Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Hsiao-Fan Chen, Chi-Hung Huang, Chung-Ji Liu, Jung-Jyh Hung, Chih-Chin Hsu, Shu-Chun Teng, Kou-Juey Wu

ABSTRACT

The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-mesenchymal transition and further differentiate into endothelial cells remains unknown. Here we show that overexpression of Twist1, a transcriptional regulator that induces and promotes cancer metastasis, leads to endothelial differentiation in head and neck cancer (HNC) cells. Induction of Jagged1 expression by Twist1 is essential for Twist1-induced endothelial differentiation. The Jagged1/Notch signalling subsequently activates KLF4, inducing stem-like properties in HNC cells and conferring them with drug resistance. Our results indicate that the Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition. More... »

PAGES

4697

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms5697

DOI

http://dx.doi.org/10.1038/ncomms5697

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019707235

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25146389


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transdifferentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Jagged-1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kruppel-Like Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serrate-Jagged Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Twist-Related Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hsiao-Fan", 
        "id": "sg:person.0726033365.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726033365.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Taiwan Advance Biopharm (TABP), Inc., Xizhi City, New Taipei City 221, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Chi-Hung", 
        "id": "sg:person.01026322021.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026322021.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mackay Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413593.9", 
          "name": [
            "Department of Dentistry, Taipei Mackay Memorial Hospital, Taipei 104, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Chung-Ji", 
        "id": "sg:person.01220551666.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220551666.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taipei Veterans General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.278247.c", 
          "name": [
            "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan", 
            "Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Jung-Jyh", 
        "id": "sg:person.01320573410.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320573410.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Physical Medicine and Rehabilitation, ChangGung Memorial Hospital, Keelung 204, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Chih-Chin", 
        "id": "sg:person.01155303404.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155303404.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University", 
          "id": "https://www.grid.ac/institutes/grid.19188.39", 
          "name": [
            "Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teng", 
        "givenName": "Shu-Chun", 
        "id": "sg:person.0625070230.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625070230.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "China Medical University", 
          "id": "https://www.grid.ac/institutes/grid.254145.3", 
          "name": [
            "Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan", 
            "Genome Research Center, National Yang-Ming University, Taipei 112, Taiwan", 
            "Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Kou-Juey", 
        "id": "sg:person.0616720636.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616720636.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.9.6.686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000566912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.185405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000991873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.185405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000991873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2010.11.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007099235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009606484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009671639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9215-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009793063", 
          "https://doi.org/10.1007/s10555-010-9215-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9215-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009793063", 
          "https://doi.org/10.1007/s10555-010-9215-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1016030108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010679739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013810124", 
          "https://doi.org/10.1038/nature09624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013810124", 
          "https://doi.org/10.1038/nature09624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017006433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fon.11.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017544742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017775126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019374287", 
          "https://doi.org/10.1038/nature09557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019374287", 
          "https://doi.org/10.1038/nature09557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.01.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020118238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021378301", 
          "https://doi.org/10.1038/onc.2008.227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024923159", 
          "https://doi.org/10.1038/onc.2010.591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025013851", 
          "https://doi.org/10.1038/nature03511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025013851", 
          "https://doi.org/10.1038/nature03511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026194864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.2.1026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027037015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2011.01859.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027680510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030755934", 
          "https://doi.org/10.1038/sj.onc.1207067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030755934", 
          "https://doi.org/10.1038/sj.onc.1207067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031152422", 
          "https://doi.org/10.1038/nm.2537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2013.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032482390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2010-s3-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034590948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1469-7580.2003.00137.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035152614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.080903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038530769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-08-0224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040632186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000165656.65359.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041173563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000165656.65359.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041173563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgt191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041950639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-3237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043069219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.607311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043829449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1734-1140(09)70004-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044437838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044693134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046589396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046795596", 
          "https://doi.org/10.1038/ncb2099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047692648", 
          "https://doi.org/10.1038/nature09229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047692648", 
          "https://doi.org/10.1038/nature09229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2012.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050205842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.0696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050930667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051063203", 
          "https://doi.org/10.1038/ncb1691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051068549", 
          "https://doi.org/10.1038/ncb1314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051068549", 
          "https://doi.org/10.1038/ncb1314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.07.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051331438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2010.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052529475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1358863x10371685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054069922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1358863x10371685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054069922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1062660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.7.14.6324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075255971", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075297605", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-mesenchymal transition and further differentiate into endothelial cells remains unknown. Here we show that overexpression of Twist1, a transcriptional regulator that induces and promotes cancer metastasis, leads to endothelial differentiation in head and neck cancer (HNC) cells. Induction of Jagged1 expression by Twist1 is essential for Twist1-induced endothelial differentiation. The Jagged1/Notch signalling subsequently activates KLF4, inducing stem-like properties in HNC cells and conferring them with drug resistance. Our results indicate that the Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms5697", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis", 
    "pagination": "4697", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5de5c6ff5cfe88a60fb5b756a0cf72c0de5b7995b3ca2ae9e00a4f91db82e40c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25146389"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms5697"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019707235"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms5697", 
      "https://app.dimensions.ai/details/publication/pub.1019707235"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms5697"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms5697'


 

This table displays all metadata directly associated to this object as RDF triples.

374 TRIPLES      21 PREDICATES      100 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms5697 schema:about N0de90c58ff5648509226c8daea0fd544
2 N1785bbce869d4fdaa9988e4d52fc60dd
3 N1ceb20094b6b4518abd966b54e0df754
4 N1f2dca9e41364df2a1351b452916bb2d
5 N201aa92180b44aad8f1df8cc24e60dc6
6 N227e7f4a341845148200b7aa12aa622b
7 N3e72a16b170d4765b9e85771224fe5e0
8 N4b84a1eddec84edda352922be6890041
9 N5f755eab879544dc8b5ee0051949decd
10 N61877fb66e124aa1be8725b891cc2ccd
11 N62a0aa3c558c4361a245b2bb57009222
12 N72335321a8a54356b8cb829d10664aa2
13 N7966f39467b8411e8e5e7ac9f5549e6a
14 Na12f30f960aa428eb73c70229a49b02c
15 Naaed350045fe46fe8538fa6e513f3675
16 Naf3151c732a24f6289974ad14b568d48
17 Nb2a21fc4998e46d18443b23876cb3a41
18 Nbeab2836106c4bc0b57c61147ae459fd
19 Nd27ff22855634d17956cdd9951fa6d0d
20 Ne4bd3fff17624f73990da6afec259c5d
21 Neac2dc08ac604b0bbf5e2a287cffbf75
22 Nf7dbb53e52504a0d9584e8789ce4b1b1
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N1dad9c065b4f41a8b89e8d4e29b61303
26 schema:citation sg:pub.10.1007/s10555-010-9215-6
27 sg:pub.10.1038/nature03511
28 sg:pub.10.1038/nature09229
29 sg:pub.10.1038/nature09557
30 sg:pub.10.1038/nature09624
31 sg:pub.10.1038/ncb1314
32 sg:pub.10.1038/ncb1691
33 sg:pub.10.1038/ncb2099
34 sg:pub.10.1038/nm.2537
35 sg:pub.10.1038/onc.2008.227
36 sg:pub.10.1038/onc.2010.591
37 sg:pub.10.1038/sj.onc.1207067
38 https://app.dimensions.ai/details/publication/pub.1075255971
39 https://app.dimensions.ai/details/publication/pub.1075297605
40 https://doi.org/10.1002/hep.23311
41 https://doi.org/10.1006/meth.2001.1262
42 https://doi.org/10.1016/j.ajpath.2010.11.021
43 https://doi.org/10.1016/j.ccr.2005.06.004
44 https://doi.org/10.1016/j.ccr.2012.12.021
45 https://doi.org/10.1016/j.cell.2006.01.040
46 https://doi.org/10.1016/j.cell.2009.11.007
47 https://doi.org/10.1016/j.cell.2011.02.013
48 https://doi.org/10.1016/j.ctrv.2013.09.006
49 https://doi.org/10.1016/j.molcel.2011.07.012
50 https://doi.org/10.1016/j.stem.2009.04.020
51 https://doi.org/10.1016/j.tig.2012.05.005
52 https://doi.org/10.1016/j.ydbio.2010.08.010
53 https://doi.org/10.1016/s1734-1140(09)70004-0
54 https://doi.org/10.1046/j.1469-7580.2003.00137.x
55 https://doi.org/10.1056/nejmoa033153
56 https://doi.org/10.1073/pnas.1016030108
57 https://doi.org/10.1074/jbc.273.2.1026
58 https://doi.org/10.1093/carcin/bgt191
59 https://doi.org/10.1101/gad.607311
60 https://doi.org/10.1101/gad.9.6.686
61 https://doi.org/10.1111/j.1349-7006.2011.01859.x
62 https://doi.org/10.1126/science.1062660
63 https://doi.org/10.1158/0008-5472.can-07-5953
64 https://doi.org/10.1158/1078-0432.ccr-11-3237
65 https://doi.org/10.1158/1541-7786.mcr-08-0224
66 https://doi.org/10.1161/01.atv.0000165656.65359.23
67 https://doi.org/10.1161/circresaha.108.185405
68 https://doi.org/10.1172/jci32086
69 https://doi.org/10.1177/1358863x10371685
70 https://doi.org/10.1200/jco.2006.09.0696
71 https://doi.org/10.1242/jcs.080903
72 https://doi.org/10.1634/theoncologist.2010-s3-03
73 https://doi.org/10.2217/fon.11.20
74 https://doi.org/10.4161/cc.7.14.6324
75 schema:datePublished 2014-12
76 schema:datePublishedReg 2014-12-01
77 schema:description The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-mesenchymal transition and further differentiate into endothelial cells remains unknown. Here we show that overexpression of Twist1, a transcriptional regulator that induces and promotes cancer metastasis, leads to endothelial differentiation in head and neck cancer (HNC) cells. Induction of Jagged1 expression by Twist1 is essential for Twist1-induced endothelial differentiation. The Jagged1/Notch signalling subsequently activates KLF4, inducing stem-like properties in HNC cells and conferring them with drug resistance. Our results indicate that the Twist1-Jagged1/KLF4 axis is essential both for transdifferentiation of tumour cells into endothelial cells and for chemoresistance acquisition.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf N677088a10232428cb1124ad6f0c6693f
82 N924c6235baf04dcda6fee1779da4757f
83 sg:journal.1043282
84 schema:name Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis
85 schema:pagination 4697
86 schema:productId N34422dc5071f48279eeece3a815b5dab
87 N61ecb1065c4e43c8b5338948fc1e5bdb
88 N70027be086b6445ba41f442c83981fd6
89 N943129e3318d494996e51c0a0efa744b
90 Nd0b18a993f4f417a9902a81ffbe1fa1b
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019707235
92 https://doi.org/10.1038/ncomms5697
93 schema:sdDatePublished 2019-04-11T00:56
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Nbd01ee1f466747edb8d9f5a5575a3a08
96 schema:url https://www.nature.com/articles/ncomms5697
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0dbf8defa99c45ab922794a22d2edbe6 rdf:first sg:person.0616720636.34
101 rdf:rest rdf:nil
102 N0de90c58ff5648509226c8daea0fd544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mice, Inbred BALB C
104 rdf:type schema:DefinedTerm
105 N17580e526891400faa7c84d13e467165 rdf:first sg:person.01320573410.54
106 rdf:rest Nb3d6bde880f548f79267f3820c5ffc54
107 N1785bbce869d4fdaa9988e4d52fc60dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Membrane Proteins
109 rdf:type schema:DefinedTerm
110 N1ceb20094b6b4518abd966b54e0df754 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Twist-Related Protein 1
112 rdf:type schema:DefinedTerm
113 N1dad9c065b4f41a8b89e8d4e29b61303 rdf:first sg:person.0726033365.24
114 rdf:rest Ne10eea544d8741e7a315c6dd01e9cb3f
115 N1f2dca9e41364df2a1351b452916bb2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Molecular Sequence Data
117 rdf:type schema:DefinedTerm
118 N201aa92180b44aad8f1df8cc24e60dc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Signal Transduction
120 rdf:type schema:DefinedTerm
121 N227e7f4a341845148200b7aa12aa622b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Endothelial Cells
123 rdf:type schema:DefinedTerm
124 N2729672454ab453dbcff993720f2edea rdf:first sg:person.01220551666.34
125 rdf:rest N17580e526891400faa7c84d13e467165
126 N34422dc5071f48279eeece3a815b5dab schema:name doi
127 schema:value 10.1038/ncomms5697
128 rdf:type schema:PropertyValue
129 N3e72a16b170d4765b9e85771224fe5e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Movement
131 rdf:type schema:DefinedTerm
132 N4b84a1eddec84edda352922be6890041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Calcium-Binding Proteins
134 rdf:type schema:DefinedTerm
135 N5a8b79271d384bb0a3ed88d9181b7ad8 schema:name Taiwan Advance Biopharm (TABP), Inc., Xizhi City, New Taipei City 221, Taiwan
136 rdf:type schema:Organization
137 N5f755eab879544dc8b5ee0051949decd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Jagged-1 Protein
139 rdf:type schema:DefinedTerm
140 N61877fb66e124aa1be8725b891cc2ccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Drug Resistance, Neoplasm
142 rdf:type schema:DefinedTerm
143 N61ecb1065c4e43c8b5338948fc1e5bdb schema:name pubmed_id
144 schema:value 25146389
145 rdf:type schema:PropertyValue
146 N62a0aa3c558c4361a245b2bb57009222 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cell Transdifferentiation
148 rdf:type schema:DefinedTerm
149 N677088a10232428cb1124ad6f0c6693f schema:volumeNumber 5
150 rdf:type schema:PublicationVolume
151 N68cbca103082401f9d84e362d78200a5 schema:name Department of Physical Medicine and Rehabilitation, ChangGung Memorial Hospital, Keelung 204, Taiwan
152 rdf:type schema:Organization
153 N70027be086b6445ba41f442c83981fd6 schema:name dimensions_id
154 schema:value pub.1019707235
155 rdf:type schema:PropertyValue
156 N72335321a8a54356b8cb829d10664aa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Xenograft Model Antitumor Assays
158 rdf:type schema:DefinedTerm
159 N7966f39467b8411e8e5e7ac9f5549e6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Intercellular Signaling Peptides and Proteins
161 rdf:type schema:DefinedTerm
162 N924c6235baf04dcda6fee1779da4757f schema:issueNumber 1
163 rdf:type schema:PublicationIssue
164 N943129e3318d494996e51c0a0efa744b schema:name readcube_id
165 schema:value 5de5c6ff5cfe88a60fb5b756a0cf72c0de5b7995b3ca2ae9e00a4f91db82e40c
166 rdf:type schema:PropertyValue
167 Na12f30f960aa428eb73c70229a49b02c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Nuclear Proteins
169 rdf:type schema:DefinedTerm
170 Naaed350045fe46fe8538fa6e513f3675 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Neoplasms, Experimental
172 rdf:type schema:DefinedTerm
173 Naf3151c732a24f6289974ad14b568d48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Female
175 rdf:type schema:DefinedTerm
176 Nb2a21fc4998e46d18443b23876cb3a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Humans
178 rdf:type schema:DefinedTerm
179 Nb3d6bde880f548f79267f3820c5ffc54 rdf:first sg:person.01155303404.12
180 rdf:rest Nf3e6689ff1ca4211a472fd8950cdf51d
181 Nbd01ee1f466747edb8d9f5a5575a3a08 schema:name Springer Nature - SN SciGraph project
182 rdf:type schema:Organization
183 Nbeab2836106c4bc0b57c61147ae459fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Serrate-Jagged Proteins
185 rdf:type schema:DefinedTerm
186 Nd0b18a993f4f417a9902a81ffbe1fa1b schema:name nlm_unique_id
187 schema:value 101528555
188 rdf:type schema:PropertyValue
189 Nd27ff22855634d17956cdd9951fa6d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Kruppel-Like Transcription Factors
191 rdf:type schema:DefinedTerm
192 Ne10eea544d8741e7a315c6dd01e9cb3f rdf:first sg:person.01026322021.26
193 rdf:rest N2729672454ab453dbcff993720f2edea
194 Ne4bd3fff17624f73990da6afec259c5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Animals
196 rdf:type schema:DefinedTerm
197 Neac2dc08ac604b0bbf5e2a287cffbf75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cell Line, Tumor
199 rdf:type schema:DefinedTerm
200 Nf3e6689ff1ca4211a472fd8950cdf51d rdf:first sg:person.0625070230.36
201 rdf:rest N0dbf8defa99c45ab922794a22d2edbe6
202 Nf7dbb53e52504a0d9584e8789ce4b1b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Cell Differentiation
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
209 schema:name Oncology and Carcinogenesis
210 rdf:type schema:DefinedTerm
211 sg:journal.1043282 schema:issn 2041-1723
212 schema:name Nature Communications
213 rdf:type schema:Periodical
214 sg:person.01026322021.26 schema:affiliation N5a8b79271d384bb0a3ed88d9181b7ad8
215 schema:familyName Huang
216 schema:givenName Chi-Hung
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026322021.26
218 rdf:type schema:Person
219 sg:person.01155303404.12 schema:affiliation N68cbca103082401f9d84e362d78200a5
220 schema:familyName Hsu
221 schema:givenName Chih-Chin
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155303404.12
223 rdf:type schema:Person
224 sg:person.01220551666.34 schema:affiliation https://www.grid.ac/institutes/grid.413593.9
225 schema:familyName Liu
226 schema:givenName Chung-Ji
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220551666.34
228 rdf:type schema:Person
229 sg:person.01320573410.54 schema:affiliation https://www.grid.ac/institutes/grid.278247.c
230 schema:familyName Hung
231 schema:givenName Jung-Jyh
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320573410.54
233 rdf:type schema:Person
234 sg:person.0616720636.34 schema:affiliation https://www.grid.ac/institutes/grid.254145.3
235 schema:familyName Wu
236 schema:givenName Kou-Juey
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616720636.34
238 rdf:type schema:Person
239 sg:person.0625070230.36 schema:affiliation https://www.grid.ac/institutes/grid.19188.39
240 schema:familyName Teng
241 schema:givenName Shu-Chun
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625070230.36
243 rdf:type schema:Person
244 sg:person.0726033365.24 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
245 schema:familyName Chen
246 schema:givenName Hsiao-Fan
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726033365.24
248 rdf:type schema:Person
249 sg:pub.10.1007/s10555-010-9215-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009793063
250 https://doi.org/10.1007/s10555-010-9215-6
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nature03511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025013851
253 https://doi.org/10.1038/nature03511
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature09229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047692648
256 https://doi.org/10.1038/nature09229
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature09557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019374287
259 https://doi.org/10.1038/nature09557
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nature09624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013810124
262 https://doi.org/10.1038/nature09624
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ncb1314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051068549
265 https://doi.org/10.1038/ncb1314
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/ncb1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051063203
268 https://doi.org/10.1038/ncb1691
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/ncb2099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046795596
271 https://doi.org/10.1038/ncb2099
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nm.2537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031152422
274 https://doi.org/10.1038/nm.2537
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/onc.2008.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021378301
277 https://doi.org/10.1038/onc.2008.227
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/onc.2010.591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024923159
280 https://doi.org/10.1038/onc.2010.591
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/sj.onc.1207067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030755934
283 https://doi.org/10.1038/sj.onc.1207067
284 rdf:type schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1075255971 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1075297605 schema:CreativeWork
287 https://doi.org/10.1002/hep.23311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009606484
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.ajpath.2010.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007099235
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.ccr.2005.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009671639
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.ccr.2012.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046589396
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.cell.2006.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020118238
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.cell.2009.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017006433
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.ctrv.2013.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032482390
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.molcel.2011.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051331438
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.stem.2009.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044693134
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.tig.2012.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050205842
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.ydbio.2010.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052529475
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s1734-1140(09)70004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044437838
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1046/j.1469-7580.2003.00137.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035152614
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1056/nejmoa033153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026194864
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1073/pnas.1016030108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010679739
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1074/jbc.273.2.1026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027037015
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/carcin/bgt191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041950639
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1101/gad.607311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043829449
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1101/gad.9.6.686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000566912
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1111/j.1349-7006.2011.01859.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027680510
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1126/science.1062660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445237
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/0008-5472.can-07-5953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017775126
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/1078-0432.ccr-11-3237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043069219
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/1541-7786.mcr-08-0224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040632186
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1161/01.atv.0000165656.65359.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041173563
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/circresaha.108.185405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000991873
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1172/jci32086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416957
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1177/1358863x10371685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054069922
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1200/jco.2006.09.0696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050930667
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1242/jcs.080903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038530769
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1634/theoncologist.2010-s3-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034590948
352 rdf:type schema:CreativeWork
353 https://doi.org/10.2217/fon.11.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017544742
354 rdf:type schema:CreativeWork
355 https://doi.org/10.4161/cc.7.14.6324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299562
356 rdf:type schema:CreativeWork
357 https://www.grid.ac/institutes/grid.19188.39 schema:alternateName National Taiwan University
358 schema:name Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.254145.3 schema:alternateName China Medical University
361 schema:name Genome Research Center, National Yang-Ming University, Taipei 112, Taiwan
362 Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
363 Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.260770.4 schema:alternateName National Yang Ming University
366 schema:name Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.278247.c schema:alternateName Taipei Veterans General Hospital
369 schema:name Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan
370 Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.413593.9 schema:alternateName Mackay Memorial Hospital
373 schema:name Department of Dentistry, Taipei Mackay Memorial Hospital, Taipei 104, Taiwan
374 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...