Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Ekaterina E. Khrameeva, Katarzyna Bozek, Liu He, Zheng Yan, Xi Jiang, Yuning Wei, Kun Tang, Mikhail S. Gelfand, Kay Prufer, Janet Kelso, Svante Paabo, Patrick Giavalisco, Michael Lachmann, Philipp Khaitovich

ABSTRACT

Although Neanderthals are extinct, fragments of their genomes persist in contemporary humans. Here we show that while the genome-wide frequency of Neanderthal-like sites is approximately constant across all contemporary out-of-Africa populations, genes involved in lipid catabolism contain more than threefold excess of such sites in contemporary humans of European descent. Evolutionally, these genes show significant association with signatures of recent positive selection in the contemporary European, but not Asian or African populations. Functionally, the excess of Neanderthal-like sites in lipid catabolism genes can be linked with a greater divergence of lipid concentrations and enzyme expression levels within this pathway, seen in contemporary Europeans, but not in the other populations. We conclude that sequence variants that evolved in Neanderthals may have given a selective advantage to anatomically modern humans that settled in the same geographical areas. More... »

PAGES

3584

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms4584

DOI

http://dx.doi.org/10.1038/ncomms4584

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052902722

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24690587


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