Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Helena C. Parkington, Janet Stevenson, Mary A. Tonta, Jonathan Paul, Trent Butler, Kaushik Maiti, Eng-Cheng Chan, Penelope M. Sheehan, Shaun P. Brennecke, Harold A. Coleman, Roger Smith

ABSTRACT

Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (α-conducting and β-inhibitory subunits) and hERG currents exist in isolated patch-clamped human myometrial cells. We show that hERG channel activity suppresses contraction amplitude and duration before labour, thereby facilitating quiescence. During established labour, expression of β-inhibitory protein is markedly enhanced, resulting in reduced hERG activity that is associated with an increased duration of uterine action potentials and contractions. Thus, changes in hERG channel activity contribute to electrophysiological mechanisms that produce contractions during labour. We also demonstrate that this system fails in women with elevated BMI, who have enhanced hERG activity as a result of low β-inhibitory protein expression, which likely contributes to the weak contractions and poor labour outcomes observed in many obese women necessitating caesarean delivery. More... »

PAGES

4108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms5108

DOI

http://dx.doi.org/10.1038/ncomms5108

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035065221

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24937480


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Action Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ether-A-Go-Go Potassium Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myometrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patch-Clamp Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channels, Voltage-Gated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uterine Contraction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Physiology, Monash University, Clayton, Victoria 3800, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parkington", 
        "givenName": "Helena C.", 
        "id": "sg:person.01177403576.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177403576.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416259.d", 
          "name": [
            "Department of Perinatal Medicine Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, Victoria 3052, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stevenson", 
        "givenName": "Janet", 
        "id": "sg:person.0630152403.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630152403.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Physiology, Monash University, Clayton, Victoria 3800, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tonta", 
        "givenName": "Mary A.", 
        "id": "sg:person.0647357610.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647357610.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Newcastle Australia", 
          "id": "https://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "Mothers and Babies Research Centre, University of Newcastle, Callaghan, New South Wales 2308, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paul", 
        "givenName": "Jonathan", 
        "id": "sg:person.01320454664.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320454664.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Newcastle Australia", 
          "id": "https://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "Mothers and Babies Research Centre, University of Newcastle, Callaghan, New South Wales 2308, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Butler", 
        "givenName": "Trent", 
        "id": "sg:person.01235267626.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235267626.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Newcastle Australia", 
          "id": "https://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "Mothers and Babies Research Centre, University of Newcastle, Callaghan, New South Wales 2308, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maiti", 
        "givenName": "Kaushik", 
        "id": "sg:person.0752216526.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752216526.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Newcastle Australia", 
          "id": "https://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "Mothers and Babies Research Centre, University of Newcastle, Callaghan, New South Wales 2308, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Eng-Cheng", 
        "id": "sg:person.01264062341.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264062341.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416259.d", 
          "name": [
            "Department of Perinatal Medicine Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, Victoria 3052, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sheehan", 
        "givenName": "Penelope M.", 
        "id": "sg:person.01240226405.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240226405.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Perinatal Medicine Pregnancy Research Centre, Royal Women\u2019s Hospital, Parkville, Victoria 3052, Australia", 
            "Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria 3010, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennecke", 
        "givenName": "Shaun P.", 
        "id": "sg:person.01313042233.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313042233.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Department of Physiology, Monash University, Clayton, Victoria 3800, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coleman", 
        "givenName": "Harold A.", 
        "id": "sg:person.0612752677.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612752677.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Newcastle Australia", 
          "id": "https://www.grid.ac/institutes/grid.266842.c", 
          "name": [
            "Mothers and Babies Research Centre, University of Newcastle, Callaghan, New South Wales 2308, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Roger", 
        "id": "sg:person.01371611016.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371611016.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1085/jgp.201210826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002222457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2004.070615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002423819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra061360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003145454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2012.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003180943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00142.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003269052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00099.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005433184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00965.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006177808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0021542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011789717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013279900", 
          "https://doi.org/10.1038/nature04710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013279900", 
          "https://doi.org/10.1038/nature04710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013279900", 
          "https://doi.org/10.1038/nature04710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1999.229af.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015638489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2010.191585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017078960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000124225.43852.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018058403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208525200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018235713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2006.01.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020460886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80728-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023234181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2170/jjphysiol.25.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024719281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e318217922a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027713102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e318217922a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027713102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00521.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031959152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.171272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032329024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.57.4.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032404030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.01252.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033502422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2008.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035592070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008469-200206000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036532387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008469-200206000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036532387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1389.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039411665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2007.137034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044381726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2010.02889.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045130122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9378(99)70390-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047755666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9378(99)70390-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047755666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m010904200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049844349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.098475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052240021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.098475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052240021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1389.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052295781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.1997.2441017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053349746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.1997.2441017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053349746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/lrb.2007.5104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059296472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00200.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063192824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00325.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063193036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00394.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063193146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1933719107306229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064078564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1933719107306229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064078564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1933719109349780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064078880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1933719109349780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064078880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2002-021862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064286564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-3481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/chan.4946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072301922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5694/mja11.11120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073072280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5694/mja11.11120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073072280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1999.277.6.c1284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074563797"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (\u03b1-conducting and \u03b2-inhibitory subunits) and hERG currents exist in isolated patch-clamped human myometrial cells. We show that hERG channel activity suppresses contraction amplitude and duration before labour, thereby facilitating quiescence. During established labour, expression of \u03b2-inhibitory protein is markedly enhanced, resulting in reduced hERG activity that is associated with an increased duration of uterine action potentials and contractions. Thus, changes in hERG channel activity contribute to electrophysiological mechanisms that produce contractions during labour. We also demonstrate that this system fails in women with elevated BMI, who have enhanced hERG activity as a result of low \u03b2-inhibitory protein expression, which likely contributes to the weak contractions and poor labour outcomes observed in many obese women necessitating caesarean delivery. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms5108", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women", 
    "pagination": "4108", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a709a37452bb4b866214f53160ec84a1c9210d3f433bdccc31c96c0cd01dbb8f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24937480"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms5108"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035065221"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms5108", 
      "https://app.dimensions.ai/details/publication/pub.1035065221"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms5108"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms5108'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms5108'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms5108'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms5108'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      21 PREDICATES      85 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms5108 schema:about N042e327fbf974278a486d570b99dfdc1
2 N35d6ef9018354d8a99a870eaf36ae688
3 N3cd15787abcf41f992a56e872c6dba7b
4 N637698239a5f4596855349fe69080706
5 N8b898305b66a4a239e10fdeac6f94f7c
6 N91d6ce59aec940d891184cbb6c41f022
7 N9748025b9487458e88019d3a65822a7f
8 Na4195d787e7045129fc261383ad0a855
9 Nd2dfdfd72dbf43acb204184eb970efc5
10 Ne2c2bbc63a044a8e83e6cf93c337a1a1
11 Ne48148e2e17c436c867b9734bdb50ca9
12 Ne69f7f74486a41899d6846adfa0d108f
13 Nef8bf0d6c1d3417baf1690edf54a3b85
14 Nf6c46900369b40dd92b8af04968ba71b
15 anzsrc-for:11
16 anzsrc-for:1114
17 schema:author Ncea1804973764fe7b73c77dd44e4fa2f
18 schema:citation sg:pub.10.1038/nature04710
19 https://doi.org/10.1016/j.ajog.2006.01.106
20 https://doi.org/10.1016/j.ajog.2012.01.032
21 https://doi.org/10.1016/j.mce.2008.06.003
22 https://doi.org/10.1016/s0002-9378(99)70390-x
23 https://doi.org/10.1016/s0092-8674(00)80728-x
24 https://doi.org/10.1046/j.1365-2265.1997.2441017.x
25 https://doi.org/10.1056/nejmra061360
26 https://doi.org/10.1074/jbc.m010904200
27 https://doi.org/10.1074/jbc.m208525200
28 https://doi.org/10.1085/jgp.201210826
29 https://doi.org/10.1089/lrb.2007.5104
30 https://doi.org/10.1097/00008469-200206000-00012
31 https://doi.org/10.1097/aog.0b013e318217922a
32 https://doi.org/10.1111/j.1469-7793.1999.229af.x
33 https://doi.org/10.1111/j.1471-0528.2010.02889.x
34 https://doi.org/10.1113/jphysiol.2004.070615
35 https://doi.org/10.1113/jphysiol.2005.098475
36 https://doi.org/10.1113/jphysiol.2007.137034
37 https://doi.org/10.1113/jphysiol.2009.171272
38 https://doi.org/10.1113/jphysiol.2010.191585
39 https://doi.org/10.1124/pr.57.4.10
40 https://doi.org/10.1152/ajpcell.00099.2002
41 https://doi.org/10.1152/ajpcell.00142.2006
42 https://doi.org/10.1152/ajpcell.1999.277.6.c1284
43 https://doi.org/10.1152/ajpgi.00200.2001
44 https://doi.org/10.1152/ajpgi.00325.2002
45 https://doi.org/10.1152/ajpgi.00394.2002
46 https://doi.org/10.1152/ajpheart.00965.2011
47 https://doi.org/10.1152/ajpheart.01252.2008
48 https://doi.org/10.1152/ajpregu.00521.2007
49 https://doi.org/10.1161/01.cir.0000124225.43852.50
50 https://doi.org/10.1177/1933719107306229
51 https://doi.org/10.1177/1933719109349780
52 https://doi.org/10.1196/annals.1389.031
53 https://doi.org/10.1196/annals.1389.038
54 https://doi.org/10.1210/jc.2002-021862
55 https://doi.org/10.1210/jc.2012-3481
56 https://doi.org/10.1371/journal.pone.0021542
57 https://doi.org/10.2170/jjphysiol.25.153
58 https://doi.org/10.4161/chan.4946
59 https://doi.org/10.5694/mja11.11120
60 schema:datePublished 2014-12
61 schema:datePublishedReg 2014-12-01
62 schema:description Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (α-conducting and β-inhibitory subunits) and hERG currents exist in isolated patch-clamped human myometrial cells. We show that hERG channel activity suppresses contraction amplitude and duration before labour, thereby facilitating quiescence. During established labour, expression of β-inhibitory protein is markedly enhanced, resulting in reduced hERG activity that is associated with an increased duration of uterine action potentials and contractions. Thus, changes in hERG channel activity contribute to electrophysiological mechanisms that produce contractions during labour. We also demonstrate that this system fails in women with elevated BMI, who have enhanced hERG activity as a result of low β-inhibitory protein expression, which likely contributes to the weak contractions and poor labour outcomes observed in many obese women necessitating caesarean delivery.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N7641f39ed3ed4de7b26067c4cfe99178
67 Nb2dc258c054a4467984b103b6fda6b42
68 sg:journal.1043282
69 schema:name Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women
70 schema:pagination 4108
71 schema:productId N7d6af611e1b641198ae5de02ab5deb90
72 N890a3b9157cc4fe3a50bbeb4b1c2b951
73 N988c740015dc4bea91d77fe6862864db
74 N9d372c69008f408dabc6e30119612c97
75 Nbedb025bcb30421eba83a559ce1c446f
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035065221
77 https://doi.org/10.1038/ncomms5108
78 schema:sdDatePublished 2019-04-10T13:57
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher Ne471fb66d513481ba37033849ead2c4b
81 schema:url https://www.nature.com/articles/ncomms5108
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N042e327fbf974278a486d570b99dfdc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Myometrium
87 rdf:type schema:DefinedTerm
88 N35d6ef9018354d8a99a870eaf36ae688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Membrane Potentials
90 rdf:type schema:DefinedTerm
91 N3cd15787abcf41f992a56e872c6dba7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Body Mass Index
93 rdf:type schema:DefinedTerm
94 N3f4ed32fe38c43ad9cdd5ac175f2c1e2 rdf:first sg:person.01320454664.44
95 rdf:rest Nefd0922e2281450aa08b357619d77f07
96 N430051c07385449f91616cbde96ff972 rdf:first sg:person.0752216526.85
97 rdf:rest Nb7447130143a4b61a7c422b67bd267d0
98 N46e75fc279b24866a2da3aa732258f12 rdf:first sg:person.01371611016.13
99 rdf:rest rdf:nil
100 N4791ea0f48c54c0793ba3d8f9853cecc rdf:first sg:person.01240226405.17
101 rdf:rest N7f1c40a566a74ad8b20dd4f8185c8af1
102 N637698239a5f4596855349fe69080706 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Uterine Contraction
104 rdf:type schema:DefinedTerm
105 N7641f39ed3ed4de7b26067c4cfe99178 schema:volumeNumber 5
106 rdf:type schema:PublicationVolume
107 N7d6af611e1b641198ae5de02ab5deb90 schema:name dimensions_id
108 schema:value pub.1035065221
109 rdf:type schema:PropertyValue
110 N7f1c40a566a74ad8b20dd4f8185c8af1 rdf:first sg:person.01313042233.96
111 rdf:rest Nd91dce6817da48108fb2a8fa1b65b720
112 N890a3b9157cc4fe3a50bbeb4b1c2b951 schema:name doi
113 schema:value 10.1038/ncomms5108
114 rdf:type schema:PropertyValue
115 N8b6b2113d7254580b9118042cd329f8c rdf:first sg:person.0647357610.58
116 rdf:rest N3f4ed32fe38c43ad9cdd5ac175f2c1e2
117 N8b898305b66a4a239e10fdeac6f94f7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Ether-A-Go-Go Potassium Channels
119 rdf:type schema:DefinedTerm
120 N91d6ce59aec940d891184cbb6c41f022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Statistics, Nonparametric
122 rdf:type schema:DefinedTerm
123 N9748025b9487458e88019d3a65822a7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Potassium Channels, Voltage-Gated
125 rdf:type schema:DefinedTerm
126 N988c740015dc4bea91d77fe6862864db schema:name nlm_unique_id
127 schema:value 101528555
128 rdf:type schema:PropertyValue
129 N9d372c69008f408dabc6e30119612c97 schema:name readcube_id
130 schema:value a709a37452bb4b866214f53160ec84a1c9210d3f433bdccc31c96c0cd01dbb8f
131 rdf:type schema:PropertyValue
132 Na4195d787e7045129fc261383ad0a855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Adult
134 rdf:type schema:DefinedTerm
135 Nb2dc258c054a4467984b103b6fda6b42 schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 Nb7447130143a4b61a7c422b67bd267d0 rdf:first sg:person.01264062341.56
138 rdf:rest N4791ea0f48c54c0793ba3d8f9853cecc
139 Nbedb025bcb30421eba83a559ce1c446f schema:name pubmed_id
140 schema:value 24937480
141 rdf:type schema:PropertyValue
142 Ncea1804973764fe7b73c77dd44e4fa2f rdf:first sg:person.01177403576.67
143 rdf:rest Nf7f3a331cc5243eb92988510755a1a40
144 Nd2dfdfd72dbf43acb204184eb970efc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Patch-Clamp Techniques
146 rdf:type schema:DefinedTerm
147 Nd91dce6817da48108fb2a8fa1b65b720 rdf:first sg:person.0612752677.56
148 rdf:rest N46e75fc279b24866a2da3aa732258f12
149 Ne2c2bbc63a044a8e83e6cf93c337a1a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Action Potentials
151 rdf:type schema:DefinedTerm
152 Ne471fb66d513481ba37033849ead2c4b schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Ne48148e2e17c436c867b9734bdb50ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Blotting, Western
156 rdf:type schema:DefinedTerm
157 Ne69f7f74486a41899d6846adfa0d108f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 Nef8bf0d6c1d3417baf1690edf54a3b85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Obesity
162 rdf:type schema:DefinedTerm
163 Nefd0922e2281450aa08b357619d77f07 rdf:first sg:person.01235267626.45
164 rdf:rest N430051c07385449f91616cbde96ff972
165 Nf6c46900369b40dd92b8af04968ba71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 Nf7f3a331cc5243eb92988510755a1a40 rdf:first sg:person.0630152403.51
169 rdf:rest N8b6b2113d7254580b9118042cd329f8c
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
174 schema:name Paediatrics and Reproductive Medicine
175 rdf:type schema:DefinedTerm
176 sg:journal.1043282 schema:issn 2041-1723
177 schema:name Nature Communications
178 rdf:type schema:Periodical
179 sg:person.01177403576.67 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
180 schema:familyName Parkington
181 schema:givenName Helena C.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177403576.67
183 rdf:type schema:Person
184 sg:person.01235267626.45 schema:affiliation https://www.grid.ac/institutes/grid.266842.c
185 schema:familyName Butler
186 schema:givenName Trent
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235267626.45
188 rdf:type schema:Person
189 sg:person.01240226405.17 schema:affiliation https://www.grid.ac/institutes/grid.416259.d
190 schema:familyName Sheehan
191 schema:givenName Penelope M.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240226405.17
193 rdf:type schema:Person
194 sg:person.01264062341.56 schema:affiliation https://www.grid.ac/institutes/grid.266842.c
195 schema:familyName Chan
196 schema:givenName Eng-Cheng
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264062341.56
198 rdf:type schema:Person
199 sg:person.01313042233.96 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
200 schema:familyName Brennecke
201 schema:givenName Shaun P.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313042233.96
203 rdf:type schema:Person
204 sg:person.01320454664.44 schema:affiliation https://www.grid.ac/institutes/grid.266842.c
205 schema:familyName Paul
206 schema:givenName Jonathan
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320454664.44
208 rdf:type schema:Person
209 sg:person.01371611016.13 schema:affiliation https://www.grid.ac/institutes/grid.266842.c
210 schema:familyName Smith
211 schema:givenName Roger
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371611016.13
213 rdf:type schema:Person
214 sg:person.0612752677.56 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
215 schema:familyName Coleman
216 schema:givenName Harold A.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612752677.56
218 rdf:type schema:Person
219 sg:person.0630152403.51 schema:affiliation https://www.grid.ac/institutes/grid.416259.d
220 schema:familyName Stevenson
221 schema:givenName Janet
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630152403.51
223 rdf:type schema:Person
224 sg:person.0647357610.58 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
225 schema:familyName Tonta
226 schema:givenName Mary A.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647357610.58
228 rdf:type schema:Person
229 sg:person.0752216526.85 schema:affiliation https://www.grid.ac/institutes/grid.266842.c
230 schema:familyName Maiti
231 schema:givenName Kaushik
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752216526.85
233 rdf:type schema:Person
234 sg:pub.10.1038/nature04710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013279900
235 https://doi.org/10.1038/nature04710
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.ajog.2006.01.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020460886
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.ajog.2012.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003180943
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.mce.2008.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035592070
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0002-9378(99)70390-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047755666
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0092-8674(00)80728-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023234181
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1046/j.1365-2265.1997.2441017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053349746
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1056/nejmra061360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003145454
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.m010904200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049844349
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1074/jbc.m208525200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018235713
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1085/jgp.201210826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002222457
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1089/lrb.2007.5104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059296472
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/00008469-200206000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036532387
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/aog.0b013e318217922a schema:sameAs https://app.dimensions.ai/details/publication/pub.1027713102
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1469-7793.1999.229af.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015638489
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1111/j.1471-0528.2010.02889.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045130122
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1113/jphysiol.2004.070615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002423819
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1113/jphysiol.2005.098475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052240021
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1113/jphysiol.2007.137034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044381726
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1113/jphysiol.2009.171272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032329024
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1113/jphysiol.2010.191585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017078960
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1124/pr.57.4.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032404030
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1152/ajpcell.00099.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005433184
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1152/ajpcell.00142.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003269052
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1152/ajpcell.1999.277.6.c1284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074563797
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1152/ajpgi.00200.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063192824
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1152/ajpgi.00325.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063193036
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1152/ajpgi.00394.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063193146
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1152/ajpheart.00965.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006177808
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1152/ajpheart.01252.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033502422
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1152/ajpregu.00521.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031959152
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/01.cir.0000124225.43852.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018058403
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1177/1933719107306229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064078564
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1177/1933719109349780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064078880
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1196/annals.1389.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039411665
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1196/annals.1389.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052295781
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1210/jc.2002-021862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286564
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1210/jc.2012-3481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293929
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1371/journal.pone.0021542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011789717
312 rdf:type schema:CreativeWork
313 https://doi.org/10.2170/jjphysiol.25.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024719281
314 rdf:type schema:CreativeWork
315 https://doi.org/10.4161/chan.4946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301922
316 rdf:type schema:CreativeWork
317 https://doi.org/10.5694/mja11.11120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073072280
318 rdf:type schema:CreativeWork
319 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
320 schema:name Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
323 schema:name Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria 3010, Australia
324 Department of Perinatal Medicine Pregnancy Research Centre, Royal Women’s Hospital, Parkville, Victoria 3052, Australia
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.266842.c schema:alternateName University of Newcastle Australia
327 schema:name Mothers and Babies Research Centre, University of Newcastle, Callaghan, New South Wales 2308, Australia
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.416259.d schema:alternateName Royal Women's Hospital
330 schema:name Department of Perinatal Medicine Pregnancy Research Centre, Royal Women’s Hospital, Parkville, Victoria 3052, Australia
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...