Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09-19

AUTHORS

Miyako Tanaka, Kenji Ikeda, Takayoshi Suganami, Chikara Komiya, Kozue Ochi, Ibuki Shirakawa, Miho Hamaguchi, Satoshi Nishimura, Ichiro Manabe, Takahisa Matsuda, Kumi Kimura, Hiroshi Inoue, Yutaka Inagaki, Seiichiro Aoe, Sho Yamasaki, Yoshihiro Ogawa

ABSTRACT

In obesity, a paracrine loop between adipocytes and macrophages augments chronic inflammation of adipose tissue, thereby inducing systemic insulin resistance and ectopic lipid accumulation. Obese adipose tissue contains a unique histological structure termed crown-like structure (CLS), where adipocyte-macrophage crosstalk is known to occur in close proximity. Here we show that Macrophage-inducible C-type lectin (Mincle), a pathogen sensor for Mycobacterium tuberculosis, is localized to macrophages in CLS, the number of which correlates with the extent of interstitial fibrosis. Mincle induces obesity-induced adipose tissue fibrosis, thereby leading to steatosis and insulin resistance in liver. We further show that Mincle in macrophages is crucial for CLS formation, expression of fibrosis-related genes and myofibroblast activation. This study indicates that Mincle, when activated by an endogenous ligand released from dying adipocytes, is involved in adipose tissue remodelling, thereby suggesting that sustained interactions between adipocytes and macrophages within CLS could be a therapeutic target for obesity-induced ectopic lipid accumulation. More... »

PAGES

4982

Journal

TITLE

Nature Communications

ISSUE

1

VOLUME

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms5982

DOI

http://dx.doi.org/10.1038/ncomms5982

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053398307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25236782


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lectins, C-Type", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, G-Protein-Coupled", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Miyako", 
        "id": "sg:person.013270564004.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013270564004.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikeda", 
        "givenName": "Kenji", 
        "id": "sg:person.01172136364.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172136364.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Science and Technology Agency, PRESTO, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
            "Japan Science and Technology Agency, PRESTO, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suganami", 
        "givenName": "Takayoshi", 
        "id": "sg:person.01077470252.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077470252.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komiya", 
        "givenName": "Chikara", 
        "id": "sg:person.01306364764.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306364764.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ochi", 
        "givenName": "Kozue", 
        "id": "sg:person.01034644474.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034644474.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirakawa", 
        "givenName": "Ibuki", 
        "id": "sg:person.01056260324.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056260324.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamaguchi", 
        "givenName": "Miho", 
        "id": "sg:person.01072213550.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072213550.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University, 329-0498, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Cardiovascular Medicine, The University of Tokyo, 113-8655, Tokyo, Japan", 
            "Translational Systems Biology and Medicine Initiative, The University of Tokyo, 113-8655, Tokyo, Japan", 
            "Jichi Medical University, 329-0498, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishimura", 
        "givenName": "Satoshi", 
        "id": "sg:person.07504546042.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07504546042.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, The University of Tokyo, 113-8655, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, The University of Tokyo, 113-8655, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manabe", 
        "givenName": "Ichiro", 
        "id": "sg:person.0577123423.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577123423.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmaceutical Research Division, Takeda Pharmaceutical Company, 251-8555, Fujisawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419841.1", 
          "name": [
            "Pharmaceutical Research Division, Takeda Pharmaceutical Company, 251-8555, Fujisawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuda", 
        "givenName": "Takahisa", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Kumi", 
        "id": "sg:person.01171701243.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171701243.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, 920-8641, Kanazawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, 920-8641, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Hiroshi", 
        "id": "sg:person.0757722527.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757722527.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Regenerative Medicine, Center for Matrix Biology and Medicine, Tokai University School of Medicine, 259-1193, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Regenerative Medicine, Center for Matrix Biology and Medicine, Tokai University School of Medicine, 259-1193, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inagaki", 
        "givenName": "Yutaka", 
        "id": "sg:person.01050444134.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050444134.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Home Economics, Otsuma Women\u2019s University, 102-8357, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412426.7", 
          "name": [
            "Department of Home Economics, Otsuma Women\u2019s University, 102-8357, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoe", 
        "givenName": "Seiichiro", 
        "id": "sg:person.01113546445.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113546445.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamasaki", 
        "givenName": "Sho", 
        "id": "sg:person.016611052015.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016611052015.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265073.5", 
          "name": [
            "Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogawa", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.01053527727.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053527727.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042166283", 
          "https://doi.org/10.1038/nature05485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-012-3696-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021282532", 
          "https://doi.org/10.1007/s11745-012-3696-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049248840", 
          "https://doi.org/10.1038/nm.2807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049858476", 
          "https://doi.org/10.1038/nature10998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030679586", 
          "https://doi.org/10.1038/nm.1994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010554833", 
          "https://doi.org/10.1038/ni.1651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0803632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053602749", 
          "https://doi.org/10.1038/sj.ijo.0803632"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09-19", 
    "datePublishedReg": "2014-09-19", 
    "description": "In obesity, a paracrine loop between adipocytes and macrophages augments chronic inflammation of adipose tissue, thereby inducing systemic insulin resistance and ectopic lipid accumulation. Obese adipose tissue contains a unique histological structure termed crown-like structure (CLS), where adipocyte-macrophage crosstalk is known to occur in close proximity. Here we show that Macrophage-inducible C-type lectin (Mincle), a pathogen sensor for Mycobacterium tuberculosis, is localized to macrophages in CLS, the number of which correlates with the extent of interstitial fibrosis. Mincle induces obesity-induced adipose tissue fibrosis, thereby leading to steatosis and insulin resistance in liver. We further show that Mincle in macrophages is crucial for CLS formation, expression of fibrosis-related genes and myofibroblast activation. This study indicates that Mincle, when activated by an endogenous ligand released from dying adipocytes, is involved in adipose tissue remodelling, thereby suggesting that sustained interactions between adipocytes and macrophages within CLS could be a therapeutic target for obesity-induced ectopic lipid accumulation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms5982", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6135848", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6146667", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6152343", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6115800", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6113444", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6141892", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6112845", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6127900", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6125463", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "crown-like structures", 
      "ectopic lipid accumulation", 
      "adipose tissue fibrosis", 
      "insulin resistance", 
      "tissue fibrosis", 
      "lipid accumulation", 
      "unique histological structure", 
      "adipose tissue remodelling", 
      "systemic insulin resistance", 
      "fibrosis-related genes", 
      "macrophage crosstalk", 
      "pathogen sensors", 
      "interstitial fibrosis", 
      "chronic inflammation", 
      "paracrine loop", 
      "myofibroblast activation", 
      "type lectin", 
      "therapeutic target", 
      "adipose tissue", 
      "endogenous ligand", 
      "tissue remodelling", 
      "fibrosis", 
      "macrophages", 
      "Mycobacterium tuberculosis", 
      "Mincle", 
      "histological structure", 
      "adipocytes", 
      "CL formation", 
      "tissue", 
      "accumulation", 
      "close proximity", 
      "genes", 
      "steatosis", 
      "obesity", 
      "inflammation", 
      "tuberculosis", 
      "liver", 
      "crosstalk", 
      "expression", 
      "remodelling", 
      "lectin", 
      "activation", 
      "resistance", 
      "target", 
      "ligands", 
      "structure", 
      "interaction", 
      "study", 
      "loop", 
      "formation", 
      "proximity", 
      "extent", 
      "number", 
      "sensors"
    ], 
    "name": "Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis", 
    "pagination": "4982", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053398307"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms5982"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25236782"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms5982", 
      "https://app.dimensions.ai/details/publication/pub.1053398307"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_647.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms5982"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms5982'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms5982'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms5982'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms5982'


 

This table displays all metadata directly associated to this object as RDF triples.

386 TRIPLES      22 PREDICATES      110 URIs      93 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms5982 schema:about N1878a1cdcb62402082974a4c43cb1010
2 N19cd882224364094bda610e8d397fd90
3 N2235d657b7504a1fb7de929ec0ffffb6
4 N47edfdd1f4b9483498cf65475b30a42b
5 N4b70de9cef3143d1b67f5e87c9174fdf
6 N7a46475aaed64e0ca4f9ce2ca17b8787
7 N81eb4ade21004fa08a672ada37d2c008
8 N8e59f009ff994b00bd20773571e4c4f7
9 Na42810fc000741cd89fbb50ae7504392
10 Naaf925907ac7496e89b26e158e81c3b7
11 Nad2d80e799434c7abdcc8da7bf490608
12 Nb4e7a79f008f4e5fb215cb5be6af1015
13 Nbf907060b575405eacf734b7a2a68e83
14 Nd4d471c5d6544e7493b1bf430226b3da
15 Ne3ee4c62f1ca494f8042f11ba805909b
16 Ne8125666e67d47528d47407983e68d17
17 Neab577e1588a424abdb6d7887c585bc7
18 Nf003e77dae8a4097b8339429ccb72961
19 Nf64e46ebb7f34c528c1cec7b28a06caa
20 Nfcd3654ddb6c4704b335d50e49a977dd
21 Nff1f94341c7c4c89a9b93b3158fcf61f
22 anzsrc-for:06
23 anzsrc-for:0601
24 anzsrc-for:11
25 anzsrc-for:1116
26 schema:author N36fafbd2d43847eeb386b87b779a5136
27 schema:citation sg:pub.10.1007/s11745-012-3696-8
28 sg:pub.10.1038/nature05485
29 sg:pub.10.1038/nature10998
30 sg:pub.10.1038/ni.1651
31 sg:pub.10.1038/nm.1994
32 sg:pub.10.1038/nm.2807
33 sg:pub.10.1038/sj.ijo.0803632
34 schema:datePublished 2014-09-19
35 schema:datePublishedReg 2014-09-19
36 schema:description In obesity, a paracrine loop between adipocytes and macrophages augments chronic inflammation of adipose tissue, thereby inducing systemic insulin resistance and ectopic lipid accumulation. Obese adipose tissue contains a unique histological structure termed crown-like structure (CLS), where adipocyte-macrophage crosstalk is known to occur in close proximity. Here we show that Macrophage-inducible C-type lectin (Mincle), a pathogen sensor for Mycobacterium tuberculosis, is localized to macrophages in CLS, the number of which correlates with the extent of interstitial fibrosis. Mincle induces obesity-induced adipose tissue fibrosis, thereby leading to steatosis and insulin resistance in liver. We further show that Mincle in macrophages is crucial for CLS formation, expression of fibrosis-related genes and myofibroblast activation. This study indicates that Mincle, when activated by an endogenous ligand released from dying adipocytes, is involved in adipose tissue remodelling, thereby suggesting that sustained interactions between adipocytes and macrophages within CLS could be a therapeutic target for obesity-induced ectopic lipid accumulation.
37 schema:genre article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N2550efc184084e05a53f38c75849c56e
41 N35276d4d3cff4da7b4356ef3d43f7c3b
42 sg:journal.1043282
43 schema:keywords CL formation
44 Mincle
45 Mycobacterium tuberculosis
46 accumulation
47 activation
48 adipocytes
49 adipose tissue
50 adipose tissue fibrosis
51 adipose tissue remodelling
52 chronic inflammation
53 close proximity
54 crosstalk
55 crown-like structures
56 ectopic lipid accumulation
57 endogenous ligand
58 expression
59 extent
60 fibrosis
61 fibrosis-related genes
62 formation
63 genes
64 histological structure
65 inflammation
66 insulin resistance
67 interaction
68 interstitial fibrosis
69 lectin
70 ligands
71 lipid accumulation
72 liver
73 loop
74 macrophage crosstalk
75 macrophages
76 myofibroblast activation
77 number
78 obesity
79 paracrine loop
80 pathogen sensors
81 proximity
82 remodelling
83 resistance
84 sensors
85 steatosis
86 structure
87 study
88 systemic insulin resistance
89 target
90 therapeutic target
91 tissue
92 tissue fibrosis
93 tissue remodelling
94 tuberculosis
95 type lectin
96 unique histological structure
97 schema:name Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis
98 schema:pagination 4982
99 schema:productId N6e358bbb6aad4984a8940b8c693b8d39
100 Nae661a855ba44461854e8ec985fb1d58
101 Nfe7176a491754b908795f91480bae3ee
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053398307
103 https://doi.org/10.1038/ncomms5982
104 schema:sdDatePublished 2022-06-01T22:12
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher Nc7641157ebd545e8a243c46d9f4e1622
107 schema:url https://doi.org/10.1038/ncomms5982
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N0d9f3bd0170f4b06be7045548c5ad707 rdf:first sg:person.0757722527.61
112 rdf:rest N75ba6d23780541b1a225a874368ad887
113 N0e7406805ff641a4a5678f4a223ad73f rdf:first sg:person.0577123423.24
114 rdf:rest N60889778fc99485e9eb72774140a4583
115 N16db1034028a4f6998c3f131006d6b70 rdf:first sg:person.01113546445.02
116 rdf:rest Nd9dbac34e96c45d5b1a1c7988d8b26d7
117 N1878a1cdcb62402082974a4c43cb1010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Obesity
119 rdf:type schema:DefinedTerm
120 N19cd882224364094bda610e8d397fd90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Lipids
122 rdf:type schema:DefinedTerm
123 N2235d657b7504a1fb7de929ec0ffffb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Lectins, C-Type
125 rdf:type schema:DefinedTerm
126 N2550efc184084e05a53f38c75849c56e schema:issueNumber 1
127 rdf:type schema:PublicationIssue
128 N2d26fc995f254c88957219566843aff7 rdf:first sg:person.01306364764.81
129 rdf:rest Nce94141ef571446782af1f19cbdca8a3
130 N328aa0d465e249589eafa593658f7a4f rdf:first sg:person.01077470252.62
131 rdf:rest N2d26fc995f254c88957219566843aff7
132 N35276d4d3cff4da7b4356ef3d43f7c3b schema:volumeNumber 5
133 rdf:type schema:PublicationVolume
134 N36fafbd2d43847eeb386b87b779a5136 rdf:first sg:person.013270564004.26
135 rdf:rest N58d9a1c563704860838af961c85ea093
136 N43ee37646ae0429c953a570109687b02 schema:affiliation grid-institutes:grid.419841.1
137 schema:familyName Matsuda
138 schema:givenName Takahisa
139 rdf:type schema:Person
140 N47edfdd1f4b9483498cf65475b30a42b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Macrophages
142 rdf:type schema:DefinedTerm
143 N4b70de9cef3143d1b67f5e87c9174fdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Calcium-Binding Proteins
145 rdf:type schema:DefinedTerm
146 N58d9a1c563704860838af961c85ea093 rdf:first sg:person.01172136364.37
147 rdf:rest N328aa0d465e249589eafa593658f7a4f
148 N5b28ecd285df49e99860b586be7e73b1 rdf:first sg:person.01072213550.95
149 rdf:rest Na09291d4ffa34753bc1833c810fa72e9
150 N60889778fc99485e9eb72774140a4583 rdf:first N43ee37646ae0429c953a570109687b02
151 rdf:rest Nfe43034d646042faa171098687ab69c9
152 N6e358bbb6aad4984a8940b8c693b8d39 schema:name doi
153 schema:value 10.1038/ncomms5982
154 rdf:type schema:PropertyValue
155 N75ba6d23780541b1a225a874368ad887 rdf:first sg:person.01050444134.64
156 rdf:rest N16db1034028a4f6998c3f131006d6b70
157 N766e113b50714a2997cc473186c198e4 rdf:first sg:person.01056260324.53
158 rdf:rest N5b28ecd285df49e99860b586be7e73b1
159 N7a46475aaed64e0ca4f9ce2ca17b8787 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adipocytes
161 rdf:type schema:DefinedTerm
162 N81eb4ade21004fa08a672ada37d2c008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Liver
164 rdf:type schema:DefinedTerm
165 N8e59f009ff994b00bd20773571e4c4f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Receptors, Cell Surface
167 rdf:type schema:DefinedTerm
168 Na09291d4ffa34753bc1833c810fa72e9 rdf:first sg:person.07504546042.33
169 rdf:rest N0e7406805ff641a4a5678f4a223ad73f
170 Na42810fc000741cd89fbb50ae7504392 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Mice, Inbred C57BL
172 rdf:type schema:DefinedTerm
173 Naaf925907ac7496e89b26e158e81c3b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Adipose Tissue
175 rdf:type schema:DefinedTerm
176 Nad2d80e799434c7abdcc8da7bf490608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Ligands
178 rdf:type schema:DefinedTerm
179 Nae661a855ba44461854e8ec985fb1d58 schema:name dimensions_id
180 schema:value pub.1053398307
181 rdf:type schema:PropertyValue
182 Nb4e7a79f008f4e5fb215cb5be6af1015 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Animals
184 rdf:type schema:DefinedTerm
185 Nb6f215c840654547a1f9707c83b78278 rdf:first sg:person.01053527727.79
186 rdf:rest rdf:nil
187 Nbf907060b575405eacf734b7a2a68e83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Fibrosis
189 rdf:type schema:DefinedTerm
190 Nc7641157ebd545e8a243c46d9f4e1622 schema:name Springer Nature - SN SciGraph project
191 rdf:type schema:Organization
192 Nce94141ef571446782af1f19cbdca8a3 rdf:first sg:person.01034644474.40
193 rdf:rest N766e113b50714a2997cc473186c198e4
194 Nd4d471c5d6544e7493b1bf430226b3da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Mice
196 rdf:type schema:DefinedTerm
197 Nd9dbac34e96c45d5b1a1c7988d8b26d7 rdf:first sg:person.016611052015.00
198 rdf:rest Nb6f215c840654547a1f9707c83b78278
199 Ne3ee4c62f1ca494f8042f11ba805909b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Receptors, G-Protein-Coupled
201 rdf:type schema:DefinedTerm
202 Ne8125666e67d47528d47407983e68d17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Insulin Resistance
204 rdf:type schema:DefinedTerm
205 Neab577e1588a424abdb6d7887c585bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name RNA, Messenger
207 rdf:type schema:DefinedTerm
208 Nf003e77dae8a4097b8339429ccb72961 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Membrane Proteins
210 rdf:type schema:DefinedTerm
211 Nf64e46ebb7f34c528c1cec7b28a06caa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Mice, Knockout
213 rdf:type schema:DefinedTerm
214 Nfcd3654ddb6c4704b335d50e49a977dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Inflammation
216 rdf:type schema:DefinedTerm
217 Nfe43034d646042faa171098687ab69c9 rdf:first sg:person.01171701243.84
218 rdf:rest N0d9f3bd0170f4b06be7045548c5ad707
219 Nfe7176a491754b908795f91480bae3ee schema:name pubmed_id
220 schema:value 25236782
221 rdf:type schema:PropertyValue
222 Nff1f94341c7c4c89a9b93b3158fcf61f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Male
224 rdf:type schema:DefinedTerm
225 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
226 schema:name Biological Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
229 schema:name Biochemistry and Cell Biology
230 rdf:type schema:DefinedTerm
231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
232 schema:name Medical and Health Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
235 schema:name Medical Physiology
236 rdf:type schema:DefinedTerm
237 sg:grant.6112845 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
238 rdf:type schema:MonetaryGrant
239 sg:grant.6113444 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
240 rdf:type schema:MonetaryGrant
241 sg:grant.6115800 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
242 rdf:type schema:MonetaryGrant
243 sg:grant.6125463 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
244 rdf:type schema:MonetaryGrant
245 sg:grant.6127900 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
246 rdf:type schema:MonetaryGrant
247 sg:grant.6135848 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
248 rdf:type schema:MonetaryGrant
249 sg:grant.6141892 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
250 rdf:type schema:MonetaryGrant
251 sg:grant.6146667 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
252 rdf:type schema:MonetaryGrant
253 sg:grant.6152343 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms5982
254 rdf:type schema:MonetaryGrant
255 sg:journal.1043282 schema:issn 2041-1723
256 schema:name Nature Communications
257 schema:publisher Springer Nature
258 rdf:type schema:Periodical
259 sg:person.01034644474.40 schema:affiliation grid-institutes:grid.265073.5
260 schema:familyName Ochi
261 schema:givenName Kozue
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034644474.40
263 rdf:type schema:Person
264 sg:person.01050444134.64 schema:affiliation grid-institutes:grid.265061.6
265 schema:familyName Inagaki
266 schema:givenName Yutaka
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050444134.64
268 rdf:type schema:Person
269 sg:person.01053527727.79 schema:affiliation grid-institutes:grid.265073.5
270 schema:familyName Ogawa
271 schema:givenName Yoshihiro
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053527727.79
273 rdf:type schema:Person
274 sg:person.01056260324.53 schema:affiliation grid-institutes:grid.265073.5
275 schema:familyName Shirakawa
276 schema:givenName Ibuki
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056260324.53
278 rdf:type schema:Person
279 sg:person.01072213550.95 schema:affiliation grid-institutes:grid.265073.5
280 schema:familyName Hamaguchi
281 schema:givenName Miho
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072213550.95
283 rdf:type schema:Person
284 sg:person.01077470252.62 schema:affiliation grid-institutes:grid.419082.6
285 schema:familyName Suganami
286 schema:givenName Takayoshi
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077470252.62
288 rdf:type schema:Person
289 sg:person.01113546445.02 schema:affiliation grid-institutes:grid.412426.7
290 schema:familyName Aoe
291 schema:givenName Seiichiro
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113546445.02
293 rdf:type schema:Person
294 sg:person.01171701243.84 schema:affiliation grid-institutes:grid.9707.9
295 schema:familyName Kimura
296 schema:givenName Kumi
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171701243.84
298 rdf:type schema:Person
299 sg:person.01172136364.37 schema:affiliation grid-institutes:grid.265073.5
300 schema:familyName Ikeda
301 schema:givenName Kenji
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172136364.37
303 rdf:type schema:Person
304 sg:person.01306364764.81 schema:affiliation grid-institutes:grid.265073.5
305 schema:familyName Komiya
306 schema:givenName Chikara
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306364764.81
308 rdf:type schema:Person
309 sg:person.013270564004.26 schema:affiliation grid-institutes:grid.265073.5
310 schema:familyName Tanaka
311 schema:givenName Miyako
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013270564004.26
313 rdf:type schema:Person
314 sg:person.016611052015.00 schema:affiliation grid-institutes:grid.177174.3
315 schema:familyName Yamasaki
316 schema:givenName Sho
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016611052015.00
318 rdf:type schema:Person
319 sg:person.0577123423.24 schema:affiliation grid-institutes:grid.26999.3d
320 schema:familyName Manabe
321 schema:givenName Ichiro
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577123423.24
323 rdf:type schema:Person
324 sg:person.07504546042.33 schema:affiliation grid-institutes:grid.410804.9
325 schema:familyName Nishimura
326 schema:givenName Satoshi
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07504546042.33
328 rdf:type schema:Person
329 sg:person.0757722527.61 schema:affiliation grid-institutes:grid.9707.9
330 schema:familyName Inoue
331 schema:givenName Hiroshi
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757722527.61
333 rdf:type schema:Person
334 sg:pub.10.1007/s11745-012-3696-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021282532
335 https://doi.org/10.1007/s11745-012-3696-8
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nature05485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042166283
338 https://doi.org/10.1038/nature05485
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nature10998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049858476
341 https://doi.org/10.1038/nature10998
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/ni.1651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010554833
344 https://doi.org/10.1038/ni.1651
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/nm.1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030679586
347 https://doi.org/10.1038/nm.1994
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/nm.2807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049248840
350 https://doi.org/10.1038/nm.2807
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/sj.ijo.0803632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053602749
353 https://doi.org/10.1038/sj.ijo.0803632
354 rdf:type schema:CreativeWork
355 grid-institutes:grid.177174.3 schema:alternateName Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan
356 schema:name Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, 812-8582, Fukuoka, Japan
357 rdf:type schema:Organization
358 grid-institutes:grid.265061.6 schema:alternateName Department of Regenerative Medicine, Center for Matrix Biology and Medicine, Tokai University School of Medicine, 259-1193, Isehara, Japan
359 schema:name Department of Regenerative Medicine, Center for Matrix Biology and Medicine, Tokai University School of Medicine, 259-1193, Isehara, Japan
360 rdf:type schema:Organization
361 grid-institutes:grid.265073.5 schema:alternateName Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
362 Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
363 schema:name Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
364 Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
365 rdf:type schema:Organization
366 grid-institutes:grid.26999.3d schema:alternateName Department of Cardiovascular Medicine, The University of Tokyo, 113-8655, Tokyo, Japan
367 schema:name Department of Cardiovascular Medicine, The University of Tokyo, 113-8655, Tokyo, Japan
368 rdf:type schema:Organization
369 grid-institutes:grid.410804.9 schema:alternateName Jichi Medical University, 329-0498, Tochigi, Japan
370 schema:name Department of Cardiovascular Medicine, The University of Tokyo, 113-8655, Tokyo, Japan
371 Jichi Medical University, 329-0498, Tochigi, Japan
372 Translational Systems Biology and Medicine Initiative, The University of Tokyo, 113-8655, Tokyo, Japan
373 rdf:type schema:Organization
374 grid-institutes:grid.412426.7 schema:alternateName Department of Home Economics, Otsuma Women’s University, 102-8357, Tokyo, Japan
375 schema:name Department of Home Economics, Otsuma Women’s University, 102-8357, Tokyo, Japan
376 rdf:type schema:Organization
377 grid-institutes:grid.419082.6 schema:alternateName Japan Science and Technology Agency, PRESTO, Tokyo, Japan
378 schema:name Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510, Tokyo, Japan
379 Japan Science and Technology Agency, PRESTO, Tokyo, Japan
380 rdf:type schema:Organization
381 grid-institutes:grid.419841.1 schema:alternateName Pharmaceutical Research Division, Takeda Pharmaceutical Company, 251-8555, Fujisawa, Japan
382 schema:name Pharmaceutical Research Division, Takeda Pharmaceutical Company, 251-8555, Fujisawa, Japan
383 rdf:type schema:Organization
384 grid-institutes:grid.9707.9 schema:alternateName Department of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, 920-8641, Kanazawa, Japan
385 schema:name Department of Physiology and Metabolism, Brain/Liver Interface Medicine Research Center, Kanazawa University, 920-8641, Kanazawa, Japan
386 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...