Sox17 is indispensable for acquisition and maintenance of arterial identity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-24

AUTHORS

Monica Corada, Fabrizio Orsenigo, Marco Francesco Morini, Mara Elena Pitulescu, Ganesh Bhat, Daniel Nyqvist, Ferruccio Breviario, Valentina Conti, Anais Briot, M. Luisa Iruela-Arispe, Ralf H. Adams, Elisabetta Dejana

ABSTRACT

The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the mouse embryo and in mouse postnatal retina and adult. Endothelial cell-specific inactivation of Sox17 in the mouse embryo is accompanied by a lack of arterial differentiation and vascular remodelling that results in embryo death in utero. In mouse postnatal retina, abrogation of Sox17 expression in endothelial cells leads to strong vascular hypersprouting, loss of arterial identity and large arteriovenous malformations. Mechanistically, Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system. These data introduce Sox17 as a component of the complex signalling network that orchestrates arterial/venous specification. More... »

PAGES

2609

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms3609

DOI

http://dx.doi.org/10.1038/ncomms3609

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002050615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24153254


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arteries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endoderm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HMGB Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Morphogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Notch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SOXF Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Veins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7678.e", 
          "name": [
            "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corada", 
        "givenName": "Monica", 
        "id": "sg:person.01212440413.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212440413.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7678.e", 
          "name": [
            "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orsenigo", 
        "givenName": "Fabrizio", 
        "id": "sg:person.0651376113.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651376113.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7678.e", 
          "name": [
            "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morini", 
        "givenName": "Marco Francesco", 
        "id": "sg:person.01337313631.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337313631.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of M\u00fcnster, 48149, M\u00fcnster, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of M\u00fcnster, 48149, M\u00fcnster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pitulescu", 
        "givenName": "Mara Elena", 
        "id": "sg:person.01146442273.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146442273.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7678.e", 
          "name": [
            "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhat", 
        "givenName": "Ganesh", 
        "id": "sg:person.0664527027.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664527027.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nyqvist", 
        "givenName": "Daniel", 
        "id": "sg:person.01002313742.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002313742.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7678.e", 
          "name": [
            "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Breviario", 
        "givenName": "Ferruccio", 
        "id": "sg:person.01107151035.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107151035.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Regenerative Medicine, Stem Cells and Gene Therapy DIBIT H San Raffaele, 20132, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Division of Regenerative Medicine, Stem Cells and Gene Therapy DIBIT H San Raffaele, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conti", 
        "givenName": "Valentina", 
        "id": "sg:person.01350305365.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350305365.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular, Cell and Developmental Biology, University of California, 90095, Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Molecular, Cell and Developmental Biology, University of California, 90095, Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Briot", 
        "givenName": "Anais", 
        "id": "sg:person.01363516304.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363516304.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular, Cell and Developmental Biology, University of California, 90095, Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Molecular, Cell and Developmental Biology, University of California, 90095, Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iruela-Arispe", 
        "givenName": "M. Luisa", 
        "id": "sg:person.012267523157.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267523157.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of M\u00fcnster, 48149, M\u00fcnster, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of M\u00fcnster, 48149, M\u00fcnster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "Ralf H.", 
        "id": "sg:person.0702247561.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702247561.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, School of Sciences, University of Milan, 20122, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy", 
            "Department of Biological Sciences, School of Sciences, University of Milan, 20122, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dejana", 
        "givenName": "Elisabetta", 
        "id": "sg:person.0735202624.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735202624.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncb2724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002628015", 
          "https://doi.org/10.1038/ncb2724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2040-2384-1-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050872056", 
          "https://doi.org/10.1186/2040-2384-1-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008937050", 
          "https://doi.org/10.1038/ng.240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040300876", 
          "https://doi.org/10.1038/nature07391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029404187", 
          "https://doi.org/10.1038/nature10908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049496060", 
          "https://doi.org/10.1038/nrm2183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048727190", 
          "https://doi.org/10.1038/ncb1752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028883419", 
          "https://doi.org/10.1038/nature09002"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10-24", 
    "datePublishedReg": "2013-10-24", 
    "description": "The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the mouse embryo and in mouse postnatal retina and adult. Endothelial cell-specific inactivation of Sox17 in the mouse embryo is accompanied by a lack of arterial differentiation and vascular remodelling that results in embryo death in utero. In mouse postnatal retina, abrogation of Sox17 expression in endothelial cells leads to strong vascular hypersprouting, loss of arterial identity and large arteriovenous malformations. Mechanistically, Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system. These data introduce Sox17 as a component of the complex signalling network that orchestrates arterial/venous specification.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ncomms3609", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3779225", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3778115", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "mouse postnatal retina", 
      "mouse embryos", 
      "arterial identity", 
      "downstream transcription factors", 
      "postnatal retina", 
      "transcription factor Sox17", 
      "cell-specific inactivation", 
      "venous specification", 
      "functional diversity", 
      "arterial differentiation", 
      "transcription factors", 
      "hemopoietic differentiation", 
      "SOX17", 
      "SOX17 expression", 
      "Wnt system", 
      "Notch system", 
      "embryo death", 
      "embryos", 
      "endothelial cells", 
      "differentiation", 
      "hypersprouting", 
      "vascular remodelling", 
      "regulator", 
      "diversity", 
      "venous endothelium", 
      "upstream", 
      "pathway", 
      "Mechanistically", 
      "abrogation", 
      "inactivation", 
      "expression", 
      "downstream", 
      "identity", 
      "cells", 
      "remodelling", 
      "maintenance", 
      "retina", 
      "endothelium", 
      "death", 
      "loss", 
      "components", 
      "factors", 
      "acquisition", 
      "system", 
      "complex systems", 
      "lack", 
      "utero", 
      "malformations", 
      "data", 
      "results", 
      "network", 
      "specification", 
      "adults", 
      "large arteriovenous malformations", 
      "arteriovenous malformations", 
      "vein", 
      "artery"
    ], 
    "name": "Sox17 is indispensable for acquisition and maintenance of arterial identity", 
    "pagination": "2609", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002050615"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms3609"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24153254"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms3609", 
      "https://app.dimensions.ai/details/publication/pub.1002050615"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_594.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ncomms3609"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms3609'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms3609'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms3609'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms3609'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      108 URIs      92 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms3609 schema:about N0cb301e74ede48d483648d6b513e7264
2 N19cceaf1255649e59224ece4acc9bfe1
3 N3113b1fee4ac4f919c275d1e0c3f7e22
4 N6bd5d9fdb20049f288da4cc160a0d837
5 N716c592f437646f78bfd28e517e76d1f
6 N758cb228ea6c4b6584e9ec0f2de0b98e
7 N8b7361995b12461c9d20b909ebb16171
8 N9628ee4f2e6b4b83ad1e05444e3f68e1
9 N987551998b9343c09fa6d4a05fdf0dba
10 Nb300829b770e450bbc7bba2f2615b257
11 Nbb8a1ca81a44410796b1e4d1942bd53d
12 Nc0c19e899ae24f92965ee19537fcfa7e
13 Nc1873dc2f896496f852205980062d088
14 Nc6a652a0fadc4a97b3eb1efdf1104364
15 Ncd01bfbbc4b943509caf322eefe10ba6
16 Ndd89916481414824b81515e731b8782b
17 Nf18103f7a4524b4fa038c83bf67add54
18 Nf533a07de6254446923cea843e735e38
19 anzsrc-for:06
20 anzsrc-for:0604
21 schema:author N0be713f99bad45f28cb290c961941aec
22 schema:citation sg:pub.10.1038/nature07391
23 sg:pub.10.1038/nature09002
24 sg:pub.10.1038/nature10908
25 sg:pub.10.1038/ncb1752
26 sg:pub.10.1038/ncb2724
27 sg:pub.10.1038/ng.240
28 sg:pub.10.1038/nrm2183
29 sg:pub.10.1186/2040-2384-1-8
30 schema:datePublished 2013-10-24
31 schema:datePublishedReg 2013-10-24
32 schema:description The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the mouse embryo and in mouse postnatal retina and adult. Endothelial cell-specific inactivation of Sox17 in the mouse embryo is accompanied by a lack of arterial differentiation and vascular remodelling that results in embryo death in utero. In mouse postnatal retina, abrogation of Sox17 expression in endothelial cells leads to strong vascular hypersprouting, loss of arterial identity and large arteriovenous malformations. Mechanistically, Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system. These data introduce Sox17 as a component of the complex signalling network that orchestrates arterial/venous specification.
33 schema:genre article
34 schema:isAccessibleForFree true
35 schema:isPartOf N75f6f271df054116934fa58e2aafcb44
36 Ne4c819f25ea0472788dd1431e38dbe56
37 sg:journal.1043282
38 schema:keywords Mechanistically
39 Notch system
40 SOX17
41 SOX17 expression
42 Wnt system
43 abrogation
44 acquisition
45 adults
46 arterial differentiation
47 arterial identity
48 arteriovenous malformations
49 artery
50 cell-specific inactivation
51 cells
52 complex systems
53 components
54 data
55 death
56 differentiation
57 diversity
58 downstream
59 downstream transcription factors
60 embryo death
61 embryos
62 endothelial cells
63 endothelium
64 expression
65 factors
66 functional diversity
67 hemopoietic differentiation
68 hypersprouting
69 identity
70 inactivation
71 lack
72 large arteriovenous malformations
73 loss
74 maintenance
75 malformations
76 mouse embryos
77 mouse postnatal retina
78 network
79 pathway
80 postnatal retina
81 regulator
82 remodelling
83 results
84 retina
85 specification
86 system
87 transcription factor Sox17
88 transcription factors
89 upstream
90 utero
91 vascular remodelling
92 vein
93 venous endothelium
94 venous specification
95 schema:name Sox17 is indispensable for acquisition and maintenance of arterial identity
96 schema:pagination 2609
97 schema:productId N99273a8dfe564933959d52a96edcbe17
98 Na941feb3b0e74012a95c8b80ac3fa460
99 Nd8bdd0fd520c41c7975369ead97a3df4
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002050615
101 https://doi.org/10.1038/ncomms3609
102 schema:sdDatePublished 2022-10-01T06:38
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nb01afa502ef048ab9d6e77b67b7d218f
105 schema:url https://doi.org/10.1038/ncomms3609
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0be713f99bad45f28cb290c961941aec rdf:first sg:person.01212440413.97
110 rdf:rest Ne8fd62074dbe4fa891e2fc29a3093e29
111 N0cb301e74ede48d483648d6b513e7264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name SOXF Transcription Factors
113 rdf:type schema:DefinedTerm
114 N0e0e114526e643a885bb01debb1c4273 rdf:first sg:person.01146442273.21
115 rdf:rest N787cc4811eec4d539ab79a1ef84bdc6d
116 N19cceaf1255649e59224ece4acc9bfe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Mice
118 rdf:type schema:DefinedTerm
119 N28f00feb9470434093eb57877525d7b2 rdf:first sg:person.01337313631.16
120 rdf:rest N0e0e114526e643a885bb01debb1c4273
121 N3113b1fee4ac4f919c275d1e0c3f7e22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Receptors, Notch
123 rdf:type schema:DefinedTerm
124 N336759bda2be48ff99ed413b190b5844 rdf:first sg:person.01107151035.00
125 rdf:rest Ndd1d37a930d84b29993be6956e82dd66
126 N5927cc593e6e4efbbba07cbd3dfcd44e rdf:first sg:person.0735202624.49
127 rdf:rest rdf:nil
128 N5fef0d10847f4cbf95db38874881a229 rdf:first sg:person.0702247561.03
129 rdf:rest N5927cc593e6e4efbbba07cbd3dfcd44e
130 N6bd5d9fdb20049f288da4cc160a0d837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals
132 rdf:type schema:DefinedTerm
133 N6c838edbba8448d8b87c5a5d6d95f34f rdf:first sg:person.01363516304.85
134 rdf:rest Nfc26e3c2392546d1b48183830602914f
135 N716c592f437646f78bfd28e517e76d1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Retina
137 rdf:type schema:DefinedTerm
138 N758cb228ea6c4b6584e9ec0f2de0b98e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Neovascularization, Pathologic
140 rdf:type schema:DefinedTerm
141 N75f6f271df054116934fa58e2aafcb44 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 N787cc4811eec4d539ab79a1ef84bdc6d rdf:first sg:person.0664527027.01
144 rdf:rest N90db3c0f27df4649b7e84a4715e9c31b
145 N8b7361995b12461c9d20b909ebb16171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Morphogenesis
147 rdf:type schema:DefinedTerm
148 N90db3c0f27df4649b7e84a4715e9c31b rdf:first sg:person.01002313742.46
149 rdf:rest N336759bda2be48ff99ed413b190b5844
150 N9628ee4f2e6b4b83ad1e05444e3f68e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cell Proliferation
152 rdf:type schema:DefinedTerm
153 N987551998b9343c09fa6d4a05fdf0dba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cell Differentiation
155 rdf:type schema:DefinedTerm
156 N99273a8dfe564933959d52a96edcbe17 schema:name pubmed_id
157 schema:value 24153254
158 rdf:type schema:PropertyValue
159 Na941feb3b0e74012a95c8b80ac3fa460 schema:name dimensions_id
160 schema:value pub.1002050615
161 rdf:type schema:PropertyValue
162 Nb01afa502ef048ab9d6e77b67b7d218f schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 Nb300829b770e450bbc7bba2f2615b257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Endoderm
166 rdf:type schema:DefinedTerm
167 Nbb8a1ca81a44410796b1e4d1942bd53d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Expression Regulation, Developmental
169 rdf:type schema:DefinedTerm
170 Nc0c19e899ae24f92965ee19537fcfa7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Endothelial Cells
172 rdf:type schema:DefinedTerm
173 Nc1873dc2f896496f852205980062d088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Wnt Proteins
175 rdf:type schema:DefinedTerm
176 Nc6a652a0fadc4a97b3eb1efdf1104364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Veins
178 rdf:type schema:DefinedTerm
179 Ncd01bfbbc4b943509caf322eefe10ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Embryo, Mammalian
181 rdf:type schema:DefinedTerm
182 Nd8bdd0fd520c41c7975369ead97a3df4 schema:name doi
183 schema:value 10.1038/ncomms3609
184 rdf:type schema:PropertyValue
185 Ndd1d37a930d84b29993be6956e82dd66 rdf:first sg:person.01350305365.23
186 rdf:rest N6c838edbba8448d8b87c5a5d6d95f34f
187 Ndd89916481414824b81515e731b8782b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Signal Transduction
189 rdf:type schema:DefinedTerm
190 Ne4c819f25ea0472788dd1431e38dbe56 schema:volumeNumber 4
191 rdf:type schema:PublicationVolume
192 Ne8fd62074dbe4fa891e2fc29a3093e29 rdf:first sg:person.0651376113.68
193 rdf:rest N28f00feb9470434093eb57877525d7b2
194 Nf18103f7a4524b4fa038c83bf67add54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name HMGB Proteins
196 rdf:type schema:DefinedTerm
197 Nf533a07de6254446923cea843e735e38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Arteries
199 rdf:type schema:DefinedTerm
200 Nfc26e3c2392546d1b48183830602914f rdf:first sg:person.012267523157.16
201 rdf:rest N5fef0d10847f4cbf95db38874881a229
202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biological Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
206 schema:name Genetics
207 rdf:type schema:DefinedTerm
208 sg:grant.3778115 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3609
209 rdf:type schema:MonetaryGrant
210 sg:grant.3779225 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3609
211 rdf:type schema:MonetaryGrant
212 sg:journal.1043282 schema:issn 2041-1723
213 schema:name Nature Communications
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.01002313742.46 schema:affiliation grid-institutes:grid.4714.6
217 schema:familyName Nyqvist
218 schema:givenName Daniel
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002313742.46
220 rdf:type schema:Person
221 sg:person.01107151035.00 schema:affiliation grid-institutes:grid.7678.e
222 schema:familyName Breviario
223 schema:givenName Ferruccio
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107151035.00
225 rdf:type schema:Person
226 sg:person.01146442273.21 schema:affiliation grid-institutes:grid.5949.1
227 schema:familyName Pitulescu
228 schema:givenName Mara Elena
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146442273.21
230 rdf:type schema:Person
231 sg:person.01212440413.97 schema:affiliation grid-institutes:grid.7678.e
232 schema:familyName Corada
233 schema:givenName Monica
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212440413.97
235 rdf:type schema:Person
236 sg:person.012267523157.16 schema:affiliation grid-institutes:grid.19006.3e
237 schema:familyName Iruela-Arispe
238 schema:givenName M. Luisa
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267523157.16
240 rdf:type schema:Person
241 sg:person.01337313631.16 schema:affiliation grid-institutes:grid.7678.e
242 schema:familyName Morini
243 schema:givenName Marco Francesco
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337313631.16
245 rdf:type schema:Person
246 sg:person.01350305365.23 schema:affiliation grid-institutes:None
247 schema:familyName Conti
248 schema:givenName Valentina
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350305365.23
250 rdf:type schema:Person
251 sg:person.01363516304.85 schema:affiliation grid-institutes:grid.19006.3e
252 schema:familyName Briot
253 schema:givenName Anais
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363516304.85
255 rdf:type schema:Person
256 sg:person.0651376113.68 schema:affiliation grid-institutes:grid.7678.e
257 schema:familyName Orsenigo
258 schema:givenName Fabrizio
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651376113.68
260 rdf:type schema:Person
261 sg:person.0664527027.01 schema:affiliation grid-institutes:grid.7678.e
262 schema:familyName Bhat
263 schema:givenName Ganesh
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664527027.01
265 rdf:type schema:Person
266 sg:person.0702247561.03 schema:affiliation grid-institutes:grid.5949.1
267 schema:familyName Adams
268 schema:givenName Ralf H.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702247561.03
270 rdf:type schema:Person
271 sg:person.0735202624.49 schema:affiliation grid-institutes:grid.4708.b
272 schema:familyName Dejana
273 schema:givenName Elisabetta
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735202624.49
275 rdf:type schema:Person
276 sg:pub.10.1038/nature07391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040300876
277 https://doi.org/10.1038/nature07391
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nature09002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028883419
280 https://doi.org/10.1038/nature09002
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nature10908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029404187
283 https://doi.org/10.1038/nature10908
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/ncb1752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048727190
286 https://doi.org/10.1038/ncb1752
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/ncb2724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002628015
289 https://doi.org/10.1038/ncb2724
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/ng.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008937050
292 https://doi.org/10.1038/ng.240
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrm2183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049496060
295 https://doi.org/10.1038/nrm2183
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/2040-2384-1-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050872056
298 https://doi.org/10.1186/2040-2384-1-8
299 rdf:type schema:CreativeWork
300 grid-institutes:None schema:alternateName Division of Regenerative Medicine, Stem Cells and Gene Therapy DIBIT H San Raffaele, 20132, Milan, Italy
301 schema:name Division of Regenerative Medicine, Stem Cells and Gene Therapy DIBIT H San Raffaele, 20132, Milan, Italy
302 rdf:type schema:Organization
303 grid-institutes:grid.19006.3e schema:alternateName Department of Molecular, Cell and Developmental Biology, University of California, 90095, Los Angeles, California, USA
304 schema:name Department of Molecular, Cell and Developmental Biology, University of California, 90095, Los Angeles, California, USA
305 rdf:type schema:Organization
306 grid-institutes:grid.4708.b schema:alternateName Department of Biological Sciences, School of Sciences, University of Milan, 20122, Milan, Italy
307 schema:name Department of Biological Sciences, School of Sciences, University of Milan, 20122, Milan, Italy
308 FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy
309 rdf:type schema:Organization
310 grid-institutes:grid.4714.6 schema:alternateName Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden
311 schema:name Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77, Stockholm, Sweden
312 rdf:type schema:Organization
313 grid-institutes:grid.5949.1 schema:alternateName Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of Münster, 48149, Münster, Germany
314 schema:name Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of Münster, 48149, Münster, Germany
315 rdf:type schema:Organization
316 grid-institutes:grid.7678.e schema:alternateName FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy
317 schema:name FIRC Institute of Molecular Oncology (IFOM), 20139, Milan, Italy
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...