Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-31

AUTHORS

Priyank Maindola, Rahul Raina, Parveen Goyal, Krishnamohan Atmakuri, Abhishek Ojha, Sourabh Gupta, Peter J. Christie, Lakshminarayan M. Iyer, L. Aravind, Arulandu Arockiasamy

ABSTRACT

Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts. More... »

PAGES

5322-5322

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms6322

DOI

http://dx.doi.org/10.1038/ncomms6322

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021643359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25358815


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conjugation, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fertility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Multimerization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Type IV Secretion Systems", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maindola", 
        "givenName": "Priyank", 
        "id": "sg:person.0660715212.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660715212.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raina", 
        "givenName": "Rahul", 
        "id": "sg:person.0727030412.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727030412.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goyal", 
        "givenName": "Parveen", 
        "id": "sg:person.01202610400.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202610400.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atmakuri", 
        "givenName": "Krishnamohan", 
        "id": "sg:person.01032050352.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032050352.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ojha", 
        "givenName": "Abhishek", 
        "id": "sg:person.01241513464.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241513464.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Sourabh", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christie", 
        "givenName": "Peter J.", 
        "id": "sg:person.01145607040.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145607040.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iyer", 
        "givenName": "Lakshminarayan M.", 
        "id": "sg:person.012162224357.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA", 
          "id": "http://www.grid.ac/institutes/grid.419234.9", 
          "name": [
            "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aravind", 
        "givenName": "L.", 
        "id": "sg:person.01106662166.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arockiasamy", 
        "givenName": "Arulandu", 
        "id": "sg:person.01046024123.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046024123.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature04149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025433172", 
          "https://doi.org/10.1038/nature04149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053603492", 
          "https://doi.org/10.1038/nature06415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.2007.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041150506", 
          "https://doi.org/10.1038/nchembio.2007.39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6150-8-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034075663", 
          "https://doi.org/10.1186/1745-6150-8-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017826253", 
          "https://doi.org/10.1038/nprot.2006.286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025213356", 
          "https://doi.org/10.1038/ncb2083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-12-r81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016542336", 
          "https://doi.org/10.1186/gb-2003-4-12-r81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00290681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035818697", 
          "https://doi.org/10.1007/bf00290681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-003-3387-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041122654", 
          "https://doi.org/10.1007/s00018-003-3387-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6150-7-18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040385591", 
          "https://doi.org/10.1186/1745-6150-7-18"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-11-r237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033209125", 
          "https://doi.org/10.1186/gb-2007-8-11-r237"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10-31", 
    "datePublishedReg": "2014-10-31", 
    "description": "Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts. ", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms6322", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2726065", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2514016", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "Agrobacterium tumefaciens VirB/D4 type IV secretion system", 
      "sexual conflict", 
      "VirB/D4 type IV secretion system", 
      "type IV secretion system", 
      "diverse biological contexts", 
      "DNase activity", 
      "multiple enzymatic activities", 
      "conjugative plasmids", 
      "first crystal structure", 
      "proteobacterial plasmids", 
      "P1 ParB", 
      "conjugative T4SS", 
      "secretion system", 
      "DNA transfer", 
      "biological context", 
      "active version", 
      "enzymatic activity", 
      "functional implications", 
      "sulfiredoxin", 
      "T4SS", 
      "plasmid", 
      "translocation", 
      "ATPase", 
      "ParB", 
      "KorB", 
      "plants", 
      "DNA", 
      "conservation", 
      "activity", 
      "crystal structure", 
      "family", 
      "Srx", 
      "complexes", 
      "members", 
      "relatives", 
      "interplay", 
      "switch", 
      "evidence", 
      "factors", 
      "structure", 
      "transfer", 
      "inhibition factor", 
      "implications", 
      "system", 
      "context", 
      "rivals", 
      "conflict", 
      "OSA", 
      "version", 
      "co-resident rivals", 
      "fertility inhibition factors", 
      "enigmatic FIN Osa", 
      "FIN Osa", 
      "ParB/Sulfiredoxin", 
      "ATP-dependent switch", 
      "tumefaciens VirB/D4 type IV secretion system", 
      "D4 type IV secretion system", 
      "IV secretion system", 
      "active Osa", 
      "DNA-VirD2 complex", 
      "RK2 KorB", 
      "general functional implications", 
      "ParB/Srx"
    ], 
    "name": "Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids", 
    "pagination": "5322-5322", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021643359"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms6322"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25358815"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms6322", 
      "https://app.dimensions.ai/details/publication/pub.1021643359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_644.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms6322"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6322'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      22 PREDICATES      109 URIs      90 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms6322 schema:about N02f20bee114d4a78baedd05e93f9e4ae
2 N602ef48a214a4d0c83b2ec35c9986a87
3 N8b270338c0aa4c04ab6a00ca12d8cea6
4 N9d4712256a5043e5b1e8c88cfb50e28f
5 Nc47b13c3d90c4e1fb9b068e5b9e2a3da
6 Ne0bfd47f26cf4706bb2370f84297f691
7 Ne9c663c2f5054e3db3b0d35e5d3772d0
8 Ned2584194c91453ab79064c14d37282a
9 Nfc816d623a764ce485c05ebb811e6504
10 anzsrc-for:06
11 anzsrc-for:0604
12 schema:author N4fdfde22fd854621b550aa64d4856cb3
13 schema:citation sg:pub.10.1007/bf00290681
14 sg:pub.10.1007/s00018-003-3387-y
15 sg:pub.10.1038/nature04149
16 sg:pub.10.1038/nature06415
17 sg:pub.10.1038/ncb2083
18 sg:pub.10.1038/nchembio.2007.39
19 sg:pub.10.1038/nprot.2006.286
20 sg:pub.10.1186/1745-6150-7-18
21 sg:pub.10.1186/1745-6150-8-15
22 sg:pub.10.1186/gb-2003-4-12-r81
23 sg:pub.10.1186/gb-2007-8-11-r237
24 schema:datePublished 2014-10-31
25 schema:datePublishedReg 2014-10-31
26 schema:description Conjugative plasmids are typically locked in intergenomic and sexual conflicts with co-resident rivals, whose translocation they block using fertility inhibition factors (FINs). We describe here the first crystal structure of an enigmatic FIN Osa deployed by the proteobacterial plasmid pSa. Osa contains a catalytically active version of the ParB/Sulfiredoxin fold with both ATPase and DNase activity, the latter being regulated by an ATP-dependent switch. Using the Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS), a relative of the conjugative T4SS, we demonstrate that catalytically active Osa blocks T-DNA transfer into plants. With a partially reconstituted T4SS in vitro, we show that Osa degrades T-DNA in the T-DNA-VirD2 complex before its translocation. Further, we present evidence for conservation and interplay between ATPase and DNase activities throughout the ParB/Sulfiredoxin fold, using other members of the family, namely P1 ParB and RK2 KorB, which have general functional implications across diverse biological contexts.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N583087bc1de14e83a02a75b79b0d5dcf
31 N95f9a33cf8134c9da289607bbed16111
32 sg:journal.1043282
33 schema:keywords ATP-dependent switch
34 ATPase
35 Agrobacterium tumefaciens VirB/D4 type IV secretion system
36 D4 type IV secretion system
37 DNA
38 DNA transfer
39 DNA-VirD2 complex
40 DNase activity
41 FIN Osa
42 IV secretion system
43 KorB
44 OSA
45 P1 ParB
46 ParB
47 ParB/Srx
48 ParB/Sulfiredoxin
49 RK2 KorB
50 Srx
51 T4SS
52 VirB/D4 type IV secretion system
53 active Osa
54 active version
55 activity
56 biological context
57 co-resident rivals
58 complexes
59 conflict
60 conjugative T4SS
61 conjugative plasmids
62 conservation
63 context
64 crystal structure
65 diverse biological contexts
66 enigmatic FIN Osa
67 enzymatic activity
68 evidence
69 factors
70 family
71 fertility inhibition factors
72 first crystal structure
73 functional implications
74 general functional implications
75 implications
76 inhibition factor
77 interplay
78 members
79 multiple enzymatic activities
80 plants
81 plasmid
82 proteobacterial plasmids
83 relatives
84 rivals
85 secretion system
86 sexual conflict
87 structure
88 sulfiredoxin
89 switch
90 system
91 transfer
92 translocation
93 tumefaciens VirB/D4 type IV secretion system
94 type IV secretion system
95 version
96 schema:name Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids
97 schema:pagination 5322-5322
98 schema:productId N21d577c502504e13837af138f71180b9
99 N7412769f7c2d4504b18166d032c2a4a9
100 Na8cea6ab8ebc406c90e4e1a8913df92b
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021643359
102 https://doi.org/10.1038/ncomms6322
103 schema:sdDatePublished 2021-11-01T18:23
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N358dbfc063be4716bf92416323d05742
106 schema:url https://doi.org/10.1038/ncomms6322
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N02f20bee114d4a78baedd05e93f9e4ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Plasmids
112 rdf:type schema:DefinedTerm
113 N0e41f640e1c44296b42ed864d3645cc5 rdf:first sg:person.01032050352.04
114 rdf:rest N6bbbc0ec6cad42dfb76afc342492b1d8
115 N21d577c502504e13837af138f71180b9 schema:name doi
116 schema:value 10.1038/ncomms6322
117 rdf:type schema:PropertyValue
118 N2a37e99bc7714b9193eab5a32c829558 rdf:first sg:person.012162224357.20
119 rdf:rest N50136d96dbe9462ea601cab1d960130d
120 N337ff9d2d7e74237a9c53ebed7f3771f schema:affiliation grid-institutes:None
121 schema:familyName Gupta
122 schema:givenName Sourabh
123 rdf:type schema:Person
124 N358dbfc063be4716bf92416323d05742 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N36969b4cef0e4468a25c621766e95bdb rdf:first sg:person.01202610400.79
127 rdf:rest N0e41f640e1c44296b42ed864d3645cc5
128 N4fdfde22fd854621b550aa64d4856cb3 rdf:first sg:person.0660715212.88
129 rdf:rest N61a68ab26bfc408a890ab14cd745dbcf
130 N50136d96dbe9462ea601cab1d960130d rdf:first sg:person.01106662166.38
131 rdf:rest Nc34cefdf138549a59da0c252da5209f5
132 N583087bc1de14e83a02a75b79b0d5dcf schema:volumeNumber 5
133 rdf:type schema:PublicationVolume
134 N602ef48a214a4d0c83b2ec35c9986a87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Bacterial Proteins
136 rdf:type schema:DefinedTerm
137 N61a68ab26bfc408a890ab14cd745dbcf rdf:first sg:person.0727030412.86
138 rdf:rest N36969b4cef0e4468a25c621766e95bdb
139 N6bbbc0ec6cad42dfb76afc342492b1d8 rdf:first sg:person.01241513464.87
140 rdf:rest N893eb585b5904221acb3bde7f661a1c9
141 N7412769f7c2d4504b18166d032c2a4a9 schema:name dimensions_id
142 schema:value pub.1021643359
143 rdf:type schema:PropertyValue
144 N893eb585b5904221acb3bde7f661a1c9 rdf:first N337ff9d2d7e74237a9c53ebed7f3771f
145 rdf:rest N9cf314cf7dec408baf8bc9ae2a65c149
146 N8b270338c0aa4c04ab6a00ca12d8cea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Adenosine Triphosphatases
148 rdf:type schema:DefinedTerm
149 N95f9a33cf8134c9da289607bbed16111 schema:issueNumber 1
150 rdf:type schema:PublicationIssue
151 N9cf314cf7dec408baf8bc9ae2a65c149 rdf:first sg:person.01145607040.20
152 rdf:rest N2a37e99bc7714b9193eab5a32c829558
153 N9d4712256a5043e5b1e8c88cfb50e28f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Type IV Secretion Systems
155 rdf:type schema:DefinedTerm
156 Na8cea6ab8ebc406c90e4e1a8913df92b schema:name pubmed_id
157 schema:value 25358815
158 rdf:type schema:PropertyValue
159 Nc34cefdf138549a59da0c252da5209f5 rdf:first sg:person.01046024123.13
160 rdf:rest rdf:nil
161 Nc47b13c3d90c4e1fb9b068e5b9e2a3da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Fertility
163 rdf:type schema:DefinedTerm
164 Ne0bfd47f26cf4706bb2370f84297f691 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Protein Multimerization
166 rdf:type schema:DefinedTerm
167 Ne9c663c2f5054e3db3b0d35e5d3772d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Conjugation, Genetic
169 rdf:type schema:DefinedTerm
170 Ned2584194c91453ab79064c14d37282a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name DNA, Bacterial
172 rdf:type schema:DefinedTerm
173 Nfc816d623a764ce485c05ebb811e6504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Deoxyribonucleases
175 rdf:type schema:DefinedTerm
176 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biological Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
180 schema:name Genetics
181 rdf:type schema:DefinedTerm
182 sg:grant.2514016 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6322
183 rdf:type schema:MonetaryGrant
184 sg:grant.2726065 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms6322
185 rdf:type schema:MonetaryGrant
186 sg:journal.1043282 schema:issn 2041-1723
187 schema:name Nature Communications
188 schema:publisher Springer Nature
189 rdf:type schema:Periodical
190 sg:person.01032050352.04 schema:affiliation grid-institutes:grid.267308.8
191 schema:familyName Atmakuri
192 schema:givenName Krishnamohan
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032050352.04
194 rdf:type schema:Person
195 sg:person.01046024123.13 schema:affiliation grid-institutes:None
196 schema:familyName Arockiasamy
197 schema:givenName Arulandu
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046024123.13
199 rdf:type schema:Person
200 sg:person.01106662166.38 schema:affiliation grid-institutes:grid.419234.9
201 schema:familyName Aravind
202 schema:givenName L.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
204 rdf:type schema:Person
205 sg:person.01145607040.20 schema:affiliation grid-institutes:grid.267308.8
206 schema:familyName Christie
207 schema:givenName Peter J.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145607040.20
209 rdf:type schema:Person
210 sg:person.01202610400.79 schema:affiliation grid-institutes:None
211 schema:familyName Goyal
212 schema:givenName Parveen
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202610400.79
214 rdf:type schema:Person
215 sg:person.012162224357.20 schema:affiliation grid-institutes:grid.419234.9
216 schema:familyName Iyer
217 schema:givenName Lakshminarayan M.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20
219 rdf:type schema:Person
220 sg:person.01241513464.87 schema:affiliation grid-institutes:None
221 schema:familyName Ojha
222 schema:givenName Abhishek
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241513464.87
224 rdf:type schema:Person
225 sg:person.0660715212.88 schema:affiliation grid-institutes:None
226 schema:familyName Maindola
227 schema:givenName Priyank
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660715212.88
229 rdf:type schema:Person
230 sg:person.0727030412.86 schema:affiliation grid-institutes:None
231 schema:familyName Raina
232 schema:givenName Rahul
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727030412.86
234 rdf:type schema:Person
235 sg:pub.10.1007/bf00290681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818697
236 https://doi.org/10.1007/bf00290681
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s00018-003-3387-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041122654
239 https://doi.org/10.1007/s00018-003-3387-y
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/nature04149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025433172
242 https://doi.org/10.1038/nature04149
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nature06415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053603492
245 https://doi.org/10.1038/nature06415
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/ncb2083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025213356
248 https://doi.org/10.1038/ncb2083
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nchembio.2007.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041150506
251 https://doi.org/10.1038/nchembio.2007.39
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nprot.2006.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017826253
254 https://doi.org/10.1038/nprot.2006.286
255 rdf:type schema:CreativeWork
256 sg:pub.10.1186/1745-6150-7-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040385591
257 https://doi.org/10.1186/1745-6150-7-18
258 rdf:type schema:CreativeWork
259 sg:pub.10.1186/1745-6150-8-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034075663
260 https://doi.org/10.1186/1745-6150-8-15
261 rdf:type schema:CreativeWork
262 sg:pub.10.1186/gb-2003-4-12-r81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016542336
263 https://doi.org/10.1186/gb-2003-4-12-r81
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/gb-2007-8-11-r237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033209125
266 https://doi.org/10.1186/gb-2007-8-11-r237
267 rdf:type schema:CreativeWork
268 grid-institutes:None schema:alternateName Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India
269 schema:name Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology, ArunaAsaf Ali Marg, New Delhi-110067. India
270 rdf:type schema:Organization
271 grid-institutes:grid.267308.8 schema:alternateName Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA
272 schema:name Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030, USA
273 rdf:type schema:Organization
274 grid-institutes:grid.419234.9 schema:alternateName National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA
275 schema:name National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD20894-6075, USA. MSC 6075, Bethesda, MD 20894-6075, USA
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...