Ontology type: schema:ScholarlyArticle Open Access: True
2013-12
AUTHORSL. de Vivo, S. Landi, M. Panniello, L. Baroncelli, S. Chierzi, L. Mariotti, M. Spolidoro, T. Pizzorusso, L. Maffei, G.M. Ratto
ABSTRACTBrain cells are immersed in a complex structure forming the extracellular matrix. The composition of the matrix gradually matures during postnatal development, as the brain circuitry reaches its adult form. The fully developed extracellular environment stabilizes neuronal connectivity and decreases cortical plasticity as highlighted by the demonstration that treatments degrading the matrix are able to restore synaptic plasticity in the adult brain. The mechanisms through which the matrix inhibits cortical plasticity are not fully clarified. Here we show that a prominent component of the matrix, chondroitin sulfate proteoglycans (CSPGs), restrains morphological changes of dendritic spines in the visual cortex of adult mice. By means of in vivo and in vitro two-photon imaging and electrophysiology, we find that after enzymatic digestion of CSPGs, cortical spines become more motile and express a larger degree of structural and functional plasticity. More... »
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http://scigraph.springernature.com/pub.10.1038/ncomms2491
DOIhttp://dx.doi.org/10.1038/ncomms2491
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"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101528555"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ncomms2491"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1042137777"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ncomms2491",
"https://app.dimensions.ai/details/publication/pub.1042137777"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T14:49",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000436.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ncomms2491"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ncomms2491'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ncomms2491'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ncomms2491'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ncomms2491'
This table displays all metadata directly associated to this object as RDF triples.
351 TRIPLES
21 PREDICATES
86 URIs
38 LITERALS
26 BLANK NODES