Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06-30

AUTHORS

Daniela Piazzolla, Adelaida R. Palla, Cristina Pantoja, Marta Cañamero, Ignacio Perez de Castro, Sagrario Ortega, Gonzalo Gómez-López, Orlando Dominguez, Diego Megías, Giovanna Roncador, Jose L. Luque-Garcia, Beatriz Fernandez-Tresguerres, Agustin F. Fernandez, Mario F. Fraga, Manuel Rodriguez-Justo, Miguel Manzanares, Marta Sánchez-Carbayo, Juana María García-Pedrero, Juan P. Rodrigo, Marcos Malumbres, Manuel Serrano

ABSTRACT

NANOG is a pluripotency transcription factor in embryonic stem cells; however, its role in adult tissues remains largely unexplored. Here we show that mouse NANOG is selectively expressed in stratified epithelia, most notably in the oesophagus where the Nanog promoter is hypomethylated. Interestingly, inducible ubiquitous overexpression of NANOG in mice causes hyperplasia selectively in the oesophagus, in association with increased cell proliferation. NANOG transcriptionally activates the mitotic programme, including Aurora A kinase (Aurka), in stratified epithelia, and endogenous NANOG directly binds to the Aurka promoter in primary keratinocytes. Interestingly, overexpression of Nanog or Aurka in mice increased proliferation and aneuploidy in the oesophageal basal epithelium. Finally, inactivation of NANOG in cell lines from oesophageal or head and neck squamous cell carcinomas (ESCCs or HNSCCs, respectively) results in lower levels of AURKA and decreased proliferation, and NANOG and AURKA expression are positively correlated in HNSCCs. Together, these results indicate that NANOG has a lineage-restricted mitogenic function in stratified epithelia. More... »

PAGES

4226

References to SciGraph publications

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  • Journal

    TITLE

    Nature Communications

    ISSUE

    1

    VOLUME

    5

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms5226

    DOI

    http://dx.doi.org/10.1038/ncomms5226

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023606673

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24979572


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