Brown fat in a protoendothermic mammal fuels eutherian evolution View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Rebecca Oelkrug, Nadja Goetze, Cornelia Exner, Yang Lee, Goutham K. Ganjam, Maria Kutschke, Saskia Müller, Sigrid Stöhr, Matthias H. Tschöp, Paul G. Crichton, Gerhard Heldmaier, Martin Jastroch, Carola W. Meyer

ABSTRACT

Endothermy has facilitated mammalian species radiation, but the sequence of events leading to sustained thermogenesis is debated in multiple evolutionary models. Here we study the Lesser hedgehog tenrec (Echinops telfairi), a phylogenetically ancient, 'protoendothermic' eutherian mammal, in which constantly high body temperatures are reported only during reproduction. Evidence for nonshivering thermogenesis is found in vivo during periodic ectothermic-endothermic transitions. Anatomical studies reveal large brown fat-like structures in the proximity of the reproductive organs, suggesting physiological significance for parental care. Biochemical analysis demonstrates high mitochondrial proton leak catalysed by an uncoupling protein 1 ortholog. Strikingly, bioenergetic profiling of tenrec uncoupling protein 1 reveals similar thermogenic potency as modern mouse uncoupling protein 1, despite the large phylogenetic distance. The discovery of functional brown adipose tissue in this 'protoendothermic' mammal links nonshivering thermogenesis directly to the roots of eutherian evolution, suggesting physiological importance prior to sustained body temperatures and migration to the cold. More... »

PAGES

2140

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms3140

DOI

http://dx.doi.org/10.1038/ncomms3140

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002714632

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23860571


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms3140'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms3140'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms3140'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms3140'


 

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310 schema:name Department of Animal Physiology, Faculty of Biology, Philipps-Universität, Karl-von-Frisch Strasse 8, 35043 Marburg, Germany
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