Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Binggang Xiang, Guoying Zhang, Ling Guo, Xiang-An Li, Andrew J. Morris, Alan Daugherty, Sidney W. Whiteheart, Susan S. Smyth, Zhenyu Li

ABSTRACT

Although it has long been known that patients with sepsis often have thrombocytopenia and that septic patients with severe thrombocytopenia have a poor prognosis and higher mortality, the role of platelets in the pathogenesis of sepsis is poorly understood. Here we report a protective role of platelets in septic shock. We show that experimental thrombocytopenia induced by intraperitoneal injection of an anti-glycoprotein Ibα monoclonal antibody increases mortality and aggravates organ failure, whereas transfusion of platelets reduces mortality in lipopolysaccharide-induced endotoxemia and a bacterial infusion mouse sepsis model. Plasma concentrations of proinflammatory cytokines TNF-α and IL-6 are elevated by thrombocytopenia and decreased by platelet transfusion in septic mice. Furthermore, we identify that platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the COX1/PGE₂/EP4-dependent pathway. Thus, these findings demonstrate a previously unappreciated role for platelets in septic shock and suggest that platelet transfusion may be effective in treating severely septic patients. More... »

PAGES

2657

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms3657

DOI

http://dx.doi.org/10.1038/ncomms3657

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004256814

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24150174


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Anti-Idiotypic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Platelets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dinoprostone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopolysaccharides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages, Peritoneal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Glycoprotein GPIb-IX Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Transfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Prostaglandin E, EP4 Subtype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shock, Septic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombocytopenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiang", 
        "givenName": "Binggang", 
        "id": "sg:person.01302114700.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302114700.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Guoying", 
        "id": "sg:person.0743330312.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743330312.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Pediatrics, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Ling", 
        "id": "sg:person.01114457210.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114457210.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA", 
            "Department of Pediatrics, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xiang-An", 
        "id": "sg:person.01041072320.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041072320.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morris", 
        "givenName": "Andrew J.", 
        "id": "sg:person.01246207373.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246207373.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daugherty", 
        "givenName": "Alan", 
        "id": "sg:person.0660174451.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660174451.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whiteheart", 
        "givenName": "Sidney W.", 
        "id": "sg:person.01121304105.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121304105.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lexington VA Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413837.a", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA", 
            "Veterans Affairs Medical Center, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smyth", 
        "givenName": "Susan S.", 
        "id": "sg:person.01362775372.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362775372.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zhenyu", 
        "id": "sg:person.0677541334.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677541334.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci12242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000439993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200206000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000937290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200206000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000937290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-011-0286-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002488621", 
          "https://doi.org/10.1007/s00281-011-0286-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.shk.0000108399.56565.e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005626692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.shk.0000108399.56565.e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005626692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-9255-7-53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006225025", 
          "https://doi.org/10.1186/1476-9255-7-53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.173.4.1021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007206638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.shk.0000129338.99410.5d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007563390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.shk.0000129338.99410.5d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007563390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.239608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009273230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.06-2233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009495104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009509249", 
          "https://doi.org/10.1038/38284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009509249", 
          "https://doi.org/10.1038/38284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90126-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010609542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2007.02865.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011467606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.blre.2009.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011753650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.181.5.3495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012696867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.4.2125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012772371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-02-413047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013275796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2006.02192.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014373302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-06-2202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015689477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200204000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018684308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200204000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018684308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018745714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/175.1.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019165835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021998570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021998570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90001-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022406028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-011-0283-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023666054", 
          "https://doi.org/10.1007/s00281-011-0283-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e328309ec74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025657498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e328309ec74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025657498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2004.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026307158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-08-376822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027044660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027601999", 
          "https://doi.org/10.1038/nm.1905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(97)01377-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030015972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200204000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030680935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-200204000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030680935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-6980(98)00061-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030876897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-03-0916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031065817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-02-270934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032673064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033599584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/315093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035680660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.36.10.2139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036881405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0802884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038586542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2008.06999.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039926219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci65154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041197320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000145906.63859.1a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041463270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000145906.63859.1a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041463270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-11-123620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042871764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.6.2365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044652573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci5116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045455366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046780586", 
          "https://doi.org/10.1038/nm1565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047549707", 
          "https://doi.org/10.1038/nri2956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90134-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047648459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.med.45.1.491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050494435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2010.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050979621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-06-029082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052749525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10245330512331390177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058358077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jir.2011.0062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059281304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/163.1.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059702403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci27209.", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critreveukargeneexpr.v20.i2.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068131101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074353219", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.2001.281.3.l537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074864865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076891062", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077534755", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0703500604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077534755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0703500604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077534755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0703500604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077534755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1002788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078388984"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "Although it has long been known that patients with sepsis often have thrombocytopenia and that septic patients with severe thrombocytopenia have a poor prognosis and higher mortality, the role of platelets in the pathogenesis of sepsis is poorly understood. Here we report a protective role of platelets in septic shock. We show that experimental thrombocytopenia induced by intraperitoneal injection of an anti-glycoprotein Ib\u03b1 monoclonal antibody increases mortality and aggravates organ failure, whereas transfusion of platelets reduces mortality in lipopolysaccharide-induced endotoxemia and a bacterial infusion mouse sepsis model. Plasma concentrations of proinflammatory cytokines TNF-\u03b1 and IL-6 are elevated by thrombocytopenia and decreased by platelet transfusion in septic mice. Furthermore, we identify that platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the COX1/PGE\u2082/EP4-dependent pathway. Thus, these findings demonstrate a previously unappreciated role for platelets in septic shock and suggest that platelet transfusion may be effective in treating severely septic patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms3657", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2437926", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438505", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2520141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2675081", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2674661", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway", 
    "pagination": "2657", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1448b2850e090d0f1af653a02690e2a0fb7a1a402a7b9d2a66d1cf736f3ea871"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24150174"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms3657"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004256814"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms3657", 
      "https://app.dimensions.ai/details/publication/pub.1004256814"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms3657"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms3657'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms3657'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms3657'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms3657'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      113 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms3657 schema:about N05655436c790477f9a1d276156d2b9d9
2 N0d613ae9395c4dfea29a2858888e0322
3 N112c192ad76e41cb9067092998f9ed8f
4 N1b2d181009de4e6cae29f8d700c373a0
5 N36c80d6805ab49e4b6b8d261f7533942
6 N57b19445b5c742b9b7fcda3b8af44d60
7 N5f6422ec420c46d7986061452e44e778
8 N65ae019c17244592990d018df84ff864
9 N6859bb118c484113b2d0408f7de28584
10 N6a87fb4a46124fd6bd9711f900d75b8a
11 N6ee520cd3d014cfcaa66385ce4e6e7b4
12 N6f2d47d3d38249f7b9449531544b202f
13 N6f8fd6a8172b4136aff12780043524e0
14 N7b3835f8c784471a9eb89d20c306c56d
15 Na576b23cc16e43da83487febc09f7729
16 Nbc2e329b77d242769cec6ce65a70762d
17 Nc6666b6081f4454d94eb0af8305e5a96
18 Nc6d21f4424c648d5a88de8eabbca9c39
19 Ncd8d72f2112445d594f8811fee6a317a
20 Nd002910507dc4d44b5cb34a0afb4eb28
21 Nd5720955da4d42af8e29eaad91b46d73
22 Neae4bc62644d4a299970cb63c83bb2b0
23 Nf680b1f1bb8747129b5f6e6315520b91
24 anzsrc-for:11
25 anzsrc-for:1107
26 schema:author N753c97dd594c45f685f8173932d6ac9b
27 schema:citation sg:pub.10.1007/s00281-011-0283-7
28 sg:pub.10.1007/s00281-011-0286-4
29 sg:pub.10.1038/38284
30 sg:pub.10.1038/nm.1905
31 sg:pub.10.1038/nm1565
32 sg:pub.10.1038/nri2956
33 sg:pub.10.1186/1476-9255-7-53
34 https://app.dimensions.ai/details/publication/pub.1074353219
35 https://app.dimensions.ai/details/publication/pub.1076891062
36 https://app.dimensions.ai/details/publication/pub.1077534755
37 https://doi.org/10.1016/0092-8674(93)90134-c
38 https://doi.org/10.1016/0092-8674(95)90126-4
39 https://doi.org/10.1016/1074-7613(95)90001-2
40 https://doi.org/10.1016/j.bbi.2004.05.003
41 https://doi.org/10.1016/j.blre.2009.04.001
42 https://doi.org/10.1016/j.thromres.2010.10.010
43 https://doi.org/10.1016/s0014-5793(97)01377-x
44 https://doi.org/10.1016/s0090-6980(98)00061-6
45 https://doi.org/10.1074/jbc.m111.239608
46 https://doi.org/10.1080/10245330512331390177
47 https://doi.org/10.1084/jem.173.4.1021
48 https://doi.org/10.1084/jem.180.6.2365
49 https://doi.org/10.1086/315093
50 https://doi.org/10.1089/jir.2011.0062
51 https://doi.org/10.1093/infdis/163.1.89
52 https://doi.org/10.1093/infdis/175.1.123
53 https://doi.org/10.1097/00003246-200204000-00005
54 https://doi.org/10.1097/00024382-200204000-00004
55 https://doi.org/10.1097/00024382-200206000-00004
56 https://doi.org/10.1097/01.ccm.0000145906.63859.1a
57 https://doi.org/10.1097/01.shk.0000108399.56565.e7
58 https://doi.org/10.1097/01.shk.0000129338.99410.5d
59 https://doi.org/10.1097/moh.0b013e328309ec74
60 https://doi.org/10.1111/j.1365-2141.2008.06999.x
61 https://doi.org/10.1111/j.1538-7836.2006.02192.x
62 https://doi.org/10.1111/j.1538-7836.2007.02865.x
63 https://doi.org/10.1128/aac.36.10.2139
64 https://doi.org/10.1146/annurev.med.45.1.491
65 https://doi.org/10.1152/ajplung.2001.281.3.l537
66 https://doi.org/10.1172/jci117921
67 https://doi.org/10.1172/jci118575
68 https://doi.org/10.1172/jci12242
69 https://doi.org/10.1172/jci27209.
70 https://doi.org/10.1172/jci38432
71 https://doi.org/10.1172/jci39421
72 https://doi.org/10.1172/jci5116
73 https://doi.org/10.1172/jci65154
74 https://doi.org/10.1177/0310057x0703500604
75 https://doi.org/10.1182/blood-2005-03-0916
76 https://doi.org/10.1182/blood-2005-06-2202
77 https://doi.org/10.1182/blood-2006-06-029082
78 https://doi.org/10.1182/blood-2007-11-123620
79 https://doi.org/10.1182/blood-2010-02-270934
80 https://doi.org/10.1182/blood-2011-08-376822
81 https://doi.org/10.1182/blood-2012-02-413047
82 https://doi.org/10.1378/chest.06-2233
83 https://doi.org/10.1615/critreveukargeneexpr.v20.i2.10
84 https://doi.org/10.4049/jimmunol.0802884
85 https://doi.org/10.4049/jimmunol.1002788
86 https://doi.org/10.4049/jimmunol.180.4.2125
87 https://doi.org/10.4049/jimmunol.181.5.3495
88 schema:datePublished 2013-12
89 schema:datePublishedReg 2013-12-01
90 schema:description Although it has long been known that patients with sepsis often have thrombocytopenia and that septic patients with severe thrombocytopenia have a poor prognosis and higher mortality, the role of platelets in the pathogenesis of sepsis is poorly understood. Here we report a protective role of platelets in septic shock. We show that experimental thrombocytopenia induced by intraperitoneal injection of an anti-glycoprotein Ibα monoclonal antibody increases mortality and aggravates organ failure, whereas transfusion of platelets reduces mortality in lipopolysaccharide-induced endotoxemia and a bacterial infusion mouse sepsis model. Plasma concentrations of proinflammatory cytokines TNF-α and IL-6 are elevated by thrombocytopenia and decreased by platelet transfusion in septic mice. Furthermore, we identify that platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the COX1/PGE₂/EP4-dependent pathway. Thus, these findings demonstrate a previously unappreciated role for platelets in septic shock and suggest that platelet transfusion may be effective in treating severely septic patients.
91 schema:genre research_article
92 schema:inLanguage en
93 schema:isAccessibleForFree true
94 schema:isPartOf Na1592f0cf0124f6cba16fc1c56a004ac
95 Nf9cf21a9a4d14f51a386e598691f56d4
96 sg:journal.1043282
97 schema:name Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway
98 schema:pagination 2657
99 schema:productId N0186bcc328d54293bb17a00a3e567aa7
100 N579b992d917c4579a12cbde2dc773ed2
101 Ncd9e0e93c1cc47758739271216437ab9
102 Ne1aa5cb54a4843089e78b2ffa88ee88b
103 Ne541475168d64d11a0db41d412fb3254
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004256814
105 https://doi.org/10.1038/ncomms3657
106 schema:sdDatePublished 2019-04-11T01:48
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N50c9cef9a6bd4cd0b7f95f73f619d170
109 schema:url https://www.nature.com/articles/ncomms3657
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N0186bcc328d54293bb17a00a3e567aa7 schema:name dimensions_id
114 schema:value pub.1004256814
115 rdf:type schema:PropertyValue
116 N05655436c790477f9a1d276156d2b9d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Platelet Glycoprotein GPIb-IX Complex
118 rdf:type schema:DefinedTerm
119 N0d613ae9395c4dfea29a2858888e0322 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mice
121 rdf:type schema:DefinedTerm
122 N112c192ad76e41cb9067092998f9ed8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Humans
124 rdf:type schema:DefinedTerm
125 N113be189c11245c9a40006b5d0567859 rdf:first sg:person.01246207373.87
126 rdf:rest N379c42a16977490c888097ebca67f778
127 N11734b2e2dcd4be2923ebb83ff561750 rdf:first sg:person.0677541334.50
128 rdf:rest rdf:nil
129 N1b2d181009de4e6cae29f8d700c373a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Dinoprostone
131 rdf:type schema:DefinedTerm
132 N36c80d6805ab49e4b6b8d261f7533942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Lipopolysaccharides
134 rdf:type schema:DefinedTerm
135 N379c42a16977490c888097ebca67f778 rdf:first sg:person.0660174451.14
136 rdf:rest Nfdb9b0e60e5e4b59980bb7329dab7e91
137 N50c9cef9a6bd4cd0b7f95f73f619d170 schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N579b992d917c4579a12cbde2dc773ed2 schema:name readcube_id
140 schema:value 1448b2850e090d0f1af653a02690e2a0fb7a1a402a7b9d2a66d1cf736f3ea871
141 rdf:type schema:PropertyValue
142 N57b19445b5c742b9b7fcda3b8af44d60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Inflammation
144 rdf:type schema:DefinedTerm
145 N5da5cefd38ab4a0ca6d9cbe7e35cc587 rdf:first sg:person.0743330312.44
146 rdf:rest Ne93df3e7496e4a21bde561c5106d02de
147 N5f6422ec420c46d7986061452e44e778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Shock, Septic
149 rdf:type schema:DefinedTerm
150 N65ae019c17244592990d018df84ff864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Antibodies, Anti-Idiotypic
152 rdf:type schema:DefinedTerm
153 N6859bb118c484113b2d0408f7de28584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Interleukin-6
155 rdf:type schema:DefinedTerm
156 N6a87fb4a46124fd6bd9711f900d75b8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Tumor Necrosis Factor-alpha
158 rdf:type schema:DefinedTerm
159 N6ee520cd3d014cfcaa66385ce4e6e7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Thrombocytopenia
161 rdf:type schema:DefinedTerm
162 N6f2d47d3d38249f7b9449531544b202f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Platelet Transfusion
164 rdf:type schema:DefinedTerm
165 N6f8fd6a8172b4136aff12780043524e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Disease Models, Animal
167 rdf:type schema:DefinedTerm
168 N753c97dd594c45f685f8173932d6ac9b rdf:first sg:person.01302114700.87
169 rdf:rest N5da5cefd38ab4a0ca6d9cbe7e35cc587
170 N7b3835f8c784471a9eb89d20c306c56d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Mice, Inbred C57BL
172 rdf:type schema:DefinedTerm
173 Na1592f0cf0124f6cba16fc1c56a004ac schema:issueNumber 1
174 rdf:type schema:PublicationIssue
175 Na576b23cc16e43da83487febc09f7729 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Signal Transduction
177 rdf:type schema:DefinedTerm
178 Nbc2e329b77d242769cec6ce65a70762d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Receptors, Prostaglandin E, EP4 Subtype
180 rdf:type schema:DefinedTerm
181 Nc6666b6081f4454d94eb0af8305e5a96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Animals
183 rdf:type schema:DefinedTerm
184 Nc6d21f4424c648d5a88de8eabbca9c39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Macrophages, Peritoneal
186 rdf:type schema:DefinedTerm
187 Ncd8d72f2112445d594f8811fee6a317a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Cyclooxygenase 1
189 rdf:type schema:DefinedTerm
190 Ncd9e0e93c1cc47758739271216437ab9 schema:name nlm_unique_id
191 schema:value 101528555
192 rdf:type schema:PropertyValue
193 Nd002910507dc4d44b5cb34a0afb4eb28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Membrane Proteins
195 rdf:type schema:DefinedTerm
196 Nd5720955da4d42af8e29eaad91b46d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Gene Expression Regulation
198 rdf:type schema:DefinedTerm
199 Ne1aa5cb54a4843089e78b2ffa88ee88b schema:name pubmed_id
200 schema:value 24150174
201 rdf:type schema:PropertyValue
202 Ne541475168d64d11a0db41d412fb3254 schema:name doi
203 schema:value 10.1038/ncomms3657
204 rdf:type schema:PropertyValue
205 Ne93df3e7496e4a21bde561c5106d02de rdf:first sg:person.01114457210.07
206 rdf:rest Nfc11387730a44ce393e7f6b6cbbef8cd
207 Neae4bc62644d4a299970cb63c83bb2b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Male
209 rdf:type schema:DefinedTerm
210 Nf680b1f1bb8747129b5f6e6315520b91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Blood Platelets
212 rdf:type schema:DefinedTerm
213 Nf7b75bc7c6ab40c0a5de1e037ac6442a rdf:first sg:person.01362775372.06
214 rdf:rest N11734b2e2dcd4be2923ebb83ff561750
215 Nf9cf21a9a4d14f51a386e598691f56d4 schema:volumeNumber 4
216 rdf:type schema:PublicationVolume
217 Nfc11387730a44ce393e7f6b6cbbef8cd rdf:first sg:person.01041072320.67
218 rdf:rest N113be189c11245c9a40006b5d0567859
219 Nfdb9b0e60e5e4b59980bb7329dab7e91 rdf:first sg:person.01121304105.52
220 rdf:rest Nf7b75bc7c6ab40c0a5de1e037ac6442a
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
225 schema:name Immunology
226 rdf:type schema:DefinedTerm
227 sg:grant.2437926 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3657
228 rdf:type schema:MonetaryGrant
229 sg:grant.2438505 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3657
230 rdf:type schema:MonetaryGrant
231 sg:grant.2520141 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3657
232 rdf:type schema:MonetaryGrant
233 sg:grant.2674661 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3657
234 rdf:type schema:MonetaryGrant
235 sg:grant.2675081 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3657
236 rdf:type schema:MonetaryGrant
237 sg:journal.1043282 schema:issn 2041-1723
238 schema:name Nature Communications
239 rdf:type schema:Periodical
240 sg:person.01041072320.67 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
241 schema:familyName Li
242 schema:givenName Xiang-An
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041072320.67
244 rdf:type schema:Person
245 sg:person.01114457210.07 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
246 schema:familyName Guo
247 schema:givenName Ling
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114457210.07
249 rdf:type schema:Person
250 sg:person.01121304105.52 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
251 schema:familyName Whiteheart
252 schema:givenName Sidney W.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121304105.52
254 rdf:type schema:Person
255 sg:person.01246207373.87 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
256 schema:familyName Morris
257 schema:givenName Andrew J.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246207373.87
259 rdf:type schema:Person
260 sg:person.01302114700.87 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
261 schema:familyName Xiang
262 schema:givenName Binggang
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302114700.87
264 rdf:type schema:Person
265 sg:person.01362775372.06 schema:affiliation https://www.grid.ac/institutes/grid.413837.a
266 schema:familyName Smyth
267 schema:givenName Susan S.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362775372.06
269 rdf:type schema:Person
270 sg:person.0660174451.14 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
271 schema:familyName Daugherty
272 schema:givenName Alan
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660174451.14
274 rdf:type schema:Person
275 sg:person.0677541334.50 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
276 schema:familyName Li
277 schema:givenName Zhenyu
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677541334.50
279 rdf:type schema:Person
280 sg:person.0743330312.44 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
281 schema:familyName Zhang
282 schema:givenName Guoying
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743330312.44
284 rdf:type schema:Person
285 sg:pub.10.1007/s00281-011-0283-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023666054
286 https://doi.org/10.1007/s00281-011-0283-7
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00281-011-0286-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002488621
289 https://doi.org/10.1007/s00281-011-0286-4
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/38284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009509249
292 https://doi.org/10.1038/38284
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nm.1905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027601999
295 https://doi.org/10.1038/nm.1905
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nm1565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046780586
298 https://doi.org/10.1038/nm1565
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nri2956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047549707
301 https://doi.org/10.1038/nri2956
302 rdf:type schema:CreativeWork
303 sg:pub.10.1186/1476-9255-7-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006225025
304 https://doi.org/10.1186/1476-9255-7-53
305 rdf:type schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1074353219 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1076891062 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1077534755 schema:CreativeWork
309 https://doi.org/10.1016/0092-8674(93)90134-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1047648459
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/0092-8674(95)90126-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010609542
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/1074-7613(95)90001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022406028
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.bbi.2004.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026307158
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.blre.2009.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011753650
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.thromres.2010.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050979621
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0014-5793(97)01377-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030015972
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0090-6980(98)00061-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030876897
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.m111.239608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009273230
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1080/10245330512331390177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058358077
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1084/jem.173.4.1021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007206638
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1084/jem.180.6.2365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044652573
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1086/315093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035680660
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1089/jir.2011.0062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059281304
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/infdis/163.1.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059702403
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/infdis/175.1.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019165835
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1097/00003246-200204000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030680935
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1097/00024382-200204000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018684308
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1097/00024382-200206000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000937290
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1097/01.ccm.0000145906.63859.1a schema:sameAs https://app.dimensions.ai/details/publication/pub.1041463270
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1097/01.shk.0000108399.56565.e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005626692
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1097/01.shk.0000129338.99410.5d schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563390
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1097/moh.0b013e328309ec74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025657498
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1111/j.1365-2141.2008.06999.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039926219
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1111/j.1538-7836.2006.02192.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014373302
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1111/j.1538-7836.2007.02865.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011467606
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1128/aac.36.10.2139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036881405
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1146/annurev.med.45.1.491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050494435
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1152/ajplung.2001.281.3.l537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074864865
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1172/jci117921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033599584
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1172/jci118575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018745714
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1172/jci12242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000439993
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1172/jci27209. schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416916
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1172/jci38432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021998570
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1172/jci39421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002558827
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1172/jci5116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045455366
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1172/jci65154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041197320
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1177/0310057x0703500604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077534755
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1182/blood-2005-03-0916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031065817
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1182/blood-2005-06-2202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015689477
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1182/blood-2006-06-029082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052749525
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1182/blood-2007-11-123620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042871764
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1182/blood-2010-02-270934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032673064
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1182/blood-2011-08-376822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027044660
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1182/blood-2012-02-413047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013275796
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1378/chest.06-2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009495104
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1615/critreveukargeneexpr.v20.i2.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131101
402 rdf:type schema:CreativeWork
403 https://doi.org/10.4049/jimmunol.0802884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038586542
404 rdf:type schema:CreativeWork
405 https://doi.org/10.4049/jimmunol.1002788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078388984
406 rdf:type schema:CreativeWork
407 https://doi.org/10.4049/jimmunol.180.4.2125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012772371
408 rdf:type schema:CreativeWork
409 https://doi.org/10.4049/jimmunol.181.5.3495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012696867
410 rdf:type schema:CreativeWork
411 https://www.grid.ac/institutes/grid.266539.d schema:alternateName University of Kentucky
412 schema:name Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
413 Department of Pediatrics, University of Kentucky, Lexington, Kentucky 40536, USA
414 Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.413837.a schema:alternateName Lexington VA Medical Center
417 schema:name Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA
418 Veterans Affairs Medical Center, Lexington, Kentucky 40536, USA
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...