Biomimetic virus-based colourimetric sensors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-01-21

AUTHORS

Jin-Woo Oh, Woo-Jae Chung, Kwang Heo, Hyo-Eon Jin, Byung Yang Lee, Eddie Wang, Chris Zueger, Winnie Wong, Joel Meyer, Chuntae Kim, So-Young Lee, Won-Geun Kim, Marcin Zemla, Manfred Auer, Alexander Hexemer, Seung-Wuk Lee

ABSTRACT

Many materials in nature change colours in response to stimuli, making them attractive for use as sensor platform. However, both natural materials and their synthetic analogues lack selectivity towards specific chemicals, and introducing such selectivity remains a challenge. Here we report the self-assembly of genetically engineered viruses (M13 phage) into target-specific, colourimetric biosensors. The sensors are composed of phage-bundle nanostructures and exhibit viewing-angle independent colour, similar to collagen structures in turkey skin. On exposure to various volatile organic chemicals, the structures rapidly swell and undergo distinct colour changes. Furthermore, sensors composed of phage displaying trinitrotoluene (TNT)-binding peptide motifs identified from a phage display selectively distinguish TNT down to 300 p.p.b. over similarly structured chemicals. Our tunable, colourimetric sensors can be useful for the detection of a variety of harmful toxicants and pathogens to protect human health and national security. More... »

PAGES

3043

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms4043

DOI

http://dx.doi.org/10.1038/ncomms4043

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053666207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24448217


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29 schema:description Many materials in nature change colours in response to stimuli, making them attractive for use as sensor platform. However, both natural materials and their synthetic analogues lack selectivity towards specific chemicals, and introducing such selectivity remains a challenge. Here we report the self-assembly of genetically engineered viruses (M13 phage) into target-specific, colourimetric biosensors. The sensors are composed of phage-bundle nanostructures and exhibit viewing-angle independent colour, similar to collagen structures in turkey skin. On exposure to various volatile organic chemicals, the structures rapidly swell and undergo distinct colour changes. Furthermore, sensors composed of phage displaying trinitrotoluene (TNT)-binding peptide motifs identified from a phage display selectively distinguish TNT down to 300 p.p.b. over similarly structured chemicals. Our tunable, colourimetric sensors can be useful for the detection of a variety of harmful toxicants and pathogens to protect human health and national security.
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37 TNT
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41 changes
42 changes color
43 chemicals
44 collagen structure
45 color
46 color change
47 colourimetric biosensors
48 colourimetric sensor
49 detection
50 display
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52 distinct color change
53 exposure
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55 health
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59 motif
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61 national security
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64 organic chemicals
65 pathogens
66 peptide motifs
67 phage display
68 phage displaying trinitrotoluene
69 phage-bundle nanostructures
70 platform
71 response
72 security
73 selectivity
74 sensor platform
75 sensors
76 skin
77 specific chemicals
78 stimuli
79 structure
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81 synthetic analogues
82 toxicants
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84 turkey skin
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