Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Chih-Chung Lin, Tara R. Bradstreet, Elizabeth A. Schwarzkopf, Julia Sim, Javier A. Carrero, Chun Chou, Lindsey E. Cook, Takeshi Egawa, Reshma Taneja, Theresa L. Murphy, John H. Russell, Brian T. Edelson

ABSTRACT

TH1 and TH17 cells mediate neuroinflammation in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Pathogenic TH cells in EAE must produce the pro-inflammatory cytokine granulocyte-macrophage colony stimulating factor (GM-CSF). TH cell pathogenicity in EAE is also regulated by cell-intrinsic production of the immunosuppressive cytokine interleukin 10 (IL-10). Here we demonstrate that mice deficient for the basic helix-loop-helix (bHLH) transcription factor Bhlhe40 (Bhlhe40(-/-)) are resistant to the induction of EAE. Bhlhe40 is required in vivo in a T cell-intrinsic manner, where it positively regulates the production of GM-CSF and negatively regulates the production of IL-10. In vitro, GM-CSF secretion is selectively abrogated in polarized Bhlhe40(-/-) TH1 and TH17 cells, and these cells show increased production of IL-10. Blockade of IL-10 receptor in Bhlhe40(-/-) mice renders them susceptible to EAE. These findings identify Bhlhe40 as a critical regulator of autoreactive T-cell pathogenicity. More... »

PAGES

3551

References to SciGraph publications

  • 2010-03. The regulation of IL-10 production by immune cells in NATURE REVIEWS IMMUNOLOGY
  • 2011-06. The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF in NATURE IMMUNOLOGY
  • 2005-11. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 in NATURE IMMUNOLOGY
  • 2007-12. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology in NATURE IMMUNOLOGY
  • 2010-10. Generation of pathogenic TH17 cells in the absence of TGF-β signalling in NATURE
  • 2012-10. Induction and molecular signature of pathogenic TH17 cells in NATURE IMMUNOLOGY
  • 2006-06. The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter in ONCOGENE
  • 2011-05. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells in NATURE IMMUNOLOGY
  • 2009-12. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment in NATURE IMMUNOLOGY
  • 2010-08. Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences in GENOME BIOLOGY
  • 2010-09. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 in NATURE IMMUNOLOGY
  • 2001-11. Defective T cell activation and autoimmune disorder in Stra13-deficient mice in NATURE IMMUNOLOGY
  • 2007-12. A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells in NATURE IMMUNOLOGY
  • 2007-12. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells in NATURE IMMUNOLOGY
  • 2011-06. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation in NATURE IMMUNOLOGY
  • 2011-06. GM-CSF: the secret weapon in the TH17 arsenal in NATURE IMMUNOLOGY
  • 2012-09-19. BATF–JUN is critical for IRF4-mediated transcription in T cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms4551

    DOI

    http://dx.doi.org/10.1038/ncomms4551

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043502520

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24699451


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