Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05-02

AUTHORS

Saihong Jin, Jeehee Kim, Torsten Willert, Tanja Klein-Rodewald, Mario Garcia-Dominguez, Matias Mosqueira, Rainer Fink, Irene Esposito, Lorenz C. Hofbauer, Patrick Charnay, Matthias Kieslinger

ABSTRACT

Myogenic regulatory factors such as MyoD and Myf5 lie at the core of vertebrate muscle differentiation. However, E-boxes, the cognate binding sites for these transcription factors, are not restricted to the promoters/enhancers of muscle cell-specific genes. Thus, the specificity in myogenic transcription is poorly defined. Here we describe the transcription factor Ebf3 as a new determinant of muscle cell-specific transcription. In the absence of Ebf3 the lung does not unfold at birth, resulting in respiratory failure and perinatal death. This is due to a hypercontractile diaphragm with impaired Ca2+ efflux-related muscle functions. Expression of the Ca2+ pump Serca1 (Atp2a1) is downregulated in the absence of Ebf3, and its transgenic expression rescues this phenotype. Ebf3 binds directly to the promoter of Atp2a1 and synergises with MyoD in the induction of Atp2a1. In skeletal muscle, the homologous family member Ebf1 is strongly expressed and together with MyoD induces Atp2a1. Thus, Ebf3 is a new regulator of terminal muscle differentiation in the diaphragm, and Ebf factors cooperate with MyoD in the induction of muscle-specific genes. More... »

PAGES

3793

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms4793

DOI

http://dx.doi.org/10.1038/ncomms4793

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032755860

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24786561


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Relaxation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MyoD Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Insufficiency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoplasmic Reticulum Calcium-Transporting ATPases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Saihong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jeehee", 
        "id": "sg:person.01023342040.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023342040.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willert", 
        "givenName": "Torsten", 
        "id": "sg:person.01137570440.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137570440.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, 85764 Neuherberg, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, 85764 Neuherberg, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein-Rodewald", 
        "givenName": "Tanja", 
        "id": "sg:person.01342413344.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342413344.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stem Cells Department, CABIMER (CISC), Av Am\u00e9rico Vespucio, 41092, Sevilla, Spain", 
          "id": "http://www.grid.ac/institutes/grid.427489.4", 
          "name": [
            "Developmental Biology Section, Ecole Normale Sup\u00e9rieure, Rue d'Ulm 46, 75230, Paris, France", 
            "Stem Cells Department, CABIMER (CISC), Av Am\u00e9rico Vespucio, 41092, Sevilla, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia-Dominguez", 
        "givenName": "Mario", 
        "id": "sg:person.0627304433.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627304433.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mosqueira", 
        "givenName": "Matias", 
        "id": "sg:person.01367541335.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367541335.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fink", 
        "givenName": "Rainer", 
        "id": "sg:person.0662341126.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662341126.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pathology, Technische Universit\u00e4t M\u00fcnchen, Ismaningerstrasse 22, 81675, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Pathology, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, 85764 Neuherberg, 81377, Munich, Germany", 
            "Institute of Pathology, Technische Universit\u00e4t M\u00fcnchen, Ismaningerstrasse 22, 81675, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Esposito", 
        "givenName": "Irene", 
        "id": "sg:person.01265770032.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265770032.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Endocrinology, Department of Medicine III, Diabetes and Metabolic Bone Diseases, TU Dresden Medical Center, Fetscherstrasse 74, 01307, Dresden, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4488.0", 
          "name": [
            "Division of Endocrinology, Department of Medicine III, Diabetes and Metabolic Bone Diseases, TU Dresden Medical Center, Fetscherstrasse 74, 01307, Dresden, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofbauer", 
        "givenName": "Lorenz C.", 
        "id": "sg:person.0735622564.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735622564.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Developmental Biology Section, Ecole Normale Sup\u00e9rieure, Rue d'Ulm 46, 75230, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Developmental Biology Section, Ecole Normale Sup\u00e9rieure, Rue d'Ulm 46, 75230, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charnay", 
        "givenName": "Patrick", 
        "id": "sg:person.01147632731.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147632731.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum M\u00fcnchen, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kieslinger", 
        "givenName": "Matthias", 
        "id": "sg:person.01370245440.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370245440.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1008868325009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032413250", 
          "https://doi.org/10.1023/a:1008868325009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1096-191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032759532", 
          "https://doi.org/10.1038/ng1096-191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046680129", 
          "https://doi.org/10.1038/nature03594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316696a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008533494", 
          "https://doi.org/10.1038/316696a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2148-8-131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034165204", 
          "https://doi.org/10.1186/1471-2148-8-131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012988744", 
          "https://doi.org/10.1038/ng1007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005213848", 
          "https://doi.org/10.1038/nature05650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003359900236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050037872", 
          "https://doi.org/10.1007/s003359900236"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05-02", 
    "datePublishedReg": "2014-05-02", 
    "description": "Myogenic regulatory factors such as MyoD and Myf5 lie at the core of vertebrate muscle differentiation. However, E-boxes, the cognate binding sites for these transcription factors, are not restricted to the promoters/enhancers of muscle cell-specific genes. Thus, the specificity in myogenic transcription is poorly defined. Here we describe the transcription factor Ebf3 as a new determinant of muscle cell-specific transcription. In the absence of Ebf3 the lung does not unfold at birth, resulting in respiratory failure and perinatal death. This is due to a hypercontractile diaphragm with impaired Ca2+ efflux-related muscle functions. Expression of the Ca2+ pump Serca1 (Atp2a1) is downregulated in the absence of Ebf3, and its transgenic expression rescues this phenotype. Ebf3 binds directly to the promoter of Atp2a1 and synergises with MyoD in the induction of Atp2a1. In skeletal muscle, the homologous family member Ebf1 is strongly expressed and together with MyoD induces Atp2a1. Thus, Ebf3 is a new regulator of terminal muscle differentiation in the diaphragm, and Ebf factors cooperate with MyoD in the induction of muscle-specific genes.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms4793", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "respiratory failure", 
      "perinatal death", 
      "Impaired Ca2", 
      "muscle relaxation", 
      "muscle function", 
      "muscle differentiation", 
      "promoter/enhancer", 
      "skeletal muscle", 
      "vertebrate muscle differentiation", 
      "transgenic expression", 
      "ATP2A1", 
      "terminal muscle differentiation", 
      "cell-specific transcription", 
      "muscle-specific genes", 
      "cell-specific genes", 
      "myogenic regulatory factors", 
      "EBF3", 
      "myogenic transcription", 
      "induction", 
      "diaphragm", 
      "regulatory factors", 
      "transcription factors", 
      "E-box", 
      "new regulator", 
      "Ca2", 
      "factors", 
      "MyoD", 
      "lung", 
      "expression", 
      "new determinants", 
      "differentiation", 
      "muscle", 
      "death", 
      "birth", 
      "absence", 
      "transcription", 
      "genes", 
      "SERCA1", 
      "efflux", 
      "phenotype", 
      "failure", 
      "specificity", 
      "EBF1", 
      "determinants", 
      "promoter", 
      "enhancer", 
      "regulator", 
      "binds", 
      "function", 
      "sites", 
      "relaxation", 
      "core", 
      "lies"
    ], 
    "name": "Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1", 
    "pagination": "3793", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032755860"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms4793"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24786561"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms4793", 
      "https://app.dimensions.ai/details/publication/pub.1032755860"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_638.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms4793"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms4793'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms4793'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms4793'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms4793'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      22 PREDICATES      95 URIs      79 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms4793 schema:about N02d42e7d2d0e4f2098a077e819ab3a46
2 N21f2da8aa93a42139ffc8e8264f9672e
3 N3b957276c7f6417387583919ac85daa5
4 N4ec259fc237a4b6a9a9455adb2b3bbdb
5 Na58e9d01d6d7409dbd2772e416f5ab89
6 Nbd1ee2a9b7154abf96021d38fc674cfb
7 Nc79c1399f72c4c1a908a2ea4c4404ee9
8 Nfa67b738f89e433594fa293b518a76c5
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author N3702d11a538941278dec39b09e97bc98
12 schema:citation sg:pub.10.1007/s003359900236
13 sg:pub.10.1023/a:1008868325009
14 sg:pub.10.1038/316696a0
15 sg:pub.10.1038/nature03594
16 sg:pub.10.1038/nature05650
17 sg:pub.10.1038/ng1007
18 sg:pub.10.1038/ng1096-191
19 sg:pub.10.1186/1471-2148-8-131
20 schema:datePublished 2014-05-02
21 schema:datePublishedReg 2014-05-02
22 schema:description Myogenic regulatory factors such as MyoD and Myf5 lie at the core of vertebrate muscle differentiation. However, E-boxes, the cognate binding sites for these transcription factors, are not restricted to the promoters/enhancers of muscle cell-specific genes. Thus, the specificity in myogenic transcription is poorly defined. Here we describe the transcription factor Ebf3 as a new determinant of muscle cell-specific transcription. In the absence of Ebf3 the lung does not unfold at birth, resulting in respiratory failure and perinatal death. This is due to a hypercontractile diaphragm with impaired Ca2+ efflux-related muscle functions. Expression of the Ca2+ pump Serca1 (Atp2a1) is downregulated in the absence of Ebf3, and its transgenic expression rescues this phenotype. Ebf3 binds directly to the promoter of Atp2a1 and synergises with MyoD in the induction of Atp2a1. In skeletal muscle, the homologous family member Ebf1 is strongly expressed and together with MyoD induces Atp2a1. Thus, Ebf3 is a new regulator of terminal muscle differentiation in the diaphragm, and Ebf factors cooperate with MyoD in the induction of muscle-specific genes.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree true
26 schema:isPartOf N31fb0184776249afaa38819c6711b946
27 Ncbb3bec98b4346b289186558f958fc98
28 sg:journal.1043282
29 schema:keywords ATP2A1
30 Ca2
31 E-box
32 EBF1
33 EBF3
34 Impaired Ca2
35 MyoD
36 SERCA1
37 absence
38 binds
39 birth
40 cell-specific genes
41 cell-specific transcription
42 core
43 death
44 determinants
45 diaphragm
46 differentiation
47 efflux
48 enhancer
49 expression
50 factors
51 failure
52 function
53 genes
54 induction
55 lies
56 lung
57 muscle
58 muscle differentiation
59 muscle function
60 muscle relaxation
61 muscle-specific genes
62 myogenic regulatory factors
63 myogenic transcription
64 new determinants
65 new regulator
66 perinatal death
67 phenotype
68 promoter
69 promoter/enhancer
70 regulator
71 regulatory factors
72 relaxation
73 respiratory failure
74 sites
75 skeletal muscle
76 specificity
77 terminal muscle differentiation
78 transcription
79 transcription factors
80 transgenic expression
81 vertebrate muscle differentiation
82 schema:name Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1
83 schema:pagination 3793
84 schema:productId N87cbe3f2dbf542068972f1aa15c1fd8f
85 Na28db5e5a9da4454887e94e2fbf3874f
86 Nf5ffe5d9dfef4ad7959883a182b02b56
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032755860
88 https://doi.org/10.1038/ncomms4793
89 schema:sdDatePublished 2022-05-20T07:30
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N583a4c634dab4727b532a9dcc22ee1a2
92 schema:url https://doi.org/10.1038/ncomms4793
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N02d42e7d2d0e4f2098a077e819ab3a46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Mice
98 rdf:type schema:DefinedTerm
99 N07efd03a0a164ba0bb88f5dd3eea355e rdf:first sg:person.01370245440.84
100 rdf:rest rdf:nil
101 N0aa75127401742179b450d4db71be2f9 rdf:first sg:person.01367541335.62
102 rdf:rest N436fe58c49d24d2a909c316d1af0e905
103 N0ca7e81d24f34e9bbc578a85763c58e0 rdf:first sg:person.0627304433.81
104 rdf:rest N0aa75127401742179b450d4db71be2f9
105 N0ceb8c87b3d74f6da0279c985c2d594b rdf:first sg:person.01023342040.37
106 rdf:rest Nb11393f75d0d4e928f02f0e7ba3702ff
107 N21f2da8aa93a42139ffc8e8264f9672e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Muscle Relaxation
109 rdf:type schema:DefinedTerm
110 N27d5232416cd4b85ace33bed1f04c4b4 schema:affiliation grid-institutes:grid.4567.0
111 schema:familyName Jin
112 schema:givenName Saihong
113 rdf:type schema:Person
114 N31fb0184776249afaa38819c6711b946 schema:volumeNumber 5
115 rdf:type schema:PublicationVolume
116 N3702d11a538941278dec39b09e97bc98 rdf:first N27d5232416cd4b85ace33bed1f04c4b4
117 rdf:rest N0ceb8c87b3d74f6da0279c985c2d594b
118 N3b957276c7f6417387583919ac85daa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name MyoD Protein
120 rdf:type schema:DefinedTerm
121 N436fe58c49d24d2a909c316d1af0e905 rdf:first sg:person.0662341126.47
122 rdf:rest Na433ef27881b4fbfb7089401112f1a0f
123 N4ec259fc237a4b6a9a9455adb2b3bbdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Transcription Factors
125 rdf:type schema:DefinedTerm
126 N583a4c634dab4727b532a9dcc22ee1a2 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N5b96ec37750740a3ba48d07211e24f62 rdf:first sg:person.01342413344.78
129 rdf:rest N0ca7e81d24f34e9bbc578a85763c58e0
130 N87cbe3f2dbf542068972f1aa15c1fd8f schema:name doi
131 schema:value 10.1038/ncomms4793
132 rdf:type schema:PropertyValue
133 N9348238943f74621ab696d417fc1ce59 rdf:first sg:person.01147632731.85
134 rdf:rest N07efd03a0a164ba0bb88f5dd3eea355e
135 Na28db5e5a9da4454887e94e2fbf3874f schema:name pubmed_id
136 schema:value 24786561
137 rdf:type schema:PropertyValue
138 Na433ef27881b4fbfb7089401112f1a0f rdf:first sg:person.01265770032.11
139 rdf:rest Nfceb455b2ae049af8827695d38d6f5dc
140 Na58e9d01d6d7409dbd2772e416f5ab89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 Nb11393f75d0d4e928f02f0e7ba3702ff rdf:first sg:person.01137570440.15
144 rdf:rest N5b96ec37750740a3ba48d07211e24f62
145 Nbd1ee2a9b7154abf96021d38fc674cfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Sarcoplasmic Reticulum Calcium-Transporting ATPases
147 rdf:type schema:DefinedTerm
148 Nc79c1399f72c4c1a908a2ea4c4404ee9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Respiratory Insufficiency
150 rdf:type schema:DefinedTerm
151 Ncbb3bec98b4346b289186558f958fc98 schema:issueNumber 1
152 rdf:type schema:PublicationIssue
153 Nf5ffe5d9dfef4ad7959883a182b02b56 schema:name dimensions_id
154 schema:value pub.1032755860
155 rdf:type schema:PropertyValue
156 Nfa67b738f89e433594fa293b518a76c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mice, Knockout
158 rdf:type schema:DefinedTerm
159 Nfceb455b2ae049af8827695d38d6f5dc rdf:first sg:person.0735622564.61
160 rdf:rest N9348238943f74621ab696d417fc1ce59
161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
162 schema:name Biological Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
165 schema:name Genetics
166 rdf:type schema:DefinedTerm
167 sg:journal.1043282 schema:issn 2041-1723
168 schema:name Nature Communications
169 schema:publisher Springer Nature
170 rdf:type schema:Periodical
171 sg:person.01023342040.37 schema:affiliation grid-institutes:grid.4567.0
172 schema:familyName Kim
173 schema:givenName Jeehee
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023342040.37
175 rdf:type schema:Person
176 sg:person.01137570440.15 schema:affiliation grid-institutes:grid.4567.0
177 schema:familyName Willert
178 schema:givenName Torsten
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137570440.15
180 rdf:type schema:Person
181 sg:person.01147632731.85 schema:affiliation grid-institutes:None
182 schema:familyName Charnay
183 schema:givenName Patrick
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147632731.85
185 rdf:type schema:Person
186 sg:person.01265770032.11 schema:affiliation grid-institutes:None
187 schema:familyName Esposito
188 schema:givenName Irene
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265770032.11
190 rdf:type schema:Person
191 sg:person.01342413344.78 schema:affiliation grid-institutes:grid.4567.0
192 schema:familyName Klein-Rodewald
193 schema:givenName Tanja
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342413344.78
195 rdf:type schema:Person
196 sg:person.01367541335.62 schema:affiliation grid-institutes:grid.7700.0
197 schema:familyName Mosqueira
198 schema:givenName Matias
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367541335.62
200 rdf:type schema:Person
201 sg:person.01370245440.84 schema:affiliation grid-institutes:grid.4567.0
202 schema:familyName Kieslinger
203 schema:givenName Matthias
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370245440.84
205 rdf:type schema:Person
206 sg:person.0627304433.81 schema:affiliation grid-institutes:grid.427489.4
207 schema:familyName Garcia-Dominguez
208 schema:givenName Mario
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627304433.81
210 rdf:type schema:Person
211 sg:person.0662341126.47 schema:affiliation grid-institutes:grid.7700.0
212 schema:familyName Fink
213 schema:givenName Rainer
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662341126.47
215 rdf:type schema:Person
216 sg:person.0735622564.61 schema:affiliation grid-institutes:grid.4488.0
217 schema:familyName Hofbauer
218 schema:givenName Lorenz C.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735622564.61
220 rdf:type schema:Person
221 sg:pub.10.1007/s003359900236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050037872
222 https://doi.org/10.1007/s003359900236
223 rdf:type schema:CreativeWork
224 sg:pub.10.1023/a:1008868325009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032413250
225 https://doi.org/10.1023/a:1008868325009
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/316696a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008533494
228 https://doi.org/10.1038/316696a0
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nature03594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046680129
231 https://doi.org/10.1038/nature03594
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nature05650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005213848
234 https://doi.org/10.1038/nature05650
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/ng1007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012988744
237 https://doi.org/10.1038/ng1007
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/ng1096-191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032759532
240 https://doi.org/10.1038/ng1096-191
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/1471-2148-8-131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034165204
243 https://doi.org/10.1186/1471-2148-8-131
244 rdf:type schema:CreativeWork
245 grid-institutes:None schema:alternateName Developmental Biology Section, Ecole Normale Supérieure, Rue d'Ulm 46, 75230, Paris, France
246 Institute of Pathology, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany
247 schema:name Developmental Biology Section, Ecole Normale Supérieure, Rue d'Ulm 46, 75230, Paris, France
248 Institute of Pathology, Helmholtz Zentrum München, National Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, 81377, Munich, Germany
249 Institute of Pathology, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany
250 rdf:type schema:Organization
251 grid-institutes:grid.427489.4 schema:alternateName Stem Cells Department, CABIMER (CISC), Av Américo Vespucio, 41092, Sevilla, Spain
252 schema:name Developmental Biology Section, Ecole Normale Supérieure, Rue d'Ulm 46, 75230, Paris, France
253 Stem Cells Department, CABIMER (CISC), Av Américo Vespucio, 41092, Sevilla, Spain
254 rdf:type schema:Organization
255 grid-institutes:grid.4488.0 schema:alternateName Division of Endocrinology, Department of Medicine III, Diabetes and Metabolic Bone Diseases, TU Dresden Medical Center, Fetscherstrasse 74, 01307, Dresden, Germany
256 schema:name Division of Endocrinology, Department of Medicine III, Diabetes and Metabolic Bone Diseases, TU Dresden Medical Center, Fetscherstrasse 74, 01307, Dresden, Germany
257 rdf:type schema:Organization
258 grid-institutes:grid.4567.0 schema:alternateName Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany
259 Institute of Pathology, Helmholtz Zentrum München, National Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, 81377, Munich, Germany
260 schema:name Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, National Research Center for Environmental Health, Marchioninistrasse 25, 81377, Munich, Germany
261 Institute of Pathology, Helmholtz Zentrum München, National Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, 81377, Munich, Germany
262 rdf:type schema:Organization
263 grid-institutes:grid.7700.0 schema:alternateName Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
264 schema:name Medical Biophysics Unit, Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...