A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Vincent Caval, Rodolphe Suspène, Milana Shapira, Jean-Pierre Vartanian, Simon Wain-Hobson

ABSTRACT

Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked to a higher odds ratio of developing breast, ovarian and liver cancer. Interestingly, breast cancer genomes from ΔA3B(-/-) patients show a higher overall mutation burden. Here it is shown that germline A3B can hypermutate nuclear DNA, albeit less efficiently than A3A. Chimaeric A3A mRNA resulting from ΔA3B was more stable, resulting in higher intracellular A3A levels and greater DNA damage. The cancer burden implied by the higher A3A levels could be considerable given the high penetration of the ΔA3B allele in South East Asia. More... »

PAGES

5129

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms6129

DOI

http://dx.doi.org/10.1038/ncomms6129

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050779071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25298230


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3' Untranslated Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minor Histocompatibility Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caval", 
        "givenName": "Vincent", 
        "id": "sg:person.01274264236.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Susp\u00e8ne", 
        "givenName": "Rodolphe", 
        "id": "sg:person.01171112422.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112422.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shapira", 
        "givenName": "Milana", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vartanian", 
        "givenName": "Jean-Pierre", 
        "id": "sg:person.01260647435.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260647435.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wain-Hobson", 
        "givenName": "Simon", 
        "id": "sg:person.055642406.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/gkq174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000987600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002028443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002579839", 
          "https://doi.org/10.1038/ng.2955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.80973-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003734365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01089-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004445400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.13.8201-8207.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004818938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.80426-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008503228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.01.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009285166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.2002.6718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011191861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1009687108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014441277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.504175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016331944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.201300140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018507646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020175364", 
          "https://doi.org/10.1038/ng.2702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/dds513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021305887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021821176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408223102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023631355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408223102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023631355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.1999.00682.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030182044", 
          "https://doi.org/10.1046/j.1523-1747.1999.00682.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2013.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030576598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032796931", 
          "https://doi.org/10.1038/nature11881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep00806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032985769", 
          "https://doi.org/10.1038/srep00806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2011.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033286983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033482125", 
          "https://doi.org/10.1038/nature05610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.06570-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033535759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034041413", 
          "https://doi.org/10.1038/nature11017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0063461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035667992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m408802200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036446738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/mst195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036590406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039324410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2014.176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039442540", 
          "https://doi.org/10.1038/bjc.2014.176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0073641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041446057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045023132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045023132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045709558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.385161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047104476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)04046-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047972304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050004918", 
          "https://doi.org/10.1038/nature12477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051500167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgt185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051722504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.83149-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060401587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077677032", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (\u0394A3B), which is linked to a higher odds ratio of developing breast, ovarian and liver cancer. Interestingly, breast cancer genomes from \u0394A3B(-/-) patients show a higher overall mutation burden. Here it is shown that germline A3B can hypermutate nuclear DNA, albeit less efficiently than A3A. Chimaeric A3A mRNA resulting from \u0394A3B was more stable, resulting in higher intracellular A3A levels and greater DNA damage. The cancer burden implied by the higher A3A levels could be considerable given the high penetration of the \u0394A3B allele in South East Asia. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms6129", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3\u2032UTR enhances chromosomal DNA damage", 
    "pagination": "5129", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f1e42134ce734cf531f3d2d6c11af0939c5c5a2c11d6d67c7ab42b44c504d93b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25298230"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms6129"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050779071"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms6129", 
      "https://app.dimensions.ai/details/publication/pub.1050779071"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms6129"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms6129'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      83 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms6129 schema:about N06fc4bba10ec4197875b1b97b8fd882a
2 N1658d9cd930f481c8a72973e10ece4db
3 N1df46469f15e43c492a9e6189e13c113
4 N2a4a6c23500441749ceac696d90ce90e
5 N356941b249384f3fa2b49e3cdd698f4b
6 N4ef143467b374a68a35eb1684b46ea1b
7 N544f29b381094bf7b31007623262d8f4
8 N5e2a27ca9432467da7c5cd57b5e65cc7
9 N783919155a174bfc83d17cade72294d8
10 N7a85cf278a7d4cd4b7e1c8331a83f467
11 N8e583aa691314833a9e26f41e152812d
12 Nd28758e4fef343f5aa661768f23de994
13 Ne18ec07fc04f4cc882c92467ca13156e
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N765f5e8aae10425883b7aaea93da278b
17 schema:citation sg:pub.10.1038/bjc.2014.176
18 sg:pub.10.1038/nature05610
19 sg:pub.10.1038/nature08645
20 sg:pub.10.1038/nature11017
21 sg:pub.10.1038/nature11881
22 sg:pub.10.1038/nature12477
23 sg:pub.10.1038/ng.2702
24 sg:pub.10.1038/ng.2955
25 sg:pub.10.1038/nsmb.1744
26 sg:pub.10.1038/srep00806
27 sg:pub.10.1046/j.1523-1747.1999.00682.x
28 https://app.dimensions.ai/details/publication/pub.1077677032
29 https://doi.org/10.1002/bies.201300140
30 https://doi.org/10.1006/geno.2002.6718
31 https://doi.org/10.1016/j.cell.2007.01.029
32 https://doi.org/10.1016/j.cell.2012.04.024
33 https://doi.org/10.1016/j.virol.2013.03.003
34 https://doi.org/10.1016/s0140-6736(00)04046-0
35 https://doi.org/10.1038/embor.2011.46
36 https://doi.org/10.1073/pnas.0408223102
37 https://doi.org/10.1073/pnas.1009687108
38 https://doi.org/10.1074/jbc.m112.385161
39 https://doi.org/10.1074/jbc.m113.504175
40 https://doi.org/10.1074/jbc.m408802200
41 https://doi.org/10.1093/carcin/bgt185
42 https://doi.org/10.1093/hmg/dds513
43 https://doi.org/10.1093/jnci/djt018
44 https://doi.org/10.1093/molbev/mst195
45 https://doi.org/10.1093/nar/gkm181
46 https://doi.org/10.1093/nar/gkq174
47 https://doi.org/10.1093/nar/gks685
48 https://doi.org/10.1099/vir.0.80426-0
49 https://doi.org/10.1099/vir.0.80973-0
50 https://doi.org/10.1099/vir.0.83149-0
51 https://doi.org/10.1128/jvi.01089-09
52 https://doi.org/10.1128/jvi.06570-11
53 https://doi.org/10.1128/jvi.79.13.8201-8207.2005
54 https://doi.org/10.1371/journal.pgen.0030063
55 https://doi.org/10.1371/journal.pone.0004277
56 https://doi.org/10.1371/journal.pone.0063461
57 https://doi.org/10.1371/journal.pone.0073641
58 schema:datePublished 2014-12
59 schema:datePublishedReg 2014-12-01
60 schema:description Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked to a higher odds ratio of developing breast, ovarian and liver cancer. Interestingly, breast cancer genomes from ΔA3B(-/-) patients show a higher overall mutation burden. Here it is shown that germline A3B can hypermutate nuclear DNA, albeit less efficiently than A3A. Chimaeric A3A mRNA resulting from ΔA3B was more stable, resulting in higher intracellular A3A levels and greater DNA damage. The cancer burden implied by the higher A3A levels could be considerable given the high penetration of the ΔA3B allele in South East Asia.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N14690cc4d70b4c61846b5b9210e8f754
65 Nf64250ecc6c64aa1981f3c2d2505a233
66 sg:journal.1043282
67 schema:name A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage
68 schema:pagination 5129
69 schema:productId N288a7079bde74ab5b7d7eb24f1589ef7
70 N3fbe1eb9f87b45ffbc6d34eb9c210f9a
71 Na7048fe12fcb4070a5dee664e628ce51
72 Ncb9d446043e040f7a2af72519b76c355
73 Nf72448485bfd475dabe72ee6f20f2242
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050779071
75 https://doi.org/10.1038/ncomms6129
76 schema:sdDatePublished 2019-04-10T13:01
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N3f70363e0cec4f6ab555a4a39bcd974d
79 schema:url https://www.nature.com/articles/ncomms6129
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N06fc4bba10ec4197875b1b97b8fd882a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name 3' Untranslated Regions
85 rdf:type schema:DefinedTerm
86 N14690cc4d70b4c61846b5b9210e8f754 schema:volumeNumber 5
87 rdf:type schema:PublicationVolume
88 N1658d9cd930f481c8a72973e10ece4db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name DNA Damage
90 rdf:type schema:DefinedTerm
91 N1df46469f15e43c492a9e6189e13c113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cytidine Deaminase
93 rdf:type schema:DefinedTerm
94 N288a7079bde74ab5b7d7eb24f1589ef7 schema:name doi
95 schema:value 10.1038/ncomms6129
96 rdf:type schema:PropertyValue
97 N2a4a6c23500441749ceac696d90ce90e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Alleles
99 rdf:type schema:DefinedTerm
100 N356941b249384f3fa2b49e3cdd698f4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Cell Line, Tumor
102 rdf:type schema:DefinedTerm
103 N3e0f5a81a4f348fe845f5bc921777213 rdf:first sg:person.055642406.07
104 rdf:rest rdf:nil
105 N3f70363e0cec4f6ab555a4a39bcd974d schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N3fbe1eb9f87b45ffbc6d34eb9c210f9a schema:name pubmed_id
108 schema:value 25298230
109 rdf:type schema:PropertyValue
110 N4ef143467b374a68a35eb1684b46ea1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Genetic Predisposition to Disease
112 rdf:type schema:DefinedTerm
113 N544f29b381094bf7b31007623262d8f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Neoplasms
115 rdf:type schema:DefinedTerm
116 N5ceb047736d345058dd2aff8df3d329d rdf:first sg:person.01260647435.89
117 rdf:rest N3e0f5a81a4f348fe845f5bc921777213
118 N5e2a27ca9432467da7c5cd57b5e65cc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Humans
120 rdf:type schema:DefinedTerm
121 N612ca78b625044318c75f3c3b9f3fe1b schema:affiliation https://www.grid.ac/institutes/grid.428999.7
122 schema:familyName Shapira
123 schema:givenName Milana
124 rdf:type schema:Person
125 N765f5e8aae10425883b7aaea93da278b rdf:first sg:person.01274264236.49
126 rdf:rest Nbc0f2623811f49d4b1cbfa857f55ed37
127 N783919155a174bfc83d17cade72294d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name HEK293 Cells
129 rdf:type schema:DefinedTerm
130 N7a85cf278a7d4cd4b7e1c8331a83f467 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Proteins
132 rdf:type schema:DefinedTerm
133 N8e583aa691314833a9e26f41e152812d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mutation
135 rdf:type schema:DefinedTerm
136 Na7048fe12fcb4070a5dee664e628ce51 schema:name dimensions_id
137 schema:value pub.1050779071
138 rdf:type schema:PropertyValue
139 Nbc0f2623811f49d4b1cbfa857f55ed37 rdf:first sg:person.01171112422.54
140 rdf:rest Nd708dee264fd41108d81774b7dab08b0
141 Ncb9d446043e040f7a2af72519b76c355 schema:name readcube_id
142 schema:value f1e42134ce734cf531f3d2d6c11af0939c5c5a2c11d6d67c7ab42b44c504d93b
143 rdf:type schema:PropertyValue
144 Nd28758e4fef343f5aa661768f23de994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Minor Histocompatibility Antigens
146 rdf:type schema:DefinedTerm
147 Nd708dee264fd41108d81774b7dab08b0 rdf:first N612ca78b625044318c75f3c3b9f3fe1b
148 rdf:rest N5ceb047736d345058dd2aff8df3d329d
149 Ne18ec07fc04f4cc882c92467ca13156e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name HeLa Cells
151 rdf:type schema:DefinedTerm
152 Nf64250ecc6c64aa1981f3c2d2505a233 schema:issueNumber 1
153 rdf:type schema:PublicationIssue
154 Nf72448485bfd475dabe72ee6f20f2242 schema:name nlm_unique_id
155 schema:value 101528555
156 rdf:type schema:PropertyValue
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
161 schema:name Oncology and Carcinogenesis
162 rdf:type schema:DefinedTerm
163 sg:journal.1043282 schema:issn 2041-1723
164 schema:name Nature Communications
165 rdf:type schema:Periodical
166 sg:person.01171112422.54 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
167 schema:familyName Suspène
168 schema:givenName Rodolphe
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112422.54
170 rdf:type schema:Person
171 sg:person.01260647435.89 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
172 schema:familyName Vartanian
173 schema:givenName Jean-Pierre
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260647435.89
175 rdf:type schema:Person
176 sg:person.01274264236.49 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
177 schema:familyName Caval
178 schema:givenName Vincent
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49
180 rdf:type schema:Person
181 sg:person.055642406.07 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
182 schema:familyName Wain-Hobson
183 schema:givenName Simon
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07
185 rdf:type schema:Person
186 sg:pub.10.1038/bjc.2014.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039442540
187 https://doi.org/10.1038/bjc.2014.176
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nature05610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482125
190 https://doi.org/10.1038/nature05610
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nature08645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729897
193 https://doi.org/10.1038/nature08645
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nature11017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034041413
196 https://doi.org/10.1038/nature11017
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nature11881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032796931
199 https://doi.org/10.1038/nature11881
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
202 https://doi.org/10.1038/nature12477
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/ng.2702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020175364
205 https://doi.org/10.1038/ng.2702
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ng.2955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002579839
208 https://doi.org/10.1038/ng.2955
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/nsmb.1744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002558962
211 https://doi.org/10.1038/nsmb.1744
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/srep00806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032985769
214 https://doi.org/10.1038/srep00806
215 rdf:type schema:CreativeWork
216 sg:pub.10.1046/j.1523-1747.1999.00682.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030182044
217 https://doi.org/10.1046/j.1523-1747.1999.00682.x
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1077677032 schema:CreativeWork
220 https://doi.org/10.1002/bies.201300140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018507646
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1006/geno.2002.6718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011191861
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.cell.2007.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009285166
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.cell.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045709558
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.virol.2013.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030576598
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0140-6736(00)04046-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047972304
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1038/embor.2011.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033286983
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1073/pnas.0408223102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023631355
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.1009687108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014441277
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1074/jbc.m112.385161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047104476
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1074/jbc.m113.504175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016331944
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1074/jbc.m408802200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036446738
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/carcin/bgt185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051722504
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1093/hmg/dds513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021305887
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/jnci/djt018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051500167
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/molbev/mst195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036590406
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/nar/gkm181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002028443
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/nar/gkq174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000987600
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1093/nar/gks685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039324410
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1099/vir.0.80426-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008503228
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1099/vir.0.80973-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003734365
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1099/vir.0.83149-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060401587
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1128/jvi.01089-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004445400
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1128/jvi.06570-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033535759
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1128/jvi.79.13.8201-8207.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004818938
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1371/journal.pgen.0030063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045023132
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1371/journal.pone.0004277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021821176
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1371/journal.pone.0063461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035667992
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1371/journal.pone.0073641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041446057
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
279 schema:name Molecular Retrovirology Unit, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...