Evaluating cell lines as tumour models by comparison of genomic profiles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Silvia Domcke, Rileen Sinha, Douglas A. Levine, Chris Sander, Nikolaus Schultz

ABSTRACT

Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour samples from the Cancer Genome Atlas now allow a systematic genomic comparison of cell lines and tumours. Here we analyse a panel of 47 ovarian cancer cell lines and identify those that have the highest genetic similarity to ovarian tumours. Our comparison of copy-number changes, mutations and mRNA expression profiles reveals pronounced differences in molecular profiles between commonly used ovarian cancer cell lines and high-grade serous ovarian cancer tumour samples. We identify several rarely used cell lines that more closely resemble cognate tumour profiles than commonly used cell lines, and we propose these lines as the most suitable models of ovarian cancer. Our results indicate that the gap between cell lines and tumours can be bridged by genomically informed choices of cell line models for all tumour types. More... »

PAGES

2126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms3126

DOI

http://dx.doi.org/10.1038/ncomms3126

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043513580

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23839242


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystadenocarcinoma, Serous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multigene Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, New York 10065, USA", 
            "Department of Chemistry, Technische Universit\u00e4t M\u00fcnchen, Lichtenbergstra\u00dfe 4, 85747 Garching bei M\u00fcnchen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Domcke", 
        "givenName": "Silvia", 
        "id": "sg:person.0773623227.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773623227.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, New York 10065, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sinha", 
        "givenName": "Rileen", 
        "id": "sg:person.0740326163.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740326163.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levine", 
        "givenName": "Douglas A.", 
        "id": "sg:person.0632441651.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632441651.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, New York 10065, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sander", 
        "givenName": "Chris", 
        "id": "sg:person.01265512777.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265512777.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, New York 10065, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schultz", 
        "givenName": "Nikolaus", 
        "id": "sg:person.0714746277.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714746277.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0603672103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000087419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000736346", 
          "https://doi.org/10.1038/nature10166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-5-55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002743293", 
          "https://doi.org/10.1186/1476-4598-5-55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(01)02659-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003575805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910530415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005521211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.4002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006074645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1008433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006460072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006485690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408105102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007202718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009226044", 
          "https://doi.org/10.1038/nrc2946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009226044", 
          "https://doi.org/10.1038/nrc2946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pathol.4.110807.092246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009704640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010131460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010584001", 
          "https://doi.org/10.1038/modpathol.3800017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010584001", 
          "https://doi.org/10.1038/modpathol.3800017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-7-166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010693402", 
          "https://doi.org/10.1186/1471-2164-7-166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011831914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012708027", 
          "https://doi.org/10.1038/onc.2010.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012708027", 
          "https://doi.org/10.1038/onc.2010.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015648147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1111840108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016078211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000227787.24587.d1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017432913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000227787.24587.d1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017432913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000227787.24587.d1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017432913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457673", 
          "https://doi.org/10.1186/gb-2004-5-10-r80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.22082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018806178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019307928", 
          "https://doi.org/10.1038/nbt.1754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b4fffa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019505999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b4fffa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019505999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pap.0b013e3181b4fffa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019505999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020886244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020886244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2006.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022342259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-11-0323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023906170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4644(20010601)81:3<488::aid-jcb1062>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023969065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10540-005-2797-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023969276", 
          "https://doi.org/10.1007/s10540-005-2797-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10540-005-2797-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023969276", 
          "https://doi.org/10.1007/s10540-005-2797-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024285779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030499478", 
          "https://doi.org/10.1038/sj.onc.1207979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030499478", 
          "https://doi.org/10.1038/sj.onc.1207979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2012.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030768250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032388482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033031313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2012-0028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035357486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036060000", 
          "https://doi.org/10.1038/nature11003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037243238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0410-322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038433746", 
          "https://doi.org/10.1038/nbt0410-322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039985972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040039999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2007.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041084171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042069193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2008.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043377409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043525752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2011.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047621265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101080.35393.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048334618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101080.35393.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048334618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/95.6.484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049943179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050184498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051717242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-2178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052105944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053036406", 
          "https://doi.org/10.1038/nrc3144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1963.10500845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058299788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074658148", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079998605", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081653406", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082133877", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083269026", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour samples from the Cancer Genome Atlas now allow a systematic genomic comparison of cell lines and tumours. Here we analyse a panel of 47 ovarian cancer cell lines and identify those that have the highest genetic similarity to ovarian tumours. Our comparison of copy-number changes, mutations and mRNA expression profiles reveals pronounced differences in molecular profiles between commonly used ovarian cancer cell lines and high-grade serous ovarian cancer tumour samples. We identify several rarely used cell lines that more closely resemble cognate tumour profiles than commonly used cell lines, and we propose these lines as the most suitable models of ovarian cancer. Our results indicate that the gap between cell lines and tumours can be bridged by genomically informed choices of cell line models for all tumour types. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms3126", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696332", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Evaluating cell lines as tumour models by comparison of genomic profiles", 
    "pagination": "2126", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cf458ffc236ae3923ac8676b02142e858e0524ed41b4598e5beb4ea116245088"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23839242"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms3126"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043513580"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms3126", 
      "https://app.dimensions.ai/details/publication/pub.1043513580"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms3126"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms3126'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms3126'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms3126'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms3126'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      100 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms3126 schema:about N013652e1ace8473e9dc648453ab30709
2 N0fb5788553044b33bc4a5395df4971cc
3 N1902bc71a25647e9bab66d1f28a60ec2
4 N2c52ca764f6242bd9c3384fd6cad1601
5 N4acf5e7711e0456fbf132827e69c360e
6 N6a240401d49d4ff883e86fc600aa059f
7 N912c912636874ffea1a35d7e58953044
8 Na5827eaae3fe4169b7d35b2f4e831633
9 Na5905e96952040e4aa3985c0391e027f
10 Nbeb4c4bf78624796a7301f87f6ed8142
11 Nc57433990f0e44cd81b4bf44e76f9386
12 Nd35b471686f84855badda660a814c597
13 Ndf35cc8f2c844f8b9f9abe1d4164c35b
14 Ne7907ec3e9264de5a21f54bd7d59ec8f
15 Necf3d980b6fd421297c46cca1ebf31a4
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author Nf2d9e8ca668144998a037ee7d2cfbc28
19 schema:citation sg:pub.10.1007/s10540-005-2797-5
20 sg:pub.10.1038/modpathol.3800017
21 sg:pub.10.1038/nature10166
22 sg:pub.10.1038/nature11003
23 sg:pub.10.1038/nbt.1754
24 sg:pub.10.1038/nbt0410-322
25 sg:pub.10.1038/nrc2946
26 sg:pub.10.1038/nrc3144
27 sg:pub.10.1038/onc.2010.245
28 sg:pub.10.1038/sj.onc.1207979
29 sg:pub.10.1186/1471-2164-7-166
30 sg:pub.10.1186/1476-4598-5-55
31 sg:pub.10.1186/gb-2004-5-10-r80
32 https://app.dimensions.ai/details/publication/pub.1074658148
33 https://app.dimensions.ai/details/publication/pub.1079998605
34 https://app.dimensions.ai/details/publication/pub.1081653406
35 https://app.dimensions.ai/details/publication/pub.1082133877
36 https://app.dimensions.ai/details/publication/pub.1083269026
37 https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2
38 https://doi.org/10.1002/1097-4644(20010601)81:3<488::aid-jcb1062>3.0.co;2-4
39 https://doi.org/10.1002/ijc.22082
40 https://doi.org/10.1002/ijc.2910530415
41 https://doi.org/10.1002/path.1521
42 https://doi.org/10.1002/path.2659
43 https://doi.org/10.1002/path.2696
44 https://doi.org/10.1002/path.4002
45 https://doi.org/10.1016/j.canlet.2011.12.003
46 https://doi.org/10.1016/j.humpath.2006.10.007
47 https://doi.org/10.1016/j.humpath.2008.01.003
48 https://doi.org/10.1016/j.ygyno.2007.12.013
49 https://doi.org/10.1016/j.ygyno.2012.06.017
50 https://doi.org/10.1016/s0014-5793(01)02659-x
51 https://doi.org/10.1056/nejmoa1008433
52 https://doi.org/10.1073/pnas.0408105102
53 https://doi.org/10.1073/pnas.0603672103
54 https://doi.org/10.1073/pnas.1111840108
55 https://doi.org/10.1080/01621459.1963.10500845
56 https://doi.org/10.1093/jnci/95.6.484
57 https://doi.org/10.1097/01.aog.0000227787.24587.d1
58 https://doi.org/10.1097/01.pgp.0000101080.35393.16
59 https://doi.org/10.1097/pap.0b013e3181b4fffa
60 https://doi.org/10.1146/annurev.pathol.4.110807.092246
61 https://doi.org/10.1158/0008-5472.can-03-3383
62 https://doi.org/10.1158/0008-5472.can-04-2933
63 https://doi.org/10.1158/0008-5472.can-05-2620
64 https://doi.org/10.1158/0008-5472.can-05-3434
65 https://doi.org/10.1158/0008-5472.can-08-0755
66 https://doi.org/10.1158/0008-5472.can-09-3833
67 https://doi.org/10.1158/0008-5472.can-11-2178
68 https://doi.org/10.1158/0008-5472.can-11-3911
69 https://doi.org/10.1158/1078-0432.ccr-03-0537
70 https://doi.org/10.1158/1078-0432.ccr-11-0945
71 https://doi.org/10.1158/2159-8290.cd-11-0323
72 https://doi.org/10.1158/2159-8290.cd-12-0095
73 https://doi.org/10.1634/theoncologist.2012-0028
74 https://doi.org/10.3322/caac.20073
75 schema:datePublished 2013-12
76 schema:datePublishedReg 2013-12-01
77 schema:description Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour samples from the Cancer Genome Atlas now allow a systematic genomic comparison of cell lines and tumours. Here we analyse a panel of 47 ovarian cancer cell lines and identify those that have the highest genetic similarity to ovarian tumours. Our comparison of copy-number changes, mutations and mRNA expression profiles reveals pronounced differences in molecular profiles between commonly used ovarian cancer cell lines and high-grade serous ovarian cancer tumour samples. We identify several rarely used cell lines that more closely resemble cognate tumour profiles than commonly used cell lines, and we propose these lines as the most suitable models of ovarian cancer. Our results indicate that the gap between cell lines and tumours can be bridged by genomically informed choices of cell line models for all tumour types.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf N2c65c8e70c9f4d3881463cd63d585460
82 N564b0c17c7e3468999ada85f6c075326
83 sg:journal.1043282
84 schema:name Evaluating cell lines as tumour models by comparison of genomic profiles
85 schema:pagination 2126
86 schema:productId N2e684f6c4676434e915c069e1be96779
87 N3f6bfa4fc4ea4fc18bbb1f2cb44494a3
88 N5d15c7a122de4b0493d411cc0e9abc0f
89 Nc66dc58de6004b9989da814aadd18ec8
90 Nfaff1056eb5144b098f2c56fce375968
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043513580
92 https://doi.org/10.1038/ncomms3126
93 schema:sdDatePublished 2019-04-11T00:56
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Nd8d2eddff26843a0a604c89969378ec5
96 schema:url https://www.nature.com/articles/ncomms3126
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N013652e1ace8473e9dc648453ab30709 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Cystadenocarcinoma, Serous
102 rdf:type schema:DefinedTerm
103 N03e6074bafa74544aef027993a5c0c28 rdf:first sg:person.0632441651.51
104 rdf:rest N186c95860011464a838eb20d8b19644e
105 N0fb5788553044b33bc4a5395df4971cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Transcriptome
107 rdf:type schema:DefinedTerm
108 N186c95860011464a838eb20d8b19644e rdf:first sg:person.01265512777.31
109 rdf:rest N67f28b8429ae4be1af5a68e7c5a6fa7d
110 N1902bc71a25647e9bab66d1f28a60ec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N2c52ca764f6242bd9c3384fd6cad1601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Organ Specificity
115 rdf:type schema:DefinedTerm
116 N2c65c8e70c9f4d3881463cd63d585460 schema:issueNumber 1
117 rdf:type schema:PublicationIssue
118 N2e684f6c4676434e915c069e1be96779 schema:name doi
119 schema:value 10.1038/ncomms3126
120 rdf:type schema:PropertyValue
121 N3f6bfa4fc4ea4fc18bbb1f2cb44494a3 schema:name pubmed_id
122 schema:value 23839242
123 rdf:type schema:PropertyValue
124 N4acf5e7711e0456fbf132827e69c360e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Genome, Human
126 rdf:type schema:DefinedTerm
127 N564b0c17c7e3468999ada85f6c075326 schema:volumeNumber 4
128 rdf:type schema:PublicationVolume
129 N5d15c7a122de4b0493d411cc0e9abc0f schema:name readcube_id
130 schema:value cf458ffc236ae3923ac8676b02142e858e0524ed41b4598e5beb4ea116245088
131 rdf:type schema:PropertyValue
132 N67f28b8429ae4be1af5a68e7c5a6fa7d rdf:first sg:person.0714746277.26
133 rdf:rest rdf:nil
134 N6a240401d49d4ff883e86fc600aa059f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Ovarian Neoplasms
136 rdf:type schema:DefinedTerm
137 N6cdb9161d4174f069dfa8a830a9ae994 rdf:first sg:person.0740326163.34
138 rdf:rest N03e6074bafa74544aef027993a5c0c28
139 N912c912636874ffea1a35d7e58953044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Gene Dosage
141 rdf:type schema:DefinedTerm
142 Na5827eaae3fe4169b7d35b2f4e831633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name RNA, Messenger
144 rdf:type schema:DefinedTerm
145 Na5905e96952040e4aa3985c0391e027f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Female
147 rdf:type schema:DefinedTerm
148 Nbeb4c4bf78624796a7301f87f6ed8142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Genome-Wide Association Study
150 rdf:type schema:DefinedTerm
151 Nc57433990f0e44cd81b4bf44e76f9386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mutation
153 rdf:type schema:DefinedTerm
154 Nc66dc58de6004b9989da814aadd18ec8 schema:name dimensions_id
155 schema:value pub.1043513580
156 rdf:type schema:PropertyValue
157 Nd35b471686f84855badda660a814c597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Models, Biological
159 rdf:type schema:DefinedTerm
160 Nd8d2eddff26843a0a604c89969378ec5 schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 Ndf35cc8f2c844f8b9f9abe1d4164c35b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Multigene Family
164 rdf:type schema:DefinedTerm
165 Ne7907ec3e9264de5a21f54bd7d59ec8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gene Expression Regulation, Neoplastic
167 rdf:type schema:DefinedTerm
168 Necf3d980b6fd421297c46cca1ebf31a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cell Line, Tumor
170 rdf:type schema:DefinedTerm
171 Nf2d9e8ca668144998a037ee7d2cfbc28 rdf:first sg:person.0773623227.34
172 rdf:rest N6cdb9161d4174f069dfa8a830a9ae994
173 Nfaff1056eb5144b098f2c56fce375968 schema:name nlm_unique_id
174 schema:value 101528555
175 rdf:type schema:PropertyValue
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
180 schema:name Oncology and Carcinogenesis
181 rdf:type schema:DefinedTerm
182 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3126
183 rdf:type schema:MonetaryGrant
184 sg:grant.2696332 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms3126
185 rdf:type schema:MonetaryGrant
186 sg:journal.1043282 schema:issn 2041-1723
187 schema:name Nature Communications
188 rdf:type schema:Periodical
189 sg:person.01265512777.31 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
190 schema:familyName Sander
191 schema:givenName Chris
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265512777.31
193 rdf:type schema:Person
194 sg:person.0632441651.51 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
195 schema:familyName Levine
196 schema:givenName Douglas A.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632441651.51
198 rdf:type schema:Person
199 sg:person.0714746277.26 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
200 schema:familyName Schultz
201 schema:givenName Nikolaus
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714746277.26
203 rdf:type schema:Person
204 sg:person.0740326163.34 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
205 schema:familyName Sinha
206 schema:givenName Rileen
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740326163.34
208 rdf:type schema:Person
209 sg:person.0773623227.34 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
210 schema:familyName Domcke
211 schema:givenName Silvia
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773623227.34
213 rdf:type schema:Person
214 sg:pub.10.1007/s10540-005-2797-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023969276
215 https://doi.org/10.1007/s10540-005-2797-5
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/modpathol.3800017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010584001
218 https://doi.org/10.1038/modpathol.3800017
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
221 https://doi.org/10.1038/nature10166
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nature11003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060000
224 https://doi.org/10.1038/nature11003
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
227 https://doi.org/10.1038/nbt.1754
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/nbt0410-322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038433746
230 https://doi.org/10.1038/nbt0410-322
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nrc2946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009226044
233 https://doi.org/10.1038/nrc2946
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/nrc3144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053036406
236 https://doi.org/10.1038/nrc3144
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/onc.2010.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012708027
239 https://doi.org/10.1038/onc.2010.245
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/sj.onc.1207979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030499478
242 https://doi.org/10.1038/sj.onc.1207979
243 rdf:type schema:CreativeWork
244 sg:pub.10.1186/1471-2164-7-166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010693402
245 https://doi.org/10.1186/1471-2164-7-166
246 rdf:type schema:CreativeWork
247 sg:pub.10.1186/1476-4598-5-55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002743293
248 https://doi.org/10.1186/1476-4598-5-55
249 rdf:type schema:CreativeWork
250 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
251 https://doi.org/10.1186/gb-2004-5-10-r80
252 rdf:type schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1074658148 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1079998605 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1081653406 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082133877 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1083269026 schema:CreativeWork
258 https://doi.org/10.1002/(sici)1097-0215(19990827)82:5<625::aid-ijc1>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015648147
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/1097-4644(20010601)81:3<488::aid-jcb1062>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023969065
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/ijc.22082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018806178
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/ijc.2910530415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005521211
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/path.1521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050184498
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1002/path.2659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020886244
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/path.2696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006485690
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/path.4002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006074645
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.canlet.2011.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047621265
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.humpath.2006.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022342259
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.humpath.2008.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043377409
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.ygyno.2007.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041084171
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.ygyno.2012.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030768250
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0014-5793(01)02659-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003575805
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1056/nejmoa1008433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006460072
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.0408105102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007202718
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.0603672103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000087419
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.1111840108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016078211
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1080/01621459.1963.10500845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058299788
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/jnci/95.6.484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049943179
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/01.aog.0000227787.24587.d1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017432913
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/01.pgp.0000101080.35393.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048334618
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/pap.0b013e3181b4fffa schema:sameAs https://app.dimensions.ai/details/publication/pub.1019505999
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1146/annurev.pathol.4.110807.092246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009704640
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1158/0008-5472.can-03-3383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039985972
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1158/0008-5472.can-04-2933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010131460
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1158/0008-5472.can-05-2620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032388482
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1158/0008-5472.can-05-3434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024285779
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1158/0008-5472.can-08-0755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040039999
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1158/0008-5472.can-09-3833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037243238
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1158/0008-5472.can-11-2178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052105944
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1158/0008-5472.can-11-3911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043525752
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1158/1078-0432.ccr-03-0537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051717242
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1158/1078-0432.ccr-11-0945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033031313
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/2159-8290.cd-11-0323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023906170
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1634/theoncologist.2012-0028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035357486
331 rdf:type schema:CreativeWork
332 https://doi.org/10.3322/caac.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069193
333 rdf:type schema:CreativeWork
334 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
335 schema:name Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, New York 10065, USA
336 Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
339 schema:name Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, New York 10065, USA
340 Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching bei München, Germany
341 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...