Genome-wide transcriptome profiling of homologous recombination DNA repair View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Guang Peng, Curtis Chun-Jen Lin, Wei Mo, Hui Dai, Yun-Yong Park, Soo Mi Kim, Yang Peng, Qianxing Mo, Stefan Siwko, Ruozhen Hu, Ju-Seog Lee, Bryan Hennessy, Samir Hanash, Gordon B. Mills, Shiaw-Yih Lin

ABSTRACT

Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as a functional network analysis tool, we discover that simultaneous loss of two major tumour suppressors BRCA1 and PTEN extensively rewire the HR repair-deficient phenotype, which is found in cells with defects in either BRCA1 or PTEN alone. Moreover, the HRD gene signature serves as an effective drug discovery platform to identify agents targeting HR repair as potential chemo/radio sensitizers. More importantly, this HRD gene signature is able to predict clinical outcomes across multiple cancer lineages. Our findings, therefore, provide a molecular profile of HR repair to assess its status at a functional network level, which can provide both biological insights and have clinical implications in cancer. More... »

PAGES

3361

References to SciGraph publications

  • 2008-01. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair in NATURE GENETICS
  • 2010-10. Purified human BRCA2 stimulates RAD51-mediated recombination in NATURE
  • 2012-01. The DNA damage response and cancer therapy in NATURE
  • 2009-05. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle in NATURE
  • 2012-03. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response in NATURE CELL BIOLOGY
  • 2006-10. The NCI60 human tumour cell line anticancer drug screen in NATURE REVIEWS CANCER
  • 2005-04. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase in NATURE
  • 2011-10. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance in NATURE CELL BIOLOGY
  • 2005-04. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy in NATURE
  • 2009-05. RAD18 transmits DNA damage signalling to elicit homologous recombination repair in NATURE CELL BIOLOGY
  • 2010-06. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-06. Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype in NATURE
  • 2010-03. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-02. Resistance to therapy caused by intragenic deletion in BRCA2 in NATURE
  • 2009-07. BRIT1/MCPH1 links chromatin remodelling to DNA damage response in NATURE CELL BIOLOGY
  • 2011-09. Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms4361

    DOI

    http://dx.doi.org/10.1038/ncomms4361

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025701533

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24553445


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "BRCA1 Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Flow Cytometry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "PTEN Phosphohydrolase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinational DNA Repair", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Clinical Cancer Prevention, Unit 1013, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA", 
                "Department of Oncology, Tongji Hospital, Tongji Medical College, The University of Huazhong Science & Technology, Wuhan, Hubei Province 430022, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Guang", 
            "id": "sg:person.012157310057.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012157310057.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Curtis Chun-Jen", 
            "id": "sg:person.01247341325.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247341325.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mo", 
            "givenName": "Wei", 
            "id": "sg:person.0650357302.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650357302.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dai", 
            "givenName": "Hui", 
            "id": "sg:person.01061421542.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061421542.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Yun-Yong", 
            "id": "sg:person.013134664337.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013134664337.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chonbuk National University", 
              "id": "https://www.grid.ac/institutes/grid.411545.0", 
              "name": [
                "Department of Physiology, Chonbuk National University Medical School, Jeonju 561-181, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Soo Mi", 
            "id": "sg:person.0745372135.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745372135.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Yang", 
            "id": "sg:person.01101034302.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101034302.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mo", 
            "givenName": "Qianxing", 
            "id": "sg:person.0727612675.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727612675.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siwko", 
            "givenName": "Stefan", 
            "id": "sg:person.0716645340.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716645340.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Ruozhen", 
            "id": "sg:person.0605405274.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605405274.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Ju-Seog", 
            "id": "sg:person.014435770224.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014435770224.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal College of Surgeons in Ireland", 
              "id": "https://www.grid.ac/institutes/grid.4912.e", 
              "name": [
                "Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen\u2019s Green, Dublin 2, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hennessy", 
            "givenName": "Bryan", 
            "id": "sg:person.01153534336.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153534336.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Clinical Cancer Prevention, Unit 1013, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanash", 
            "givenName": "Samir", 
            "id": "sg:person.016103106037.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016103106037.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mills", 
            "givenName": "Gordon B.", 
            "id": "sg:person.012742742357.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Shiaw-Yih", 
            "id": "sg:person.01251443701.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251443701.49"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1146/annurev.biochem.77.061306.125255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000560477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1133427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000786924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000929920", 
              "https://doi.org/10.1038/nature07955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000929920", 
              "https://doi.org/10.1038/nature07955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-1947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003525343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.58.3.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004815059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005296571", 
              "https://doi.org/10.1038/nature06973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005421334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1203326109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008958306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60893-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010088435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1132939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013321903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-0088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014334547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4914(02)02298-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015763908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2007.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020569710", 
              "https://doi.org/10.1038/ng.2007.39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgs167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021945525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2012.11.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022341035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023008521", 
              "https://doi.org/10.1038/ncomms1319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-0853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026447097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.200900041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028475219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.03.2755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030958683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032911270", 
              "https://doi.org/10.1038/nsmb.1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032911270", 
              "https://doi.org/10.1038/nsmb.1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034455568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035040826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035943457", 
              "https://doi.org/10.1038/nature09399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035943457", 
              "https://doi.org/10.1038/nature09399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0900212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036199013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036374993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036499081", 
              "https://doi.org/10.1038/nature03443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036499081", 
              "https://doi.org/10.1038/nature03443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(11)70214-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037513376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037618359", 
              "https://doi.org/10.1038/ncb2426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa021967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038600096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039649759", 
              "https://doi.org/10.1038/nature03445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039649759", 
              "https://doi.org/10.1038/nature03445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040539424", 
              "https://doi.org/10.1038/nature06548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040586971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040713307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041866743", 
              "https://doi.org/10.1038/ncb2344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042677464", 
              "https://doi.org/10.1038/ncb1895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042677464", 
              "https://doi.org/10.1038/ncb1895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.11.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043835193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046079148", 
              "https://doi.org/10.1038/ncb1865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mam.2012.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048322116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048636387", 
              "https://doi.org/10.1038/nature10760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051814387", 
              "https://doi.org/10.1038/nrm2851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051814387", 
              "https://doi.org/10.1038/nrm2851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00422.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053470985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053488336", 
              "https://doi.org/10.1038/nrc1951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053488336", 
              "https://doi.org/10.1038/nrc1951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1145720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053548183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m804080200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053629400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077171616", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/117693510700300022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077901890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/117693510700300022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077901890"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-12", 
        "datePublishedReg": "2014-12-01", 
        "description": "Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as a functional network analysis tool, we discover that simultaneous loss of two major tumour suppressors BRCA1 and PTEN extensively rewire the HR repair-deficient phenotype, which is found in cells with defects in either BRCA1 or PTEN alone. Moreover, the HRD gene signature serves as an effective drug discovery platform to identify agents targeting HR repair as potential chemo/radio sensitizers. More importantly, this HRD gene signature is able to predict clinical outcomes across multiple cancer lineages. Our findings, therefore, provide a molecular profile of HR repair to assess its status at a functional network level, which can provide both biological insights and have clinical implications in cancer. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ncomms4361", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7136556", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2441559", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440196", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2422103", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2477886", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438826", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043282", 
            "issn": [
              "2041-1723"
            ], 
            "name": "Nature Communications", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "name": "Genome-wide transcriptome profiling of homologous recombination DNA repair", 
        "pagination": "3361", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7a719e9799d93f5101ac8cbb156ae1409de15c2f515bed07efe44369df046198"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24553445"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101528555"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ncomms4361"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1025701533"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ncomms4361", 
          "https://app.dimensions.ai/details/publication/pub.1025701533"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000550.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/ncomms4361"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms4361'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms4361'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms4361'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms4361'


     

    This table displays all metadata directly associated to this object as RDF triples.

    380 TRIPLES      21 PREDICATES      85 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ncomms4361 schema:about N266edab9e3e4407f804751ac8ae244e7
    2 N5554cf5b346045449b844d5f9dfec13a
    3 N78e448e7a6344bfc8dc9d354a866aa7f
    4 N87b80e4dcd70460abe511ee250997dde
    5 Nbc9589468dd64f93b34cd2513b49dedb
    6 Nd11e1683109d4f21a844f50d4d167103
    7 Nda41aca2e99d446f907ee38fdcc99546
    8 Ne12ed20439aa4975b1a23a27fb5eac38
    9 anzsrc-for:11
    10 anzsrc-for:1112
    11 schema:author Nc77ea0839fbe43c7923070c15b0e6c2d
    12 schema:citation sg:pub.10.1038/nature03443
    13 sg:pub.10.1038/nature03445
    14 sg:pub.10.1038/nature06548
    15 sg:pub.10.1038/nature06973
    16 sg:pub.10.1038/nature07955
    17 sg:pub.10.1038/nature09399
    18 sg:pub.10.1038/nature10760
    19 sg:pub.10.1038/ncb1865
    20 sg:pub.10.1038/ncb1895
    21 sg:pub.10.1038/ncb2344
    22 sg:pub.10.1038/ncb2426
    23 sg:pub.10.1038/ncomms1319
    24 sg:pub.10.1038/ng.2007.39
    25 sg:pub.10.1038/nrc1951
    26 sg:pub.10.1038/nrm2851
    27 sg:pub.10.1038/nsmb.1831
    28 https://app.dimensions.ai/details/publication/pub.1077171616
    29 https://doi.org/10.1002/emmm.200900041
    30 https://doi.org/10.1016/j.ccr.2006.10.008
    31 https://doi.org/10.1016/j.cell.2006.11.042
    32 https://doi.org/10.1016/j.cell.2010.03.012
    33 https://doi.org/10.1016/j.cell.2011.02.013
    34 https://doi.org/10.1016/j.febslet.2012.11.018
    35 https://doi.org/10.1016/j.mam.2012.12.005
    36 https://doi.org/10.1016/j.molcel.2010.09.019
    37 https://doi.org/10.1016/s0140-6736(10)60893-8
    38 https://doi.org/10.1016/s1470-2045(11)70214-5
    39 https://doi.org/10.1016/s1471-4914(02)02298-0
    40 https://doi.org/10.1056/nejmoa021967
    41 https://doi.org/10.1056/nejmoa0900212
    42 https://doi.org/10.1073/pnas.1203326109
    43 https://doi.org/10.1074/jbc.m804080200
    44 https://doi.org/10.1093/carcin/bgs167
    45 https://doi.org/10.1093/nar/gks486
    46 https://doi.org/10.1124/pr.58.3.10
    47 https://doi.org/10.1126/science.1132939
    48 https://doi.org/10.1126/science.1133427
    49 https://doi.org/10.1126/science.1145720
    50 https://doi.org/10.1146/annurev.biochem.77.061306.125255
    51 https://doi.org/10.1152/ajpcell.00422.2003
    52 https://doi.org/10.1158/0008-5472.can-08-0088
    53 https://doi.org/10.1158/0008-5472.can-09-1947
    54 https://doi.org/10.1158/0008-5472.can-11-0853
    55 https://doi.org/10.1158/2159-8290.cd-11-0336
    56 https://doi.org/10.1158/2159-8290.cd-11-0348
    57 https://doi.org/10.1177/117693510700300022
    58 https://doi.org/10.1200/jco.2005.03.2755
    59 https://doi.org/10.1371/journal.pbio.1000408
    60 schema:datePublished 2014-12
    61 schema:datePublishedReg 2014-12-01
    62 schema:description Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as a functional network analysis tool, we discover that simultaneous loss of two major tumour suppressors BRCA1 and PTEN extensively rewire the HR repair-deficient phenotype, which is found in cells with defects in either BRCA1 or PTEN alone. Moreover, the HRD gene signature serves as an effective drug discovery platform to identify agents targeting HR repair as potential chemo/radio sensitizers. More importantly, this HRD gene signature is able to predict clinical outcomes across multiple cancer lineages. Our findings, therefore, provide a molecular profile of HR repair to assess its status at a functional network level, which can provide both biological insights and have clinical implications in cancer.
    63 schema:genre research_article
    64 schema:inLanguage en
    65 schema:isAccessibleForFree true
    66 schema:isPartOf Na5f5baf4cac9407197b2ddbf70d889fa
    67 Nc7dc8901842343048d2ed3b24c734b30
    68 sg:journal.1043282
    69 schema:name Genome-wide transcriptome profiling of homologous recombination DNA repair
    70 schema:pagination 3361
    71 schema:productId N0936e70c44f5467bb804b827e0bc5bf0
    72 N5f592ddac01c47d9960aaadbd33a3ed6
    73 N6c5c75bfe4804ababf5f978375d5fbfa
    74 Nb12b9377106747358487d4726add966c
    75 Ncdb91754dbe74af19f7eadaf05321a9d
    76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025701533
    77 https://doi.org/10.1038/ncomms4361
    78 schema:sdDatePublished 2019-04-10T22:39
    79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    80 schema:sdPublisher N700dc701a845418aaa004caba318614a
    81 schema:url https://www.nature.com/articles/ncomms4361
    82 sgo:license sg:explorer/license/
    83 sgo:sdDataset articles
    84 rdf:type schema:ScholarlyArticle
    85 N0500c3e0e9de4a1a93b31367fe0c52ec rdf:first sg:person.0727612675.43
    86 rdf:rest N7e662d8d63814f05952689a25c36c5e4
    87 N0936e70c44f5467bb804b827e0bc5bf0 schema:name readcube_id
    88 schema:value 7a719e9799d93f5101ac8cbb156ae1409de15c2f515bed07efe44369df046198
    89 rdf:type schema:PropertyValue
    90 N1665cdbf58bb4442be9fc258fe5d5eaa rdf:first sg:person.01153534336.84
    91 rdf:rest N51910b73357648b286dd88a88458c112
    92 N266edab9e3e4407f804751ac8ae244e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name PTEN Phosphohydrolase
    94 rdf:type schema:DefinedTerm
    95 N51910b73357648b286dd88a88458c112 rdf:first sg:person.016103106037.44
    96 rdf:rest N69442cb15dbb4508b4d2cc84d16e434a
    97 N53cff8443dd64a9591ccb401b3514644 rdf:first sg:person.013134664337.85
    98 rdf:rest Nab3cde0837ca4200912dde892bb5e437
    99 N5554cf5b346045449b844d5f9dfec13a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Gene Expression Profiling
    101 rdf:type schema:DefinedTerm
    102 N5daf0cef853c41beb7290e39122c38f3 rdf:first sg:person.0650357302.80
    103 rdf:rest N8446946ab2fd42a8922d67b2274099ed
    104 N5f592ddac01c47d9960aaadbd33a3ed6 schema:name nlm_unique_id
    105 schema:value 101528555
    106 rdf:type schema:PropertyValue
    107 N678e3c0210ef4d30985296720aa991ce rdf:first sg:person.0605405274.23
    108 rdf:rest Ne2ed35eda6e445a6ad45a29d20bac64c
    109 N69442cb15dbb4508b4d2cc84d16e434a rdf:first sg:person.012742742357.13
    110 rdf:rest Ncbb368f43c4e4ac991324c48547b9c26
    111 N6c5c75bfe4804ababf5f978375d5fbfa schema:name dimensions_id
    112 schema:value pub.1025701533
    113 rdf:type schema:PropertyValue
    114 N700dc701a845418aaa004caba318614a schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N78e448e7a6344bfc8dc9d354a866aa7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Cell Line, Tumor
    118 rdf:type schema:DefinedTerm
    119 N7e662d8d63814f05952689a25c36c5e4 rdf:first sg:person.0716645340.39
    120 rdf:rest N678e3c0210ef4d30985296720aa991ce
    121 N8446946ab2fd42a8922d67b2274099ed rdf:first sg:person.01061421542.02
    122 rdf:rest N53cff8443dd64a9591ccb401b3514644
    123 N8770cc93cbdd4fd3a30003563968acc5 rdf:first sg:person.01101034302.93
    124 rdf:rest N0500c3e0e9de4a1a93b31367fe0c52ec
    125 N87b80e4dcd70460abe511ee250997dde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Humans
    127 rdf:type schema:DefinedTerm
    128 Na26721fc246d4f02b11729cff30380dd rdf:first sg:person.01247341325.59
    129 rdf:rest N5daf0cef853c41beb7290e39122c38f3
    130 Na5f5baf4cac9407197b2ddbf70d889fa schema:volumeNumber 5
    131 rdf:type schema:PublicationVolume
    132 Nab3cde0837ca4200912dde892bb5e437 rdf:first sg:person.0745372135.17
    133 rdf:rest N8770cc93cbdd4fd3a30003563968acc5
    134 Nb12b9377106747358487d4726add966c schema:name doi
    135 schema:value 10.1038/ncomms4361
    136 rdf:type schema:PropertyValue
    137 Nbc9589468dd64f93b34cd2513b49dedb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Recombinational DNA Repair
    139 rdf:type schema:DefinedTerm
    140 Nc77ea0839fbe43c7923070c15b0e6c2d rdf:first sg:person.012157310057.23
    141 rdf:rest Na26721fc246d4f02b11729cff30380dd
    142 Nc7dc8901842343048d2ed3b24c734b30 schema:issueNumber 1
    143 rdf:type schema:PublicationIssue
    144 Ncbb368f43c4e4ac991324c48547b9c26 rdf:first sg:person.01251443701.49
    145 rdf:rest rdf:nil
    146 Ncdb91754dbe74af19f7eadaf05321a9d schema:name pubmed_id
    147 schema:value 24553445
    148 rdf:type schema:PropertyValue
    149 Nd11e1683109d4f21a844f50d4d167103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Cell Proliferation
    151 rdf:type schema:DefinedTerm
    152 Nda41aca2e99d446f907ee38fdcc99546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Flow Cytometry
    154 rdf:type schema:DefinedTerm
    155 Ne12ed20439aa4975b1a23a27fb5eac38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name BRCA1 Protein
    157 rdf:type schema:DefinedTerm
    158 Ne2ed35eda6e445a6ad45a29d20bac64c rdf:first sg:person.014435770224.65
    159 rdf:rest N1665cdbf58bb4442be9fc258fe5d5eaa
    160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Medical and Health Sciences
    162 rdf:type schema:DefinedTerm
    163 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Oncology and Carcinogenesis
    165 rdf:type schema:DefinedTerm
    166 sg:grant.2422103 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms4361
    167 rdf:type schema:MonetaryGrant
    168 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms4361
    169 rdf:type schema:MonetaryGrant
    170 sg:grant.2440196 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms4361
    171 rdf:type schema:MonetaryGrant
    172 sg:grant.2441559 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms4361
    173 rdf:type schema:MonetaryGrant
    174 sg:grant.2477886 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms4361
    175 rdf:type schema:MonetaryGrant
    176 sg:grant.7136556 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms4361
    177 rdf:type schema:MonetaryGrant
    178 sg:journal.1043282 schema:issn 2041-1723
    179 schema:name Nature Communications
    180 rdf:type schema:Periodical
    181 sg:person.01061421542.02 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    182 schema:familyName Dai
    183 schema:givenName Hui
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061421542.02
    185 rdf:type schema:Person
    186 sg:person.01101034302.93 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    187 schema:familyName Peng
    188 schema:givenName Yang
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101034302.93
    190 rdf:type schema:Person
    191 sg:person.01153534336.84 schema:affiliation https://www.grid.ac/institutes/grid.4912.e
    192 schema:familyName Hennessy
    193 schema:givenName Bryan
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153534336.84
    195 rdf:type schema:Person
    196 sg:person.012157310057.23 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    197 schema:familyName Peng
    198 schema:givenName Guang
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012157310057.23
    200 rdf:type schema:Person
    201 sg:person.01247341325.59 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    202 schema:familyName Lin
    203 schema:givenName Curtis Chun-Jen
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247341325.59
    205 rdf:type schema:Person
    206 sg:person.01251443701.49 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    207 schema:familyName Lin
    208 schema:givenName Shiaw-Yih
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251443701.49
    210 rdf:type schema:Person
    211 sg:person.012742742357.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    212 schema:familyName Mills
    213 schema:givenName Gordon B.
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13
    215 rdf:type schema:Person
    216 sg:person.013134664337.85 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    217 schema:familyName Park
    218 schema:givenName Yun-Yong
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013134664337.85
    220 rdf:type schema:Person
    221 sg:person.014435770224.65 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    222 schema:familyName Lee
    223 schema:givenName Ju-Seog
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014435770224.65
    225 rdf:type schema:Person
    226 sg:person.016103106037.44 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    227 schema:familyName Hanash
    228 schema:givenName Samir
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016103106037.44
    230 rdf:type schema:Person
    231 sg:person.0605405274.23 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    232 schema:familyName Hu
    233 schema:givenName Ruozhen
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605405274.23
    235 rdf:type schema:Person
    236 sg:person.0650357302.80 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    237 schema:familyName Mo
    238 schema:givenName Wei
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650357302.80
    240 rdf:type schema:Person
    241 sg:person.0716645340.39 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    242 schema:familyName Siwko
    243 schema:givenName Stefan
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716645340.39
    245 rdf:type schema:Person
    246 sg:person.0727612675.43 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    247 schema:familyName Mo
    248 schema:givenName Qianxing
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727612675.43
    250 rdf:type schema:Person
    251 sg:person.0745372135.17 schema:affiliation https://www.grid.ac/institutes/grid.411545.0
    252 schema:familyName Kim
    253 schema:givenName Soo Mi
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745372135.17
    255 rdf:type schema:Person
    256 sg:pub.10.1038/nature03443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036499081
    257 https://doi.org/10.1038/nature03443
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nature03445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649759
    260 https://doi.org/10.1038/nature03445
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nature06548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040539424
    263 https://doi.org/10.1038/nature06548
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature06973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005296571
    266 https://doi.org/10.1038/nature06973
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature07955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929920
    269 https://doi.org/10.1038/nature07955
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature09399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035943457
    272 https://doi.org/10.1038/nature09399
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature10760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048636387
    275 https://doi.org/10.1038/nature10760
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/ncb1865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046079148
    278 https://doi.org/10.1038/ncb1865
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/ncb1895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042677464
    281 https://doi.org/10.1038/ncb1895
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/ncb2344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041866743
    284 https://doi.org/10.1038/ncb2344
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/ncb2426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037618359
    287 https://doi.org/10.1038/ncb2426
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/ncomms1319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023008521
    290 https://doi.org/10.1038/ncomms1319
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/ng.2007.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020569710
    293 https://doi.org/10.1038/ng.2007.39
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nrc1951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053488336
    296 https://doi.org/10.1038/nrc1951
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nrm2851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051814387
    299 https://doi.org/10.1038/nrm2851
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nsmb.1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032911270
    302 https://doi.org/10.1038/nsmb.1831
    303 rdf:type schema:CreativeWork
    304 https://app.dimensions.ai/details/publication/pub.1077171616 schema:CreativeWork
    305 https://doi.org/10.1002/emmm.200900041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028475219
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.ccr.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040586971
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.cell.2006.11.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043835193
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.cell.2010.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035040826
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.febslet.2012.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022341035
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.mam.2012.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048322116
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.molcel.2010.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198160
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0140-6736(10)60893-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010088435
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s1470-2045(11)70214-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037513376
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s1471-4914(02)02298-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015763908
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1056/nejmoa021967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038600096
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1056/nejmoa0900212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199013
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1073/pnas.1203326109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008958306
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1074/jbc.m804080200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053629400
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1093/carcin/bgs167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021945525
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/nar/gks486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036374993
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1124/pr.58.3.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004815059
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1126/science.1132939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321903
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1126/science.1133427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000786924
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.1145720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053548183
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1146/annurev.biochem.77.061306.125255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000560477
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1152/ajpcell.00422.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053470985
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1158/0008-5472.can-08-0088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014334547
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1158/0008-5472.can-09-1947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003525343
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1158/0008-5472.can-11-0853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026447097
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1158/2159-8290.cd-11-0336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040713307
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1158/2159-8290.cd-11-0348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034455568
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1177/117693510700300022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077901890
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1200/jco.2005.03.2755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030958683
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1371/journal.pbio.1000408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005421334
    366 rdf:type schema:CreativeWork
    367 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    368 schema:name Department of Clinical Cancer Prevention, Unit 1013, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    369 Department of Oncology, Tongji Hospital, Tongji Medical College, The University of Huazhong Science & Technology, Wuhan, Hubei Province 430022, China
    370 Department of Systems Biology, Unit 950, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    371 rdf:type schema:Organization
    372 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
    373 schema:name Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    374 rdf:type schema:Organization
    375 https://www.grid.ac/institutes/grid.411545.0 schema:alternateName Chonbuk National University
    376 schema:name Department of Physiology, Chonbuk National University Medical School, Jeonju 561-181, Republic of Korea
    377 rdf:type schema:Organization
    378 https://www.grid.ac/institutes/grid.4912.e schema:alternateName Royal College of Surgeons in Ireland
    379 schema:name Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland
    380 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...