Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Euan S. Polson, John L. Lewis, Hamza Celik, Vincent M. Mann, Michael J. Stower, Matthew S. Simms, Greta Rodrigues, Anne T. Collins, Norman J. Maitland

ABSTRACT

While chromosomal translocations have a fundamental role in the development of several human leukaemias, their role in solid tumour development has been somewhat more controversial. Recently, it was shown that up to 80% of prostate tumours harbour at least one such gene fusion, and that the most common fusion event, between the prostate-specific TMPRSS2 gene and the ERG oncogene, is a critical, and probably early factor in prostate cancer development. Here we demonstrate the presence and expression of this significant chromosomal rearrangement in prostate cancer stem cells. Moreover, we show that in the prostate epithelial hierarchy from both normal and tumour tissues, TMPRSS2 transcription is subjected to tight monoallelic regulation, which is retained upon asymmetric division and relaxed during epithelial cell differentiation. The presence and expression of TMPRSS2/ERG in prostate stem cells would provide ERG-driven survival advantages, allowing maintenance of this mutated genotype. More... »

PAGES

1623

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ncomms2627

DOI

http://dx.doi.org/10.1038/ncomms2627

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025003374

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23535644


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Southern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire YO10 5DD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polson", 
        "givenName": "Euan S.", 
        "id": "sg:person.011457371357.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011457371357.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire YO10 5DD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewis", 
        "givenName": "John L.", 
        "id": "sg:person.01010326164.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010326164.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Chimie Bact\u00e9rienne", 
          "id": "https://www.grid.ac/institutes/grid.469471.9", 
          "name": [
            "Laboratoire de Chimie Bact\u00e9rienne, UMR7283-CNRS, Aix-Marseille Universit\u00e9, 13009 Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Celik", 
        "givenName": "Hamza", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hull York Medical School, University of Hull, Hull, Humberside HU6 7RX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "Vincent M.", 
        "id": "sg:person.01017057336.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017057336.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "York Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417375.3", 
          "name": [
            "York District Hospital, York, North Yorkshire YO31 8HE, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stower", 
        "givenName": "Michael J.", 
        "id": "sg:person.011060642347.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011060642347.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Castle Hill Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413509.a", 
          "name": [
            "Hull York Medical School, University of Hull, Hull, Humberside HU6 7RX, UK", 
            "Department of Urology, Castle Hill Hospital, Cottingham, Humberside HU16 5JQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simms", 
        "givenName": "Matthew S.", 
        "id": "sg:person.01333711416.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333711416.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hull Royal Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.417704.1", 
          "name": [
            "Department of Pathology, Hull Royal Infirmary, Hull, Humberside HU3 2JZ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodrigues", 
        "givenName": "Greta", 
        "id": "sg:person.01307116364.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307116364.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire YO10 5DD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collins", 
        "givenName": "Anne T.", 
        "id": "sg:person.013171204102.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013171204102.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire YO10 5DD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maitland", 
        "givenName": "Norman J.", 
        "id": "sg:person.01201421136.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201421136.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/pros.2990150506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003914374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007374245", 
          "https://doi.org/10.1038/sj.onc.1210070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007374245", 
          "https://doi.org/10.1038/sj.onc.1210070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009573885", 
          "https://doi.org/10.1038/ni.1617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0028162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013620247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014026121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-1761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018691337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pcan.2009.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019990129", 
          "https://doi.org/10.1038/pcan.2009.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022771587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1150648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024710638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12672-010-0058-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025567991", 
          "https://doi.org/10.1007/s12672-010-0058-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372143a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027517345", 
          "https://doi.org/10.1038/372143a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1117679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028743308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2011.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028803687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrurol.2009.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030944708", 
          "https://doi.org/10.1038/nrurol.2009.127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrurol.2009.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030944708", 
          "https://doi.org/10.1038/nrurol.2009.127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1430269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033478042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2005.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035160848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2011.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036916816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0026348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038583646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-2051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040908649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043696319", 
          "https://doi.org/10.1038/sj.onc.1210640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2008-9-5-r83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044588961", 
          "https://doi.org/10.1186/gb-2008-9-5-r83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-2449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044890392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045432573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045810309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.06421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046533863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0041668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049756982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049961568", 
          "https://doi.org/10.1038/ng.370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050855811", 
          "https://doi.org/10.1186/1471-2407-10-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.15.1472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051492042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-10-94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052268947", 
          "https://doi.org/10.1186/1476-4598-10-94"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2009211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052326834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074517585", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074957528", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/25.1.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076512026"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "While chromosomal translocations have a fundamental role in the development of several human leukaemias, their role in solid tumour development has been somewhat more controversial. Recently, it was shown that up to 80% of prostate tumours harbour at least one such gene fusion, and that the most common fusion event, between the prostate-specific TMPRSS2 gene and the ERG oncogene, is a critical, and probably early factor in prostate cancer development. Here we demonstrate the presence and expression of this significant chromosomal rearrangement in prostate cancer stem cells. Moreover, we show that in the prostate epithelial hierarchy from both normal and tumour tissues, TMPRSS2 transcription is subjected to tight monoallelic regulation, which is retained upon asymmetric division and relaxed during epithelial cell differentiation. The presence and expression of TMPRSS2/ERG in prostate stem cells would provide ERG-driven survival advantages, allowing maintenance of this mutated genotype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ncomms2627", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2759136", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells", 
    "pagination": "1623", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "771d6293ddbf31e83646f5be07fe32ad39a4af8200cda4468e899518b09c010c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23535644"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ncomms2627"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025003374"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ncomms2627", 
      "https://app.dimensions.ai/details/publication/pub.1025003374"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ncomms2627"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms2627'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms2627'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms2627'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms2627'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ncomms2627 schema:about N0e64a2cc7db041dd98dd64388b6ee5fa
2 N2444741f0b6249369520fc3d09d9219f
3 N2cd3ab5bcf224b1ab6a4b26c5eb5de98
4 N52db8f143a8e4c8aafd1f992c57700dc
5 N6d5473d8ca77425dbdbf2728d0539742
6 N969f7727722b4d14b4f117ce648869bc
7 N98033702c6e94ff7afa7a5c9b98ff8f3
8 N9b657cb0ccaf410280b1a54ab82e5f4c
9 N9b8b1bcb4db9411bb7f1c3f7dce18da4
10 Nb5e8f48f5e4a477c8c8f653f5826e0f4
11 Nde444b73579f4abf97cebc30457af029
12 Ndeee5052417b4b0b84b4796e62464507
13 Nf2636453890745ee9de7e03554937b70
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author Nf0100c556a714a8db7f0e7f4401bfc7c
17 schema:citation sg:pub.10.1007/s12672-010-0058-y
18 sg:pub.10.1038/372143a0
19 sg:pub.10.1038/ng.370
20 sg:pub.10.1038/ni.1617
21 sg:pub.10.1038/nrurol.2009.127
22 sg:pub.10.1038/pcan.2009.28
23 sg:pub.10.1038/sj.onc.1210070
24 sg:pub.10.1038/sj.onc.1210640
25 sg:pub.10.1186/1471-2407-10-3
26 sg:pub.10.1186/1476-4598-10-94
27 sg:pub.10.1186/gb-2008-9-5-r83
28 https://app.dimensions.ai/details/publication/pub.1074517585
29 https://app.dimensions.ai/details/publication/pub.1074957528
30 https://doi.org/10.1002/pros.2990150506
31 https://doi.org/10.1016/j.mce.2011.07.008
32 https://doi.org/10.1016/j.stem.2011.07.007
33 https://doi.org/10.1016/j.tcb.2005.07.004
34 https://doi.org/10.1093/jnci/25.1.85
35 https://doi.org/10.1093/jnci/djn150
36 https://doi.org/10.1101/gad.2009211
37 https://doi.org/10.1126/science.1117679
38 https://doi.org/10.1126/science.1150648
39 https://doi.org/10.1158/0008-5472.can-05-2018
40 https://doi.org/10.1158/0008-5472.can-07-1761
41 https://doi.org/10.1158/0008-5472.can-07-6154
42 https://doi.org/10.1158/1078-0432.ccr-07-2051
43 https://doi.org/10.1158/1078-0432.ccr-11-2449
44 https://doi.org/10.1200/jco.2007.15.1472
45 https://doi.org/10.1242/jcs.01222
46 https://doi.org/10.1371/journal.pone.0026348
47 https://doi.org/10.1371/journal.pone.0028162
48 https://doi.org/10.1371/journal.pone.0041668
49 https://doi.org/10.1593/neo.06421
50 https://doi.org/10.1677/joe.0.1430269
51 schema:datePublished 2013-12
52 schema:datePublishedReg 2013-12-01
53 schema:description While chromosomal translocations have a fundamental role in the development of several human leukaemias, their role in solid tumour development has been somewhat more controversial. Recently, it was shown that up to 80% of prostate tumours harbour at least one such gene fusion, and that the most common fusion event, between the prostate-specific TMPRSS2 gene and the ERG oncogene, is a critical, and probably early factor in prostate cancer development. Here we demonstrate the presence and expression of this significant chromosomal rearrangement in prostate cancer stem cells. Moreover, we show that in the prostate epithelial hierarchy from both normal and tumour tissues, TMPRSS2 transcription is subjected to tight monoallelic regulation, which is retained upon asymmetric division and relaxed during epithelial cell differentiation. The presence and expression of TMPRSS2/ERG in prostate stem cells would provide ERG-driven survival advantages, allowing maintenance of this mutated genotype.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N18a28a20f4d04de79edcc394261090ba
58 N7997bd01da8c45ffa8d707c06fb7ac77
59 sg:journal.1043282
60 schema:name Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells
61 schema:pagination 1623
62 schema:productId N0ec02c9c97c94df79a91046715e0fd47
63 N6b026b1d5d5a4ec0ad857a6b4c8618a8
64 N7634aeaa67734ffc909ed6dc52391fe2
65 N7ebb1365e858469bb57519749db99f90
66 Nc322ad02e0244bc9aec735199db68418
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025003374
68 https://doi.org/10.1038/ncomms2627
69 schema:sdDatePublished 2019-04-11T00:05
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N7bc09c04b6704a9189449b7884e379d1
72 schema:url https://www.nature.com/articles/ncomms2627
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0e64a2cc7db041dd98dd64388b6ee5fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name DNA Methylation
78 rdf:type schema:DefinedTerm
79 N0ec02c9c97c94df79a91046715e0fd47 schema:name dimensions_id
80 schema:value pub.1025003374
81 rdf:type schema:PropertyValue
82 N18a28a20f4d04de79edcc394261090ba schema:issueNumber 1
83 rdf:type schema:PublicationIssue
84 N2444741f0b6249369520fc3d09d9219f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Neoplastic Stem Cells
86 rdf:type schema:DefinedTerm
87 N2cd3ab5bcf224b1ab6a4b26c5eb5de98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name In Situ Hybridization, Fluorescence
89 rdf:type schema:DefinedTerm
90 N44bb951e6759448ab5f23d96ad515968 rdf:first sg:person.011060642347.14
91 rdf:rest Nab007f61698448429a139b1df4887373
92 N4a86c767de25488093b53a8532a566da rdf:first Ne7e3cda6ce3945988bf782c7ca32aa87
93 rdf:rest Nbc822f3fc75b4421acf2d8ebdc86c8c7
94 N52db8f143a8e4c8aafd1f992c57700dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Male
96 rdf:type schema:DefinedTerm
97 N66b4c6f74cec41348f7b189472945cc4 rdf:first sg:person.01307116364.41
98 rdf:rest N8801cbb104434c249261f35744cc4688
99 N6b026b1d5d5a4ec0ad857a6b4c8618a8 schema:name readcube_id
100 schema:value 771d6293ddbf31e83646f5be07fe32ad39a4af8200cda4468e899518b09c010c
101 rdf:type schema:PropertyValue
102 N6b7f49e5fe564c158a6b686fc3079c2a rdf:first sg:person.01201421136.25
103 rdf:rest rdf:nil
104 N6d5473d8ca77425dbdbf2728d0539742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Humans
106 rdf:type schema:DefinedTerm
107 N7634aeaa67734ffc909ed6dc52391fe2 schema:name doi
108 schema:value 10.1038/ncomms2627
109 rdf:type schema:PropertyValue
110 N7997bd01da8c45ffa8d707c06fb7ac77 schema:volumeNumber 4
111 rdf:type schema:PublicationVolume
112 N7bc09c04b6704a9189449b7884e379d1 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N7ebb1365e858469bb57519749db99f90 schema:name nlm_unique_id
115 schema:value 101528555
116 rdf:type schema:PropertyValue
117 N8801cbb104434c249261f35744cc4688 rdf:first sg:person.013171204102.03
118 rdf:rest N6b7f49e5fe564c158a6b686fc3079c2a
119 N8c10d11ad4eb431a86220b01ebfe7215 rdf:first sg:person.01010326164.38
120 rdf:rest N4a86c767de25488093b53a8532a566da
121 N95b5ff1cb9754f3289dff0f609a54375 schema:name Hull York Medical School, University of Hull, Hull, Humberside HU6 7RX, UK
122 rdf:type schema:Organization
123 N969f7727722b4d14b4f117ce648869bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Blotting, Southern
125 rdf:type schema:DefinedTerm
126 N98033702c6e94ff7afa7a5c9b98ff8f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Immunohistochemistry
128 rdf:type schema:DefinedTerm
129 N9b657cb0ccaf410280b1a54ab82e5f4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name DNA Primers
131 rdf:type schema:DefinedTerm
132 N9b8b1bcb4db9411bb7f1c3f7dce18da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Alleles
134 rdf:type schema:DefinedTerm
135 Nab007f61698448429a139b1df4887373 rdf:first sg:person.01333711416.82
136 rdf:rest N66b4c6f74cec41348f7b189472945cc4
137 Nb5e8f48f5e4a477c8c8f653f5826e0f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Base Sequence
139 rdf:type schema:DefinedTerm
140 Nbc822f3fc75b4421acf2d8ebdc86c8c7 rdf:first sg:person.01017057336.93
141 rdf:rest N44bb951e6759448ab5f23d96ad515968
142 Nc322ad02e0244bc9aec735199db68418 schema:name pubmed_id
143 schema:value 23535644
144 rdf:type schema:PropertyValue
145 Nde444b73579f4abf97cebc30457af029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Oncogene Proteins, Fusion
147 rdf:type schema:DefinedTerm
148 Ndeee5052417b4b0b84b4796e62464507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Prostatic Neoplasms
150 rdf:type schema:DefinedTerm
151 Ne7e3cda6ce3945988bf782c7ca32aa87 schema:affiliation https://www.grid.ac/institutes/grid.469471.9
152 schema:familyName Celik
153 schema:givenName Hamza
154 rdf:type schema:Person
155 Nf0100c556a714a8db7f0e7f4401bfc7c rdf:first sg:person.011457371357.67
156 rdf:rest N8c10d11ad4eb431a86220b01ebfe7215
157 Nf2636453890745ee9de7e03554937b70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Reverse Transcriptase Polymerase Chain Reaction
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
164 schema:name Oncology and Carcinogenesis
165 rdf:type schema:DefinedTerm
166 sg:grant.2759136 http://pending.schema.org/fundedItem sg:pub.10.1038/ncomms2627
167 rdf:type schema:MonetaryGrant
168 sg:journal.1043282 schema:issn 2041-1723
169 schema:name Nature Communications
170 rdf:type schema:Periodical
171 sg:person.01010326164.38 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
172 schema:familyName Lewis
173 schema:givenName John L.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010326164.38
175 rdf:type schema:Person
176 sg:person.01017057336.93 schema:affiliation N95b5ff1cb9754f3289dff0f609a54375
177 schema:familyName Mann
178 schema:givenName Vincent M.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017057336.93
180 rdf:type schema:Person
181 sg:person.011060642347.14 schema:affiliation https://www.grid.ac/institutes/grid.417375.3
182 schema:familyName Stower
183 schema:givenName Michael J.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011060642347.14
185 rdf:type schema:Person
186 sg:person.011457371357.67 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
187 schema:familyName Polson
188 schema:givenName Euan S.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011457371357.67
190 rdf:type schema:Person
191 sg:person.01201421136.25 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
192 schema:familyName Maitland
193 schema:givenName Norman J.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201421136.25
195 rdf:type schema:Person
196 sg:person.01307116364.41 schema:affiliation https://www.grid.ac/institutes/grid.417704.1
197 schema:familyName Rodrigues
198 schema:givenName Greta
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307116364.41
200 rdf:type schema:Person
201 sg:person.013171204102.03 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
202 schema:familyName Collins
203 schema:givenName Anne T.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013171204102.03
205 rdf:type schema:Person
206 sg:person.01333711416.82 schema:affiliation https://www.grid.ac/institutes/grid.413509.a
207 schema:familyName Simms
208 schema:givenName Matthew S.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333711416.82
210 rdf:type schema:Person
211 sg:pub.10.1007/s12672-010-0058-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025567991
212 https://doi.org/10.1007/s12672-010-0058-y
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/372143a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027517345
215 https://doi.org/10.1038/372143a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ng.370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049961568
218 https://doi.org/10.1038/ng.370
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/ni.1617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009573885
221 https://doi.org/10.1038/ni.1617
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nrurol.2009.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030944708
224 https://doi.org/10.1038/nrurol.2009.127
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/pcan.2009.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019990129
227 https://doi.org/10.1038/pcan.2009.28
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/sj.onc.1210070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007374245
230 https://doi.org/10.1038/sj.onc.1210070
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.onc.1210640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043696319
233 https://doi.org/10.1038/sj.onc.1210640
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/1471-2407-10-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050855811
236 https://doi.org/10.1186/1471-2407-10-3
237 rdf:type schema:CreativeWork
238 sg:pub.10.1186/1476-4598-10-94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052268947
239 https://doi.org/10.1186/1476-4598-10-94
240 rdf:type schema:CreativeWork
241 sg:pub.10.1186/gb-2008-9-5-r83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044588961
242 https://doi.org/10.1186/gb-2008-9-5-r83
243 rdf:type schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1074517585 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1074957528 schema:CreativeWork
246 https://doi.org/10.1002/pros.2990150506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003914374
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.mce.2011.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036916816
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.stem.2011.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028803687
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.tcb.2005.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035160848
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/jnci/25.1.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076512026
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1093/jnci/djn150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045432573
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1101/gad.2009211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052326834
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1126/science.1117679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028743308
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.1150648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024710638
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1158/0008-5472.can-05-2018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014026121
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1158/0008-5472.can-07-1761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018691337
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1158/0008-5472.can-07-6154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045810309
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1158/1078-0432.ccr-07-2051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040908649
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1158/1078-0432.ccr-11-2449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044890392
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1200/jco.2007.15.1472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051492042
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1242/jcs.01222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022771587
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1371/journal.pone.0026348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038583646
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1371/journal.pone.0028162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013620247
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1371/journal.pone.0041668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049756982
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1593/neo.06421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046533863
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1677/joe.0.1430269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033478042
287 rdf:type schema:CreativeWork
288 https://www.grid.ac/institutes/grid.413509.a schema:alternateName Castle Hill Hospital
289 schema:name Department of Urology, Castle Hill Hospital, Cottingham, Humberside HU16 5JQ, UK
290 Hull York Medical School, University of Hull, Hull, Humberside HU6 7RX, UK
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.417375.3 schema:alternateName York Hospital
293 schema:name York District Hospital, York, North Yorkshire YO31 8HE, UK
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.417704.1 schema:alternateName Hull Royal Infirmary
296 schema:name Department of Pathology, Hull Royal Infirmary, Hull, Humberside HU3 2JZ, UK
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.469471.9 schema:alternateName Laboratoire de Chimie Bactérienne
299 schema:name Laboratoire de Chimie Bactérienne, UMR7283-CNRS, Aix-Marseille Université, 13009 Marseille, France
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.5685.e schema:alternateName University of York
302 schema:name YCR Cancer Research Unit, Department of Biology, University of York, York, North Yorkshire YO10 5DD, UK
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...