Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Nicholas E. Ilott, James A. Heward, Benoit Roux, Eleni Tsitsiou, Peter S. Fenwick, Luca Lenzi, Ian Goodhead, Christiane Hertz-Fowler, Andreas Heger, Neil Hall, Louise E. Donnelly, David Sims, Mark A. Lindsay

ABSTRACT

Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence against infection, is largely unexplored. To address this issue, here we characterize the long non-coding RNA transcriptome in primary human monocytes using RNA sequencing. We identify 76 enhancer RNAs (eRNAs), 40 canonical lncRNAs, 65 antisense lncRNAs and 35 regions of bidirectional transcription (RBT) that are differentially expressed in response to bacterial lipopolysaccharide (LPS). Crucially, we demonstrate that knockdown of nuclear-localized, NF-κB-regulated, eRNAs (IL1β-eRNA) and RBT (IL1β-RBT46) surrounding the IL1β locus, attenuates LPS-induced messenger RNA transcription and release of the proinflammatory mediators, IL1β and CXCL8. We predict that lncRNAs can be important regulators of the human innate immune response. More... »

PAGES

3979

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms4979

    DOI

    http://dx.doi.org/10.1038/ncomms4979

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004327109

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24909122


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