Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Alaguraj Veluchamy, Xin Lin, Florian Maumus, Maximo Rivarola, Jaysheel Bhavsar, Todd Creasy, Kimberly O’Brien, Naomi A. Sengamalay, Luke J. Tallon, Andrew D. Smith, Edda Rayko, Ikhlak Ahmed, Stéphane Le Crom, Gregory K. Farrant, Jean-Yves Sgro, Sue A. Olson, Sandra Splinter Bondurant, Andrew E. Allen, Pablo D. Rabinowicz, Michael R. Sussman, Chris Bowler, Leïla Tirichine

ABSTRACT

DNA cytosine methylation is a widely conserved epigenetic mark in eukaryotes that appears to have critical roles in the regulation of genome structure and transcription. Genome-wide methylation maps have so far only been established from the supergroups Archaeplastida and Unikont. Here we report the first whole-genome methylome from a stramenopile, the marine model diatom Phaeodactylum tricornutum. Around 6% of the genome is intermittently methylated in a mosaic pattern. We find extensive methylation in transposable elements. We also detect methylation in over 320 genes. Extensive gene methylation correlates strongly with transcriptional silencing and differential expression under specific conditions. By contrast, we find that genes with partial methylation tend to be constitutively expressed. These patterns contrast with those found previously in other eukaryotes. By going beyond plants, animals and fungi, this stramenopile methylome adds significantly to our understanding of the evolution of DNA methylation in eukaryotes. More... »

PAGES

2091

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ncomms3091

    DOI

    http://dx.doi.org/10.1038/ncomms3091

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008160641

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23820484


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