Ontology type: schema:ScholarlyArticle Open Access: True
2014-10-09
AUTHORSVincent Caval, Rodolphe Suspène, Milana Shapira, Jean-Pierre Vartanian, Simon Wain-Hobson
ABSTRACTHuman APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A–A3B deletion allele (ΔA3B), which is linked to a higher odds ratio of developing breast, ovarian and liver cancer. Interestingly, breast cancer genomes from ΔA3B−/− patients show a higher overall mutation burden. Here it is shown that germline A3B can hypermutate nuclear DNA, albeit less efficiently than A3A. Chimaeric A3A mRNA resulting from ΔA3B was more stable, resulting in higher intracellular A3A levels and greater DNA damage. The cancer burden implied by the higher A3A levels could be considerable given the high penetration of the ΔA3B allele in South East Asia. More... »
PAGES5129
http://scigraph.springernature.com/pub.10.1038/ncomms6129
DOIhttp://dx.doi.org/10.1038/ncomms6129
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1050779071
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25298230
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "3' Untranslated Regions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alleles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytidine Deaminase",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Damage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HEK293 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HeLa Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Minor Histocompatibility Antigens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France"
],
"type": "Organization"
},
"familyName": "Caval",
"givenName": "Vincent",
"id": "sg:person.01274264236.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France"
],
"type": "Organization"
},
"familyName": "Susp\u00e8ne",
"givenName": "Rodolphe",
"id": "sg:person.01171112422.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112422.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France"
],
"type": "Organization"
},
"familyName": "Shapira",
"givenName": "Milana",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France"
],
"type": "Organization"
},
"familyName": "Vartanian",
"givenName": "Jean-Pierre",
"id": "sg:person.01260647435.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260647435.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Department of Virology, Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, Cedex 15, France"
],
"type": "Organization"
},
"familyName": "Wain-Hobson",
"givenName": "Simon",
"id": "sg:person.055642406.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature08645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050729897",
"https://doi.org/10.1038/nature08645"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11881",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032796931",
"https://doi.org/10.1038/nature11881"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2014.176",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039442540",
"https://doi.org/10.1038/bjc.2014.176"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.2702",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020175364",
"https://doi.org/10.1038/ng.2702"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034041413",
"https://doi.org/10.1038/nature11017"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12477",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050004918",
"https://doi.org/10.1038/nature12477"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.1744",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002558962",
"https://doi.org/10.1038/nsmb.1744"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.2955",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002579839",
"https://doi.org/10.1038/ng.2955"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033482125",
"https://doi.org/10.1038/nature05610"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep00806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032985769",
"https://doi.org/10.1038/srep00806"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-10-09",
"datePublishedReg": "2014-10-09",
"description": "Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A\u2013A3B deletion allele (\u0394A3B), which is linked to a higher odds ratio of developing breast, ovarian and liver cancer. Interestingly, breast cancer genomes from \u0394A3B\u2212/\u2212 patients show a higher overall mutation burden. Here it is shown that germline A3B can hypermutate nuclear DNA, albeit less efficiently than A3A. Chimaeric A3A mRNA resulting from \u0394A3B was more stable, resulting in higher intracellular A3A levels and greater DNA damage. The cancer burden implied by the higher A3A levels could be considerable given the high penetration of the \u0394A3B allele in South East Asia.",
"genre": "article",
"id": "sg:pub.10.1038/ncomms6129",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1043282",
"issn": [
"2041-1723"
],
"name": "Nature Communications",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "5"
}
],
"keywords": [
"DNA damage",
"terminal catalytic domain",
"APOBEC3A cytidine deaminase",
"breast cancer genomes",
"chromosomal DNA damage",
"catalytic domain",
"nuclear DNA",
"cancer genomes",
"chromosomal DNA",
"host enzymes",
"greater DNA damage",
"cytidine deaminase",
"deletion allele",
"hybrid alleles",
"cancer susceptibility",
"overall mutation burden",
"alleles",
"higher odds ratio",
"DNA",
"genotoxic potential",
"cancer burden",
"South East Asia",
"odds ratio",
"liver cancer",
"mutation burden",
"genome",
"A3A.",
"mutations",
"A3A",
"enzyme",
"mRNA",
"APOBEC3B",
"deaminase",
"East Asia",
"burden",
"domain",
"patients",
"damage",
"cancer",
"breast",
"A3B",
"levels",
"susceptibility",
"Asia",
"potential",
"ratio",
"penetration",
"high penetration"
],
"name": "A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3\u2032UTR enhances chromosomal DNA damage",
"pagination": "5129",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1050779071"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ncomms6129"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25298230"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ncomms6129",
"https://app.dimensions.ai/details/publication/pub.1050779071"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:01",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_632.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/ncomms6129"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'
This table displays all metadata directly associated to this object as RDF triples.
227 TRIPLES
21 PREDICATES
96 URIs
78 LITERALS
20 BLANK NODES