Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Hsiao-Fan Chen, Chi-Hung Huang, Chung-Ji Liu, Jung-Jyh Hung, Chih-Chin Hsu, Shu-Chun Teng, Kou-Juey Wu

ABSTRACT

The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-mesenchymal transition and further differentiate into endothelial cells remains unknown. Here we show that overexpression of Twist1, a transcriptional regulator that induces and promotes cancer metastasis, leads to endothelial differentiation in head and neck cancer (HNC) cells. Induction of Jagged1 expression by Twist1 is essential for Twist1-induced endothelial differentiation. The Jagged1/Notch signalling subsequently activates KLF4, inducing stem-like properties in HNC cells and conferring them with drug resistance. Our results indicate that the Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition. More... »

PAGES

4697

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms5697

DOI

http://dx.doi.org/10.1038/ncomms5697

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019707235

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25146389


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transdifferentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Jagged-1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kruppel-Like Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serrate-Jagged Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Twist-Related Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hsiao-Fan", 
        "id": "sg:person.0726033365.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726033365.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Taiwan Advance Biopharm (TABP), Inc., Xizhi City, New Taipei City 221, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Chi-Hung", 
        "id": "sg:person.01026322021.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026322021.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mackay Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413593.9", 
          "name": [
            "Department of Dentistry, Taipei Mackay Memorial Hospital, Taipei 104, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Chung-Ji", 
        "id": "sg:person.01220551666.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220551666.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taipei Veterans General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.278247.c", 
          "name": [
            "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan", 
            "Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Jung-Jyh", 
        "id": "sg:person.01320573410.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320573410.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Physical Medicine and Rehabilitation, ChangGung Memorial Hospital, Keelung 204, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Chih-Chin", 
        "id": "sg:person.01155303404.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155303404.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University", 
          "id": "https://www.grid.ac/institutes/grid.19188.39", 
          "name": [
            "Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teng", 
        "givenName": "Shu-Chun", 
        "id": "sg:person.0625070230.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625070230.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "China Medical University", 
          "id": "https://www.grid.ac/institutes/grid.254145.3", 
          "name": [
            "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan", 
            "Genome Research Center, National Yang-Ming University, Taipei 112, Taiwan", 
            "Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Kou-Juey", 
        "id": "sg:person.0616720636.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616720636.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.9.6.686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000566912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.185405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000991873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.185405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000991873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2010.11.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007099235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009606484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009671639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9215-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009793063", 
          "https://doi.org/10.1007/s10555-010-9215-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9215-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009793063", 
          "https://doi.org/10.1007/s10555-010-9215-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1016030108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010679739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013810124", 
          "https://doi.org/10.1038/nature09624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013810124", 
          "https://doi.org/10.1038/nature09624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017006433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fon.11.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017544742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017775126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019374287", 
          "https://doi.org/10.1038/nature09557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019374287", 
          "https://doi.org/10.1038/nature09557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.01.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020118238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021378301", 
          "https://doi.org/10.1038/onc.2008.227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024923159", 
          "https://doi.org/10.1038/onc.2010.591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025013851", 
          "https://doi.org/10.1038/nature03511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025013851", 
          "https://doi.org/10.1038/nature03511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026194864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.2.1026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027037015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2011.01859.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027680510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030755934", 
          "https://doi.org/10.1038/sj.onc.1207067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030755934", 
          "https://doi.org/10.1038/sj.onc.1207067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031152422", 
          "https://doi.org/10.1038/nm.2537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2013.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032482390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2010-s3-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034590948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1469-7580.2003.00137.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035152614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.080903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038530769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-08-0224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040632186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000165656.65359.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041173563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000165656.65359.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041173563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgt191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041950639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-3237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043069219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.607311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043829449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1734-1140(09)70004-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044437838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044693134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046589396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047692648", 
          "https://doi.org/10.1038/nature09229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047692648", 
          "https://doi.org/10.1038/nature09229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2012.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050205842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.0696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050930667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051063203", 
          "https://doi.org/10.1038/ncb1691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051068549", 
          "https://doi.org/10.1038/ncb1314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051068549", 
          "https://doi.org/10.1038/ncb1314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051331438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2010.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052529475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1358863x10371685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054069922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1358863x10371685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054069922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1062660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.7.14.6324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075255971", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075297605", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-mesenchymal transition and further differentiate into endothelial cells remains unknown. Here we show that overexpression of Twist1, a transcriptional regulator that induces and promotes cancer metastasis, leads to endothelial differentiation in head and neck cancer (HNC) cells. Induction of Jagged1 expression by Twist1 is essential for Twist1-induced endothelial differentiation. The Jagged1/Notch signalling subsequently activates KLF4, inducing stem-like properties in HNC cells and conferring them with drug resistance. Our results indicate that the Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms5697", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis", 
    "pagination": "4697", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5de5c6ff5cfe88a60fb5b756a0cf72c0de5b7995b3ca2ae9e00a4f91db82e40c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25146389"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms5697"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019707235"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms5697", 
      "https://app.dimensions.ai/details/publication/pub.1019707235"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms5697"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'


 

This table displays all metadata directly associated to this object as RDF triples.

374 TRIPLES      21 PREDICATES      100 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms5697 schema:about N1a4c2840c58545d3943b7aed31469269
2 N22d4a7e390ff49ad9a077e6f5f0ef5a6
3 N324bf33b74514558ab7692d3632b6a0d
4 N3a66a2a93c484e1bb67b93f4ec93bb81
5 N3f9348e2d8a44186934a7c4c896d916e
6 N485d4bc8f1704ebdac9660ba1edcbe36
7 N4b91b5001f774c6ab26be3bab254a5d7
8 N5008471382944da3a0f88e862fba7778
9 N57da80d3391c416fb930bc9e98b2c1c2
10 N79f9f5991ecc4ee1b79fc1367a34cf19
11 N7a1f061a6c334d3a8ff7fc6972aac586
12 N7f64cfa812ee48a0a0d1bbc3a92ba5d4
13 N92bd548d04794c3a82160bfd163e3981
14 Na0cba043c9864b4b8dd73e1256aadb4a
15 Na6c225dae7cb40dc9d6a9d1fd8cf17dc
16 Nb83c412fc1d04a268f3b9ffe9273d82e
17 Nc56819ad0be24380ada84cd6fea140e2
18 Nd5eef370dee443729e21ea506bfae70b
19 Ndace36230523482381993e5877cfab99
20 Ne1f535d6e22d47ea86a077fb2c502fd8
21 Ne979d91fc72149078d4183e2ba7fa500
22 Ned4bdce070ce4e298a11580d198584e1
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N9b68097f512a4309954f155c48b23da3
26 schema:citation sg:pub.10.1007/s10555-010-9215-6
27 sg:pub.10.1038/nature03511
28 sg:pub.10.1038/nature09229
29 sg:pub.10.1038/nature09557
30 sg:pub.10.1038/nature09624
31 sg:pub.10.1038/ncb1314
32 sg:pub.10.1038/ncb1691
33 sg:pub.10.1038/ncb2099
34 sg:pub.10.1038/nm.2537
35 sg:pub.10.1038/onc.2008.227
36 sg:pub.10.1038/onc.2010.591
37 sg:pub.10.1038/sj.onc.1207067
38 https://app.dimensions.ai/details/publication/pub.1075255971
39 https://app.dimensions.ai/details/publication/pub.1075297605
40 https://doi.org/10.1002/hep.23311
41 https://doi.org/10.1006/meth.2001.1262
42 https://doi.org/10.1016/j.ajpath.2010.11.021
43 https://doi.org/10.1016/j.ccr.2005.06.004
44 https://doi.org/10.1016/j.ccr.2012.12.021
45 https://doi.org/10.1016/j.cell.2006.01.040
46 https://doi.org/10.1016/j.cell.2009.11.007
47 https://doi.org/10.1016/j.cell.2011.02.013
48 https://doi.org/10.1016/j.ctrv.2013.09.006
49 https://doi.org/10.1016/j.molcel.2011.07.012
50 https://doi.org/10.1016/j.stem.2009.04.020
51 https://doi.org/10.1016/j.tig.2012.05.005
52 https://doi.org/10.1016/j.ydbio.2010.08.010
53 https://doi.org/10.1016/s1734-1140(09)70004-0
54 https://doi.org/10.1046/j.1469-7580.2003.00137.x
55 https://doi.org/10.1056/nejmoa033153
56 https://doi.org/10.1073/pnas.1016030108
57 https://doi.org/10.1074/jbc.273.2.1026
58 https://doi.org/10.1093/carcin/bgt191
59 https://doi.org/10.1101/gad.607311
60 https://doi.org/10.1101/gad.9.6.686
61 https://doi.org/10.1111/j.1349-7006.2011.01859.x
62 https://doi.org/10.1126/science.1062660
63 https://doi.org/10.1158/0008-5472.can-07-5953
64 https://doi.org/10.1158/1078-0432.ccr-11-3237
65 https://doi.org/10.1158/1541-7786.mcr-08-0224
66 https://doi.org/10.1161/01.atv.0000165656.65359.23
67 https://doi.org/10.1161/circresaha.108.185405
68 https://doi.org/10.1172/jci32086
69 https://doi.org/10.1177/1358863x10371685
70 https://doi.org/10.1200/jco.2006.09.0696
71 https://doi.org/10.1242/jcs.080903
72 https://doi.org/10.1634/theoncologist.2010-s3-03
73 https://doi.org/10.2217/fon.11.20
74 https://doi.org/10.4161/cc.7.14.6324
75 schema:datePublished 2014-12
76 schema:datePublishedReg 2014-12-01
77 schema:description The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-mesenchymal transition and further differentiate into endothelial cells remains unknown. Here we show that overexpression of Twist1, a transcriptional regulator that induces and promotes cancer metastasis, leads to endothelial differentiation in head and neck cancer (HNC) cells. Induction of Jagged1 expression by Twist1 is essential for Twist1-induced endothelial differentiation. The Jagged1/Notch signalling subsequently activates KLF4, inducing stem-like properties in HNC cells and conferring them with drug resistance. Our results indicate that the Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf N58fa5efced3b44359e3217712edc0347
82 Ne4c7dd44a82143f5949c054677dc9464
83 sg:journal.1043282
84 schema:name Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis
85 schema:pagination 4697
86 schema:productId N2c1036b1054745deb29274f15f62666c
87 N71bde7076e694c9d8538ccfc7ec9ca14
88 N9b53c533489743beb924c30068645243
89 N9e3a7401e5be403bbe9df2c000af3a03
90 Nb540135739fa40c9a8abcf573214fc3b
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019707235
92 https://doi.org/10.1038/ncomms5697
93 schema:sdDatePublished 2019-04-11T00:56
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N6116347203f14a969adb35f1937043f1
96 schema:url https://www.nature.com/articles/ncomms5697
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0015c532d4574d05b8037a508d94bb6d rdf:first sg:person.0616720636.34
101 rdf:rest rdf:nil
102 N1a4c2840c58545d3943b7aed31469269 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Intercellular Signaling Peptides and Proteins
104 rdf:type schema:DefinedTerm
105 N1de95743d0fb49d4a412e1972984c1e2 rdf:first sg:person.01320573410.54
106 rdf:rest N67918a537bab4b53ad2aead9e89ab63a
107 N22d4a7e390ff49ad9a077e6f5f0ef5a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N2c1036b1054745deb29274f15f62666c schema:name doi
111 schema:value 10.1038/ncomms5697
112 rdf:type schema:PropertyValue
113 N324bf33b74514558ab7692d3632b6a0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Jagged-1 Protein
115 rdf:type schema:DefinedTerm
116 N3a66a2a93c484e1bb67b93f4ec93bb81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Signal Transduction
118 rdf:type schema:DefinedTerm
119 N3f4b7c486dbd42aa9cc0b501db7f2593 schema:name Taiwan Advance Biopharm (TABP), Inc., Xizhi City, New Taipei City 221, Taiwan
120 rdf:type schema:Organization
121 N3f9348e2d8a44186934a7c4c896d916e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Membrane Proteins
123 rdf:type schema:DefinedTerm
124 N45aab452514d42de86ed8c29fbf0c9c1 rdf:first sg:person.01026322021.26
125 rdf:rest Nb74e98d6cbc94b838d91017190fae61e
126 N485d4bc8f1704ebdac9660ba1edcbe36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mice, Inbred BALB C
128 rdf:type schema:DefinedTerm
129 N4b91b5001f774c6ab26be3bab254a5d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 N5008471382944da3a0f88e862fba7778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Twist-Related Protein 1
134 rdf:type schema:DefinedTerm
135 N57da80d3391c416fb930bc9e98b2c1c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Movement
137 rdf:type schema:DefinedTerm
138 N58fa5efced3b44359e3217712edc0347 schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 N6116347203f14a969adb35f1937043f1 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 N67918a537bab4b53ad2aead9e89ab63a rdf:first sg:person.01155303404.12
143 rdf:rest Nd5f094e7079b48e2a72c34aa4aa00538
144 N71bde7076e694c9d8538ccfc7ec9ca14 schema:name nlm_unique_id
145 schema:value 101528555
146 rdf:type schema:PropertyValue
147 N79f9f5991ecc4ee1b79fc1367a34cf19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Line, Tumor
149 rdf:type schema:DefinedTerm
150 N7a1f061a6c334d3a8ff7fc6972aac586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Molecular Sequence Data
152 rdf:type schema:DefinedTerm
153 N7f64cfa812ee48a0a0d1bbc3a92ba5d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Neoplasms, Experimental
155 rdf:type schema:DefinedTerm
156 N8e8a74279d9648d2ba8ad73b4d8d01d5 schema:name Department of Physical Medicine and Rehabilitation, ChangGung Memorial Hospital, Keelung 204, Taiwan
157 rdf:type schema:Organization
158 N92bd548d04794c3a82160bfd163e3981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Kruppel-Like Transcription Factors
160 rdf:type schema:DefinedTerm
161 N9b53c533489743beb924c30068645243 schema:name pubmed_id
162 schema:value 25146389
163 rdf:type schema:PropertyValue
164 N9b68097f512a4309954f155c48b23da3 rdf:first sg:person.0726033365.24
165 rdf:rest N45aab452514d42de86ed8c29fbf0c9c1
166 N9e3a7401e5be403bbe9df2c000af3a03 schema:name dimensions_id
167 schema:value pub.1019707235
168 rdf:type schema:PropertyValue
169 Na0cba043c9864b4b8dd73e1256aadb4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Nuclear Proteins
171 rdf:type schema:DefinedTerm
172 Na6c225dae7cb40dc9d6a9d1fd8cf17dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Calcium-Binding Proteins
174 rdf:type schema:DefinedTerm
175 Nb540135739fa40c9a8abcf573214fc3b schema:name readcube_id
176 schema:value 5de5c6ff5cfe88a60fb5b756a0cf72c0de5b7995b3ca2ae9e00a4f91db82e40c
177 rdf:type schema:PropertyValue
178 Nb74e98d6cbc94b838d91017190fae61e rdf:first sg:person.01220551666.34
179 rdf:rest N1de95743d0fb49d4a412e1972984c1e2
180 Nb83c412fc1d04a268f3b9ffe9273d82e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Endothelial Cells
182 rdf:type schema:DefinedTerm
183 Nc56819ad0be24380ada84cd6fea140e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Cell Transdifferentiation
185 rdf:type schema:DefinedTerm
186 Nd5eef370dee443729e21ea506bfae70b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Humans
188 rdf:type schema:DefinedTerm
189 Nd5f094e7079b48e2a72c34aa4aa00538 rdf:first sg:person.0625070230.36
190 rdf:rest N0015c532d4574d05b8037a508d94bb6d
191 Ndace36230523482381993e5877cfab99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Drug Resistance, Neoplasm
193 rdf:type schema:DefinedTerm
194 Ne1f535d6e22d47ea86a077fb2c502fd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Serrate-Jagged Proteins
196 rdf:type schema:DefinedTerm
197 Ne4c7dd44a82143f5949c054677dc9464 schema:volumeNumber 5
198 rdf:type schema:PublicationVolume
199 Ne979d91fc72149078d4183e2ba7fa500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Cell Differentiation
201 rdf:type schema:DefinedTerm
202 Ned4bdce070ce4e298a11580d198584e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Xenograft Model Antitumor Assays
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
209 schema:name Oncology and Carcinogenesis
210 rdf:type schema:DefinedTerm
211 sg:journal.1043282 schema:issn 2041-1723
212 schema:name Nature Communications
213 rdf:type schema:Periodical
214 sg:person.01026322021.26 schema:affiliation N3f4b7c486dbd42aa9cc0b501db7f2593
215 schema:familyName Huang
216 schema:givenName Chi-Hung
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026322021.26
218 rdf:type schema:Person
219 sg:person.01155303404.12 schema:affiliation N8e8a74279d9648d2ba8ad73b4d8d01d5
220 schema:familyName Hsu
221 schema:givenName Chih-Chin
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155303404.12
223 rdf:type schema:Person
224 sg:person.01220551666.34 schema:affiliation https://www.grid.ac/institutes/grid.413593.9
225 schema:familyName Liu
226 schema:givenName Chung-Ji
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220551666.34
228 rdf:type schema:Person
229 sg:person.01320573410.54 schema:affiliation https://www.grid.ac/institutes/grid.278247.c
230 schema:familyName Hung
231 schema:givenName Jung-Jyh
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320573410.54
233 rdf:type schema:Person
234 sg:person.0616720636.34 schema:affiliation https://www.grid.ac/institutes/grid.254145.3
235 schema:familyName Wu
236 schema:givenName Kou-Juey
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616720636.34
238 rdf:type schema:Person
239 sg:person.0625070230.36 schema:affiliation https://www.grid.ac/institutes/grid.19188.39
240 schema:familyName Teng
241 schema:givenName Shu-Chun
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625070230.36
243 rdf:type schema:Person
244 sg:person.0726033365.24 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
245 schema:familyName Chen
246 schema:givenName Hsiao-Fan
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726033365.24
248 rdf:type schema:Person
249 sg:pub.10.1007/s10555-010-9215-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009793063
250 https://doi.org/10.1007/s10555-010-9215-6
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nature03511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025013851
253 https://doi.org/10.1038/nature03511
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature09229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047692648
256 https://doi.org/10.1038/nature09229
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature09557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019374287
259 https://doi.org/10.1038/nature09557
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature09624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013810124
262 https://doi.org/10.1038/nature09624
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ncb1314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051068549
265 https://doi.org/10.1038/ncb1314
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/ncb1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051063203
268 https://doi.org/10.1038/ncb1691
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/ncb2099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046795596
271 https://doi.org/10.1038/ncb2099
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nm.2537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031152422
274 https://doi.org/10.1038/nm.2537
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/onc.2008.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021378301
277 https://doi.org/10.1038/onc.2008.227
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/onc.2010.591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024923159
280 https://doi.org/10.1038/onc.2010.591
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/sj.onc.1207067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030755934
283 https://doi.org/10.1038/sj.onc.1207067
284 rdf:type schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1075255971 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1075297605 schema:CreativeWork
287 https://doi.org/10.1002/hep.23311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009606484
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.ajpath.2010.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007099235
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.ccr.2005.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009671639
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.ccr.2012.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046589396
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.cell.2006.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020118238
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.cell.2009.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017006433
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.ctrv.2013.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032482390
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.molcel.2011.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051331438
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.stem.2009.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044693134
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.tig.2012.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050205842
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.ydbio.2010.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052529475
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s1734-1140(09)70004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044437838
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1046/j.1469-7580.2003.00137.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035152614
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1056/nejmoa033153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026194864
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1073/pnas.1016030108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010679739
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1074/jbc.273.2.1026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027037015
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/carcin/bgt191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041950639
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1101/gad.607311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043829449
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1101/gad.9.6.686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000566912
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1111/j.1349-7006.2011.01859.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027680510
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/science.1062660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445237
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/0008-5472.can-07-5953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017775126
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/1078-0432.ccr-11-3237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043069219
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/1541-7786.mcr-08-0224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040632186
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1161/01.atv.0000165656.65359.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041173563
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/circresaha.108.185405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000991873
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1172/jci32086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416957
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1177/1358863x10371685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054069922
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1200/jco.2006.09.0696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050930667
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1242/jcs.080903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038530769
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1634/theoncologist.2010-s3-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034590948
352 rdf:type schema:CreativeWork
353 https://doi.org/10.2217/fon.11.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017544742
354 rdf:type schema:CreativeWork
355 https://doi.org/10.4161/cc.7.14.6324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299562
356 rdf:type schema:CreativeWork
357 https://www.grid.ac/institutes/grid.19188.39 schema:alternateName National Taiwan University
358 schema:name Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.254145.3 schema:alternateName China Medical University
361 schema:name Genome Research Center, National Yang-Ming University, Taipei 112, Taiwan
362 Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
363 Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.260770.4 schema:alternateName National Yang Ming University
366 schema:name Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.278247.c schema:alternateName Taipei Veterans General Hospital
369 schema:name Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan
370 Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.413593.9 schema:alternateName Mackay Memorial Hospital
373 schema:name Department of Dentistry, Taipei Mackay Memorial Hospital, Taipei 104, Taiwan
374 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...