflict
87 structure
88 sulfiredoxin
89 switch
90 system
91 transfer
92 translocation
93 tumefaciens VirB/D4 type IV secretion system
94 type IV secretion system
95 version
96 schema:name Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids
97 schema:pagination 5322-5322
98 schema:productId N6f7a384ad87b4e71941554728b634dbe
99 Nf5dd9aa479be4310adf408fa7bf38885
100 Nff428f11822d48a3bd1e3ebff9f9bfce
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021643359
102 https://doi.org/10.1038/ncomms6322
103 schema:sdDatePublished 2022-01-01T18:33
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N710aeb8fe3ca4047b9ca376c39d0152a
106 schema:url https://doi.org/10.1038/ncomms6322
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N05f59f66e185454fbd85de0d3afa90e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Conjugation, Genetic
112 rdf:type schema:DefinedTerm
113 N070d21d9440446c8bdb718f68ee81927 schema:volumeNumber 5
114 rdf:type schema:PublicationVolume
115 N0eb7096125464e4a93d47e4d63665882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adenosine Triphosphatases
117 rdf:type schema:DefinedTerm
118 N13dd28c05e954ebbb653f9eb3306b13b rdf:first sg:person.01145607040.20
119 rdf:rest N5dfd750c5d7d45cba9fbb0abf5a2ff09
120 N22d62b59a1dc46f5a657be614b0724d3 rdf:first sg:person.01046024123.13
121 rdf:rest rdf:nil
122 N2508cf3cbef24159b6ec7b0bfce8f86f rdf:first sg:person.01241513464.87
123 rdf:rest N734556f25ee64f5da0619ac47755fd60
124 N25959e0a8cd54ed28375425965b19022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Deoxyribonucleases
126 rdf:type schema:DefinedTerm
127 N2c4438cb752640cabfa3a16e3be11105 rdf:first sg:person.0727030412.86
128 rdf:rest N384b2f233fe040c2b951bf88496b0567
129 N384b2f233fe040c2b951bf88496b0567 rdf:first sg:person.01202610400.79
130 rdf:rest N9eb39858ff7f42ce8570b7d140c5fc21
131 N4f2c76f2c9b74ed3bc81caad2f07045c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Type IV Secretion Systems
133 rdf:type schema:DefinedTerm
134 N5dfd750c5d7d45cba9fbb0abf5a2ff09 rdf:first sg:person.012162224357.20
135 rdf:rest Ncab88d58230f45f2849aee80556714f1
136 N6f7a384ad87b4e71941554728b634dbe schema:name pubmed_id
137 schema:value 25358815
138 rdf:type schema:PropertyValue
139 N710aeb8fe3ca4047b9ca376c39d0152a schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N734556f25ee64f5da0619ac47755fd60 rdf:first N9fa2352c0e1d43af93cd391dcc3dac84
142 rdf:rest N13dd28c05e954ebbb653f9eb3306b13b
143 N911cc1879955495a920874913407ac46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Protein Multimerization
145 rdf:type schema:DefinedTerm
146 N9daafe6fc8c44ef1b0c4916daab40782 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name DNA, Bacterial
148 rdf:type schema:DefinedTerm
149 N9eb39858ff7f42ce8570b7d140c5fc21 rdf:first sg:person.01032050352.04
150 rdf:rest N2508cf3cbef24159b6ec7b0bfce8f86f
151 N9fa2352c0e1d43af93cd391dcc3dac84 schema:affiliation grid-institutes:None
152 schema:familyName Gupta
153 schema:givenName Sourabh
154 rdf:type schema:Person
155 Na166b48a216842f1a3b9a489caa2623b schema:issueNumber 1
156 rdf:type schema:PublicationIssue
157 Na1f2d938036843f5bfa9573479d31804 rdf:first sg:person.0660715212.88
158 rdf:rest N2c4438cb752640cabfa3a16e3be11105
159 Ncab88d58230f45f2849aee80556714f1 rdf:first sg:person.01106662166.38
160 rdf:rest N22d62b59a1dc46f5a657be614b0724d3
161 Nd76a2996a7c4407fbe5d291cb6d67c1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Fertility
163 rdf:type schema:DefinedTerm
164 Nf5dd9aa479be4310adf408fa7bf38885 schema:name dimensions_id
165 schema:value pub.1021643359
166 rdf:type schema:PropertyValue
167 Nf81c8e9c1d7c42a3acf932434ae26623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Plasmids
169 rdf:type schema:DefinedTerm
170 Nfe3e6c416fd5461399082ed1194104a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Bacterial Proteins
172 rdf:type schema:DefinedTerm
173 Nff428f11822d48a3bd1e3ebff9f9bfce schema:name doi
174 schema:value 10.1038/ncomms6322
175 rdf:type schema:PropertyValue
176 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biological Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
180 schema:name Genetics
181 rdf:type schema:DefinedTerm
182 sg:grant.2514016 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6322
183 rdf:type schema:MonetaryGrant
184 sg:grant.2726065 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6322
185 rdf:type schema:MonetaryGrant
186 sg:journal.1043282 schema:issn 2041-1723
187 schema:name Nature Communications
188 schema:publisher Springer Nature
189 rdf:type schema:Periodical
190 sg:person.01032050352.04 schema:affiliation grid-institutes:grid.267308.8
191 schema:familyName Atmakuri
192 schema:givenName Krishnamohan
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032050352.04
194 rdf:type schema:Person
195 sg:person.01046024123.13 schema:affiliation grid-institutes:None
196 schema:familyName Arockiasamy
197 schema:givenName Arulandu
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046024123.13
199 rdf:type schema:Person
200 sg:person.01106662166.38 schema:affiliation grid-institutes:grid.419234.9
201 schema:familyName Aravind
202 schema:givenName L.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
204 rdf:type schema:Person
205 sg:person.01145607040.20 schema:affiliation grid-institutes:grid.267308.8
206 schema:familyName Christie
207 schema:givenName Peter J.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145607040.20
209 rdf:type schema:Person
210 sg:person.01202610400.79 schema:affiliation grid-institutes:None
211 schema:familyName Goyal
212 schema:givenName Parveen
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202610400.79
214 rdf:type schema:Person
215 sg:person.012162224357.20 schema:affiliation grid-institutes:grid.419234.9
216 schema:familyName Iyer
217 schema:givenName Lakshminarayan M.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20
219 rdf:type schema:Person
220 sg:person.01241513464.87 schema:affiliation grid-institutes:None
221 schema:familyName Ojha
222 schema:givenName Abhishek
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241513464.87
224 rdf:type schema:Person
225 sg:person.0660715212.88 schema:affiliation grid-institutes:None
226 schema:familyName Maindola
227 schema:givenName Priyank
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660715212.88
229 rdf:type schema:Person
230 sg:person.0727030412.86 schema:affiliation grid-institutes:None
231 schema:familyName Raina
232 schema:givenName Rahul
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727030412.86
234 rdf:type schema:Person
235 sg:pub.10.1007/bf00290681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818697
236 https://doi.org/10.1007/bf00290681
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s00018-003-3387-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041122654
239 https://doi.org/10.1007/s00018-003-3387-y
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/nature04149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025433172
242 https://doi.org/10.1038/nature04149
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nature06415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053603492
245 https://doi.org/10.1038/nature06415
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/ncb2083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025213356
248 https://doi.org/10.1038/ncb2083
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nchembio.2007.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041150506
251 https://doi.org/10.1038/nchembio.2007.39
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nprot.2006.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017826253
254 https://doi.org/10.1038/nprot.2006.286
255 rdf:type schema:CreativeWork
256 sg:pub.10.1186/1745-6150-7-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040385591
257 https://doi.org/10.1186/1745-6150-7-18
258 rdf:type schema:CreativeWork
259 sg:pub.10.1186/1745-6150-8-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034075663
260 https://doi.org/10.1186/1745-6150-8-15
261 rdf:type schema:CreativeWork
262 sg:pub.10.1186/gb-2003-4-12-r81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016542336
263 https://doi.org/10.1186/gb-2003-4-12-r81
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/gb-2007-8-11-r237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033209125
266 https://doi.org/10.1186/gb-2007-8-11-r237
267 rdf:type schema:CreativeWork
268 grid-institutes:None schema:alternateName Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India
269 schema:name Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India
270 rdf:type schema:Organization
271 grid-institutes:grid.267308.8 schema:alternateName Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA
272 schema:name Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA
273 rdf:type schema:Organization
274 grid-institutes:grid.419234.9 schema:alternateName National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA
275 schema:name National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...