Ontology type: schema:ScholarlyArticle Open Access: True
2014-12
AUTHORSJ.T. Bell, A.K. Loomis, L.M. Butcher, F. Gao, B. Zhang, C.L. Hyde, J. Sun, H. Wu, K. Ward, J. Harris, S. Scollen, M.N. Davies, L.C. Schalkwyk, J. Mill, The MuTHER Consortium, Kourosh R. Ahmadi, Chrysanthi Ainali, Amy Barrett, Veronique Bataille, Jordana T. Bell, Alfonso Buil, Panos Deloukas, Emmanoil T. Dermitzakis, Antigone S. Dimas, Richard Durbin, Daniel Glass, Elin Grundberg, Neelam Hassanali, Asa K. Hedman, Catherine Ingle, David Knowles, Maria Krestyaninova, Cecilia M. Lindgren, Christopher E. Lowe, Mark I. McCarthy, Eshwar Meduri, Paola di Meglio, Josine L. Min, Stephen B. Montgomery, Frank O. Nestle, Alexandra C. Nica, James Nisbet, Stephen O’Rahilly, Leopold Parts, Simon Potter, Magdalena Sekowska, So-Youn Shin, Kerrin S. Small, Nicole Soranzo, Tim D. Spector, Gabriela Surdulescu, Mary E. Travers, Loukia Tsaprouni, Sophia Tsoka, Alicja Wilk, Tsun-Po Yang, Krina T. Zondervan, F.M.K. Williams, N. Li, P. Deloukas, S. Beck, S.B. McMahon, J. Wang, S.L. John, T.D. Spector
ABSTRACTChronic pain is a global public health problem, but the underlying molecular mechanisms are not fully understood. Here we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals. Whole-blood DNA methylation was characterized at 5.2 million loci by MeDIP sequencing and assessed longitudinally to identify differentially methylated regions associated with high or low pain sensitivity (pain DMRs). Nine meta-analysis pain DMRs show robust evidence for association (false discovery rate 5%) with the strongest signal in the pain gene TRPA1 (P=1.2 × 10(-13)). Several pain DMRs show longitudinal stability consistent with susceptibility effects, have similar methylation levels in the brain and altered expression in the skin. Our approach identifies epigenetic changes in both novel and established candidate genes that provide molecular insights into pain and may generalize to other complex traits. More... »
PAGES2978
http://scigraph.springernature.com/pub.10.1038/ncomms3978
DOIhttp://dx.doi.org/10.1038/ncomms3978
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24496475
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